NP-MRD: Showing NP-Card for Undobolin F (NP0333589)

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Record Information

Version

2.0

Created at

2024-07-10 10:26:35 UTC

Updated at

2026-02-05 09:02:14 UTC

NP-MRD ID

NP0333589

Natural Product DOI

https://doi.org/10.57994/3064

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Undobolin F

Description

Undobolin F belongs to the class of organic compounds known as ophiobolane sesterterpenoids. These are sesterterpnoids with a structure based on the ophiobolane backbone. Ophiobolane is a tricyclic compound consisting of two cyclopentane rings joined by a cyclooctane ring, and carries a methyl group at the 1-, 4-, and 8-position, as well as a 6-methylheptane group at the 12-position. Undobolin F was first documented in 2024 (PMID: 39051441). Based on a literature review very few articles have been published on Undobolin F.

Structure

MOL SDF PDB SMILES InChI


  Mrv2104 03242313012D          

 30 32  0  0  1  0            999 V2000
    0.2797   -3.0898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0043   -2.3121    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.8069   -2.1618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3427   -2.7891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1539   -2.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4293   -1.8611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8935   -1.2337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2404   -1.7107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5158   -0.9330    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5401   -1.6848    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8558   -2.4470    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3475   -0.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0509   -0.4515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6783   -0.9873    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.8073   -0.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4405   -0.6716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2027   -0.9873    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0736   -0.1724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5184   -1.7495    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.3408   -1.6848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5334   -0.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8300   -0.4515    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.7653    0.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6934   -1.7495    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2027   -2.5117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7860   -3.0951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4405   -2.8274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6783   -2.5117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3625   -1.7495    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1875   -1.7495    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  2  1  1  0  0  0
 10 11  1  6  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 15  1  1  0  0  0
 14 16  1  0  0  0  0
 17 16  1  0  0  0  0
 17 18  1  6  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 22 21  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  6  0  0  0
 19 24  1  1  0  0  0
 19 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 27 28  1  0  0  0  0
 29 28  1  0  0  0  0
 29 14  1  0  0  0  0
 10 29  1  0  0  0  0
 29 30  1  6  0  0  0
M  END


  Mrv2104 03242313012D          

 30 32  0  0  1  0            999 V2000
    0.2797   -3.0898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0043   -2.3121    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.8069   -2.1618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3427   -2.7891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1539   -2.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4293   -1.8611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8935   -1.2337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2404   -1.7107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5158   -0.9330    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5401   -1.6848    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8558   -2.4470    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3475   -0.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0509   -0.4515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6783   -0.9873    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.8073   -0.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4405   -0.6716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2027   -0.9873    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0736   -0.1724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5184   -1.7495    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.3408   -1.6848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5334   -0.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8300   -0.4515    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.7653    0.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6934   -1.7495    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2027   -2.5117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7860   -3.0951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4405   -2.8274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6783   -2.5117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3625   -1.7495    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1875   -1.7495    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  2  1  1  0  0  0
 10 11  1  6  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 15  1  1  0  0  0
 14 16  1  0  0  0  0
 17 16  1  0  0  0  0
 17 18  1  6  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 22 21  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  6  0  0  0
 19 24  1  1  0  0  0
 19 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 27 28  1  0  0  0  0
 29 28  1  0  0  0  0
 29 14  1  0  0  0  0
 10 29  1  0  0  0  0
 29 30  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0333589

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H][C@@]1(CC[C@]2(C)C[C@@]3(O)[C@H](C)CC[C@]3([H])\C(C)=C/C[C@@]12[H])[C@@H](C)CC\C=C(/C)CO

> <INCHI_IDENTIFIER>
InChI=1S/C25H42O2/c1-17(15-26)7-6-8-18(2)21-13-14-24(5)16-25(27)20(4)10-12-22(25)19(3)9-11-23(21)24/h7,9,18,20-23,26-27H,6,8,10-16H2,1-5H3/b17-7+,19-9-/t18-,20+,21+,22+,23-,24+,25+/m0/s1

> <INCHI_KEY>
GKPHHAGCSFUFNE-IONKGDNDSA-N

> <FORMULA>
C25H42O2

> <MOLECULAR_WEIGHT>
374.609

> <EXACT_MASS>
374.318480592

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
69

> <JCHEM_AVERAGE_POLARIZABILITY>
46.568150560041786

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,3R,6R,7S,9Z,11R,14R)-6-[(2S,5E)-7-hydroxy-6-methylhept-5-en-2-yl]-3,10,14-trimethyltricyclo[9.3.0.0^{3,7}]tetradec-9-en-1-ol

> <JCHEM_LOGP>
5.3730672723333335

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
16.64402356141912

> <JCHEM_PKA_STRONGEST_BASIC>
0.11039552114745804

> <JCHEM_POLAR_SURFACE_AREA>
40.46

> <JCHEM_REFRACTIVITY>
115.82589999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(1R,3R,6R,7S,9Z,11R,14R)-6-[(2S,5E)-7-hydroxy-6-methylhept-5-en-2-yl]-3,10,14-trimethyltricyclo[9.3.0.0^{3,7}]tetradec-9-en-1-ol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-MAR-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-MAR-23         0                                  
HETATM    1  C   UNK     0       0.522  -5.768   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.008  -4.316   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.506  -4.035   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -2.506  -5.206   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -4.021  -4.926   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -4.535  -3.474   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -3.534  -2.303   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -6.049  -3.193   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0      -6.563  -1.742   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       1.008  -3.145   0.000  0.00  0.00           C+0
HETATM   11  H   UNK     0       1.597  -4.568   0.000  0.00  0.00           H+0
HETATM   12  C   UNK     0       0.649  -1.647   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       1.962  -0.843   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.133  -1.843   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.374  -0.322   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       4.556  -1.254   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.978  -1.843   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       5.737  -0.322   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       6.568  -3.266   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       8.103  -3.145   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       8.462  -1.647   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       7.149  -0.843   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       7.028   0.692   0.000  0.00  0.00           C+0
HETATM   24  H   UNK     0       5.028  -3.266   0.000  0.00  0.00           H+0
HETATM   25  C   UNK     0       5.978  -4.688   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       7.067  -5.777   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       4.556  -5.278   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       3.133  -4.688   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       2.543  -3.266   0.000  0.00  0.00           C+0
HETATM   30  H   UNK     0       4.083  -3.266   0.000  0.00  0.00           H+0
CONECT    1    2                                                            
CONECT    2    1    3   10                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8                                                            
CONECT   10    2   11   12   29                                             
CONECT   11   10                                                            
CONECT   12   10   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   16   29                                             
CONECT   15   14                                                            
CONECT   16   14   17                                                       
CONECT   17   16   18   19   22                                             
CONECT   18   17                                                            
CONECT   19   17   20   24   25                                             
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   17   23                                                  
CONECT   23   22                                                            
CONECT   24   19                                                            
CONECT   25   19   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   14   10   30                                             
CONECT   30   29                                                            
MASTER        0    0    0    0    0    0    0    0   30    0   64    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₅H₄₂O₂

Average Mass

374.6090 Da

Monoisotopic Mass

374.31848 Da

IUPAC Name

(1R,3R,6R,7S,9Z,11R,14R)-6-[(2S,5E)-7-hydroxy-6-methylhept-5-en-2-yl]-3,10,14-trimethyltricyclo[9.3.0.0^{3,7}]tetradec-9-en-1-ol

Traditional Name

(1R,3R,6R,7S,9Z,11R,14R)-6-[(2S,5E)-7-hydroxy-6-methylhept-5-en-2-yl]-3,10,14-trimethyltricyclo[9.3.0.0^{3,7}]tetradec-9-en-1-ol

CAS Registry Number

Not Available

SMILES

[H][C@@]1(CC[C@]2(C)C[C@@]3(O)[C@H](C)CC[C@]3([H])\C(C)=C/C[C@@]12[H])[C@@H](C)CC\C=C(/C)CO

InChI Identifier

InChI=1S/C25H42O2/c1-17(15-26)7-6-8-18(2)21-13-14-24(5)16-25(27)20(4)10-12-22(25)19(3)9-11-23(21)24/h7,9,18,20-23,26-27H,6,8,10-16H2,1-5H3/b17-7+,19-9-/t18-,20+,21+,22+,23-,24+,25+/m0/s1

InChI Key

GKPHHAGCSFUFNE-IONKGDNDSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
COSY NMR	[¹H, ¹H] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	[email protected]	Huazhong University if Science and technology	Yuyi Zheng	2024-07-10	View Spectrum
NOESY NMR	[¹H, ¹H] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	[email protected]	Huazhong University if Science and technology	Yuyi Zheng	2024-07-10	View Spectrum
HMBC NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	[email protected]	Huazhong University if Science and technology	Yuyi Zheng	2024-07-10	View Spectrum
HSQC NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	[email protected]	Huazhong University if Science and technology	Yuyi Zheng	2024-07-10	View Spectrum
1D_DEPT NMR	¹³C NMR Spectrum (1D, 151 MHz, CDCl3, experimental)	[email protected]	Huazhong University if Science and technology	Yuyi Zheng	2024-07-10	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, CDCl3, experimental)	[email protected]	Huazhong University if Science and technology	Yuyi Zheng	2024-07-10	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, CDCl3, experimental)	[email protected]	Huazhong University if Science and technology	Yuyi Zheng	2024-07-10	View Spectrum

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View

Chemical Shift Submissions

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 600.0, Chloroform-d, simulated)	[email protected]	Not Available	Not Available	2026-02-05	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 150.0, Chloroform-d, simulated)	[email protected]	Not Available	Not Available	2026-02-05	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600.203706235, CDCl₃, simulated)	[email protected]	Huazhong University if Science and technology	Yuyi Zheng	2024-07-10	View Spectrum

Species

Species of Origin

Species Name	Source	Reference
Aspergillus undulatus		Not Available
Aspergillus undulatus		Not Available

Chemical Taxonomy

Description

This compound belongs to the class of organic compounds known as ophiobolane sesterterpenoids. These are sesterterpnoids with a structure based on the ophiobolane backbone. Ophiobolane is a tricyclic compound consisting of two cyclopentane rings joined by a cyclooctane ring, and carries a methyl group at the 1-, 4-, and 8-position, as well as a 6-methylheptane group at the 12-position.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesterterpenoids

Direct Parent

Ophiobolane sesterterpenoids

Alternative Parents

Substituents

Ophiobolane sesterterpenoid
Long chain fatty alcohol
Fatty alcohol
Fatty acyl
Tertiary alcohol
Cyclic alcohol
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.37	ChemAxon
pKa (Strongest Acidic)	16.64	ChemAxon
pKa (Strongest Basic)	0.11	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	40.46 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	115.83 m³·mol⁻¹	ChemAxon
Polarizability	46.57 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Zheng Y, Li Q, Gu M, Liao H, Liang Y, Liu F, Li XN, Sun W, Chen C, Zhang Y, Zhu H: Undobolins A-L, Ophiobolin-Type Sesterterpenoids from Aspergillus undulatus. J Nat Prod. 2024 Aug 23;87(8):1965-1974. doi: 10.1021/acs.jnatprod.4c00385. Epub 2024 Jul 25. [PubMed:39051441 ]
DOI: 10.1021/acs.jnatprod.4c00385

Showing NP-Card for Undobolin F (NP0333589)

MOL for NP0333589 (Undobolin F)

3D MOL for NP0333589 (Undobolin F)

3D SDF for NP0333589 (Undobolin F)

3D-SDF for NP0333589 (Undobolin F)

PDB for NP0333589 (Undobolin F)

3D PDB for NP0333589 (Undobolin F)

SMILES for NP0333589 (Undobolin F)

INCHI for NP0333589 (Undobolin F)

Structure for NP0333589 (Undobolin F)

3D Structure for NP0333589 (Undobolin F)