NP-MRD: Showing NP-Card for Cicholosumin B (NP0333670)

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Record Information

Version

2.0

Created at

2024-07-31 23:46:00 UTC

Updated at

2025-02-11 15:49:26 UTC

NP-MRD ID

NP0333670

Natural Product DOI

https://doi.org/10.57994/3149

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Cicholosumin B

Description

Cicholosumin B belongs to the class of organic compounds known as guaianolides and derivatives. These are diterpene lactones with a structure characterized by the presence of a gamma-lactone fused to a guaiane, forming 3,6,9-trimethyl-azuleno[4,5-b]furan-2-one or a derivative. Cicholosumin B was first documented in 2024 (PMID: 39032793). Based on a literature review very few articles have been published on Cicholosumin B.

Structure

MOL SDF PDB SMILES InChI


  Mrv2104 04152302192D          

 28 30  0  0  1  0            999 V2000
    2.7845    4.9135    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5524    4.6121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1974    5.1265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654    4.8251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0884    4.0093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6104    5.3394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3784    5.0380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6754    3.7963    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0304    3.2819    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2140    2.4776    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6996    1.8326    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.1541    1.1441    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9493    1.3636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9864    2.1877    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6749    2.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5944    0.8492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8746    1.8326    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.3602    2.4776    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1645    2.6612    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5438    3.2819    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8988    3.7963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2871    3.6399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2655    1.1061    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4201    1.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7100    0.3717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6248    1.3636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5878    2.1877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1007    2.6422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  8  1  0  0  0  0
  9  8  1  6  0  0  0
 10  9  1  0  0  0  0
 10 11  1  1  0  0  0
 11 12  1  6  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  6  0  0  0
 13 16  2  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  6  0  0  0
 18 20  1  0  0  0  0
 20 21  1  1  0  0  0
 20 22  1  0  0  0  0
  9 22  1  0  0  0  0
 17 23  1  6  0  0  0
 17 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
 18 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  END


  Mrv2104 04152302192D          

 28 30  0  0  1  0            999 V2000
    2.7845    4.9135    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5524    4.6121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1974    5.1265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654    4.8251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0884    4.0093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6104    5.3394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3784    5.0380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6754    3.7963    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0304    3.2819    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2140    2.4776    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6996    1.8326    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.1541    1.1441    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9493    1.3636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9864    2.1877    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6749    2.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5944    0.8492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8746    1.8326    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.3602    2.4776    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1645    2.6612    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5438    3.2819    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8988    3.7963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2871    3.6399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2655    1.1061    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4201    1.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7100    0.3717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6248    1.3636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5878    2.1877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1007    2.6422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  8  1  0  0  0  0
  9  8  1  6  0  0  0
 10  9  1  0  0  0  0
 10 11  1  1  0  0  0
 11 12  1  6  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  6  0  0  0
 13 16  2  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  6  0  0  0
 18 20  1  0  0  0  0
 20 21  1  1  0  0  0
 20 22  1  0  0  0  0
  9 22  1  0  0  0  0
 17 23  1  6  0  0  0
 17 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
 18 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0333670

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H][C@@]12[C@H]3OC(=O)[C@@H](C)[C@@H]3[C@H](C[C@H](C)[C@]1([H])C(=O)C=C2C)OC(=O)\C=C(/C)CC

> <INCHI_IDENTIFIER>
InChI=1S/C21H28O5/c1-6-10(2)7-16(23)25-15-9-12(4)17-14(22)8-11(3)18(17)20-19(15)13(5)21(24)26-20/h7-8,12-13,15,17-20H,6,9H2,1-5H3/b10-7+/t12-,13-,15-,17+,18-,19+,20+/m0/s1

> <INCHI_KEY>
IZQSHHRRKPKORK-AIEQARGOSA-N

> <FORMULA>
C21H28O5

> <MOLECULAR_WEIGHT>
360.45

> <EXACT_MASS>
360.193674002

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
54

> <JCHEM_AVERAGE_POLARIZABILITY>
39.08755156543421

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3S,3aR,4S,6S,6aS,9aR,9bR)-3,6,9-trimethyl-2,7-dioxo-2H,3H,3aH,4H,5H,6H,6aH,7H,9aH,9bH-azuleno[4,5-b]furan-4-yl (2E)-3-methylpent-2-enoate

> <JCHEM_LOGP>
3.819962138666667

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
16.722365760683825

> <JCHEM_PKA_STRONGEST_BASIC>
-4.972366421574039

> <JCHEM_POLAR_SURFACE_AREA>
69.67

> <JCHEM_REFRACTIVITY>
98.03339999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(3S,3aR,4S,6S,6aS,9aR,9bR)-3,6,9-trimethyl-2,7-dioxo-3H,3aH,4H,5H,6H,6aH,9aH,9bH-azuleno[4,5-b]furan-4-yl (2E)-3-methylpent-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 15-APR-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-APR-23         0                                  
HETATM    1  O   UNK     0       5.198   9.172   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       6.631   8.609   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       7.835   9.569   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       9.269   9.007   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       9.498   7.484   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.473   9.967   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      11.906   9.404   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       6.861   7.086   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       5.657   6.126   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.999   4.625   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.039   3.421   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       5.888   2.136   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       7.372   2.545   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.441   4.084   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       8.726   4.932   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       8.576   1.585   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       3.499   3.421   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       2.539   4.625   0.000  0.00  0.00           C+0
HETATM   19  H   UNK     0       4.040   4.968   0.000  0.00  0.00           H+0
HETATM   20  C   UNK     0       2.882   6.126   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.678   7.086   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       4.269   6.794   0.000  0.00  0.00           C+0
HETATM   23  H   UNK     0       4.229   2.065   0.000  0.00  0.00           H+0
HETATM   24  C   UNK     0       2.651   2.136   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       3.192   0.694   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       1.166   2.545   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       1.097   4.084   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0      -0.188   4.932   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    8                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7                                                       
CONECT    7    6                                                            
CONECT    8    2    9                                                       
CONECT    9    8   10   22                                                  
CONECT   10    9   11   14                                                  
CONECT   11   10   12   17                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   16                                                  
CONECT   14   13   10   15                                                  
CONECT   15   14                                                            
CONECT   16   13                                                            
CONECT   17   11   18   23   24                                             
CONECT   18   17   19   20   27                                             
CONECT   19   18                                                            
CONECT   20   18   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20    9                                                       
CONECT   23   17                                                            
CONECT   24   17   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27                                                       
CONECT   27   26   18   28                                                  
CONECT   28   27                                                            
MASTER        0    0    0    0    0    0    0    0   28    0   60    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₁H₂₈O₅

Average Mass

360.4500 Da

Monoisotopic Mass

360.19367 Da

IUPAC Name

(3S,3aR,4S,6S,6aS,9aR,9bR)-3,6,9-trimethyl-2,7-dioxo-2H,3H,3aH,4H,5H,6H,6aH,7H,9aH,9bH-azuleno[4,5-b]furan-4-yl (2E)-3-methylpent-2-enoate

Traditional Name

(3S,3aR,4S,6S,6aS,9aR,9bR)-3,6,9-trimethyl-2,7-dioxo-3H,3aH,4H,5H,6H,6aH,9aH,9bH-azuleno[4,5-b]furan-4-yl (2E)-3-methylpent-2-enoate

CAS Registry Number

Not Available

SMILES

[H][C@@]12[C@H]3OC(=O)[C@@H](C)[C@@H]3[C@H](C[C@H](C)[C@]1([H])C(=O)C=C2C)OC(=O)\C=C(/C)CC

InChI Identifier

InChI=1S/C21H28O5/c1-6-10(2)7-16(23)25-15-9-12(4)17-14(22)8-11(3)18(17)20-19(15)13(5)21(24)26-20/h7-8,12-13,15,17-20H,6,9H2,1-5H3/b10-7+/t12-,13-,15-,17+,18-,19+,20+/m0/s1

InChI Key

IZQSHHRRKPKORK-AIEQARGOSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, CDCL3, experimental)	weizheyang1002@126.com	XinJiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences	Zheyang Wei	2024-07-31	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 400, CDCl₃, simulated)	weizheyang1002@126.com	XinJiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences	Zheyang Wei	2024-07-31	View Spectrum

Species

Species of Origin

Species Name	Source	Reference
Cichorium glandulosum		Not Available

Chemical Taxonomy

Description

This compound belongs to the class of organic compounds known as guaianolides and derivatives. These are diterpene lactones with a structure characterized by the presence of a gamma-lactone fused to a guaiane, forming 3,6,9-trimethyl-azuleno[4,5-b]furan-2-one or a derivative.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Guaianolides and derivatives

Alternative Parents

Substituents

Guaianolide-skeleton
Farsesane sesquiterpenoid
Sesquiterpenoid
Guaiane sesquiterpenoid
Fatty alcohol ester
Fatty acid ester
Fatty acyl
Gamma butyrolactone
Dicarboxylic acid or derivatives
Alpha,beta-unsaturated ketone
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Tetrahydrofuran
Enone
Acryloyl-group
Lactone
Ketone
Carboxylic acid ester
Oxacycle
Organoheterocyclic compound
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.82	ChemAxon
pKa (Strongest Acidic)	16.72	ChemAxon
pKa (Strongest Basic)	-5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	69.67 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	98.03 m³·mol⁻¹	ChemAxon
Polarizability	39.09 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Wei Z, Turak A, Li B, Aisa HA: Guaianolide sesquiterpene lactones from Cichorium glandulosum and their anti-neuroinflammation activities. Phytochemistry. 2024 Jul 19;226:114223. doi: 10.1016/j.phytochem.2024.114223. [PubMed:39032793 ]
DOI: 10.1016/j.phytochem.2024.114223
PII: s0031942224002607

Showing NP-Card for Cicholosumin B (NP0333670)

MOL for NP0333670 (Cicholosumin B)

3D MOL for NP0333670 (Cicholosumin B)

3D SDF for NP0333670 (Cicholosumin B)

3D-SDF for NP0333670 (Cicholosumin B)

PDB for NP0333670 (Cicholosumin B)

3D PDB for NP0333670 (Cicholosumin B)

SMILES for NP0333670 (Cicholosumin B)

INCHI for NP0333670 (Cicholosumin B)

Structure for NP0333670 (Cicholosumin B)

3D Structure for NP0333670 (Cicholosumin B)