Record Information |
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Version | 2.0 |
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Created at | 2023-10-19 00:00:26 UTC |
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Updated at | 2024-09-03 04:17:41 UTC |
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NP-MRD ID | NP0332008 |
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Natural Product DOI | https://doi.org/10.57994/1131 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | Aminosalicylic Acid |
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Description | Aminosalicylic Acid, also known as 4-aminosalicylate or paser, belongs to the class of organic compounds known as aminosalicylic acids. These are salicylic acids carrying an amino group on the benzene ring. An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4. Aminosalicylic Acid is a drug which is used for the treatment of tuberculosis. Aminosalicylic Acid was first documented in 1959 (PMID: 14408481). Aminosalicylic Acid is a moderately basic compound (based on its pKa) (PMID: 13790963) (PMID: 14670340) (PMID: 8444944) (PMID: 5755895) (PMID: 13684569) (PMID: 15494824). |
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Structure | InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11) |
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Synonyms | Value | Source |
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2-HYDROXY-4-aminobenzoIC ACID | ChEBI | 4-Aminosalicylate | ChEBI | p-Aminosalicylic acid | ChEBI | Para-amino salicylic acid | ChEBI | PAS | ChEBI | Paser | ChEBI | 4-Aminosalicylic acid | Kegg | Pamisyl | Kegg | 2-HYDROXY-4-aminobenzoate | Generator | p-Aminosalicylate | Generator | Para-amino salicylate | Generator | Aminosalicylate | Generator | 4-ASA | HMDB | Amino-pas | HMDB | Aminosalicylate sodium | HMDB | APAS | HMDB | Para-aminosalicylic acid | HMDB | PASK | HMDB | 4 Aminosalicylic acid | HMDB | Rezipas | HMDB | p-Aminosalicylic acid monolithium salt | HMDB | p-Aminosalicylic acid, monosodium salt, dihydrate | HMDB | Acid, aminosalicylic | HMDB | Alumino 4 aminosalicylic acid | HMDB | p Aminosalicylic acid monolithium salt | HMDB | p-Aminosalicylic acid monopotassium salt | HMDB | p Aminosalicylic acid | HMDB | p Aminosalicylic acid monopotassium salt | HMDB | p Aminosalicylic acid monosodium salt | HMDB | p-Aminosalicylic acid, aluminum (2:1) salt | HMDB | Para aminosalicylic acid | HMDB | Alumino-4-aminosalicylic acid | HMDB | p-Aminosalicylic acid monosodium salt | HMDB | p-Aminosalicylic acid, calcium (2:1) salt | HMDB | Aminosalicylic acid | ChEBI |
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Chemical Formula | C7H7NO3 |
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Average Mass | 153.1354 Da |
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Monoisotopic Mass | 153.04259 Da |
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IUPAC Name | 4-amino-2-hydroxybenzoic acid |
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Traditional Name | aminosalicylic acid |
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CAS Registry Number | Not Available |
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SMILES | NC1=CC(O)=C(C=C1)C(O)=O |
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InChI Identifier | InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11) |
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InChI Key | WUBBRNOQWQTFEX-UHFFFAOYSA-N |
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Experimental Spectra |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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HSQC NMR | [1H, 13C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2023-10-19 | View Spectrum | HMBC NMR | [1H, 13C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2023-10-19 | View Spectrum | COSY NMR | [1H, 1H] NMR Spectrum (2D, 600 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2023-10-19 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 201 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2023-10-19 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600 MHz, CD3OD, experimental) | bgnzk@missouri.edu | MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2023-10-19 | View Spectrum |
| Predicted Spectra |
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| Spectrum Type | Description | Depositor ID | Depositor Organization | Depositor | Deposition Date | View |
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| Chemical Shift Submissions |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 1H NMR Spectrum (1D, 600, CD3OD, simulated) | bgnzk@missouri.edu | Sumner Lab, MU Metabolomics Center, University of Missouri, Columbia. MO, USA | Dr. Bharat Goel | 2024-05-14 | View Spectrum |
| Species |
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Species of Origin | Not Available |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as aminosalicylic acids. These are salicylic acids carrying an amino group on the benzene ring. |
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Kingdom | Organic compounds |
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Super Class | Benzenoids |
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Class | Benzene and substituted derivatives |
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Sub Class | Benzoic acids and derivatives |
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Direct Parent | Aminosalicylic acids |
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Alternative Parents | |
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Substituents | - 4-aminosalicylic acid
- Aminosalicylic acid
- Salicylic acid
- Aminobenzoic acid or derivatives
- Aminobenzoic acid
- Benzoic acid
- Aniline or substituted anilines
- M-aminophenol
- Aminophenol
- Benzoyl
- 1-hydroxy-2-unsubstituted benzenoid
- 1-hydroxy-4-unsubstituted benzenoid
- Phenol
- Vinylogous acid
- Amino acid
- Amino acid or derivatives
- Carboxylic acid derivative
- Monocarboxylic acid or derivatives
- Carboxylic acid
- Organic nitrogen compound
- Organonitrogen compound
- Organooxygen compound
- Primary amine
- Hydrocarbon derivative
- Organic oxide
- Organopnictogen compound
- Organic oxygen compound
- Amine
- Aromatic homomonocyclic compound
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Molecular Framework | Aromatic homomonocyclic compounds |
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External Descriptors | |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - JUHASZ P, GALAMBOS G: [A simple paper-indicator method for the demonstration of paraaminosalicylic acid (PAS) in urine]. Tuberkulozis. 1961 Jun;14:186-7. [PubMed:13790963 ]
- Iyawoo K: Tuberculosis in Malaysia: problems and prospect of treatment and control. Tuberculosis (Edinb). 2004;84(1-2):4-7. doi: 10.1016/j.tube.2003.08.014. [PubMed:14670340 ]
- Authors unspecified: Controlled trial of short-course regimens of chemotherapy in the ambulatory treatment of spinal tuberculosis. Results at three years of a study in Korea. Twelfth report of the Medical Research Council Working Party on Tuberculosis of the Spine. J Bone Joint Surg Br. 1993 Mar;75(2):240-8. doi: 10.1302/0301-620X.75B2.8444944. [PubMed:8444944 ]
- Tiitinen H, Mattila MJ: Modification of the serum isoniazid levels by different preparations of paraaminosalicylic acid. Arzneimittelforschung. 1968 May;18(5):623-5. [PubMed:5755895 ]
- ARTIS RD, JOHNSON PK, FREE AH: A simplified test for the detection of paraaminosalicylic acid and acetylsalicylic acid metabolites in urine. Am Rev Respir Dis. 1961 Sep;84:435-9. doi: 10.1164/arrd.1961.84.3.435. [PubMed:13684569 ]
- Shah A, Panjabi C, Maurya V, Khanna P: Multidrug resistant miliary tuberculosis and Pott's disease in an immunocompetent patient. Saudi Med J. 2004 Oct;25(10):1468-70. [PubMed:15494824 ]
- NAITO M: [Combined therapy of massive doses of isoniazid, pyrazinamide, and sulfisoxazole for patients with pulmonary tuberculosis resistant to streptomycin, paraaminosalicylic acid, and isoniazid]. Kyoto Daigaku Kekkaku Kenkyusho Kiyo. 1961 Mar;9:136-41. [PubMed:14478036 ]
- KENDIG EL Jr, HUDGENS RO: The effect of rubeola on tuberculosis under antimicrobial therapy. II. Tuberculous meningitis treated with isoniazid, streptomycin and paraaminosalicylic acid. Pediatrics. 1959 Oct;24:619-22. [PubMed:14408481 ]
- Joshi JV, Joshi UM, Sankolli GM, Gupta K, Rao AP, Hazari K, Sheth UK, Saxena BN: A study of interaction of a low-dose combination oral contraceptive with anti-tubercular drugs. Contraception. 1980 Jun;21(6):617-29. doi: 10.1016/0010-7824(80)90034-7. [PubMed:7428368 ]
- MITROIU O, POPA M, NEGREANU W, BILCU M, POPPER M, KAUFMANN S, NICULESCU V, VANCOV Z: [The differential diagnosis of jaundices appearing during treatment with paraaminosalicylic acid (PAS) by means of serum aldolase determination]. Stud Cercet Inframicrobiol. 1960;11:125-31. [PubMed:14423031 ]
- MILLER FF, GREEN RA: Loeffler's syndrome due to paraaminosalicylic acid. Dis Chest. 1962 Jul;42:100-3. doi: 10.1378/chest.42.1.100. [PubMed:14473996 ]
- Miroshnichenko II, Sokolova GB, Mokhireva LV: [Clinical pharmacokinetics of para-aminosalicylic acid tablets]. Antibiot Khimioter. 2009;54(1-2):20-4. [PubMed:19499713 ]
- SCHMITTOVA M, ENGELBERTH O, SRAMKOVA J: [Effect of aminopyrine, paraaminobenzoic acid and paraaminosalicylic acid on experimental carditis in mice]. Cas Lek Cesk. 1959 Oct 30;98:1365-9. [PubMed:14443158 ]
- Wong SC, Ali MA: Hemoglobin E diseases: hematological, analytical, and biosynthetic studies in homozygotes and double heterozygotes for alpha-thalassemia. Am J Hematol. 1982 Aug;13(1):15-21. doi: 10.1002/ajh.2830130104. [PubMed:7137163 ]
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