NP-MRD: Showing NP-Card for N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide (NP0333539)

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Record Information

Version

2.0

Created at

2024-07-03 10:46:09 UTC

Updated at

2025-01-24 23:35:11 UTC

NP-MRD ID

NP0333539

Natural Product DOI

https://doi.org/10.57994/3008

Secondary Accession Numbers

None

Natural Product Identification

Common Name

N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide

Description

N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide belongs to the class of organic compounds known as acridones. These are acridines containing a ketone group attached to the C9 carbon atom of the acridine moiety. Based on a literature review very few articles have been published on N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide.

Structure

MOL SDF PDB SMILES InChI


  Mrv2104 03172313202D          

 30 33  0  0  0  0            999 V2000
   -0.8546    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421    2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454    0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954    0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    3.6829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5575    4.1201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8867    4.5074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  2  0  0  0  0
  6 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
  4 20  1  0  0  0  0
 20 21  2  0  0  0  0
  3 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
  5 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 24 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
M  END


  Mrv2104 03172313202D          

 30 33  0  0  0  0            999 V2000
   -0.8546    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421    2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454    0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954    0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954    0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    3.6829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5575    4.1201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8867    4.5074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  2  0  0  0  0
  6 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
  4 20  1  0  0  0  0
 20 21  2  0  0  0  0
  3 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
  5 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 24 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0333539

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC2=C(C=CC(C)(C)O2)C2=C1C(=O)C1=CC=CC=C1N2CCCC(=O)NO

> <INCHI_IDENTIFIER>
InChI=1S/C23H24N2O5/c1-23(2)11-10-15-17(30-23)13-18(29-3)20-21(15)25(12-6-9-19(26)24-28)16-8-5-4-7-14(16)22(20)27/h4-5,7-8,10-11,13,28H,6,9,12H2,1-3H3,(H,24,26)

> <INCHI_KEY>
USEOCASARWQXEP-UHFFFAOYSA-N

> <FORMULA>
C23H24N2O5

> <MOLECULAR_WEIGHT>
408.454

> <EXACT_MASS>
408.168521881

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
54

> <JCHEM_AVERAGE_POLARIZABILITY>
43.71610867187985

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
N-hydroxy-4-(11-methoxy-2,2-dimethyl-10-oxo-5,10-dihydro-2H-1-oxa-5-azatetraphen-5-yl)butanamide

> <JCHEM_LOGP>
3.0594399233333327

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
17.28597342635569

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.907035076181632

> <JCHEM_PKA_STRONGEST_BASIC>
-4.606685021086292

> <JCHEM_POLAR_SURFACE_AREA>
88.10000000000001

> <JCHEM_REFRACTIVITY>
113.9408

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
N-hydroxy-4-(11-methoxy-2,2-dimethyl-10-oxo-1-oxa-5-azatetraphen-5-yl)butanamide

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-MAR-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-MAR-23         0                                  
HETATM    1  C   UNK     0      -1.595   5.541   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0      -0.825   4.207   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       0.715   4.207   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.485   2.874   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.025   2.874   0.000  0.00  0.00           C+0
HETATM    6  N   UNK     0       3.795   1.540   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.105   2.874   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.645   2.874   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       8.415   1.540   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0       9.955   1.540   0.000  0.00  0.00           N+0
HETATM   12  O   UNK     0      10.725   0.206   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0       7.645   0.206   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       3.025   0.206   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.795  -1.127   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       3.025  -2.461   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       1.485  -2.461   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       0.715  -1.127   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       1.485   0.206   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       0.715   1.540   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -0.825   1.540   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       1.485   5.541   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       3.025   5.541   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       3.795   6.875   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       3.795   4.207   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       5.335   4.207   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       6.105   5.541   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       5.335   6.875   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       6.641   7.691   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       5.388   8.414   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   22                                                  
CONECT    4    3    5   20                                                  
CONECT    5    4    6   25                                                  
CONECT    6    5    7   14                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   13                                                  
CONECT   11   10   12                                                       
CONECT   12   11                                                            
CONECT   13   10                                                            
CONECT   14    6   15   19                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   14   20                                                  
CONECT   20   19    4   21                                                  
CONECT   21   20                                                            
CONECT   22    3   23                                                       
CONECT   23   22   24   25                                                  
CONECT   24   23   28                                                       
CONECT   25   23    5   26                                                  
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   24   29   30                                             
CONECT   29   28                                                            
CONECT   30   28                                                            
MASTER        0    0    0    0    0    0    0    0   30    0   66    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₃H₂₄N₂O₅

Average Mass

408.4540 Da

Monoisotopic Mass

408.16852 Da

IUPAC Name

N-hydroxy-4-(11-methoxy-2,2-dimethyl-10-oxo-5,10-dihydro-2H-1-oxa-5-azatetraphen-5-yl)butanamide

Traditional Name

N-hydroxy-4-(11-methoxy-2,2-dimethyl-10-oxo-1-oxa-5-azatetraphen-5-yl)butanamide

CAS Registry Number

Not Available

SMILES

COC1=CC2=C(C=CC(C)(C)O2)C2=C1C(=O)C1=CC=CC=C1N2CCCC(=O)NO

InChI Identifier

InChI=1S/C23H24N2O5/c1-23(2)11-10-15-17(30-23)13-18(29-3)20-21(15)25(12-6-9-19(26)24-28)16-8-5-4-7-14(16)22(20)27/h4-5,7-8,10-11,13,28H,6,9,12H2,1-3H3,(H,24,26)

InChI Key

USEOCASARWQXEP-UHFFFAOYSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, C2D6OS, experimental)	[email protected]	NIPER-Ahmedabad	Parusu Kavya Teja	2024-07-03	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
NA NA		Not Available

Chemical Taxonomy

Description

This compound belongs to the class of organic compounds known as acridones. These are acridines containing a ketone group attached to the C9 carbon atom of the acridine moiety.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Quinolines and derivatives

Sub Class

Benzoquinolines

Direct Parent

Acridones

Alternative Parents

Substituents

Acridone
Chromenopyridine
2,2-dimethyl-1-benzopyran
1-benzopyran
Benzopyran
Anisole
Methylpyridine
Hydroxypyridine
Tetrahydropyridine
Alkyl aryl ether
Alpha-branched alpha,beta-unsaturated-ketone
Benzenoid
Pyridine
Pyran
Beta-aminoketone
Heteroaromatic compound
Vinylogous ester
Vinylogous amide
Alpha,beta-unsaturated ketone
Enone
Acryloyl-group
Tertiary aliphatic amine
Tertiary amine
Ketone
Hydroxamic acid
Amino acid or derivatives
Oxacycle
Azacycle
Ether
Enamine
Carboxylic acid derivative
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Amine
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.06	ChemAxon
pKa (Strongest Acidic)	8.91	ChemAxon
pKa (Strongest Basic)	-4.6	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	88.1 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	113.94 m³·mol⁻¹	ChemAxon
Polarizability	43.72 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Showing NP-Card for N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide (NP0333539)

MOL for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)

3D MOL for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)

3D SDF for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)

3D-SDF for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)

PDB for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)

3D PDB for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)

SMILES for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)

INCHI for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)

Structure for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)

3D Structure for NP0333539 (N-hydroxy-4-(6-methoxy-3,3-dimethyl-7-oxo-3H-pyrano[2,3-c]acridin-12(7H)-yl)butanamide)