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Showing NP-Card for Tocophersolan (NP0338503)

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Record Information
Version2.0
Created at2024-09-11 15:47:29 UTC
Updated at2024-09-11 15:47:29 UTC
NP-MRD IDNP0338503
Secondary Accession NumbersNone
Natural Product Identification
Common NameTocophersolan
Description Tocophersolan was first documented in 2011 (PMID: 23861620). Based on a literature review a small amount of articles have been published on Tocophersolan (PMID: 36986583) (PMID: 32525772) (PMID: 30776407).
Structure
Thumb
MOLSDFPDBSMILESInChI

MOL for NP0338503 (Tocophersolan)


  Mrv2104 05262318192D          

 41 42  0  0  0  0            999 V2000
    7.1843   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8987   -6.6053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7566   -6.6053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6145   -6.6053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.9438   -3.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.3189   -3.4545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.4401   -5.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.9421   -6.4123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3277   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1856   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0435   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6132   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0422   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4711   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9000   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3290   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.8775   -5.5527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.3472   -4.9207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8152   -6.2690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7579   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0027   -6.4123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.5630   -6.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.0327   -5.8982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8987   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7566   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6145   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.6617   -3.9433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8492   -4.0865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.9098   -5.3505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.0973   -5.4938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.6900   -5.4094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.5347   -5.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.1920   -4.5753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.5670   -4.8618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4724   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   25.3755   -6.3869    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   22.9721   -4.6342    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.2526   -5.8392    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   23.2203   -6.0414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.0044   -4.4320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   16.7546   -5.0050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 12  9  1  0  0  0  0
 13  9  1  0  0  0  0
 14 10  1  0  0  0  0
 15 10  1  0  0  0  0
 16 11  1  0  0  0  0
 18 17  1  0  0  0  0
 20 11  1  0  0  0  0
 21 19  1  0  0  0  0
 23 22  1  0  0  0  0
 24  1  1  0  0  0  0
 24  2  1  0  0  0  0
 24 12  1  0  0  0  0
 25  3  1  0  0  0  0
 25 13  1  0  0  0  0
 25 14  1  0  0  0  0
 26  4  1  0  0  0  0
 26 15  1  0  0  0  0
 26 16  1  0  0  0  0
 27  5  1  0  0  0  0
 28  6  1  0  0  0  0
 28 27  1  0  0  0  0
 29  7  1  0  0  0  0
 30 19  1  0  0  0  0
 30 29  2  0  0  0  0
 31 17  1  0  0  0  0
 32 18  1  0  0  0  0
 33 27  2  0  0  0  0
 33 29  1  0  0  0  0
 34 28  2  0  0  0  0
 34 30  1  0  0  0  0
 35  8  1  0  0  0  0
 35 20  1  0  0  0  0
 35 21  1  0  0  0  0
 36 22  1  0  0  0  0
 37 31  2  0  0  0  0
 38 32  2  0  0  0  0
 39 23  1  0  0  0  0
 39 31  1  0  0  0  0
 40 32  1  0  0  0  0
 40 33  1  0  0  0  0
 41 34  1  0  0  0  0
 41 35  1  0  0  0  0
M  END
Download

3D MOL for NP0338503 (Tocophersolan)

Download
3D SDF for NP0338503 (Tocophersolan)

  Mrv2104 05262318192D          

 41 42  0  0  0  0            999 V2000
    7.1843   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8987   -6.6053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7566   -6.6053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6145   -6.6053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.9438   -3.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.3189   -3.4545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.4401   -5.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.9421   -6.4123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3277   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1856   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0435   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6132   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0422   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4711   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9000   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3290   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.8775   -5.5527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.3472   -4.9207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8152   -6.2690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7579   -5.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0027   -6.4123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.5630   -6.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.0327   -5.8982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8987   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7566   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6145   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.6617   -3.9433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8492   -4.0865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.9098   -5.3505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.0973   -5.4938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.6900   -5.4094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.5347   -5.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.1920   -4.5753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.5670   -4.8618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4724   -5.7803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   25.3755   -6.3869    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   22.9721   -4.6342    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.2526   -5.8392    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   23.2203   -6.0414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.0044   -4.4320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   16.7546   -5.0050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 12  9  1  0  0  0  0
 13  9  1  0  0  0  0
 14 10  1  0  0  0  0
 15 10  1  0  0  0  0
 16 11  1  0  0  0  0
 18 17  1  0  0  0  0
 20 11  1  0  0  0  0
 21 19  1  0  0  0  0
 23 22  1  0  0  0  0
 24  1  1  0  0  0  0
 24  2  1  0  0  0  0
 24 12  1  0  0  0  0
 25  3  1  0  0  0  0
 25 13  1  0  0  0  0
 25 14  1  0  0  0  0
 26  4  1  0  0  0  0
 26 15  1  0  0  0  0
 26 16  1  0  0  0  0
 27  5  1  0  0  0  0
 28  6  1  0  0  0  0
 28 27  1  0  0  0  0
 29  7  1  0  0  0  0
 30 19  1  0  0  0  0
 30 29  2  0  0  0  0
 31 17  1  0  0  0  0
 32 18  1  0  0  0  0
 33 27  2  0  0  0  0
 33 29  1  0  0  0  0
 34 28  2  0  0  0  0
 34 30  1  0  0  0  0
 35  8  1  0  0  0  0
 35 20  1  0  0  0  0
 35 21  1  0  0  0  0
 36 22  1  0  0  0  0
 37 31  2  0  0  0  0
 38 32  2  0  0  0  0
 39 23  1  0  0  0  0
 39 31  1  0  0  0  0
 40 32  1  0  0  0  0
 40 33  1  0  0  0  0
 41 34  1  0  0  0  0
 41 35  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0338503

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(=O)CCC(=O)OCCO)=C(C)C(C)=C2O1

> <INCHI_IDENTIFIER>
InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3

> <INCHI_KEY>
AOBORMOPSGHCAX-UHFFFAOYNA-N

> <FORMULA>
C35H58O6

> <MOLECULAR_WEIGHT>
574.843

> <EXACT_MASS>
574.423339588

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
99

> <JCHEM_AVERAGE_POLARIZABILITY>
70.8373257049152

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
1-(2-hydroxyethyl) 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl butanedioate

> <JCHEM_LOGP>
9.699198347000001

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
15.096551863267063

> <JCHEM_PKA_STRONGEST_BASIC>
-2.756568215006987

> <JCHEM_POLAR_SURFACE_AREA>
82.06

> <JCHEM_REFRACTIVITY>
166.48030000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
20

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
vitamin E-tpgs

> <JCHEM_VEBER_RULE>
0

$$$$

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3D-SDF for NP0338503 (Tocophersolan)
Download
PDB for NP0338503 (Tocophersolan)
HEADER    PROTEIN                                 26-MAY-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   26-MAY-23         0                                  
HETATM    1  C   UNK     0      13.411 -10.020   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      14.744 -12.330   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      20.079 -12.330   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      25.414 -12.330   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      35.362  -5.914   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      32.329  -6.448   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      36.288 -11.167   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      29.759 -11.970   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      17.412 -10.790   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      22.746 -10.790   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      28.081 -10.790   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      16.078 -10.020   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      18.745 -10.020   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      21.413 -10.020   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      24.080 -10.020   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      26.747 -10.020   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      40.838 -10.365   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      39.848  -9.185   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      33.255 -11.702   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      29.415 -10.020   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      31.738 -11.970   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      45.851 -12.190   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      44.861 -11.010   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      14.744 -10.790   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      20.079 -10.790   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      25.414 -10.790   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      34.835  -7.361   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      33.319  -7.628   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      35.298  -9.988   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      33.782 -10.255   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      42.355 -10.098   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      38.331  -9.453   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      35.825  -8.541   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      32.792  -9.075   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0      30.748 -10.790   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0      47.368 -11.922   0.000  0.00  0.00           O+0
HETATM   37  O   UNK     0      42.881  -8.651   0.000  0.00  0.00           O+0
HETATM   38  O   UNK     0      37.805 -10.900   0.000  0.00  0.00           O+0
HETATM   39  O   UNK     0      43.345 -11.277   0.000  0.00  0.00           O+0
HETATM   40  O   UNK     0      37.342  -8.273   0.000  0.00  0.00           O+0
HETATM   41  O   UNK     0      31.275  -9.343   0.000  0.00  0.00           O+0
CONECT    1   24                                                            
CONECT    2   24                                                            
CONECT    3   25                                                            
CONECT    4   26                                                            
CONECT    5   27                                                            
CONECT    6   28                                                            
CONECT    7   29                                                            
CONECT    8   35                                                            
CONECT    9   12   13                                                       
CONECT   10   14   15                                                       
CONECT   11   16   20                                                       
CONECT   12    9   24                                                       
CONECT   13    9   25                                                       
CONECT   14   10   25                                                       
CONECT   15   10   26                                                       
CONECT   16   11   26                                                       
CONECT   17   18   31                                                       
CONECT   18   17   32                                                       
CONECT   19   21   30                                                       
CONECT   20   11   35                                                       
CONECT   21   19   35                                                       
CONECT   22   23   36                                                       
CONECT   23   22   39                                                       
CONECT   24    1    2   12                                                  
CONECT   25    3   13   14                                                  
CONECT   26    4   15   16                                                  
CONECT   27    5   28   33                                                  
CONECT   28    6   27   34                                                  
CONECT   29    7   30   33                                                  
CONECT   30   19   29   34                                                  
CONECT   31   17   37   39                                                  
CONECT   32   18   38   40                                                  
CONECT   33   27   29   40                                                  
CONECT   34   28   30   41                                                  
CONECT   35    8   20   21   41                                             
CONECT   36   22                                                            
CONECT   37   31                                                            
CONECT   38   32                                                            
CONECT   39   23   31                                                       
CONECT   40   32   33                                                       
CONECT   41   34   35                                                       
MASTER        0    0    0    0    0    0    0    0   41    0   84    0
END

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3D PDB for NP0338503 (Tocophersolan)
Download
SMILES for NP0338503 (Tocophersolan)
CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(=O)CCC(=O)OCCO)=C(C)C(C)=C2O1
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INCHI for NP0338503 (Tocophersolan)
InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
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SynonymsNot Available
Chemical FormulaC35H58O6
Average Mass574.8430 Da
Monoisotopic Mass574.42334 Da
IUPAC Name1-(2-hydroxyethyl) 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl butanedioate
Traditional Namevitamin E-tpgs
CAS Registry NumberNot Available
SMILES
CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(=O)CCC(=O)OCCO)=C(C)C(C)=C2O1
InChI Identifier
InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
InChI KeyAOBORMOPSGHCAX-UHFFFAOYNA-N
Experimental Spectra
Not Available
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of OriginNot Available
Chemical Taxonomy
ClassificationNot classified
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP9.7ChemAxon
pKa (Strongest Acidic)15.1ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area82.06 ŲChemAxon
Rotatable Bond Count20ChemAxon
Refractivity166.48 m³·mol⁻¹ChemAxon
Polarizability70.84 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkTocofersolan  
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI IDNot Available
Good Scents IDNot Available
References
General References
  1. Mehata AK, Setia A, Vikas, Malik AK, Hassani R, Dailah HG, Alhazmi HA, Albarraq AA, Mohan S, Muthu MS: Vitamin E TPGS-Based Nanomedicine, Nanotheranostics, and Targeted Drug Delivery: Past, Present, and Future. Pharmaceutics. 2023 Feb 21;15(3):722. doi: 10.3390/pharmaceutics15030722. [PubMed:36986583  ] 
  2. Wande DP, Cui Q, Chen S, Xu C, Xiong H, Yao J: Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications. Curr Drug Targets. 2021;22(8):856-869. doi: 10.2174/1389450121666200611140425. [PubMed:32525772  ] 
  3. Bapat P, Ghadi R, Chaudhari D, Katiyar SS, Jain S: Tocophersolan stabilized lipid nanocapsules with high drug loading to improve the permeability and oral bioavailability of curcumin. Int J Pharm. 2019 Apr 5;560:219-227. doi: 10.1016/j.ijpharm.2019.02.013. Epub  2019 Feb 15. [PubMed:30776407  ] 
  4. Johnson CC: Central corneal melting associated with reformulated generic diclofenac in a patient with inferior fornix foreshortening. Ophthalmol Eye Dis. 2011 Jul 25;3:21-4. doi: 10.4137/OED.S7300. Print 2011. [PubMed:23861620  ]