Np mrd loader

Showing NP-Card for Hygrocin C (NP0332653)

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Record Information
Version2.0
Created at2024-03-15 15:45:52 UTC
Updated at2026-02-09 04:07:31 UTC
NP-MRD IDNP0332653
Natural Product DOIhttps://doi.org/10.57994/1913
Secondary Accession NumbersNone
Natural Product Identification
Common NameHygrocin C
DescriptionHygrocin C belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides. Hygrocin C was first documented in 2013 (PMID: 24490633). Based on a literature review a small amount of articles have been published on Hygrocin C (PMID: 36358111) (PMID: 37694782) (PMID: 36198661) (PMID: 29189900) (PMID: 38647518).
Structure
Thumb
MOLSDFPDBSMILESInChI

MOL for NP0332653 (Hygrocin C)


  Mrv2104 03152415452D          

 37 40  0  0  1  0            999 V2000
    3.9280   -2.0993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4780   -1.4079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7156   -1.7232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8855   -2.5305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749   -0.8384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3828   -0.0100    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2867    0.8094    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.0363    1.1540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1127    1.9754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5772    0.3884    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6135    1.2863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8639    0.9418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1907    1.4187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4411    1.0741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2671    2.2401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4422    2.2302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0167    2.5847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2026    2.7179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3952    2.5480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7038    2.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2217    1.4285    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.5250    1.7795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2022    1.3083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0139    0.6301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1085   -0.1894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4929   -0.9194    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1541   -1.4314    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1150   -1.4613    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6966   -2.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8908   -1.7419    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1839    3.5427    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6899    2.1078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4395    2.4523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5159    3.2738    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1917   -0.1718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5957    0.5475    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5363   -0.9214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  2  5  2  0  0  0  0
  6  5  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  7 10  1  6  0  0  0
  7 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 21 20  1  0  0  0  0
 21 22  1  6  0  0  0
 22 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 26 25  1  0  0  0  0
 26 27  1  6  0  0  0
 26 28  1  0  0  0  0
 28 29  1  6  0  0  0
 28 30  1  0  0  0  0
  3 30  1  0  0  0  0
 18 31  2  0  0  0  0
 17 32  2  0  0  0  0
 11 32  1  0  0  0  0
 32 33  1  0  0  0  0
  9 33  1  0  0  0  0
 33 34  2  0  0  0  0
  6 35  1  6  0  0  0
 35 36  1  0  0  0  0
  8 36  1  0  0  0  0
 35 37  2  0  0  0  0
M  END
Download

3D MOL for NP0332653 (Hygrocin C)

Download
3D SDF for NP0332653 (Hygrocin C)

  Mrv2104 03152415452D          

 37 40  0  0  1  0            999 V2000
    3.9280   -2.0993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4780   -1.4079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7156   -1.7232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8855   -2.5305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749   -0.8384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3828   -0.0100    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2867    0.8094    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.0363    1.1540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1127    1.9754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5772    0.3884    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6135    1.2863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8639    0.9418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1907    1.4187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4411    1.0741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2671    2.2401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4422    2.2302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0167    2.5847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2026    2.7179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3952    2.5480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7038    2.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2217    1.4285    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.5250    1.7795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2022    1.3083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0139    0.6301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1085   -0.1894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4929   -0.9194    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1541   -1.4314    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1150   -1.4613    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6966   -2.1724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8908   -1.7419    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1839    3.5427    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6899    2.1078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4395    2.4523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5159    3.2738    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1917   -0.1718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5957    0.5475    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5363   -0.9214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  2  5  2  0  0  0  0
  6  5  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  7 10  1  6  0  0  0
  7 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 21 20  1  0  0  0  0
 21 22  1  6  0  0  0
 22 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 26 25  1  0  0  0  0
 26 27  1  6  0  0  0
 26 28  1  0  0  0  0
 28 29  1  6  0  0  0
 28 30  1  0  0  0  0
  3 30  1  0  0  0  0
 18 31  2  0  0  0  0
 17 32  2  0  0  0  0
 11 32  1  0  0  0  0
 32 33  1  0  0  0  0
  9 33  1  0  0  0  0
 33 34  2  0  0  0  0
  6 35  1  6  0  0  0
 35 36  1  0  0  0  0
  8 36  1  0  0  0  0
 35 37  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0332653

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC[C@@H]1CCC(=O)C2=C3C(=O)C=C4NC(=O)[C@H](\C=C(C)/C(=O)O[C@H](C)[C@H](O)\C=C/1)[C@@]4(O)C3=CC(C)=C2O

> <INCHI_IDENTIFIER>
InChI=1S/C28H31NO8/c1-5-16-6-8-19(30)15(4)37-27(35)14(3)11-18-26(34)29-22-12-21(32)23-17(28(18,22)36)10-13(2)25(33)24(23)20(31)9-7-16/h6,8,10-12,15-16,18-19,30,33,36H,5,7,9H2,1-4H3,(H,29,34)/b8-6-,14-11-/t15-,16+,18+,19-,28+/m1/s1

> <INCHI_KEY>
NAKWTVLAAKACFD-KMZDPJHBSA-N

> <FORMULA>
C28H31NO8

> <MOLECULAR_WEIGHT>
509.555

> <EXACT_MASS>
509.204966962

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
68

> <JCHEM_AVERAGE_POLARIZABILITY>
51.72455753865957

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(9R,10E,12R,13R,16Z,18R,25R)-9-ethyl-4,12,25-trihydroxy-3,13,16-trimethyl-14-oxa-20-azatetracyclo[16.6.1.0^{5,24}.0^{21,25}]pentacosa-1,3,5(24),10,16,21-hexaene-6,15,19,23-tetrone

> <JCHEM_LOGP>
2.7514832209999986

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.213804871894965

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.859056309762861

> <JCHEM_PKA_STRONGEST_BASIC>
-3.3160116383173306

> <JCHEM_POLAR_SURFACE_AREA>
150.23

> <JCHEM_REFRACTIVITY>
138.0831

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(9R,10E,12R,13R,16Z,18R,25R)-9-ethyl-4,12,25-trihydroxy-3,13,16-trimethyl-14-oxa-20-azatetracyclo[16.6.1.0^{5,24}.0^{21,25}]pentacosa-1,3,5(24),10,16,21-hexaene-6,15,19,23-tetrone

> <JCHEM_VEBER_RULE>
0

$$$$

Download
3D-SDF for NP0332653 (Hygrocin C)
Download
PDB for NP0332653 (Hygrocin C)
HEADER    PROTEIN                                 15-MAR-24   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   15-MAR-24         0                                  
HETATM    1  C   UNK     0       7.332  -3.919   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.492  -2.628   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.069  -3.217   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       5.386  -4.724   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       7.607  -1.565   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.181  -0.019   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       8.002   1.511   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       9.401   2.154   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.544   3.687   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       6.678   0.725   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       6.745   2.401   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.346   1.758   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.089   2.648   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       2.690   2.005   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.232   4.182   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       2.692   4.163   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       5.631   4.825   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.111   5.073   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.604   4.756   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       1.314   3.916   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       0.414   2.667   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      -0.980   3.322   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -2.244   2.442   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       0.026   1.176   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       0.203  -0.354   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       0.920  -1.716   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0      -0.288  -2.672   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       2.081  -2.728   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       1.300  -4.055   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0       3.530  -3.252   0.000  0.00  0.00           O+0
HETATM   31  O   UNK     0       4.077   6.613   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0       6.888   3.935   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       8.287   4.578   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0       8.430   6.111   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0       9.691  -0.321   0.000  0.00  0.00           C+0
HETATM   36  N   UNK     0      10.445   1.022   0.000  0.00  0.00           N+0
HETATM   37  O   UNK     0      10.334  -1.720   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    5                                                  
CONECT    3    2    4   30                                                  
CONECT    4    3                                                            
CONECT    5    2    6                                                       
CONECT    6    5    7   35                                                  
CONECT    7    6    8   10   11                                             
CONECT    8    7    9   36                                                  
CONECT    9    8   33                                                       
CONECT   10    7                                                            
CONECT   11    7   12   32                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18   32                                                  
CONECT   18   17   19   31                                                  
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22   24                                                  
CONECT   22   21   23                                                       
CONECT   23   22                                                            
CONECT   24   21   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28    3                                                       
CONECT   31   18                                                            
CONECT   32   17   11   33                                                  
CONECT   33   32    9   34                                                  
CONECT   34   33                                                            
CONECT   35    6   36   37                                                  
CONECT   36   35    8                                                       
CONECT   37   35                                                            
MASTER        0    0    0    0    0    0    0    0   37    0   80    0
END

Download
3D PDB for NP0332653 (Hygrocin C)
Download
SMILES for NP0332653 (Hygrocin C)
CC[C@@H]1CCC(=O)C2=C3C(=O)C=C4NC(=O)[C@H](\C=C(C)/C(=O)O[C@H](C)[C@H](O)\C=C/1)[C@@]4(O)C3=CC(C)=C2O
Download
INCHI for NP0332653 (Hygrocin C)
InChI=1S/C28H31NO8/c1-5-16-6-8-19(30)15(4)37-27(35)14(3)11-18-26(34)29-22-12-21(32)23-17(28(18,22)36)10-13(2)25(33)24(23)20(31)9-7-16/h6,8,10-12,15-16,18-19,30,33,36H,5,7,9H2,1-4H3,(H,29,34)/b8-6-,14-11-/t15-,16+,18+,19-,28+/m1/s1
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View in JSmol
SynonymsNot Available
Chemical FormulaC28H31NO8
Average Mass509.5550 Da
Monoisotopic Mass509.20497 Da
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry NumberNot Available
SMILES
CC[C@@H]1CCC(=O)C2=C3C(=O)C=C4NC(=O)[C@H](\C=C(C)/C(=O)O[C@H](C)[C@H](O)\C=C/1)[C@@]4(O)C3=CC(C)=C2O
InChI Identifier
InChI=1S/C28H31NO8/c1-5-16-6-8-19(30)15(4)37-27(35)14(3)11-18-26(34)29-22-12-21(32)23-17(28(18,22)36)10-13(2)25(33)24(23)20(31)9-7-16/h6,8,10-12,15-16,18-19,30,33,36H,5,7,9H2,1-4H3,(H,29,34)/b8-6-,14-11-/t15-,16+,18+,19-,28+/m1/s1
InChI KeyNAKWTVLAAKACFD-KMZDPJHBSA-N
Experimental Spectra
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
Predicted Spectra
Not Available
Chemical Shift Submissions
Spectrum TypeDescriptionDepositor EmailDepositor OrganizationDepositorDeposition DateView
1D NMR1H NMR Spectrum (1D, 800.0, Methanol-d4, simulated)[email protected]Not AvailableNot Available2026-02-06View Spectrum
Species
Species of Origin
Species NameSourceReference
Streptomyces LZ35ΔGPKS
      Not Available
Streptomyces rapamycinicus
      Not Available
Streptomyces rapamycinicus
      Not Available
Chemical Taxonomy
Description Belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.  They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.
KingdomOrganic compounds  
Super ClassPhenylpropanoids and polyketides  
ClassMacrolactams  
Sub ClassNot Available
Direct ParentMacrolactams  
Alternative Parents
Substituents
  • Macrolide
    • 

  • Macrolactam
    • 

  • Naphthalene
    • 

  • Indole or derivatives
    • 

  • Aryl alkyl ketone
    • 

  • Aryl ketone
    • 

  • Benzenoid
    • 

  • 2-pyrrolidone
    • 

  • Pyrrolidone
    • 

  • Vinylogous amide
    • 

  • Vinylogous acid
    • 

  • Alpha,beta-unsaturated carboxylic ester
    • 

  • Enoate ester
    • 

  • Tertiary alcohol
    • 

  • Pyrrolidine
    • 

  • Secondary carboxylic acid amide
    • 

  • Secondary alcohol
    • 

  • Lactone
    • 

  • Lactam
    • 

  • Ketone
    • 

  • Carboxylic acid ester
    • 

  • Carboxamide group
    • 

  • Oxacycle
    • 

  • Azacycle
    • 

  • Organoheterocyclic compound
    • 

  • Polyol
    • 

  • Monocarboxylic acid or derivatives
    • 

  • Carboxylic acid derivative
    • 

  • Organic nitrogen compound
    • 

  • Organic oxygen compound
    • 

  • Organopnictogen compound
    • 

  • Organic oxide
    • 

  • Hydrocarbon derivative
    • 

  • Organooxygen compound
    • 

  • Organonitrogen compound
    • 

  • Carbonyl group
    • 

  • Alcohol
    • 

  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI IDNot Available
Good Scents IDNot Available
References
General References
  1. Lu C, Li Y, Deng J, Li S, Shen Y, Wang H, Shen Y: Hygrocins C-G, cytotoxic naphthoquinone ansamycins from gdmAI-disrupted Streptomyces sp. LZ35. J Nat Prod. 2013 Dec 27;76(12):2175-9. doi: 10.1021/np400474s. Epub 2013 Nov 18. [PubMed:24490633  ] 
  2. Yi W, Newaz AW, Yong K, Ma M, Lian XY, Zhang Z: New Hygrocins K-U and Streptophenylpropanamide A and Bioactive Compounds from the Marine-Associated Streptomyces sp. ZZ1956. Antibiotics (Basel). 2022 Oct 22;11(11):1455. doi: 10.3390/antibiotics11111455. [PubMed:36358111  ] 
  3. Kashi ME, Ghorbani M, Badibostan H, Seidel V, Hosseini SH, Asili J, Shakeri A, Sahebkar A: Antimicrobial and Cytotoxic Naphthoquinones from Microbial Origin: An Updated Review. Mini Rev Med Chem. 2024;24(8):844-862. doi: 10.2174/1389557523666230911141331. [PubMed:37694782  ] 
  4. Jang JP, Lee B, Heo KT, Oh TH, Lee HW, Ko SK, Hwang BY, Jang JH, Hong YS: Hygrolansamycins A-D, O-Heterocyclic Macrolides from Streptomyces sp. KCB17JA11. J Microbiol Biotechnol. 2022 Oct 28;32(10):1299-1306. doi:  10.4014/jmb.2206.06039. Epub 2022 Sep 5. [PubMed:36198661  ] 
  5. Wang J, Nong XH, Amin M, Qi SH: Hygrocin C from marine-derived Streptomyces sp. SCSGAA 0027 inhibits biofilm formation in Bacillus amyloliquefaciens SCSGAB0082 isolated from South China Sea gorgonian. Appl Microbiol Biotechnol. 2018 Feb;102(3):1417-1427. doi:  10.1007/s00253-017-8672-z. Epub 2017 Nov 30. [PubMed:29189900  ] 
  6. Mahmoud Mohamed MM, Yang Z, Lum KY, Peschel G, Rosenbaum MA, Weber T, Coriani S, Gotfredsen CH, Ding L: Genome-Driven Discovery of Hygrocins in Streptomyces rapamycinicus. J Nat Prod. 2024 May 24;87(5):1321-1329. doi: 10.1021/acs.jnatprod.3c00767. Epub  2024 Apr 22. [PubMed:38647518  ] 
  7. DOI: 10.1021/acs.jnatprod.3c00767
  8. PMID: 38647518
  9. DOI: 10.1021/np400474s
  10. PMID: 24490633