Record Information |
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Version | 1.0 |
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Created at | 2022-11-21 23:29:48 UTC |
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Updated at | 2024-04-19 09:32:39 UTC |
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NP-MRD ID | NP0331186 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | Talaropeptide B |
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Description | Talaropeptide B belongs to the class of organic compounds known as hybrid peptides. Hybrid peptides are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond. It was first documented in 2023 (PMID: 37078450). Based on a literature review a significant number of articles have been published on Talaropeptide B (PMID: 37078444) (PMID: 37078443) (PMID: 37078154) (PMID: 37078114) (PMID: 37079959) (PMID: 37079958). |
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Structure | CC[C@H](C)[C@H](N(C)C(=O)[C@H](CC1=CC=CC=C1)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C)NC)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O InChI=1S/C70H120N12O14/c1-26-44(16)58(62(87)72-48(70(95)96)35-37(2)3)81(25)65(90)50(36-47-31-28-27-29-32-47)76(20)67(92)55(41(10)11)80(24)68(93)56(42(12)13)78(22)64(89)49-33-30-34-82(49)69(94)57(43(14)15)79(23)66(91)52(39(6)7)74-60(85)53(46(18)83)75-59(84)51(38(4)5)73-61(86)54(40(8)9)77(21)63(88)45(17)71-19/h27-29,31-32,37-46,48-58,71,83H,26,30,33-36H2,1-25H3,(H,72,87)(H,73,86)(H,74,85)(H,75,84)(H,95,96)/t44-,45-,46+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-/m0/s1 |
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Synonyms | Not Available |
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Chemical Formula | C70H120N12O14 |
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Average Mass | 1353.8000 Da |
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Monoisotopic Mass | 1352.90470 Da |
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IUPAC Name | Not Available |
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Traditional Name | Not Available |
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CAS Registry Number | Not Available |
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SMILES | CC[C@H](C)[C@H](N(C)C(=O)[C@H](CC1=CC=CC=C1)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C)NC)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O |
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InChI Identifier | InChI=1S/C70H120N12O14/c1-26-44(16)58(62(87)72-48(70(95)96)35-37(2)3)81(25)65(90)50(36-47-31-28-27-29-32-47)76(20)67(92)55(41(10)11)80(24)68(93)56(42(12)13)78(22)64(89)49-33-30-34-82(49)69(94)57(43(14)15)79(23)66(91)52(39(6)7)74-60(85)53(46(18)83)75-59(84)51(38(4)5)73-61(86)54(40(8)9)77(21)63(88)45(17)71-19/h27-29,31-32,37-46,48-58,71,83H,26,30,33-36H2,1-25H3,(H,72,87)(H,73,86)(H,74,85)(H,75,84)(H,95,96)/t44-,45-,46+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-/m0/s1 |
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InChI Key | CWUNJRMISPNJFK-DTNNBZDOSA-N |
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Experimental Spectra |
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| Spectrum Type | Description | Depositor Email | Depositor Organization | Depositor | Deposition Date | View |
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ROESY NMR | [1H, 1H] NMR Spectrum (2D, 600 MHz, CD3OD, experimental) | z.khalil@uq.edu.au | Not Available | Not Available | 2022-11-21 | View Spectrum | HMBC NMR | [1H, 13C] NMR Spectrum (2D, 600 MHz, CD3OD, experimental) | z.khalil@uq.edu.au | Not Available | Not Available | 2022-11-21 | View Spectrum | 1D NMR | [13C, ] NMR Spectrum (2D, 151 MHz, CD3OD, experimental) | z.khalil@uq.edu.au | Not Available | Not Available | 2022-11-21 | View Spectrum | 1D NMR | [1H, ] NMR Spectrum (2D, 600 MHz, CD3OD, experimental) | z.khalil@uq.edu.au | Not Available | Not Available | 2022-11-21 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600.13 MHz, CD3OD, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 150.92 MHz, CD3OD, simulated) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | Not Available |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as hybrid peptides. Hybrid peptides are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond. |
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Kingdom | Organic compounds |
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Super Class | Organic acids and derivatives |
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Class | Peptidomimetics |
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Sub Class | Hybrid peptides |
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Direct Parent | Hybrid peptides |
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Alternative Parents | |
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Substituents | - Hybrid peptide
- Phenylalanine or derivatives
- Leucine or derivatives
- Valine or derivatives
- Proline or derivatives
- N-acyl-alpha amino acid or derivatives
- N-acyl-alpha-amino acid
- Alpha-amino acid amide
- Alanine or derivatives
- Amphetamine or derivatives
- Alpha-amino acid or derivatives
- Pyrrolidine-2-carboxamide
- Pyrrolidine carboxylic acid or derivatives
- N-acylpyrrolidine
- Benzenoid
- N-acyl-amine
- Monocyclic benzene moiety
- Tertiary carboxylic acid amide
- Pyrrolidine
- Amino acid
- Secondary alcohol
- Carboxamide group
- Amino acid or derivatives
- Azacycle
- Organoheterocyclic compound
- Organic 1,3-dipolar compound
- Propargyl-type 1,3-dipolar organic compound
- Secondary amine
- Monocarboxylic acid or derivatives
- Secondary aliphatic amine
- Carboxylic acid
- Carboxylic acid derivative
- Carboximidic acid derivative
- Carboximidic acid
- Organic nitrogen compound
- Organic oxygen compound
- Organopnictogen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Organonitrogen compound
- Carbonyl group
- Amine
- Alcohol
- Aromatic heteromonocyclic compound
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Molecular Framework | Aromatic heteromonocyclic compounds |
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External Descriptors | Not Available |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Russi AE, Shivakumar P, Luo Z, Bezerra J: Plasticity between ILC2 subsets and amphiregulin expression regulate epithelial repair in biliary atresia. Hepatology. 2023 Apr 21. doi: 10.1097/HEP.0000000000000418. [PubMed:37078450 ]
- Hlady RA, Robertson KD: Epigenetic memory of environmental exposures as a mediator of liver disease. Hepatology. 2023 Apr 21. doi: 10.1097/HEP.0000000000000414. [PubMed:37078444 ]
- Ufere NN: Home is where the liver is?: moving beyond readmissions to time at home as a patient-centered and pragmatic quality measure in cirrhosis care. Hepatology. 2023 Apr 21. doi: 10.1097/HEP.0000000000000415. [PubMed:37078443 ]
- Arnon R, Rubinov A: [[PTOSIS AS A SIGN OF A SYSTEMIC DISEASE]]. Harefuah. 2023 Feb;162(2):119-121. [PubMed:37078154 ]
- Shemesh N, Olshaker H: [[A MULTICENTER SPANISH STUDY OF ATROPINE 0.01% IN CHILDHOOD MYOPIA PROGRESSION]]. Harefuah. 2023 Feb;162(2):116-118. [PubMed:37078114 ]
- Gonzalez Muriel RM, Garcia Rabanal D, Ramos Pascua LR: [Incidental finding in mechanical gonalgia in a patient with a history of breast cancer]. Semergen. 2023 Jul-Aug;49(5):101978. doi: 10.1016/j.semerg.2023.101978. Epub 2023 Apr 18. [PubMed:37079959 ]
- Vallina Perez JL, Taule Sanchez M, Miguel Fernandez V, Iglesias Aranda Catalan P: [<>]. Semergen. 2023 Jul-Aug;49(5):101974. doi: 10.1016/j.semerg.2023.101974. Epub 2023 Apr 18. [PubMed:37079958 ]
- Samboni-Mendez M, Benavides-Ruiz MM, Piamba-Valencia AM, Sanchez-Duque JA: [Subcutaneous analgesia in elderly palliative home care]. Semergen. 2023 Jul-Aug;49(5):101975. doi: 10.1016/j.semerg.2023.101975. Epub 2023 Apr 18. [PubMed:37079957 ]
- K B C, R H, R A, G JJB, J P D, Banjara SK, M A, K PR, B N, M SP: Macronutrient composition of term and preterm human milk of different socio economic groups. Prostaglandins Leukot Essent Fatty Acids. 2023 May;192:102571. doi: 10.1016/j.plefa.2023.102571. Epub 2023 Mar 30. [PubMed:37079956 ]
- Jyothi VGSS, Veerabomma H, Tryphena KP, Khatri DK, Singh SB, Madan J: Acute and sub-acute dermal toxicity of meloxicam emulgel: Analysis of biochemical, hematological, histopathological and immunohistochemical expression. Biochem Biophys Res Commun. 2023 Jun 11;660:88-95. doi: 10.1016/j.bbrc.2023.04.001. Epub 2023 Apr 11. [PubMed:37079955 ]
- Akhlaghpour H: Erratum to "An RNA-based theory of natural universal computation" [J. Theor. Biol. 537 (2022) 110984]. J Theor Biol. 2023 Jun 7;566:111481. doi: 10.1016/j.jtbi.2023.111481. Epub 2023 Apr 18. [PubMed:37079954 ]
- Pelletier F, Torres A, Meloche-Dumas L, Guerard-Poirier N, Kaviani A, Kapralos B, Mercier F, Dubrowski A, Patocskai E: The Role of Collaborative Observational Practice and Feedback-Discourse to Promote Remote Acquisition of Technical Surgical Skills. J Surg Res. 2023 Aug;288:372-382. doi: 10.1016/j.jss.2023.02.006. Epub 2023 Apr 18. [PubMed:37079953 ]
- Hryciuk MM, Schroter F, Hennicke L, Braun BC: Spheroid formation and luteinization of granulosa cells of felids in a long-term 3D culture. Differentiation. 2023 May-Jun;131:38-48. doi: 10.1016/j.diff.2023.03.002. Epub 2023 Apr 6. [PubMed:37079952 ]
- Chan NY, Wu WJ, Chan JWY, Chan KCC, Li AM, Chan SSM, Hau KT, Wing YK: Sleep and academic performance among students in Hong Kong: Curvilinear relationship suggesting an optimal amount of sleep. Sleep Med. 2023 Jun;106:97-105. doi: 10.1016/j.sleep.2023.04.001. Epub 2023 Apr 6. [PubMed:37079951 ]
- Toss A, Moscetti L: Are you treating ypN0 patient with adjuvant abemaciclib? ESMO Open. 2023 Jun;8(3):101217. doi: 10.1016/j.esmoop.2023.101217. Epub 2023 Apr 19. [PubMed:37079950 ]
- Gracia-Sanchez A, Lopez-Pineda A, Lazaro-Martinez JL, Perez A, Pomares-Gomez FJ, Fernandez-Seguin LM, Gil-Guillen VF, Chicharro-Luna E: Consensus-based recommendations on physical activity and exercise in patients with diabetes at risk of foot ulcerations: a Delphi study. Braz J Phys Ther. 2023 Mar-Apr;27(2):100500. doi: 10.1016/j.bjpt.2023.100500. Epub 2023 Apr 6. [PubMed:37079949 ]
- Tabata F, Wada Y, Shibasaki T, Kawakami S, Inubashiri M, Hosaka M, Noshiro K, Umazume T, Miyaji K: A lower ratio of reduced to total albumin in serum is associated with protein nutritional status of pregnant women in Japan. Nutr Res. 2023 Jun;114:1-12. doi: 10.1016/j.nutres.2023.03.006. Epub 2023 Mar 23. [PubMed:37079948 ]
- Dean B, Haroutunian V, Scarr E: Lower levels of cortical [(3)H]pirenzepine binding to postmortem tissue defines a sub-group of older people with schizophrenia with less severe cognitive deficits. Schizophr Res. 2023 May;255:274-282. doi: 10.1016/j.schres.2023.03.035. Epub 2023 Apr 19. [PubMed:37079947 ]
- Buma S, Banks L, Onwuka A, Althubaiti A, Wiet G: Maternal infant bonding in tracheostomy dependent infants: A cross sectional study. Int J Pediatr Otorhinolaryngol. 2023 May;168:111549. doi: 10.1016/j.ijporl.2023.111549. Epub 2023 Apr 7. [PubMed:37079946 ]
- Hintze JM, Afshar S, Taghinia A, Labow B, Green M, Robson CD, Marcus K, Mack J, Perez-Atayde A, Rahbar R: A multi-disciplinary team approach to pediatric malignant mandibular tumors. Int J Pediatr Otorhinolaryngol. 2023 May;168:111547. doi: 10.1016/j.ijporl.2023.111547. Epub 2023 Apr 15. [PubMed:37079945 ]
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