NP-MRD: Showing NP-Card for 12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4 (NP0339034)

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Record Information

Version

2.0

Created at

2024-09-11 19:22:05 UTC

Updated at

2024-09-11 19:22:05 UTC

NP-MRD ID

NP0339034

Secondary Accession Numbers

None

Natural Product Identification

Common Name

12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4

Description

12-Oxo-10,11-dihydro-20-COOH-LTB4, also known as 12-oxo-10,11-dihydro-20-carboxy-LTB(,4), belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms. Thus, 12-oxo-10,11-dihydro-20-COOH-LTB4 is considered to be an eicosanoid lipid molecule. 12-Oxo-10,11-dihydro-20-COOH-LTB4 is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes) and leukotrienes from leukocytes, hence the derivation of their names. Leukotrienes are eicosanoids. Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. Biologically active LTB4 is metabolized by w-oxidation carried out by specific cytochrome P450s (CYP4F) followed by beta-oxidation from the w-carboxy position and after CoA ester formation. It was first documented in 2010 (PMID: 20044567). All mammalian cells except erythrocytes synthesize eicosanoids.

Structure

MOL SDF PDB SMILES InChI


  Mrv0541 02251208062D          

 26 25  0  0  1  0            999 V2000
   15.4784   -9.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.8909  -10.3645    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   16.7159  -10.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1284  -11.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.9534  -11.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.3659  -11.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.9534  -12.5079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   19.1909  -11.7934    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.4784  -11.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6534  -11.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2409  -10.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4159  -10.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0034   -9.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1784   -9.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7659   -8.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1784   -8.2210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9409   -8.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5284   -9.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7034   -9.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2909   -8.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4659   -8.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0534   -8.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2284   -8.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8159   -7.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2284   -6.7921    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9909   -7.5066    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  2  9  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  END


  Mrv0541 02251208062D          

 26 25  0  0  1  0            999 V2000
   15.4784   -9.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.8909  -10.3645    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   16.7159  -10.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1284  -11.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.9534  -11.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.3659  -11.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.9534  -12.5079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   19.1909  -11.7934    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.4784  -11.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6534  -11.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2409  -10.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4159  -10.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0034   -9.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1784   -9.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7659   -8.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1784   -8.2210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9409   -8.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5284   -9.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7034   -9.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2909   -8.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4659   -8.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0534   -8.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2284   -8.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8159   -7.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2284   -6.7921    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9909   -7.5066    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  2  9  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0339034

> <DATABASE_NAME>
NP-MRD

> <SMILES>
O[C@H](CCCC(O)=O)\C=C/C=C/CCC(=O)C\C=C/CCCCC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-6,8,13,18,22H,1,3,7,9-12,14-16H2,(H,23,24)(H,25,26)/b5-4+,6-2-,13-8-/t18-/m0/s1

> <INCHI_KEY>
RYMSXFPLTLWXCK-VJNSNPJLSA-N

> <FORMULA>
C20H30O6

> <MOLECULAR_WEIGHT>
366.4486

> <EXACT_MASS>
366.204238692

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_AVERAGE_POLARIZABILITY>
39.81711053369462

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(5R,6Z,8E,14Z)-5-hydroxy-12-oxoicosa-6,8,14-trienedioic acid

> <ALOGPS_LOGP>
3.14

> <JCHEM_LOGP>
3.2188219103333338

> <ALOGPS_LOGS>
-3.99

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
4.839876599906946

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.2325467783024155

> <JCHEM_PKA_STRONGEST_BASIC>
-1.545515117498037

> <JCHEM_POLAR_SURFACE_AREA>
111.9

> <JCHEM_REFRACTIVITY>
102.6597

> <JCHEM_ROTATABLE_BOND_COUNT>
16

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.72e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(5R,6Z,8E,14Z)-5-hydroxy-12-oxoicosa-6,8,14-trienedioic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 25-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   25-FEB-12         0                                  
HETATM    1  O   UNK     0      28.893 -18.013   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0      29.663 -19.347   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      31.203 -19.347   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      31.973 -20.681   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      33.513 -20.681   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      34.283 -22.014   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      33.513 -23.348   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0      35.823 -22.014   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      28.893 -20.681   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      27.353 -20.681   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      26.583 -19.347   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      25.043 -19.347   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      24.273 -18.013   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      22.733 -18.013   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      21.963 -16.680   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      22.733 -15.346   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0      20.423 -16.680   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      19.653 -18.013   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      18.113 -18.013   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      17.343 -16.680   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      15.803 -16.680   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      15.033 -15.346   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      13.493 -15.346   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      12.723 -14.012   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      13.493 -12.679   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0      11.183 -14.012   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    9                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6                                                            
CONECT    9    2   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24                                                            
MASTER        0    0    0    0    0    0    0    0   26    0   50    0
END

View in JSmol

Synonyms

Value	Source
(5S)-Hydroxy-12-oxo-(6Z,8E,14Z)-eicosatrienedioate	HMDB
(5S)-Hydroxy-12-oxo-(6Z,8E,14Z)-eicosatrienedioic acid	HMDB
12-oxo-10,11-Dihydro-20-carboxy-LTB(,4)	HMDB

Chemical Formula

C₂₀H₃₀O₆

Average Mass

366.4486 Da

Monoisotopic Mass

366.20424 Da

IUPAC Name

(5R,6Z,8E,14Z)-5-hydroxy-12-oxoicosa-6,8,14-trienedioic acid

Traditional Name

(5R,6Z,8E,14Z)-5-hydroxy-12-oxoicosa-6,8,14-trienedioic acid

CAS Registry Number

Not Available

SMILES

O[C@H](CCCC(O)=O)\C=C/C=C/CCC(=O)C\C=C/CCCCC(O)=O

InChI Identifier

InChI=1S/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-6,8,13,18,22H,1,3,7,9-12,14-16H2,(H,23,24)(H,25,26)/b5-4+,6-2-,13-8-/t18-/m0/s1

InChI Key

RYMSXFPLTLWXCK-VJNSNPJLSA-N

Experimental Spectra

Not Available

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty acids and conjugates

Direct Parent

Long-chain fatty acids

Alternative Parents

Substituents

Long-chain fatty acid
Hydroxy fatty acid
Keto fatty acid
Dicarboxylic acid or derivatives
Unsaturated fatty acid
Ketone
Secondary alcohol
Carboxylic acid
Carboxylic acid derivative
Alcohol
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Carbonyl group
Organooxygen compound
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.14	ALOGPS
logP	3.22	ChemAxon
logS	-4	ALOGPS
pKa (Strongest Acidic)	4.23	ChemAxon
pKa (Strongest Basic)	-1.5	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	111.9 Å²	ChemAxon
Rotatable Bond Count	16	ChemAxon
Refractivity	102.66 m³·mol⁻¹	ChemAxon
Polarizability	39.82 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0012549

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB029116

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

CPD-9839

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

53481456

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]

Showing NP-Card for 12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4 (NP0339034)

MOL for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)

3D MOL for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)

3D SDF for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)

3D-SDF for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)

PDB for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)

3D PDB for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)

SMILES for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)

INCHI for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)

Structure for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)

3D Structure for NP0339034 (12-Oxo-10,11-dihydro-20-carboxy-leukotriene B4)