NP-MRD: Showing NP-Card for Eugeniifoline (NP0333146)

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Record Information

Version

2.0

Created at

2024-05-11 12:27:38 UTC

Updated at

2024-09-03 04:21:19 UTC

NP-MRD ID

NP0333146

Natural Product DOI

https://doi.org/10.57994/2446

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Eugeniifoline

Description

Eugeniifoline belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units. Eugeniifoline was first documented in 2023 (PMID: 36651825). Based on a literature review very few articles have been published on Eugeniifoline.

Structure

MOL SDF PDB SMILES InChI


  Mrv2104 01232315042D          

 29 33  0  0  1  0            999 V2000
    3.2715    0.3580    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3813   -0.4597    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4911   -1.2774    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8379   -1.7813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0749   -1.4676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0345    0.0442    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.0970    0.8669    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.4683    1.4010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8987    1.0616    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.2125    1.8246    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3317    0.3593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1443   -0.7734    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7975   -0.2695    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.5891   -0.5017    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9073   -1.0871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6704   -1.4008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7802   -2.2185    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5432   -2.5322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3236   -0.8969    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2541   -1.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6183   -0.1460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9651   -0.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2839   -0.1844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4822   -0.3791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0872    0.2178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1450    1.0094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9467    1.2041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5162    0.6072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3408    0.6310    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  2  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  9 10  1  1  0  0  0
  9 11  1  0  0  0  0
  6 12  1  1  0  0  0
  6 13  1  0  0  0  0
 13 11  1  0  0  0  0
 13 14  1  1  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  2  0  0  0  0
 15 20  2  0  0  0  0
  3 20  1  0  0  0  0
  2 21  1  0  0  0  0
 21 22  2  0  0  0  0
  5 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 23 28  1  0  0  0  0
 28 29  1  0  0  0  0
 21 29  1  0  0  0  0
M  END


  Mrv2104 01232315042D          

 29 33  0  0  1  0            999 V2000
    3.2715    0.3580    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3813   -0.4597    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4911   -1.2774    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8379   -1.7813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0749   -1.4676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0345    0.0442    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.0970    0.8669    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.4683    1.4010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8987    1.0616    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.2125    1.8246    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3317    0.3593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1443   -0.7734    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7975   -0.2695    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.5891   -0.5017    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9073   -1.0871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6704   -1.4008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7802   -2.2185    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5432   -2.5322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3236   -0.8969    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2541   -1.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6183   -0.1460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9651   -0.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2839   -0.1844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4822   -0.3791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0872    0.2178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1450    1.0094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9467    1.2041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5162    0.6072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3408    0.6310    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  2  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  9 10  1  1  0  0  0
  9 11  1  0  0  0  0
  6 12  1  1  0  0  0
  6 13  1  0  0  0  0
 13 11  1  0  0  0  0
 13 14  1  1  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  2  0  0  0  0
 15 20  2  0  0  0  0
  3 20  1  0  0  0  0
  2 21  1  0  0  0  0
 21 22  2  0  0  0  0
  5 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 23 28  1  0  0  0  0
 28 29  1  0  0  0  0
 21 29  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0333146

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H][C@]12C[C@H](O)[C@H](C)[C@@]1([H])[C@@]1([H])N(CCC3=C1NC1=CC=CC=C31)C=C2C(=O)OC

> <INCHI_IDENTIFIER>
InChI=1S/C21H24N2O3/c1-11-17(24)9-14-15(21(25)26-2)10-23-8-7-13-12-5-3-4-6-16(12)22-19(13)20(23)18(11)14/h3-6,10-11,14,17-18,20,22,24H,7-9H2,1-2H3/t11-,14+,17-,18+,20+/m0/s1

> <INCHI_KEY>
LTBTXKAHUWWXQG-QWXPXUONSA-N

> <FORMULA>
C21H24N2O3

> <MOLECULAR_WEIGHT>
352.434

> <EXACT_MASS>
352.178692641

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
50

> <JCHEM_AVERAGE_POLARIZABILITY>
39.8568276227067

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl (2R,3S,4R,5S,7S)-5-hydroxy-4-methyl-10,20-diazapentacyclo[11.7.0.0^{2,10}.0^{3,7}.0^{14,19}]icosa-1(13),8,14,16,18-pentaene-8-carboxylate

> <JCHEM_LOGP>
2.320776696999999

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
16.372813220475937

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.909397479876176

> <JCHEM_PKA_STRONGEST_BASIC>
-2.3532853440197634

> <JCHEM_POLAR_SURFACE_AREA>
65.56

> <JCHEM_REFRACTIVITY>
99.50800000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
methyl (2R,3S,4R,5S,7S)-5-hydroxy-4-methyl-10,20-diazapentacyclo[11.7.0.0^{2,10}.0^{3,7}.0^{14,19}]icosa-1(13),8,14,16,18-pentaene-8-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 23-JAN-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-JAN-23         0                                  
HETATM    1  H   UNK     0       6.107   0.668   0.000  0.00  0.00           H+0
HETATM    2  C   UNK     0       6.312  -0.858   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0       6.517  -2.384   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0       5.297  -3.325   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.873  -2.740   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       7.531   0.083   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.648   1.618   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.474   2.615   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.144   1.982   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       9.730   3.406   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       9.952   0.671   0.000  0.00  0.00           C+0
HETATM   12  H   UNK     0       7.736  -1.444   0.000  0.00  0.00           H+0
HETATM   13  C   UNK     0       8.955  -0.503   0.000  0.00  0.00           C+0
HETATM   14  H   UNK     0      10.433  -0.937   0.000  0.00  0.00           H+0
HETATM   15  C   UNK     0       9.160  -2.029   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      10.585  -2.615   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      10.790  -4.141   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0      12.214  -4.727   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      11.804  -1.674   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       7.941  -2.970   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       4.887  -0.273   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       3.668  -1.213   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.397  -0.344   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       0.900  -0.708   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      -0.163   0.407   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       0.271   1.884   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       1.767   2.248   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       2.830   1.133   0.000  0.00  0.00           C+0
HETATM   29  N   UNK     0       4.370   1.178   0.000  0.00  0.00           N+0
CONECT    1    2                                                            
CONECT    2    1    3    6   21                                             
CONECT    3    2    4   20                                                  
CONECT    4    3    5                                                       
CONECT    5    4   22                                                       
CONECT    6    2    7   12   13                                             
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   13                                                       
CONECT   12    6                                                            
CONECT   13    6   11   14   15                                             
CONECT   14   13                                                            
CONECT   15   13   16   20                                                  
CONECT   16   15   17   19                                                  
CONECT   17   16   18                                                       
CONECT   18   17                                                            
CONECT   19   16                                                            
CONECT   20   15    3                                                       
CONECT   21    2   22   29                                                  
CONECT   22   21    5   23                                                  
CONECT   23   22   24   28                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   23   29                                                  
CONECT   29   28   21                                                       
MASTER        0    0    0    0    0    0    0    0   29    0   66    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₁H₂₄N₂O₃

Average Mass

352.4340 Da

Monoisotopic Mass

352.17869 Da

IUPAC Name

methyl (2R,3S,4R,5S,7S)-5-hydroxy-4-methyl-10,20-diazapentacyclo[11.7.0.0^{2,10}.0^{3,7}.0^{14,19}]icosa-1(13),8,14,16,18-pentaene-8-carboxylate

Traditional Name

methyl (2R,3S,4R,5S,7S)-5-hydroxy-4-methyl-10,20-diazapentacyclo[11.7.0.0^{2,10}.0^{3,7}.0^{14,19}]icosa-1(13),8,14,16,18-pentaene-8-carboxylate

CAS Registry Number

Not Available

SMILES

[H][C@]12C[C@H](O)[C@H](C)[C@@]1([H])[C@@]1([H])N(CCC3=C1NC1=CC=CC=C31)C=C2C(=O)OC

InChI Identifier

InChI=1S/C21H24N2O3/c1-11-17(24)9-14-15(21(25)26-2)10-23-8-7-13-12-5-3-4-6-16(12)22-19(13)20(23)18(11)14/h3-6,10-11,14,17-18,20,22,24H,7-9H2,1-2H3/t11-,14+,17-,18+,20+/m0/s1

InChI Key

LTBTXKAHUWWXQG-QWXPXUONSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
NOESY NMR	[¹H, ¹H] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-05-11	View Spectrum
HMBC NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-05-11	View Spectrum
HSQC NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-05-11	View Spectrum
COSY NMR	[¹H, ¹H] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-05-11	View Spectrum
1D_DEPT NMR	¹³C NMR Spectrum (1D, 151 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-05-11	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-05-11	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-05-11	View Spectrum

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Leuconotis eugeniifolia		Not Available

Chemical Taxonomy

Description

This compound belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Sesquiterpenoids

Alternative Parents

Substituents

Farsesane sesquiterpenoid
Sesquiterpenoid
Pyridoindole
Beta-carboline
Indole or derivatives
Indole
Aralkylamine
Tetrahydropyridine
Fatty acid ester
Fatty acyl
Benzenoid
Heteroaromatic compound
Vinylogous amide
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Methyl ester
Pyrroline
Pyrrole
Cyclic alcohol
Tertiary aliphatic amine
Tertiary amine
Secondary alcohol
Carboxylic acid ester
Amino acid or derivatives
Azacycle
Organoheterocyclic compound
Secondary amine
Monocarboxylic acid or derivatives
Enamine
Secondary aliphatic amine
Carboxylic acid derivative
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Amine
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.32	ChemAxon
pKa (Strongest Acidic)	14.91	ChemAxon
pKa (Strongest Basic)	-2.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	65.56 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	99.51 m³·mol⁻¹	ChemAxon
Polarizability	39.86 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Tan YS, Wong SK, Yong KT, Lim KH, Lim SH, Low YY: Eugeniifoline, a Pentacyclic Indole Alkaloid from Leuconotis eugeniifolia, and Configurational Revision of Synthetic Eugeniifoline Isolated from a Diversity-Enhanced Extract. J Nat Prod. 2023 Jan 27;86(1):232-236. doi: 10.1021/acs.jnatprod.2c00731. Epub 2023 Jan 18. [PubMed:36651825 ]
DOI: 10.1021/acs.jnatprod.2c00731

Showing NP-Card for Eugeniifoline (NP0333146)

MOL for NP0333146 (Eugeniifoline)

3D MOL for NP0333146 (Eugeniifoline)

3D SDF for NP0333146 (Eugeniifoline)

3D-SDF for NP0333146 (Eugeniifoline)

PDB for NP0333146 (Eugeniifoline)

3D PDB for NP0333146 (Eugeniifoline)

SMILES for NP0333146 (Eugeniifoline)

INCHI for NP0333146 (Eugeniifoline)

Structure for NP0333146 (Eugeniifoline)

3D Structure for NP0333146 (Eugeniifoline)