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Showing NP-Card for Ceftiofur (NP0336649)

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Record Information
Version2.0
Created at2024-09-11 07:14:34 UTC
Updated at2024-09-11 07:14:35 UTC
NP-MRD IDNP0336649
Secondary Accession NumbersNone
Natural Product Identification
Common NameCeftiofur
DescriptionCeftiofur belongs to the class of organic compounds known as cephalosporins. Cephalosporins are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]Oct-2-ene-2-carboxylic acid moiety or a derivative thereof. Ceftiofur was first documented in 2024 (PMID: 39265834). Based on a literature review a small amount of articles have been published on Ceftiofur (PMID: 39240080) (PMID: 39217040) (PMID: 39155341) (PMID: 39134329).
Structure
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MOLSDFPDBSMILESInChI

MOL for NP0336649 (Ceftiofur)


  Mrv2104 05262309462D          

 34 37  0  0  0  0            999 V2000
   -1.6594   -2.3069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8213   -1.4971    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6304   -1.1732    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7117   -0.2828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6020   -0.0403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3304   -0.4448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9782    0.0410    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7400    0.4448    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9019   -0.2828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2541   -0.6881    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6070   -0.2022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6070    0.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2541    1.1732    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9259    0.7688    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7349    0.7688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2208    1.4971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2018    0.6873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2018   -0.2022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8497   -0.6067    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6586   -0.2022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1205    2.3069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6303   -0.8501    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1968   -0.2022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6586    0.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8497    1.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6586    2.3069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9252   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6543   -0.2828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.9307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8155   -1.5784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0066   -1.4165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  4  9  1  0  0  0  0
  5  6  2  0  0  0  0
  5 14  1  0  0  0  0
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  7 15  1  0  0  0  0
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 28 29  2  0  0  0  0
 30 31  1  0  0  0  0
 30 34  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
M  END
Download

3D MOL for NP0336649 (Ceftiofur)

Download
3D SDF for NP0336649 (Ceftiofur)

  Mrv2104 05262309462D          

 34 37  0  0  0  0            999 V2000
   -1.6594   -2.3069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8213   -1.4971    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6304   -1.1732    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7117   -0.2828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6020   -0.0403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3304   -0.4448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9782    0.0410    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7400    0.4448    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9019   -0.2828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2541   -0.6881    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6070   -0.2022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6070    0.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2541    1.1732    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9259    0.7688    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7349    0.7688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2208    1.4971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2018    0.6873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2018   -0.2022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8497   -0.6067    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6586   -0.2022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1205    2.3069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6303   -0.8501    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1968   -0.2022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1162    0.6067    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3878    1.0113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6586    0.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8497    1.0926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8497    1.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6586    2.3069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9252   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6543   -0.2828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.9307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8155   -1.5784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0066   -1.4165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  4  9  1  0  0  0  0
  5  6  2  0  0  0  0
  5 14  1  0  0  0  0
  6  7  1  0  0  0  0
  7 15  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 18  1  0  0  0  0
 12 13  2  0  0  0  0
 12 17  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 17 27  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 26  1  0  0  0  0
 21 28  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 23 30  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 30 31  1  0  0  0  0
 30 34  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0336649

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CO\N=C(/C(=O)NC1C2SCC(CSC(=O)C3=CC=CO3)=C(N2C1=O)C(O)=O)C1=CSC(N)=N1

> <INCHI_IDENTIFIER>
InChI=1/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-

> <INCHI_KEY>
ZBHXIWJRIFEVQY-KSEXSDGBNA-N

> <FORMULA>
C19H17N5O7S3

> <MOLECULAR_WEIGHT>
523.55

> <EXACT_MASS>
523.029011429

> <JCHEM_ACCEPTOR_COUNT>
9

> <JCHEM_ATOM_COUNT>
51

> <JCHEM_AVERAGE_POLARIZABILITY>
50.2982909514611

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(furan-2-carbonylsulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

> <JCHEM_LOGP>
0.11066347288200201

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
10.756716866429842

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.5157194042120965

> <JCHEM_PKA_STRONGEST_BASIC>
3.4924486846997893

> <JCHEM_POLAR_SURFACE_AREA>
177.41999999999996

> <JCHEM_REFRACTIVITY>
124.51459999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
9

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(furan-2-carbonylsulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

> <JCHEM_VEBER_RULE>
0

$$$$

Download
3D-SDF for NP0336649 (Ceftiofur)
Download
PDB for NP0336649 (Ceftiofur)
HEADER    PROTEIN                                 26-MAY-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   26-MAY-23         0                                  
HETATM    1  C   UNK     0      -3.098  -4.306   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0      -3.400  -2.795   0.000  0.00  0.00           O+0
HETATM    3  N   UNK     0      -4.910  -2.190   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0      -5.062  -0.528   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -6.724  -0.075   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -8.083  -0.830   0.000  0.00  0.00           C+0
HETATM    7  S   UNK     0      -9.293   0.077   0.000  0.00  0.00           S+0
HETATM    8  O   UNK     0      -3.248   0.830   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      -3.550  -0.528   0.000  0.00  0.00           C+0
HETATM   10  N   UNK     0      -2.341  -1.285   0.000  0.00  0.00           N+0
HETATM   11  C   UNK     0      -1.133  -0.377   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -1.133   1.283   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0      -2.341   2.190   0.000  0.00  0.00           O+0
HETATM   14  N   UNK     0      -7.328   1.435   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0      -8.839   1.435   0.000  0.00  0.00           C+0
HETATM   16  N   UNK     0      -9.745   2.795   0.000  0.00  0.00           N+0
HETATM   17  N   UNK     0       0.377   1.283   0.000  0.00  0.00           N+0
HETATM   18  C   UNK     0       0.377  -0.377   0.000  0.00  0.00           C+0
HETATM   19  S   UNK     0       1.586  -1.133   0.000  0.00  0.00           S+0
HETATM   20  C   UNK     0       3.096  -0.377   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       0.225   4.306   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0       4.910  -1.587   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       5.967  -0.377   0.000  0.00  0.00           C+0
HETATM   24  S   UNK     0       5.817   1.133   0.000  0.00  0.00           S+0
HETATM   25  C   UNK     0       4.457   1.888   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       3.096   1.283   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       1.586   2.039   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       1.586   3.550   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       3.096   4.306   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       7.327  -1.133   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       8.688  -0.528   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0       9.745  -1.737   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       8.989  -2.946   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       7.479  -2.644   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5    9                                                  
CONECT    5    4    6   14                                                  
CONECT    6    5    7                                                       
CONECT    7    6   15                                                       
CONECT    8    9                                                            
CONECT    9    4    8   10                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12   18                                                  
CONECT   12   11   13   17                                                  
CONECT   13   12                                                            
CONECT   14    5   15                                                       
CONECT   15    7   14   16                                                  
CONECT   16   15                                                            
CONECT   17   12   18   27                                                  
CONECT   18   11   17   19                                                  
CONECT   19   18   20                                                       
CONECT   20   19   26                                                       
CONECT   21   28                                                            
CONECT   22   23                                                            
CONECT   23   22   24   30                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   20   25   27                                                  
CONECT   27   17   26   28                                                  
CONECT   28   21   27   29                                                  
CONECT   29   28                                                            
CONECT   30   23   31   34                                                  
CONECT   31   30   32                                                       
CONECT   32   31   33                                                       
CONECT   33   32   34                                                       
CONECT   34   30   33                                                       
MASTER        0    0    0    0    0    0    0    0   34    0   74    0
END

Download
3D PDB for NP0336649 (Ceftiofur)
Download
SMILES for NP0336649 (Ceftiofur)
CO\N=C(/C(=O)NC1C2SCC(CSC(=O)C3=CC=CO3)=C(N2C1=O)C(O)=O)C1=CSC(N)=N1
Download
INCHI for NP0336649 (Ceftiofur)
InChI=1/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-
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View in JSmol
SynonymsNot Available
Chemical FormulaC19H17N5O7S3
Average Mass523.5500 Da
Monoisotopic Mass523.02901 Da
IUPAC Name7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(furan-2-carbonylsulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional Name7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(furan-2-carbonylsulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Registry NumberNot Available
SMILES
CO\N=C(/C(=O)NC1C2SCC(CSC(=O)C3=CC=CO3)=C(N2C1=O)C(O)=O)C1=CSC(N)=N1
InChI Identifier
InChI=1/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-
InChI KeyZBHXIWJRIFEVQY-KSEXSDGBNA-N
Experimental Spectra
Not Available
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of OriginNot Available
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as cephalosporins. These are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]Oct-2-ene-2-carboxylic acid moiety or a derivative thereof.
KingdomOrganic compounds  
Super ClassOrganoheterocyclic compounds  
ClassLactams  
Sub ClassBeta lactams  
Direct ParentCephalosporins  
Alternative Parents
Substituents
  • Cephalosporin
    • 

  • N-acyl-alpha amino acid or derivatives
    • 

  • Alpha-amino acid or derivatives
    • 

  • Furoic acid or derivatives
    • 

  • 2,4-disubstituted 1,3-thiazole
    • 

  • Meta-thiazine
    • 

  • 1,3-thiazol-2-amine
    • 

  • Azole
    • 

  • Furan
    • 

  • Heteroaromatic compound
    • 

  • Tertiary carboxylic acid amide
    • 

  • Thiazole
    • 

  • Amino acid or derivatives
    • 

  • Azetidine
    • 

  • Carboxamide group
    • 

  • Amino acid
    • 

  • Secondary carboxylic acid amide
    • 

  • Carbothioic s-ester
    • 

  • Thiocarboxylic acid ester
    • 

  • Dialkylthioether
    • 

  • Sulfenyl compound
    • 

  • Hemithioaminal
    • 

  • Thioether
    • 

  • Thiocarboxylic acid or derivatives
    • 

  • Carboxylic acid derivative
    • 

  • Carboxylic acid
    • 

  • Monocarboxylic acid or derivatives
    • 

  • Oxacycle
    • 

  • Azacycle
    • 

  • Organic oxygen compound
    • 

  • Amine
    • 

  • Hydrocarbon derivative
    • 

  • Organic oxide
    • 

  • Carbonyl group
    • 

  • Organonitrogen compound
    • 

  • Organooxygen compound
    • 

  • Organosulfur compound
    • 

  • Primary amine
    • 

  • Organic nitrogen compound
    • 

  • Organopnictogen compound
    • 

  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.11ChemAxon
pKa (Strongest Acidic)2.52ChemAxon
pKa (Strongest Basic)3.49ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area177.42 ŲChemAxon
Rotatable Bond Count9ChemAxon
Refractivity124.51 m³·mol⁻¹ChemAxon
Polarizability50.3 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkCeftiofur  
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI IDNot Available
Good Scents IDNot Available
References
General References
  1. Vasco KA, Bowcutt B, Carbonell S, Souza L, Robison C, Abuelo A, Erskine R, Norby B, Zhang L, Ruegg PL, Manning SD: Selection of antibiotic-resistant bacterial populations in the dairy cow gut following intramuscular ceftiofur treatment for metritis. J Dairy Sci. 2024 Dec;107(12):11536-11549. doi: 10.3168/jds.2023-24572. Epub 2024  Sep 17. [PubMed:39265834  ] 
  2. Gelalcha BD, Gelgie AE, Kerro Dego O: Antimicrobial resistance and prevalence of extended-spectrum beta-lactamase-producing Klebsiella species in East Tennessee dairy farms. Microbiol Spectr. 2024 Oct 3;12(10):e0353723. doi: 10.1128/spectrum.03537-23.  Epub 2024 Sep 6. [PubMed:39240080  ] 
  3. Zhao Y, Mao W, Liu B, Wang YF, Zhang SY, Guo LL, Qian YH, Gong ZG, Zhao JM, Yang XL, Qu GG, Hasi SR, Bai YT, Cao JS: Preparation of ceftiofur-encapsulated hen-egg low-density lipoproteins and their antibacterial effects on intracellular Staphylococcus aureus. Int J Biol Macromol. 2024 Oct;278(Pt 4):134840. doi:  10.1016/j.ijbiomac.2024.134840. Epub 2024 Aug 31. [PubMed:39217040  ] 
  4. Veiga RF, Clarindo LN, Fensterseifer AL, Pompelli LH, Sfaciotte RAP, Schwarz DGG, Eloy LR, Ferraz SM: Prevalence and antimicrobial susceptibility of Streptococcus equi isolated from horses in Santa Catarina state, Southern Brazil. Braz J Microbiol. 2024 Aug 19;55(4):4147-55. doi: 10.1007/s42770-024-01479-8. [PubMed:39155341  ] 
  5. Mzyk DA, Halleran JL, Sylvester HJ, Giles CB, Jacob ME, Baynes RE, Foster DM: Continuous sampling of healthy and mastitic quarters of lactating cattle by ultrafiltration after intramammary ceftiofur hydrochloride administration. J Vet Intern Med. 2024 Sep-Oct;38(5):2814-2822. doi: 10.1111/jvim.17155. Epub  2024 Aug 12. [PubMed:39134329  ]