NP-MRD: Showing NP-Card for (−)-Feionemycin A (NP0350728)

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Record Information

Version

2.0

Created at

2025-02-09 15:46:35 UTC

Updated at

2025-02-11 15:50:03 UTC

NP-MRD ID

NP0350728

Natural Product DOI

https://doi.org/10.57994/3710

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(−)-Feionemycin A

Description

Based on a literature review very few articles have been published on (−)-Feionemycin A.

Structure

MOL SDF PDB SMILES InChI

  Mrv2104 05092315542D          

 24 27  0  0  1  0            999 V2000
    1.8532    1.0630    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2273    0.3277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0422    0.4562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4163   -0.2791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2401   -0.3228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6899    0.3688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5137    0.3251    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3158    1.1041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4920    1.1478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1179    1.8832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8325   -0.8621    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0977   -0.4871    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4061   -0.0373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6708   -0.4113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0209    0.0384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7562   -0.3356    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0229    0.8623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7582    1.2363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4498    0.7866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6270   -1.2352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3186   -1.6850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0540   -1.3109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7456   -1.7607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1083   -1.6092    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  3  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 11  1  0  0  0  0
 12 11  1  6  0  0  0
 12  2  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 13 19  1  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 12 22  1  0  0  0  0
 22 23  1  0  0  0  0
 20 24  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0350728

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1=CC(O)=CC2=C1C(=O)[C@@]1(O2)C(C)=CC(=O)C2=C1C=CC=C2O

> <INCHI_IDENTIFIER>
InChI=1S/C19H14O5/c1-9-6-11(20)8-15-16(9)18(23)19(24-15)10(2)7-14(22)17-12(19)4-3-5-13(17)21/h3-8,20-21H,1-2H3/t19-/m1/s1

> <INCHI_KEY>
YKSFLYHYTKZHOJ-LJQANCHMSA-N

> <FORMULA>
C19H14O5

> <MOLECULAR_WEIGHT>
322.316

> <EXACT_MASS>
322.084123551

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
38

> <JCHEM_AVERAGE_POLARIZABILITY>
32.54700220754444

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2R)-5',6-dihydroxy-2',4-dimethyl-3H,4'H-spiro[1-benzofuran-2,1'-naphthalene]-3,4'-dione

> <JCHEM_LOGP>
3.8249718779999995

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
8.6710986876452

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.710301602762535

> <JCHEM_PKA_STRONGEST_BASIC>
-5.016961642601178

> <JCHEM_POLAR_SURFACE_AREA>
83.83000000000001

> <JCHEM_REFRACTIVITY>
88.20989999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(2R)-5',6-dihydroxy-2',4-dimethylspiro[1-benzofuran-2,1'-naphthalene]-3,4'-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 09-MAY-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   09-MAY-23         0                                  
HETATM    1  O   UNK     0       3.459   1.984   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       4.158   0.612   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.679   0.852   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.377  -0.521   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.915  -0.603   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.754   0.688   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      10.292   0.607   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       8.056   2.061   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.518   2.143   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.820   3.515   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       5.287  -1.609   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       3.916  -0.909   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.625  -0.070   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       1.252  -0.768   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -0.039   0.072   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      -1.412  -0.626   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       0.043   1.610   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       1.415   2.308   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.706   1.468   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       1.170  -2.306   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.461  -3.145   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       3.834  -2.447   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       5.125  -3.287   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      -0.202  -3.004   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   12                                                  
CONECT    3    2    4    9                                                  
CONECT    4    3    5   11                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8    3   10                                                  
CONECT   10    9                                                            
CONECT   11    4   12                                                       
CONECT   12   11    2   13   22                                             
CONECT   13   12   14   19                                                  
CONECT   14   13   15   20                                                  
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   13                                                       
CONECT   20   14   21   24                                                  
CONECT   21   20   22                                                       
CONECT   22   21   12   23                                                  
CONECT   23   22                                                            
CONECT   24   20                                                            
MASTER        0    0    0    0    0    0    0    0   24    0   54    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₉H₁₄O₅

Average Mass

322.3160 Da

Monoisotopic Mass

322.08412 Da

IUPAC Name

(2R)-5',6-dihydroxy-2',4-dimethyl-3H,4'H-spiro[1-benzofuran-2,1'-naphthalene]-3,4'-dione

Traditional Name

(2R)-5',6-dihydroxy-2',4-dimethylspiro[1-benzofuran-2,1'-naphthalene]-3,4'-dione

CAS Registry Number

Not Available

SMILES

CC1=CC(O)=CC2=C1C(=O)[C@@]1(O2)C(C)=CC(=O)C2=C1C=CC=C2O

InChI Identifier

InChI=1S/C19H14O5/c1-9-6-11(20)8-15-16(9)18(23)19(24-15)10(2)7-14(22)17-12(19)4-3-5-13(17)21/h3-8,20-21H,1-2H3/t19-/m1/s1

InChI Key

YKSFLYHYTKZHOJ-LJQANCHMSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, C2D6OS, experimental)	hxf17853102898@163.com	中国海洋大学医药学院	Xiaofei Huang	2025-02-09	View Spectrum
HMBC NMR	[¹H, ¹³C] NMR Spectrum (2D, 500 MHz, C2D6OS, experimental)	hxf17853102898@163.com	中国海洋大学医药学院	Xiaofei Huang	2025-02-09	View Spectrum
HSQC NMR	[¹H, ¹³C] NMR Spectrum (2D, 500 MHz, C2D6OS, experimental)	hxf17853102898@163.com	中国海洋大学医药学院	Xiaofei Huang	2025-02-09	View Spectrum
COSY NMR	[¹H, ¹H] NMR Spectrum (2D, 500 MHz, C2D6OS, experimental)	hxf17853102898@163.com	中国海洋大学医药学院	Xiaofei Huang	2025-02-09	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, C2D6OS, experimental)	hxf17853102898@163.com	中国海洋大学医药学院	Xiaofei Huang	2025-02-09	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 500, C2D6OS, simulated)	hxf17853102898@163.com	中国海洋大学医药学院	Xiaofei Huang	2025-02-09	View Spectrum

Species

Species of Origin

Species Name	Source	Reference
Streptomyces coelicolor		Not Available

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.82	ChemAxon
pKa (Strongest Acidic)	7.71	ChemAxon
pKa (Strongest Basic)	-5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	83.83 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	88.21 m³·mol⁻¹	ChemAxon
Polarizability	32.55 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for (−)-Feionemycin A (NP0350728)

MOL for NP0350728 ((−)-Feionemycin A)

3D MOL for NP0350728 ((−)-Feionemycin A)

3D SDF for NP0350728 ((−)-Feionemycin A)

3D-SDF for NP0350728 ((−)-Feionemycin A)

PDB for NP0350728 ((−)-Feionemycin A)

3D PDB for NP0350728 ((−)-Feionemycin A)

SMILES for NP0350728 ((−)-Feionemycin A)

INCHI for NP0350728 ((−)-Feionemycin A)

Structure for NP0350728 ((−)-Feionemycin A)

3D Structure for NP0350728 ((−)-Feionemycin A)