NP-MRD: Showing NP-Card for 10,11-Dihydro-leukotriene B4 (NP0339024)

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Record Information

Version

2.0

Created at

2024-09-11 19:18:22 UTC

Updated at

2024-09-11 19:18:22 UTC

NP-MRD ID

NP0339024

Secondary Accession Numbers

None

Natural Product Identification

Common Name

10,11-Dihydro-leukotriene B4

Description

10,11-Dihydro-leukotriene B4, also known as 10,11-dihydro-LTB(,4) or DHLTB4, belongs to the class of organic compounds known as hydroxyeicosatrienoic acids. These are eicosanoic acids with an attached hydroxyl group and three CC double bonds. Thus, 10,11-dihydro-leukotriene B4 is considered to be an eicosanoid lipid molecule. The PGs and TXs are collectively identified as prostanoids. 10,11-Dihydro-leukotriene B4 is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. LTB4 is the major metabolite in neutrophil polymorphonuclear leukocytes. Leukotrienes are eicosanoids. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of 5-LO to the perinuclear region, and phosphorylation to either enhance or inhibit the activity of 5-LO. It was first documented in 1984 (PMID: 6088485). All mammalian cells except erythrocytes synthesize eicosanoids (PMID: 11413487) (PMID: 17623009) (PMID: 7649996) (PMID: 2853166).

Structure

MOL SDF PDB SMILES InChI


  Mrv0541 02251208062D          

 24 23  0  0  1  0            999 V2000
   15.5082   -9.6398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.2227  -10.0523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.2227  -10.8773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9372  -11.2898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9372  -12.1148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.6516  -12.5273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.6516  -13.3523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9372  -13.7648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.9372  -14.5899    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   17.6516  -15.0024    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   16.2227  -15.0024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5082  -14.5899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7937  -15.0024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0792  -14.5899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3647  -15.0024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6503  -14.5899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6503  -13.7648    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   11.9358  -13.3523    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.3647  -13.3523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3647  -12.5273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0792  -12.1148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0792  -11.2898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7937  -10.8773    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.3647  -10.8773    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  6  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  6  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0339024

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCC\C=C/C[C@H](O)CC\C=C\C=C/[C@H](O)CCCC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C20H34O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-9,11,15,18-19,21-22H,2-5,10,12-14,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,15-11-/t18-,19-/m0/s1

> <INCHI_KEY>
NKUPFHTVILUPKF-RNEQFKNCSA-N

> <FORMULA>
C20H34O4

> <MOLECULAR_WEIGHT>
338.4816

> <EXACT_MASS>
338.245709576

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_AVERAGE_POLARIZABILITY>
40.21032378935661

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(5R,6Z,8E,12R,14Z)-5,12-dihydroxyicosa-6,8,14-trienoic acid

> <ALOGPS_LOGP>
5.84

> <JCHEM_LOGP>
4.331562873666666

> <ALOGPS_LOGS>
-4.46

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
17.865306559197933

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.584102239638748

> <JCHEM_PKA_STRONGEST_BASIC>
-1.0842007383674774

> <JCHEM_POLAR_SURFACE_AREA>
77.75999999999999

> <JCHEM_REFRACTIVITY>
102.02239999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
15

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.18e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(5R,6Z,8E,12R,14Z)-5,12-dihydroxyicosa-6,8,14-trienoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 25-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   25-FEB-12         0                                  
HETATM    1  C   UNK     0      28.949 -17.994   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      30.282 -18.764   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      30.282 -20.304   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      31.616 -21.074   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      31.616 -22.614   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      32.950 -23.384   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      32.950 -24.924   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      31.616 -25.694   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      31.616 -27.234   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      32.950 -28.004   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0      30.282 -28.004   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      28.949 -27.234   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      27.615 -28.004   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      26.281 -27.234   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      24.947 -28.004   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      23.614 -27.234   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      23.614 -25.694   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0      22.280 -24.924   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0      24.947 -24.924   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      24.947 -23.384   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      26.281 -22.614   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      26.281 -21.074   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      27.615 -20.304   0.000  0.00  0.00           O+0
HETATM   24  O   UNK     0      24.947 -20.304   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22                                                            
MASTER        0    0    0    0    0    0    0    0   24    0   46    0
END

View in JSmol

Synonyms

Value	Source
(5S,12R)-Dihydroxy-(6Z,8E,14Z)-eicosa-6,8,14-trienoate	HMDB
(5S,12R)-Dihydroxy-(6Z,8E,14Z)-eicosa-6,8,14-trienoic acid	HMDB
(5S,12R)-Dihydroxy-(6Z,8E,14Z)-eicosatrienoate	HMDB
(5S,12R)-Dihydroxy-(6Z,8E,14Z)-eicosatrienoic acid	HMDB
10,11-Dihydro-LTB(,4)	HMDB
DHLTB4	HMDB

Chemical Formula

C₂₀H₃₄O₄

Average Mass

338.4816 Da

Monoisotopic Mass

338.24571 Da

IUPAC Name

(5R,6Z,8E,12R,14Z)-5,12-dihydroxyicosa-6,8,14-trienoic acid

Traditional Name

(5R,6Z,8E,12R,14Z)-5,12-dihydroxyicosa-6,8,14-trienoic acid

CAS Registry Number

Not Available

SMILES

CCCCC\C=C/C[C@H](O)CC\C=C\C=C/[C@H](O)CCCC(O)=O

InChI Identifier

InChI=1S/C20H34O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-9,11,15,18-19,21-22H,2-5,10,12-14,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,15-11-/t18-,19-/m0/s1

InChI Key

NKUPFHTVILUPKF-RNEQFKNCSA-N

Experimental Spectra

Not Available

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as hydroxyeicosatrienoic acids. These are eicosanoic acids with an attached hydroxyl group and three CC double bonds.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Eicosanoids

Direct Parent

Hydroxyeicosatrienoic acids

Alternative Parents

Substituents

Hydroxyeicosatrienoic acid
Long-chain fatty acid
Hydroxy fatty acid
Fatty acid
Unsaturated fatty acid
Secondary alcohol
Carboxylic acid derivative
Carboxylic acid
Monocarboxylic acid or derivatives
Organic oxide
Organic oxygen compound
Alcohol
Hydrocarbon derivative
Carbonyl group
Organooxygen compound
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.84	ALOGPS
logP	4.33	ChemAxon
logS	-4.5	ALOGPS
pKa (Strongest Acidic)	4.58	ChemAxon
pKa (Strongest Basic)	-1.1	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	77.76 Å²	ChemAxon
Rotatable Bond Count	15	ChemAxon
Refractivity	102.02 m³·mol⁻¹	ChemAxon
Polarizability	40.21 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0012504

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB029106

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

53481449

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
Murphy RC, Gijon MA: Biosynthesis and metabolism of leukotrienes. Biochem J. 2007 Aug 1;405(3):379-95. doi: 10.1042/BJ20070289. [PubMed:17623009 ]
Wheelan P, Murphy RC: Metabolism of 6-trans-isomers of leukotriene B4 in cultured hepatoma cells and in human polymorphonuclear leukocytes. Identification of a delta 6-reductase metabolic pathway. J Biol Chem. 1995 Aug 25;270(34):19845-52. doi: 10.1074/jbc.270.34.19845. [PubMed:7649996 ]
Mita H, Yui Y, Yasueda H, Shida T: Isocratic determination of arachidonic acid 5-lipoxygenase products in human neutrophils by high-performance liquid chromatography. J Chromatogr. 1988 Sep 9;430(2):299-308. doi: 10.1016/s0378-4347(00)83165-5. [PubMed:2853166 ]
Shak S, Goldstein IM: Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. J Biol Chem. 1984 Aug 25;259(16):10181-7. [PubMed:6088485 ]

Showing NP-Card for 10,11-Dihydro-leukotriene B4 (NP0339024)

MOL for NP0339024 (10,11-Dihydro-leukotriene B4)

3D MOL for NP0339024 (10,11-Dihydro-leukotriene B4)

3D SDF for NP0339024 (10,11-Dihydro-leukotriene B4)

3D-SDF for NP0339024 (10,11-Dihydro-leukotriene B4)

PDB for NP0339024 (10,11-Dihydro-leukotriene B4)

3D PDB for NP0339024 (10,11-Dihydro-leukotriene B4)

SMILES for NP0339024 (10,11-Dihydro-leukotriene B4)

INCHI for NP0339024 (10,11-Dihydro-leukotriene B4)

Structure for NP0339024 (10,11-Dihydro-leukotriene B4)

3D Structure for NP0339024 (10,11-Dihydro-leukotriene B4)