NP-MRD: Showing NP-Card for Homomorphin B (NP0333324)

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Record Information

Version

2.0

Created at

2024-05-30 14:45:53 UTC

Updated at

2026-02-08 02:25:13 UTC

NP-MRD ID

NP0333324

Natural Product DOI

https://doi.org/10.57994/2682

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Homomorphin B

Description

Homomorphin B belongs to the class of organic compounds known as isoleucine and derivatives. Isoleucine and derivatives are compounds containing isoleucine or a derivative thereof resulting from reaction of isoleucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. Homomorphin B was first documented in 2024 (PMID: 38990199). Based on a literature review very few articles have been published on Homomorphin B.

Structure

MOL SDF PDB SMILES InChI


  Mrv2104 02112317212D          

 29 31  0  0  1  0            999 V2000
    2.8370   -5.3870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8989   -4.4309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4509   -5.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3469   -3.8178    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6908   -1.9785    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018   -3.0331    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12  7  1  0  0  0  0
 12 13  1  1  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 16 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 15 28  1  0  0  0  0
 23 28  1  0  0  0  0
 10 29  2  0  0  0  0
M  END


  Mrv2104 02112317212D          

 29 31  0  0  1  0            999 V2000
    2.8370   -5.3870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8989   -4.4309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4509   -5.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3469   -3.8178    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6908   -1.9785    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018   -3.0331    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12  7  1  0  0  0  0
 12 13  1  1  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 16 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 15 28  1  0  0  0  0
 23 28  1  0  0  0  0
 10 29  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0333324

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H][C@@]1(CC2=C(NC3=CC=CC=C23)C(C)(C)C=C)NC(=O)[C@@]([H])(NC1=O)[C@H](C)CC

> <INCHI_IDENTIFIER>
InChI=1S/C22H29N3O2/c1-6-13(3)18-21(27)24-17(20(26)25-18)12-15-14-10-8-9-11-16(14)23-19(15)22(4,5)7-2/h7-11,13,17-18,23H,2,6,12H2,1,3-5H3,(H,24,27)(H,25,26)/t13-,17+,18+/m1/s1

> <INCHI_KEY>
YGTBNZCELRCGSH-BVGQSLNGSA-N

> <FORMULA>
C22H29N3O2

> <MOLECULAR_WEIGHT>
367.493

> <EXACT_MASS>
367.225977186

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
56

> <JCHEM_AVERAGE_POLARIZABILITY>
40.144896145590536

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3S,6S)-3-[(2R)-butan-2-yl]-6-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}piperazine-2,5-dione

> <JCHEM_LOGP>
3.619752325333334

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.438956481717332

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.339995695874759

> <JCHEM_PKA_STRONGEST_BASIC>
-3.761279789853163

> <JCHEM_POLAR_SURFACE_AREA>
73.99000000000001

> <JCHEM_REFRACTIVITY>
107.08540000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(3S,6S)-3-[(2R)-butan-2-yl]-6-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}piperazine-2,5-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 11-FEB-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   11-FEB-23         0                                  
HETATM    1  C   UNK     0       5.296 -10.056   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       5.772  -8.591   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       7.278  -8.271   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       8.308  -9.415   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.741  -7.447   0.000  0.00  0.00           C+0
HETATM    6  N   UNK     0       3.235  -7.767   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0       2.204  -6.622   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       0.698  -6.943   0.000  0.00  0.00           O+0
HETATM    9  H   UNK     0       6.247  -7.126   0.000  0.00  0.00           H+0
HETATM   10  C   UNK     0       5.217  -5.982   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0       4.187  -4.838   0.000  0.00  0.00           N+0
HETATM   12  C   UNK     0       2.680  -5.158   0.000  0.00  0.00           C+0
HETATM   13  H   UNK     0       3.156  -3.693   0.000  0.00  0.00           H+0
HETATM   14  C   UNK     0       1.650  -4.013   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.126  -2.549   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       1.220  -1.303   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -0.320  -1.303   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -0.320   0.237   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -0.320  -2.843   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      -1.860  -1.303   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      -2.630  -2.637   0.000  0.00  0.00           C+0
HETATM   22  N   UNK     0       2.126  -0.057   0.000  0.00  0.00           N+0
HETATM   23  C   UNK     0       3.590  -0.533   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       4.924   0.237   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       6.258  -0.533   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       6.258  -2.073   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       4.924  -2.843   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       3.590  -2.073   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       6.723  -5.662   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    5                                                  
CONECT    3    2    4                                                       
CONECT    4    3                                                            
CONECT    5    2    6    9   10                                             
CONECT    6    5    7                                                       
CONECT    7    6    8   12                                                  
CONECT    8    7                                                            
CONECT    9    5                                                            
CONECT   10    5   11   29                                                  
CONECT   11   10   12                                                       
CONECT   12   11    7   13   14                                             
CONECT   13   12                                                            
CONECT   14   12   15                                                       
CONECT   15   14   16   28                                                  
CONECT   16   15   17   22                                                  
CONECT   17   16   18   19   20                                             
CONECT   18   17                                                            
CONECT   19   17                                                            
CONECT   20   17   21                                                       
CONECT   21   20                                                            
CONECT   22   16   23                                                       
CONECT   23   22   24   28                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   15   23                                                  
CONECT   29   10                                                            
MASTER        0    0    0    0    0    0    0    0   29    0   62    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₂H₂₉N₃O₂

Average Mass

367.4930 Da

Monoisotopic Mass

367.22598 Da

IUPAC Name

(3S,6S)-3-[(2R)-butan-2-yl]-6-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}piperazine-2,5-dione

Traditional Name

(3S,6S)-3-[(2R)-butan-2-yl]-6-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}piperazine-2,5-dione

CAS Registry Number

Not Available

SMILES

[H][C@@]1(CC2=C(NC3=CC=CC=C23)C(C)(C)C=C)NC(=O)[C@@]([H])(NC1=O)[C@H](C)CC

InChI Identifier

InChI=1S/C22H29N3O2/c1-6-13(3)18-21(27)24-17(20(26)25-18)12-15-14-10-8-9-11-16(14)23-19(15)22(4,5)7-2/h7-11,13,17-18,23H,2,6,12H2,1,3-5H3,(H,24,27)(H,25,26)/t13-,17+,18+/m1/s1

InChI Key

YGTBNZCELRCGSH-BVGQSLNGSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
NOESY NMR	[¹H, ¹H] NMR Spectrum (2D, 400 MHz, CDCL3, experimental)	[email protected]	University of Southern California	Shu-Yi Lin	2024-05-30	View Spectrum
HSQC NMR	[¹H, ¹³C] NMR Spectrum (2D, 400 MHz, CDCL3, experimental)	[email protected]	University of Southern California	Shu-Yi Lin	2024-05-30	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, CDCL3, experimental)	[email protected]	University of Southern California	Shu-Yi Lin	2024-05-30	View Spectrum
COSY NMR	[¹H, ¹H] NMR Spectrum (2D, 400 MHz, CDCL3, experimental)	[email protected]	University of Southern California	Shu-Yi Lin	2024-05-30	View Spectrum
HMBC NMR	[¹H, ¹³C] NMR Spectrum (2D, 400 MHz, CDCL3, experimental)	[email protected]	University of Southern California	Shu-Yi Lin	2024-05-30	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, CDCL3, experimental)	[email protected]	University of Southern California	Shu-Yi Lin	2024-05-30	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 400.0, CDCl₃/CD₃OD (95/5), simulated)	[email protected]	Not Available	Not Available	2026-02-08	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100.0, CDCl₃/CD₃OD (95/5), simulated)	[email protected]	Not Available	Not Available	2026-02-08	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400.065587839, CDCl₃+CD₃OD (95:5), simulated)	[email protected]	University of Southern California	Shu-Yi Lin	2024-05-30	View Spectrum

Species

Species of Origin

Species Name	Source	Reference
Aspergillus homomorphus		Not Available
Aspergillus homomorphus		Not Available

Chemical Taxonomy

Description

This compound belongs to the class of organic compounds known as isoleucine and derivatives. These are compounds containing isoleucine or a derivative thereof resulting from reaction of isoleucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Isoleucine and derivatives

Alternative Parents

Substituents

Isoleucine or derivatives
N-acyl-alpha amino acid or derivatives
Triptan
Alpha-amino acid amide
Indole or derivatives
Indole
2,5-dioxopiperazine
Dioxopiperazine
Fatty acyl
Benzenoid
Piperazine
N-acyl-amine
Fatty amide
1,4-diazinane
Heteroaromatic compound
Pyrroline
Pyrrole
Lactam
Carboxamide group
Azacycle
Organoheterocyclic compound
Secondary amine
Secondary aliphatic amine
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Amine
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.62	ChemAxon
pKa (Strongest Acidic)	11.34	ChemAxon
pKa (Strongest Basic)	-3.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	73.99 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	107.09 m³·mol⁻¹	ChemAxon
Polarizability	40.14 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Jenkinson CB, Lin SY, Villarreal M, Oakley CE, Sherman DH, Lee CK, Wang CCC, Oakley BR: Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression System. J Nat Prod. 2024 Jul 26;87(7):1704-1713. doi: 10.1021/acs.jnatprod.4c00113. Epub 2024 Jul 11. [PubMed:38990199 ]
DOI: 10.1021/acs.jnatprod.4c00113
PMID: 38990199

Showing NP-Card for Homomorphin B (NP0333324)

MOL for NP0333324 (Homomorphin B)

3D MOL for NP0333324 (Homomorphin B)

3D SDF for NP0333324 (Homomorphin B)

3D-SDF for NP0333324 (Homomorphin B)

PDB for NP0333324 (Homomorphin B)

3D PDB for NP0333324 (Homomorphin B)

SMILES for NP0333324 (Homomorphin B)

INCHI for NP0333324 (Homomorphin B)

Structure for NP0333324 (Homomorphin B)

3D Structure for NP0333324 (Homomorphin B)