NP-MRD: Showing NP-Card for Alstoboonine (NP0332015)

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Record Information

Version

2.0

Created at

2023-10-24 04:00:29 UTC

Updated at

2026-02-26 14:54:14 UTC

NP-MRD ID

NP0332015

Natural Product DOI

https://doi.org/10.57994/1143

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Alstoboonine

Description

Alstoboonine belongs to the class of organic compounds known as carbazoles. Carbazoles are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring. Alstoboonine was first documented in 2024 (PMID: 37942619). Based on a literature review very few articles have been published on Alstoboonine.

Structure

MOL SDF PDB SMILES InChI


  Mrv2104 10242304002D          

 25 29  0  0  1  0            999 V2000
    0.6079   -1.7088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0522   -0.9929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1069   -0.0964    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3397   -0.2634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2718    0.5877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9037   -0.2921    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2018    0.4568    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.9751    1.3642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1823    1.4091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7645    0.8351    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2719    0.6642    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3202    0.9002    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2525    1.9279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3878    2.3164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3044    3.1371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5737    2.7928    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3110    0.9409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5926    0.1655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4171    0.1936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898   -0.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7904   -0.2013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0184    0.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4458    1.1855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6451    0.9865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9615    1.4484    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  0  0  0  0
  3 10  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 12  5  1  0  0  0  0
 12 13  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  2  0  0  0  0
 12 17  1  0  0  0  0
 17 18  2  0  0  0  0
  6 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 19 24  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 17 25  1  0  0  0  0
M  CHG  1   7   1
M  END


  Mrv2104 10242304002D          

 25 29  0  0  1  0            999 V2000
    0.6079   -1.7088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0522   -0.9929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1069   -0.0964    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3397   -0.2634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2718    0.5877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9037   -0.2921    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2018    0.4568    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.9751    1.3642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1823    1.4091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7645    0.8351    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2719    0.6642    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3202    0.9002    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2525    1.9279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3878    2.3164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3044    3.1371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5737    2.7928    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3110    0.9409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5926    0.1655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4171    0.1936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898   -0.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7904   -0.2013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0184    0.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4458    1.1855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6451    0.9865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9615    1.4484    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  0  0  0  0
  3 10  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 12  5  1  0  0  0  0
 12 13  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  2  0  0  0  0
 12 17  1  0  0  0  0
 17 18  2  0  0  0  0
  6 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 19 24  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 17 25  1  0  0  0  0
M  CHG  1   7   1
M  END
> <DATABASE_ID>
NP0332015

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)[C@@]12CO[C@]3(C=C)[C@@H]([NH2+]CC[C@]13O)C1=C2NC2=C1C=CC=C2

> <INCHI_IDENTIFIER>
InChI=1S/C19H20N2O4/c1-3-18-15-13-11-6-4-5-7-12(11)21-14(13)17(10-25-18,16(22)24-2)19(18,23)8-9-20-15/h3-7,15,20-21,23H,1,8-10H2,2H3/p+1/t15-,17-,18+,19-/m0/s1

> <INCHI_KEY>
JOZAOIYYIKINSB-KANFNMMFSA-O

> <FORMULA>
C19H21N2O4

> <MOLECULAR_WEIGHT>
341.386

> <EXACT_MASS>
341.149583584

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
46

> <JCHEM_AVERAGE_POLARIZABILITY>
35.731527983545675

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
1

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2S,5R,6S,10S)-5-ethenyl-6-hydroxy-2-(methoxycarbonyl)-4-oxa-9,18-diazapentacyclo[9.7.0.0^{2,6}.0^{5,10}.0^{12,17}]octadeca-1(11),12(17),13,15-tetraen-9-ium

> <JCHEM_LOGP>
0.8180582480000006

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
15.037226632864492

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.743269276883998

> <JCHEM_PKA_STRONGEST_BASIC>
8.399350835504713

> <JCHEM_POLAR_SURFACE_AREA>
88.16

> <JCHEM_REFRACTIVITY>
102.04860000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(2S,5R,6S,10S)-5-ethenyl-6-hydroxy-2-(methoxycarbonyl)-4-oxa-9,18-diazapentacyclo[9.7.0.0^{2,6}.0^{5,10}.0^{12,17}]octadeca-1(11),12(17),13,15-tetraen-9-ium

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-OCT-23   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-OCT-23         0                                  
HETATM    1  C   UNK     0       1.135  -3.190   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.964  -1.853   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.066  -0.180   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       0.634  -0.492   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       0.507   1.097   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.554  -0.545   0.000  0.00  0.00           C+0
HETATM    7  N   UNK     0       4.110   0.853   0.000  0.00  0.00           N+1
HETATM    8  C   UNK     0       3.687   2.547   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.207   2.630   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.427   1.559   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0      -0.507   1.240   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       2.464   1.680   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.338   3.599   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       0.724   4.324   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       0.568   5.856   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       2.938   5.213   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       4.314   1.756   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.840   0.309   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       6.379   0.361   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       7.448  -0.747   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       8.942  -0.376   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       9.368   1.104   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       8.299   2.213   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       6.804   1.841   0.000  0.00  0.00           C+0
HETATM   25  N   UNK     0       5.528   2.704   0.000  0.00  0.00           N+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    6   10                                             
CONECT    4    3    5                                                       
CONECT    5    4   12                                                       
CONECT    6    3    7   18                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9    3   11   12                                             
CONECT   11   10                                                            
CONECT   12   10    5   13   17                                             
CONECT   13   12   14   16                                                  
CONECT   14   13   15                                                       
CONECT   15   14                                                            
CONECT   16   13                                                            
CONECT   17   12   18   25                                                  
CONECT   18   17    6   19                                                  
CONECT   19   18   20   24                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24                                                       
CONECT   24   19   23   25                                                  
CONECT   25   24   17                                                       
MASTER        0    0    0    0    0    0    0    0   25    0   58    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₉H₂₁N₂O₄

Average Mass

341.3860 Da

Monoisotopic Mass

341.14958 Da

IUPAC Name

(2S,5R,6S,10S)-5-ethenyl-6-hydroxy-2-(methoxycarbonyl)-4-oxa-9,18-diazapentacyclo[9.7.0.0^{2,6}.0^{5,10}.0^{12,17}]octadeca-1(11),12(17),13,15-tetraen-9-ium

Traditional Name

(2S,5R,6S,10S)-5-ethenyl-6-hydroxy-2-(methoxycarbonyl)-4-oxa-9,18-diazapentacyclo[9.7.0.0^{2,6}.0^{5,10}.0^{12,17}]octadeca-1(11),12(17),13,15-tetraen-9-ium

CAS Registry Number

Not Available

SMILES

COC(=O)[C@@]12CO[C@]3(C=C)[C@@H]([NH2+]CC[C@]13O)C1=C2NC2=C1C=CC=C2

InChI Identifier

InChI=1S/C19H20N2O4/c1-3-18-15-13-11-6-4-5-7-12(11)21-14(13)17(10-25-18,16(22)24-2)19(18,23)8-9-20-15/h3-7,15,20-21,23H,1,8-10H2,2H3/p+1/t15-,17-,18+,19-/m0/s1

InChI Key

JOZAOIYYIKINSB-KANFNMMFSA-O

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
ROESY NMR	[¹H, ¹H] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)	verena.spiegler@uni-muenster.de	Not Available	Not Available	2023-10-24	View Spectrum
HSQC NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)	verena.spiegler@uni-muenster.de	Not Available	Not Available	2023-10-24	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, CD3OD, experimental)	verena.spiegler@uni-muenster.de	Not Available	Not Available	2023-10-24	View Spectrum
HMBC NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)	verena.spiegler@uni-muenster.de	Not Available	Not Available	2023-10-24	View Spectrum
COSY NMR	[¹H, ¹H] NMR Spectrum (2D, 600 MHz, CD3OD, experimental)	verena.spiegler@uni-muenster.de	Not Available	Not Available	2023-10-24	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, CD3OD, experimental)	verena.spiegler@uni-muenster.de	Not Available	Not Available	2023-10-24	View Spectrum

Predicted Spectra

Not Available

Chemical Shift Submissions

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 600.0, Methanol-d4, simulated)	epoynton@sfu.ca	Not Available	Not Available	2026-02-26	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 150.0, Methanol-d4, simulated)	epoynton@sfu.ca	Not Available	Not Available	2026-02-26	View Spectrum

Species

Species of Origin

Species Name	Source	Reference
Alstonia boonei		Not Available

Chemical Taxonomy

Description

This compound belongs to the class of organic compounds known as carbazoles. These are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Carbazoles

Direct Parent

Carbazoles

Alternative Parents

Substituents

Carbazole
Indole
Fatty acid ester
Fatty acyl
Benzenoid
Substituted pyrrole
Piperidine
Monosaccharide
Heteroaromatic compound
Methyl ester
Tetrahydrofuran
Tertiary alcohol
Pyrrole
Carboxylic acid ester
Amino acid or derivatives
Oxacycle
Azacycle
Secondary amine
Monocarboxylic acid or derivatives
Ether
Secondary aliphatic amine
Dialkyl ether
Carboxylic acid derivative
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Amine
Alcohol
Organic cation
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.82	ChemAxon
pKa (Strongest Acidic)	12.74	ChemAxon
pKa (Strongest Basic)	8.4	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	88.16 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	102.05 m³·mol⁻¹	ChemAxon
Polarizability	35.73 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Grimm M, Borner R, Addotey JN, Schmidt TJ, Spiegler V: Alstoboonine, an Ulean-Type Indole Alkaloid from Alstonia boonei Leaves. J Nat Prod. 2024 Mar 22;87(3):514-519. doi: 10.1021/acs.jnatprod.3c00832. Epub 2023 Nov 9. [PubMed:37942619 ]
DOI: 10.1021/acs.jnatprod.3c00832

Showing NP-Card for Alstoboonine (NP0332015)

MOL for NP0332015 (Alstoboonine)

3D MOL for NP0332015 (Alstoboonine)

3D SDF for NP0332015 (Alstoboonine)

3D-SDF for NP0332015 (Alstoboonine)

PDB for NP0332015 (Alstoboonine)

3D PDB for NP0332015 (Alstoboonine)

SMILES for NP0332015 (Alstoboonine)

INCHI for NP0332015 (Alstoboonine)

Structure for NP0332015 (Alstoboonine)

3D Structure for NP0332015 (Alstoboonine)