NP-MRD: Showing NP-Card for (+)-eburnamenine N-oxide (NP0332333)

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Record Information

Version

2.0

Created at

2024-01-04 12:07:35 UTC

Updated at

2025-02-11 15:47:06 UTC

NP-MRD ID

NP0332333

Natural Product DOI

https://doi.org/10.57994/1535

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(+)-eburnamenine N-oxide

Description

(+)-eburnamenine N-oxide was first documented in 2024 (PMID: 38284153). Based on a literature review very few articles have been published on (+)-eburnamenine N-oxide.

Structure

MOL SDF PDB SMILES InChI


  Mrv2104 01042412072D          

 23 27  0  0  1  0            999 V2000
    2.0240    1.1662    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2003    1.1190    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3767    1.0719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0760    1.7616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8718    1.5443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5659    1.9902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2992    1.6122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3384    0.7881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6443    0.3421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9110    0.7202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0057    0.3350    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4583   -0.3547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2820   -0.3076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6530    0.4293    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1056   -0.2604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9293   -0.2133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4766    0.4764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8476    1.2133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3950    1.9031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5713    1.8559    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.9423    2.5928    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.1187    2.5456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2950    2.4985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
  3 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 14 13  1  0  0  0  0
  2 14  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
  2 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4 23  1  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
> <DATABASE_ID>
NP0332333

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H][C@@]12C3=C4CC[N+]1([O-])CCC[C@]2(CC)C=CN3C1=CC=CC=C41

> <INCHI_IDENTIFIER>
InChI=1S/C19H22N2O/c1-2-19-9-5-12-21(22)13-8-15-14-6-3-4-7-16(14)20(11-10-19)17(15)18(19)21/h3-4,6-7,10-11,18H,2,5,8-9,12-13H2,1H3/t18-,19+,21?/m0/s1

> <INCHI_KEY>
ZEQJZDNETKHVAA-KTVLMBSMSA-N

> <FORMULA>
C19H22N2O

> <MOLECULAR_WEIGHT>
294.398

> <EXACT_MASS>
294.173213336

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
44

> <JCHEM_AVERAGE_POLARIZABILITY>
33.81136242657002

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(15R,19R)-15-ethyl-1,11-diazapentacyclo[9.6.2.0^{2,7}.0^{8,18}.0^{15,19}]nonadeca-2,4,6,8(18),16-pentaen-11-ium-11-olate

> <JCHEM_LOGP>
2.708716793333334

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
3.144331106112611

> <JCHEM_POLAR_SURFACE_AREA>
27.99

> <JCHEM_REFRACTIVITY>
89.46029999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(15R,19R)-15-ethyl-1,11-diazapentacyclo[9.6.2.0^{2,7}.0^{8,18}.0^{15,19}]nonadeca-2,4,6,8(18),16-pentaen-11-ium-11-olate

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 04-JAN-24   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-JAN-24         0                                  
HETATM    1  H   UNK     0       3.778   2.177   0.000  0.00  0.00           H+0
HETATM    2  C   UNK     0       2.241   2.089   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.703   2.001   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -0.142   3.288   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -1.627   2.883   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -2.923   3.715   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -4.292   3.009   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -4.365   1.471   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -3.069   0.639   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -1.701   1.344   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0       0.011   0.625   0.000  0.00  0.00           N+0
HETATM   12  C   UNK     0       0.856  -0.662   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.393  -0.574   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.086   0.801   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.931  -0.486   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.468  -0.398   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.623   0.889   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       5.316   2.265   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       4.471   3.552   0.000  0.00  0.00           C+0
HETATM   20  N   UNK     0       2.933   3.464   0.000  0.00  0.00           N+1
HETATM   21  O   UNK     0       3.626   4.840   0.000  0.00  0.00           O-1
HETATM   22  C   UNK     0       2.088   4.752   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       0.551   4.664   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   14   20                                             
CONECT    3    2    4   11                                                  
CONECT    4    3    5   23                                                  
CONECT    5    4    6   10                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9    5   11                                                  
CONECT   11   10    3   12                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13    2   15   17                                             
CONECT   15   14   16                                                       
CONECT   16   15                                                            
CONECT   17   14   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19    2   21   22                                             
CONECT   21   20                                                            
CONECT   22   20   23                                                       
CONECT   23   22    4                                                       
MASTER        0    0    0    0    0    0    0    0   23    0   54    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₉H₂₂N₂O

Average Mass

294.3980 Da

Monoisotopic Mass

294.17321 Da

IUPAC Name

(15R,19R)-15-ethyl-1,11-diazapentacyclo[9.6.2.0^{2,7}.0^{8,18}.0^{15,19}]nonadeca-2,4,6,8(18),16-pentaen-11-ium-11-olate

Traditional Name

(15R,19R)-15-ethyl-1,11-diazapentacyclo[9.6.2.0^{2,7}.0^{8,18}.0^{15,19}]nonadeca-2,4,6,8(18),16-pentaen-11-ium-11-olate

CAS Registry Number

Not Available

SMILES

[H][C@@]12C3=C4CC[N+]1([O-])CCC[C@]2(CC)C=CN3C1=CC=CC=C41

InChI Identifier

InChI=1S/C19H22N2O/c1-2-19-9-5-12-21(22)13-8-15-14-6-3-4-7-16(14)20(11-10-19)17(15)18(19)21/h3-4,6-7,10-11,18H,2,5,8-9,12-13H2,1H3/t18-,19+,21?/m0/s1

InChI Key

ZEQJZDNETKHVAA-KTVLMBSMSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
HMBC NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-01-04	View Spectrum
HSQC NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-01-04	View Spectrum
COSY NMR	[¹H, ¹H] NMR Spectrum (2D, 600 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-01-04	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-01-04	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, CDCl3, experimental)	yylow@um.edu.my	Not Available	Not Available	2024-01-04	View Spectrum

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View

Chemical Shift Submissions

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 600.13300065, CDCl₃, simulated)	yylow@um.edu.my	Department of Chemistry, Faculty of Science, Universiti Malaya	Yun-Yee Low	2024-05-14	View Spectrum

Species

Species of Origin

Species Name	Source	Reference
Leuconotis eugeniifolia		Not Available

Chemical Taxonomy

Classification

Not classified

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.71	ChemAxon
pKa (Strongest Basic)	3.14	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	27.99 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	89.46 m³·mol⁻¹	ChemAxon
Polarizability	33.81 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Tan YS, Ng MP, Tan CH, Tang WK, Sim KS, Yong KT, Krishnan P, Lim KH, Lim SH, Low YY: Quinoline, Indole, and Isogranatanine Alkaloids from Malayan Leuconotis eugeniifolia. J Nat Prod. 2024 Feb 23;87(2):286-296. doi: 10.1021/acs.jnatprod.3c00960. Epub 2024 Jan 29. [PubMed:38284153 ]
DOI: 10.1021/acs.jnatprod.3c00960

Showing NP-Card for (+)-eburnamenine N-oxide (NP0332333)

MOL for NP0332333 ((+)-eburnamenine N-oxide)

3D MOL for NP0332333 ((+)-eburnamenine N-oxide)

3D SDF for NP0332333 ((+)-eburnamenine N-oxide)

3D-SDF for NP0332333 ((+)-eburnamenine N-oxide)

PDB for NP0332333 ((+)-eburnamenine N-oxide)

3D PDB for NP0332333 ((+)-eburnamenine N-oxide)

SMILES for NP0332333 ((+)-eburnamenine N-oxide)

INCHI for NP0332333 ((+)-eburnamenine N-oxide)

Structure for NP0332333 ((+)-eburnamenine N-oxide)

3D Structure for NP0332333 ((+)-eburnamenine N-oxide)