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Showing NP-Card for Koetjapic acid (NP0336966)

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Record Information
Version2.0
Created at2024-09-11 08:38:24 UTC
Updated at2024-09-11 08:38:25 UTC
NP-MRD IDNP0336966
Secondary Accession NumbersNone
Natural Product Identification
Common NameKoetjapic acid
DescriptionKoetjapic acid is also known as koetjapate. Koetjapic acid was first documented in 2020 (PMID: 32771894). Based on a literature review a small amount of articles have been published on Koetjapic acid (PMID: 35315091) (PMID: 33860206) (PMID: 39035582) (PMID: 38326876).
Structure
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MOLSDFPDBSMILESInChI

MOL for NP0336966 (Koetjapic acid)


  Mrv2104 05262311102D          

 35 38  0  0  0  0            999 V2000
   -1.4838   -7.2969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1982   -7.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4838   -8.9469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7693   -8.5344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7693   -7.7094    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0548   -7.2969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0548   -8.9469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6596   -8.5344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6596   -7.7094    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6596   -6.0594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0548   -6.4719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3741   -7.2969    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3741   -6.4719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0886   -6.0594    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0886   -7.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8030   -7.2969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8030   -6.4719    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8030   -4.8218    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0886   -5.2344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5175   -6.0594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5175   -5.2344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8030   -3.9968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0886   -4.4093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0886   -3.5843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3741   -4.8219    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5175   -6.8844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7693   -6.8844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9127   -7.2969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6272   -7.7094    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9127   -6.4719    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4838   -9.7719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1982   -8.5344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0886   -6.8844    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6596   -6.8844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3741   -8.1219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  4  1  1  0  0  0
  1  5  1  0  0  0  0
  6  5  1  0  0  0  0
  5  4  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 12  1  0  0  0  0
  6  9  1  0  0  0  0
 11  6  1  0  0  0  0
 10 11  1  0  0  0  0
 10 13  2  0  0  0  0
 14 13  1  0  0  0  0
 13 12  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 20  1  0  0  0  0
 14 17  1  0  0  0  0
 19 14  1  0  0  0  0
 18 19  1  0  0  0  0
 20 21  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  6  0  0  0
 18 23  1  1  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 17 26  1  1  0  0  0
  5 27  1  1  0  0  0
  2 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
  3 31  2  0  0  0  0
  3 32  1  0  0  0  0
 14 33  1  1  0  0  0
  9 34  1  1  0  0  0
 12 35  1  6  0  0  0
M  END
Download

3D MOL for NP0336966 (Koetjapic acid)

Download
3D SDF for NP0336966 (Koetjapic acid)

  Mrv2104 05262311102D          

 35 38  0  0  0  0            999 V2000
   -1.4838   -7.2969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1982   -7.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4838   -8.9469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7693   -8.5344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7693   -7.7094    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0548   -7.2969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0548   -8.9469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6596   -8.5344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6596   -7.7094    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6596   -6.0594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0548   -6.4719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3741   -7.2969    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3741   -6.4719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0886   -6.0594    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0886   -7.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8030   -7.2969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8030   -6.4719    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8030   -4.8218    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0886   -5.2344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5175   -6.0594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5175   -5.2344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8030   -3.9968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0886   -4.4093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0886   -3.5843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3741   -4.8219    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5175   -6.8844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7693   -6.8844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9127   -7.2969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6272   -7.7094    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9127   -6.4719    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4838   -9.7719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1982   -8.5344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0886   -6.8844    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6596   -6.8844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3741   -8.1219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  4  1  1  0  0  0
  1  5  1  0  0  0  0
  6  5  1  0  0  0  0
  5  4  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 12  1  0  0  0  0
  6  9  1  0  0  0  0
 11  6  1  0  0  0  0
 10 11  1  0  0  0  0
 10 13  2  0  0  0  0
 14 13  1  0  0  0  0
 13 12  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 20  1  0  0  0  0
 14 17  1  0  0  0  0
 19 14  1  0  0  0  0
 18 19  1  0  0  0  0
 20 21  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  6  0  0  0
 18 23  1  1  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 17 26  1  1  0  0  0
  5 27  1  1  0  0  0
  2 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
  3 31  2  0  0  0  0
  3 32  1  0  0  0  0
 14 33  1  1  0  0  0
  9 34  1  1  0  0  0
 12 35  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0336966

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CCC2[C@@](C)(CCC(O)=O)C(CC[C@@]12C)C(C)=C)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1/C30H46O4/c1-19(2)20-10-13-30(7)23(28(20,5)12-11-24(31)32)9-8-21-22-18-27(4,25(33)34)15-14-26(22,3)16-17-29(21,30)6/h8,20,22-23H,1,9-18H2,2-7H3,(H,31,32)(H,33,34)/t20?,22-,23?,26+,27-,28-,29+,30+/s2

> <INCHI_KEY>
ASOUKQDZWGOCBR-MOMVQDDYNA-N

> <FORMULA>
C30H46O4

> <MOLECULAR_WEIGHT>
470.694

> <EXACT_MASS>
470.339609961

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
80

> <JCHEM_AVERAGE_POLARIZABILITY>
55.422307960152125

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(3S,4aR,7S,10aR,10bS,12aS)-7-(2-carboxyethyl)-3,7,10a,10b,12a-pentamethyl-8-(prop-1-en-2-yl)-1,2,3,4,4a,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-3-carboxylic acid

> <JCHEM_LOGP>
6.766004372

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
5.062867977056491

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.423693747125916

> <JCHEM_POLAR_SURFACE_AREA>
74.6

> <JCHEM_REFRACTIVITY>
135.48

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(3S,4aR,7S,10aR,10bS,12aS)-7-(2-carboxyethyl)-3,7,10a,10b,12a-pentamethyl-8-(prop-1-en-2-yl)-2,4,4a,6,6a,8,9,10,11,12-decahydro-1H-chrysene-3-carboxylic acid

> <JCHEM_VEBER_RULE>
0

$$$$

Download
3D-SDF for NP0336966 (Koetjapic acid)
Download
PDB for NP0336966 (Koetjapic acid)
HEADER    PROTEIN                                 26-MAY-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   26-MAY-23         0                                  
HETATM    1  C   UNK     0      -2.770 -13.621   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -4.103 -14.391   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -2.770 -16.701   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.436 -15.931   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -1.436 -14.391   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -0.102 -13.621   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -0.102 -16.701   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.231 -15.931   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       1.231 -14.391   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.231 -11.311   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -0.102 -12.081   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.565 -13.621   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.565 -12.081   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.899 -11.311   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.899 -14.391   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.232 -13.621   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.232 -12.081   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       5.232  -9.001   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       3.899  -9.771   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       6.566 -11.311   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       6.566  -9.771   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       5.232  -7.461   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       3.899  -8.231   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       3.899  -6.691   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0       2.565  -9.001   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       6.566 -12.851   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -1.436 -12.851   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      -5.437 -13.621   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0      -6.771 -14.391   0.000  0.00  0.00           O+0
HETATM   30  O   UNK     0      -5.437 -12.081   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0      -2.770 -18.241   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      -4.103 -15.931   0.000  0.00  0.00           C+0
HETATM   33  H   UNK     0       3.899 -12.851   0.000  0.00  0.00           H+0
HETATM   34  C   UNK     0       1.231 -12.851   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       2.565 -15.161   0.000  0.00  0.00           C+0
CONECT    1    2    5                                                       
CONECT    2    1   28                                                       
CONECT    3    4   31   32                                                  
CONECT    4    3    5    7                                                  
CONECT    5    1    6    4   27                                             
CONECT    6    5    9   11                                                  
CONECT    7    4    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   12    6   34                                             
CONECT   10   11   13                                                       
CONECT   11    6   10                                                       
CONECT   12    9   13   15   35                                             
CONECT   13   10   14   12                                                  
CONECT   14   13   17   19   33                                             
CONECT   15   12   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   20   14   26                                             
CONECT   18   19   21   22   23                                             
CONECT   19   14   18                                                       
CONECT   20   17   21                                                       
CONECT   21   20   18                                                       
CONECT   22   18                                                            
CONECT   23   18   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23                                                            
CONECT   26   17                                                            
CONECT   27    5                                                            
CONECT   28    2   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28                                                            
CONECT   31    3                                                            
CONECT   32    3                                                            
CONECT   33   14                                                            
CONECT   34    9                                                            
CONECT   35   12                                                            
MASTER        0    0    0    0    0    0    0    0   35    0   76    0
END

Download
3D PDB for NP0336966 (Koetjapic acid)
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SMILES for NP0336966 (Koetjapic acid)
[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CCC2[C@@](C)(CCC(O)=O)C(CC[C@@]12C)C(C)=C)C(O)=O
Download
INCHI for NP0336966 (Koetjapic acid)
InChI=1/C30H46O4/c1-19(2)20-10-13-30(7)23(28(20,5)12-11-24(31)32)9-8-21-22-18-27(4,25(33)34)15-14-26(22,3)16-17-29(21,30)6/h8,20,22-23H,1,9-18H2,2-7H3,(H,31,32)(H,33,34)/t20?,22-,23?,26+,27-,28-,29+,30+/s2
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View in JSmol
Synonyms
ValueSource
KoetjapateGenerator
Chemical FormulaC30H46O4
Average Mass470.6940 Da
Monoisotopic Mass470.33961 Da
IUPAC Name(3S,4aR,7S,10aR,10bS,12aS)-7-(2-carboxyethyl)-3,7,10a,10b,12a-pentamethyl-8-(prop-1-en-2-yl)-1,2,3,4,4a,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-3-carboxylic acid
Traditional Name(3S,4aR,7S,10aR,10bS,12aS)-7-(2-carboxyethyl)-3,7,10a,10b,12a-pentamethyl-8-(prop-1-en-2-yl)-2,4,4a,6,6a,8,9,10,11,12-decahydro-1H-chrysene-3-carboxylic acid
CAS Registry NumberNot Available
SMILES
[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CCC2[C@@](C)(CCC(O)=O)C(CC[C@@]12C)C(C)=C)C(O)=O
InChI Identifier
InChI=1/C30H46O4/c1-19(2)20-10-13-30(7)23(28(20,5)12-11-24(31)32)9-8-21-22-18-27(4,25(33)34)15-14-26(22,3)16-17-29(21,30)6/h8,20,22-23H,1,9-18H2,2-7H3,(H,31,32)(H,33,34)/t20?,22-,23?,26+,27-,28-,29+,30+/s2
InChI KeyASOUKQDZWGOCBR-MOMVQDDYNA-N
Experimental Spectra
Not Available
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of OriginNot Available
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as steroid acids. These are compounds containing a carboxyl group attached to a steroid backbone.
KingdomOrganic compounds  
Super ClassLipids and lipid-like molecules  
ClassSteroids and steroid derivatives  
Sub ClassSteroid acids  
Direct ParentSteroid acids  
Alternative Parents
Substituents
  • Steroid acid
    • 

  • Diterpenoid
    • 

  • Carbocyclic fatty acid
    • 

  • Fatty acyl
    • 

  • Dicarboxylic acid or derivatives
    • 

  • Carboxylic acid
    • 

  • Carboxylic acid derivative
    • 

  • Organic oxygen compound
    • 

  • Organic oxide
    • 

  • Hydrocarbon derivative
    • 

  • Organooxygen compound
    • 

  • Carbonyl group
    • 

  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External DescriptorsNot Available
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP6.77ChemAxon
pKa (Strongest Acidic)4.42ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area74.6 ŲChemAxon
Rotatable Bond Count5ChemAxon
Refractivity135.48 m³·mol⁻¹ChemAxon
Polarizability55.42 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI IDNot Available
Good Scents IDNot Available
References
General References
  1. Bailly C: The health benefits of santol fruits and bioactive products isolated from Sandoricum koetjape Merr.: A scoping review. J Food Biochem. 2022 Jul;46(7):e14152. doi: 10.1111/jfbc.14152. Epub 2022 Mar 21. [PubMed:35315091  ] 
  2. Aswathy M, Banik K, Parama D, Sasikumar P, Harsha C, Joseph AG, Sherin DR, Thanathu MK, Kunnumakkara AB, Vasu RK: Exploring the Cytotoxic Effects of the Extracts and Bioactive Triterpenoids from Dillenia indica against Oral Squamous Cell Carcinoma: A Scientific Interpretation and Validation of Indigenous Knowledge. ACS Pharmacol Transl Sci. 2021 Mar 9;4(2):834-847. doi: 10.1021/acsptsci.1c00011.  eCollection 2021 Apr 9. [PubMed:33860206  ] 
  3. Jafari SF, Al-Suede FSR, Yehya AHS, Ahamed MBK, Shafaei A, Asif M, Tabana YM, Majid AMSA, Baharetha HM: Pharmacokinetics and antiangiogenic studies of potassium koetjapate in rats. Biomed Pharmacother. 2020 Oct;130:110602. doi: 10.1016/j.biopha.2020.110602. Epub  2020 Aug 6. [PubMed:32771894  ] 
  4. Jafari SF, Keshavarzi M, AbdulMajid AM, Al-Suede FSR, Asif M, Ahamed MBK, Khan MSS, Hassan LAE, Majid ASA, Naseri M: Evaluation of in vitro and in vivo anticancer activities of potassium koetjapate: a solubility improved formulation of koetjapic acid against human colon cancer. Res Pharm Sci. 2024 Apr 1;19(2):203-216. doi: 10.4103/RPS.RPS_247_22. eCollection  2024 Apr. [PubMed:39035582  ] 
  5. Armaghan M, Khan K, Irfan M, Hafeez A, Zafar S, Javed Z, Sharifi-Rad J, Butnariu M, Sarac I, Bagiu IC, Bagiu RV: Koetjapic acid: unveiling its potential as a saviour in the realm of biological and medicinal properties, with a focus on anticancer mechanism of action. Eur J Med Res. 2024 Feb 7;29(1):106. doi: 10.1186/s40001-024-01699-6. [PubMed:38326876  ]