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Showing NP-Card for Folinic acid (NP0334575)

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Record Information
Version2.0
Created at2024-09-10 18:58:14 UTC
Updated at2024-09-10 18:58:14 UTC
NP-MRD IDNP0334575
Secondary Accession NumbersNone
Natural Product Identification
Common NameFolinic acid
DescriptionFolinic acid is also known as folinate. Folinic acid was first documented in 2024 (PMID: 39264626). Based on a literature review a small amount of articles have been published on Folinic acid (PMID: 39247241) (PMID: 39243316) (PMID: 39236564).
Structure
Thumb
MOLSDFPDBSMILESInChI

MOL for NP0334575 (Folinic acid)


  Mrv2104 05252321302D          

 34 36  0  0  0  0            999 V2000
 9995.5441 9999.2056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.2593 9999.6166    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9996.9725 9998.3756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.6878 9997.9637    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10000.5489 9999.6145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.2634 9999.2015    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10001.9799 9999.6145    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10002.6944 9999.2015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10003.4108 9999.6145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.1274 9999.2015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.8417 9999.6145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10004.1274 9998.3756    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.979910000.4405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.694410000.8534    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.263410000.8534    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.548910000.4405    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9994.1155 9999.2056    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9992.6871 9996.7175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9999.8335 9999.2013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.1193 9999.6136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.4047 9999.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.4047 9998.3763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.1192 9997.9638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.8336 9998.3763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.1156 9998.3725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.4013 9997.9601    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9993.4013 9997.1351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.1156 9996.7227    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9994.8301 9997.1351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.8301 9997.9601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9995.5445 9996.7226    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9996.2588 9997.1352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.2589 9997.9600    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9995.5444 9998.3725    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  3  4  1  0  0  0  0
  5  6  1  0  0  0  0
  5 16  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7 13  1  6  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 19  1  0  0  0  0
  4 22  1  0  0  0  0
 19  5  1  0  0  0  0
 25 30  1  0  0  0  0
 29 30  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  1  0  0  0  0
 31 32  1  0  0  0  0
 29 31  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  1 34  1  0  0  0  0
 33  3  1  1  0  0  0
 27 18  1  0  0  0  0
 25 17  2  0  0  0  0
M  END
Download

3D MOL for NP0334575 (Folinic acid)

Download
3D SDF for NP0334575 (Folinic acid)

  Mrv2104 05252321302D          

 34 36  0  0  0  0            999 V2000
 9995.5441 9999.2056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.2593 9999.6166    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9996.9725 9998.3756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9997.6878 9997.9637    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10000.5489 9999.6145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10001.2634 9999.2015    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
10001.9799 9999.6145    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
10002.6944 9999.2015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10003.4108 9999.6145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.1274 9999.2015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10004.8417 9999.6145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10004.1274 9998.3756    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.979910000.4405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
10002.694410000.8534    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10001.263410000.8534    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
10000.548910000.4405    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9994.1155 9999.2056    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 9992.6871 9996.7175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9999.8335 9999.2013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.1193 9999.6136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.4047 9999.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9998.4047 9998.3763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.1192 9997.9638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9999.8336 9998.3763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.1156 9998.3725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9993.4013 9997.9601    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9993.4013 9997.1351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.1156 9996.7227    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9994.8301 9997.1351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9994.8301 9997.9601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9995.5445 9996.7226    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 9996.2588 9997.1352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 9996.2589 9997.9600    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 9995.5444 9998.3725    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  3  4  1  0  0  0  0
  5  6  1  0  0  0  0
  5 16  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7 13  1  6  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 19  1  0  0  0  0
  4 22  1  0  0  0  0
 19  5  1  0  0  0  0
 25 30  1  0  0  0  0
 29 30  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  1  0  0  0  0
 31 32  1  0  0  0  0
 29 31  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  1 34  1  0  0  0  0
 33  3  1  1  0  0  0
 27 18  1  0  0  0  0
 25 17  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0334575

> <DATABASE_NAME>
NP-MRD

> <SMILES>
NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2C=O)N1

> <INCHI_IDENTIFIER>
InChI=1/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/s2

> <INCHI_KEY>
VVIAGPKUTFNRDU-NVHKGDCHNA-N

> <FORMULA>
C20H23N7O7

> <MOLECULAR_WEIGHT>
473.446

> <EXACT_MASS>
473.165896109

> <JCHEM_ACCEPTOR_COUNT>
12

> <JCHEM_ATOM_COUNT>
57

> <JCHEM_AVERAGE_POLARIZABILITY>
46.34154214681111

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
7

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid

> <JCHEM_LOGP>
-3.7550977381380006

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
3.866920226655101

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.210813073793943

> <JCHEM_PKA_STRONGEST_BASIC>
4.6572664399214485

> <JCHEM_POLAR_SURFACE_AREA>
215.55

> <JCHEM_REFRACTIVITY>
126.46200000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
9

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
levoleucovorin

> <JCHEM_VEBER_RULE>
0

$$$$

Download
3D-SDF for NP0334575 (Folinic acid)
Download
PDB for NP0334575 (Folinic acid)
HEADER    PROTEIN                                 25-MAY-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   25-MAY-23         0                                  
HETATM    1  C   UNK     0    8658.3498665.184   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0    8659.6848665.951   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0    8661.0158663.634   0.000  0.00  0.00           C+0
HETATM    4  N   UNK     0    8662.3518662.866   0.000  0.00  0.00           N+0
HETATM    5  C   UNK     0    8667.6918665.947   0.000  0.00  0.00           C+0
HETATM    6  N   UNK     0    8669.0258665.176   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0    8670.3628665.947   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    8671.6968665.176   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0    8673.0338665.947   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0    8674.3718665.176   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0    8675.7058665.947   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0    8674.3718663.634   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0    8670.3628667.489   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0    8671.6968668.260   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0    8669.0258668.260   0.000  0.00  0.00           O+0
HETATM   16  O   UNK     0    8667.6918667.489   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0    8655.6828665.184   0.000  0.00  0.00           O+0
HETATM   18  N   UNK     0    8653.0168660.539   0.000  0.00  0.00           N+0
HETATM   19  C   UNK     0    8666.3568665.176   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0    8665.0238665.945   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0    8663.6898665.176   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0    8663.6898663.636   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0    8665.0238662.866   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0    8666.3568663.636   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0    8655.6828663.629   0.000  0.00  0.00           C+0
HETATM   26  N   UNK     0    8654.3498662.859   0.000  0.00  0.00           N+0
HETATM   27  C   UNK     0    8654.3498661.319   0.000  0.00  0.00           C+0
HETATM   28  N   UNK     0    8655.6828660.549   0.000  0.00  0.00           N+0
HETATM   29  C   UNK     0    8657.0168661.319   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0    8657.0168662.859   0.000  0.00  0.00           C+0
HETATM   31  N   UNK     0    8658.3508660.549   0.000  0.00  0.00           N+0
HETATM   32  C   UNK     0    8659.6838661.319   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0    8659.6838662.859   0.000  0.00  0.00           C+0
HETATM   34  N   UNK     0    8658.3508663.629   0.000  0.00  0.00           N+0
CONECT    1    2   34                                                       
CONECT    2    1                                                            
CONECT    3    4   33                                                       
CONECT    4    3   22                                                       
CONECT    5    6   16   19                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8   13                                                  
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10                                                            
CONECT   13    7   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13                                                            
CONECT   16    5                                                            
CONECT   17   25                                                            
CONECT   18   27                                                            
CONECT   19   20   24    5                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23    4                                                  
CONECT   23   22   24                                                       
CONECT   24   23   19                                                       
CONECT   25   30   26   17                                                  
CONECT   26   25   27                                                       
CONECT   27   26   28   18                                                  
CONECT   28   27   29                                                       
CONECT   29   30   31   28                                                  
CONECT   30   25   29   34                                                  
CONECT   31   32   29                                                       
CONECT   32   33   31                                                       
CONECT   33   32   34    3                                                  
CONECT   34   33   30    1                                                  
MASTER        0    0    0    0    0    0    0    0   34    0   72    0
END

Download
3D PDB for NP0334575 (Folinic acid)
Download
SMILES for NP0334575 (Folinic acid)
NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2C=O)N1
Download
INCHI for NP0334575 (Folinic acid)
InChI=1/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/s2
Download
View in JSmol
Synonyms
ValueSource
FolinateGenerator
Chemical FormulaC20H23N7O7
Average Mass473.4460 Da
Monoisotopic Mass473.16590 Da
IUPAC Name(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid
Traditional Namelevoleucovorin
CAS Registry NumberNot Available
SMILES
NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2C=O)N1
InChI Identifier
InChI=1/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/s2
InChI KeyVVIAGPKUTFNRDU-NVHKGDCHNA-N
Experimental Spectra
Not Available
Predicted Spectra
Not Available
Chemical Shift Submissions
Not Available
Species
Species of OriginNot Available
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tetrahydrofolic acids. These are heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with at least one L-glutamic acid unit.
KingdomOrganic compounds  
Super ClassOrganoheterocyclic compounds  
ClassPteridines and derivatives  
Sub ClassPterins and derivatives  
Direct ParentTetrahydrofolic acids  
Alternative Parents
Substituents
  • Tetrahydrofolic acid
    • 

  • Glutamic acid or derivatives
    • 

  • N-acyl-alpha amino acid or derivatives
    • 

  • N-acyl-alpha-amino acid
    • 

  • Hippuric acid
    • 

  • Hippuric acid or derivatives
    • 

  • Alpha-amino acid or derivatives
    • 

  • Aminobenzamide
    • 

  • Aminobenzoic acid or derivatives
    • 

  • Benzamide
    • 

  • Benzoic acid or derivatives
    • 

  • Benzoyl
    • 

  • Aniline or substituted anilines
    • 

  • Phenylalkylamine
    • 

  • Aminopyrimidine
    • 

  • Secondary aliphatic/aromatic amine
    • 

  • Pyrimidone
    • 

  • Dicarboxylic acid or derivatives
    • 

  • Benzenoid
    • 

  • Pyrimidine
    • 

  • Monocyclic benzene moiety
    • 

  • Heteroaromatic compound
    • 

  • Vinylogous amide
    • 

  • Tertiary carboxylic acid amide
    • 

  • Secondary carboxylic acid amide
    • 

  • Amino acid or derivatives
    • 

  • Amino acid
    • 

  • Carboxamide group
    • 

  • Secondary amine
    • 

  • Carboxylic acid
    • 

  • Carboxylic acid derivative
    • 

  • Azacycle
    • 

  • Organooxygen compound
    • 

  • Carbonyl group
    • 

  • Organic nitrogen compound
    • 

  • Hydrocarbon derivative
    • 

  • Amine
    • 

  • Organic oxide
    • 

  • Organopnictogen compound
    • 

  • Organic oxygen compound
    • 

  • Primary amine
    • 

  • Organonitrogen compound
    • 

  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-3.8ChemAxon
pKa (Strongest Acidic)3.21ChemAxon
pKa (Strongest Basic)4.66ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area215.55 ŲChemAxon
Rotatable Bond Count9ChemAxon
Refractivity126.46 m³·mol⁻¹ChemAxon
Polarizability46.34 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkFolinic acid  
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI IDNot Available
Good Scents IDNot Available
References
General References
  1. Diefenhardt M, Martin D, Hofheinz RD, Ghadimi M, Fokas E, Rodel C, Fleischmann M: Persistent Lymph Node Metastases After Neoadjuvant Chemoradiotherapy for Rectal Cancer. JAMA Netw Open. 2024 Sep 3;7(9):e2432927. doi:  10.1001/jamanetworkopen.2024.32927. [PubMed:39264626  ] 
  2. Senturk M, Altundag O: Oxaliplatin-Induced Immune Thrombocytopenia in a Patient with Pancreatic Cancer. Eur J Case Rep Intern Med. 2024 Aug 21;11(9):004782. doi: 10.12890/2024_004782.  eCollection 2024. [PubMed:39247241  ] 
  3. Panda PK, Sharawat IK, Saha S, Gupta D, Palayullakandi A, Meena K: Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial. Eur J Pediatr. 2024 Sep 7. doi: 10.1007/s00431-024-05762-6. [PubMed:39243316  ] 
  4. Almutair M, Thabet F, Hundallah K, Tabarki B: CIC variants and folinic acid-responsive seizures. Mol Genet Metab. 2024 Aug 30;143(1-2):108574. doi: 10.1016/j.ymgme.2024.108574. [PubMed:39236564  ]