Record Information |
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Version | 2.0 |
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Created at | 2022-09-12 16:57:28 UTC |
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Updated at | 2022-09-12 16:57:29 UTC |
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NP-MRD ID | NP0331025 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | 1,4-bis[(4-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl] (2r,3s)-2,3-dihydroxy-2-(2-methylpropyl)butanedioate |
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Description | Loroglossin belongs to the class of organic compounds known as phenolic glycosides. These are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose. 1,4-bis[(4-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl] (2r,3s)-2,3-dihydroxy-2-(2-methylpropyl)butanedioate is found in Cremastra appendiculata, Gymnadenia conopsea and Dactylorhiza hatagirea. 1,4-bis[(4-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl] (2r,3s)-2,3-dihydroxy-2-(2-methylpropyl)butanedioate was first documented in 2004 (PMID: 14989381). Based on a literature review a significant number of articles have been published on Loroglossin (PMID: 21322946) (PMID: 19894516) (PMID: 19772750) (PMID: 18507346) (PMID: 16934540). |
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Structure | CC(C)C[C@@](O)([C@H](O)C(=O)OCC1=CC=C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1)C(=O)OCC1=CC=C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1 InChI=1S/C34H46O18/c1-16(2)11-34(46,33(45)48-15-18-5-9-20(10-6-18)50-32-28(42)26(40)24(38)22(13-36)52-32)29(43)30(44)47-14-17-3-7-19(8-4-17)49-31-27(41)25(39)23(37)21(12-35)51-31/h3-10,16,21-29,31-32,35-43,46H,11-15H2,1-2H3/t21-,22-,23-,24-,25+,26+,27-,28-,29-,31-,32-,34-/m1/s1 |
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Synonyms | Not Available |
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Chemical Formula | C34H46O18 |
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Average Mass | 742.7240 Da |
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Monoisotopic Mass | 742.26841 Da |
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IUPAC Name | 1,4-bis[(4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl] (2R,3S)-2,3-dihydroxy-2-(2-methylpropyl)butanedioate |
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Traditional Name | loroglossin |
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CAS Registry Number | Not Available |
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SMILES | CC(C)C[C@@](O)([C@H](O)C(=O)OCC1=CC=C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1)C(=O)OCC1=CC=C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1 |
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InChI Identifier | InChI=1S/C34H46O18/c1-16(2)11-34(46,33(45)48-15-18-5-9-20(10-6-18)50-32-28(42)26(40)24(38)22(13-36)52-32)29(43)30(44)47-14-17-3-7-19(8-4-17)49-31-27(41)25(39)23(37)21(12-35)51-31/h3-10,16,21-29,31-32,35-43,46H,11-15H2,1-2H3/t21-,22-,23-,24-,25+,26+,27-,28-,29-,31-,32-,34-/m1/s1 |
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InChI Key | QABASLXUKXNHMC-PIFIRMJRSA-N |
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Experimental Spectra |
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| Not Available | Predicted Spectra |
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| Not Available | Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as phenolic glycosides. These are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose. |
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Kingdom | Organic compounds |
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Super Class | Organic oxygen compounds |
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Class | Organooxygen compounds |
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Sub Class | Carbohydrates and carbohydrate conjugates |
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Direct Parent | Phenolic glycosides |
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Alternative Parents | |
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Substituents | - Phenolic glycoside
- Hexose monosaccharide
- O-glycosyl compound
- Benzyloxycarbonyl
- Phenoxy compound
- Phenol ether
- Beta-hydroxy acid
- Fatty acid ester
- Monocyclic benzene moiety
- Dicarboxylic acid or derivatives
- Fatty acyl
- Hydroxy acid
- Monosaccharide
- Oxane
- Benzenoid
- Tertiary alcohol
- Carboxylic acid ester
- Secondary alcohol
- Acetal
- Oxacycle
- Carboxylic acid derivative
- Organoheterocyclic compound
- Polyol
- Organic oxide
- Alcohol
- Hydrocarbon derivative
- Carbonyl group
- Primary alcohol
- Aromatic heteromonocyclic compound
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Molecular Framework | Aromatic heteromonocyclic compounds |
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External Descriptors | Not Available |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Yue Z, Zi J, Zhu C, Lin S, Yang Y, Shi J: [Constituents of Gymnadenia conopsea]. Zhongguo Zhong Yao Za Zhi. 2010 Nov;35(21):2852-61. [PubMed:21322946 ]
- Yang B, Li S, Zhang R, Wang Y, Shi J: [Quantitative analysis of four active constituents in Tibetan herb Gymnadenia conopsea by high-performance liquid chromatography]. Zhongguo Zhong Yao Za Zhi. 2009 Jul;34(14):1819-22. [PubMed:19894516 ]
- Li M, Guo SX, Wang CL, Xiao PG: Quantitative determination of five glucosyloxybenzyl 2-isobutylmalates in the tubers of Gymnadenia conopsea and Coeloglossum viride var. bracteatum by HPLC. J Chromatogr Sci. 2009 Sep;47(8):709-13. doi: 10.1093/chromsci/47.8.709. [PubMed:19772750 ]
- Liu J, Yu ZB, Ye YH, Zhou YW: [Chemical constituents from the tuber of Cremastra appendiculata]. Yao Xue Xue Bao. 2008 Feb;43(2):181-4. [PubMed:18507346 ]
- Cai M, Zhou Y, Gesang S, Bianba C, Ding LS: Chemical fingerprint analysis of rhizomes of Gymnadenia conopsea by HPLC-DAD-MSn. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Dec 5;844(2):301-7. doi: 10.1016/j.jchromb.2006.07.043. Epub 2006 Aug 23. [PubMed:16934540 ]
- Huang SY, Li GQ, Shi JG, Mo SY: Chemical constituents of the rhizomes of Coeloglossum viride var. bracteatum. J Asian Nat Prod Res. 2004 Mar;6(1):49-61. doi: 10.1080/1028602031000119826. [PubMed:14989381 ]
- LOTUS database [Link]
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