NP-MRD: Showing NP-Card for (3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione (NP0330792)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

1.0

Created at

2022-09-12 16:29:44 UTC

Updated at

2022-09-12 16:29:45 UTC

NP-MRD ID

NP0330792

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione

Description

Phomasetin belongs to the class of organic compounds known as n-alkylpyrrolidines. N-alkylpyrrolidines are compounds containing a pyrrolidine moiety that is substituted at the N1-position with an alkyl group. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms. Based on a literature review very few articles have been published on Phomasetin.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309122218292D          

 30 32  0  0  1  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.2868   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.8163   -2.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0416   -2.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2171   -2.4072    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4788   -3.0781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1698   -3.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3693   -4.0426    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8017   -4.3733    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7442   -5.1963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0027   -5.5579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5014   -3.9361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2663   -4.2452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3018   -3.1356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8321   -2.5036    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  6  5  1  1  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  1  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  6  0  0  0
 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
  6 17  1  0  0  0  0
 17 18  1  6  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  6  0  0  0
 25 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 21 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END

     RDKit          3D

 65 67  0  0  0  0  0  0  0  0999 V2000
   -2.4787    5.0835   -2.9250 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5612    3.9705   -1.9236 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5196    3.4945   -1.3032 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6348    2.4117   -0.3352 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5916    1.9132    0.3059 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6910    0.8509    1.2596 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.0700    0.6239    1.7029 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7916    1.8011    2.3167 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7563   -0.5129    1.6461 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1098   -1.7128    1.0864 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.0903   -2.5156    0.2099 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3700   -3.8082   -0.1160 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.8446   -4.3979   -1.4239 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8650   -3.6384   -0.1091 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5311   -2.3014   -0.7445 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0582   -1.2269    0.1559 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0623   -0.4747    0.9097 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.2784   -0.9862    2.2506 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0180   -0.0100   -0.0432 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3899    0.5950   -1.2151 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3101   -0.0066   -0.1102 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1559    0.5419   -1.2107 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.8435   -2.3490 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5293    0.6436   -0.6693 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.8488    2.0229   -0.1541 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8002    2.8938   -1.2498 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5411   -0.3620    0.3435 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6647   -1.1143    0.8478 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2093   -0.5770    0.8659 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8991   -1.1300    1.9183 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5851    5.6708   -2.6489 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3813    4.6760   -3.9432 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4090    5.7008   -2.9111 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5259    3.5427   -1.7050 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5525    3.9401   -1.5376 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6081    1.9942   -0.1392 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3559    2.4215    0.0434 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1679    1.2531    2.2127 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7846    1.6949    3.4271 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2415    2.7182    2.0866 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8086    1.8543    1.9081 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7764   -0.5747    2.0012 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7762   -2.4523    1.8344 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2528   -1.9560   -0.7545 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0374   -2.6857    0.7243 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6071   -4.5453    0.6760 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6488   -3.7493   -2.2814 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9414   -4.5483   -1.3382 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3908   -5.4073   -1.5029 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4573   -3.7439    0.9065 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4469   -4.4232   -0.7798 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5476   -2.1993   -0.9651 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0320   -2.3227   -1.7393 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5451   -0.4981   -0.5176 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5558   -2.0284    2.4215 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7512   -0.2258    2.9362 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7377   -1.0427    2.8392 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0118   -0.0107   -1.9028 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3056    0.3800   -1.4323 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8942    2.0108    0.1920 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1276    2.3763    0.5822 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6926    3.1781   -1.5454 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3814   -1.9988    1.4132 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3161   -0.4890    1.5264 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3033   -1.4252   -0.0238 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  7  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 12 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 17 19  1  6
 19 20  1  0
 19 21  2  0
 21 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 26  1  0
 24 27  1  0
 27 28  1  0
 27 29  1  0
 29 30  2  0
 17  6  1  0
 29 21  1  0
 16 10  1  0
  1 31  1  0
  1 32  1  0
  1 33  1  0
  2 34  1  0
  3 35  1  0
  4 36  1  0
  5 37  1  0
  6 38  1  1
  8 39  1  0
  8 40  1  0
  8 41  1  0
  9 42  1  0
 10 43  1  1
 11 44  1  0
 11 45  1  0
 12 46  1  1
 13 47  1  0
 13 48  1  0
 13 49  1  0
 14 50  1  0
 14 51  1  0
 15 52  1  0
 15 53  1  0
 16 54  1  6
 18 55  1  0
 18 56  1  0
 18 57  1  0
 20 58  1  0
 24 59  1  6
 25 60  1  0
 25 61  1  0
 26 62  1  0
 28 63  1  0
 28 64  1  0
 28 65  1  0
M  END


  Mrv1652309122218292D          

 30 32  0  0  1  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.2868   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.8163   -2.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0416   -2.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2171   -2.4072    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4788   -3.0781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1698   -3.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3693   -4.0426    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8017   -4.3733    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7442   -5.1963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0027   -5.5579    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5014   -3.9361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2663   -4.2452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3018   -3.1356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8321   -2.5036    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  6  5  1  1  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  1  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  6  0  0  0
 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
  6 17  1  0  0  0  0
 17 18  1  6  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  6  0  0  0
 25 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 21 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0330792

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C=C\C=C\[C@H]1C(C)=C[C@H]2C[C@@H](C)CC[C@@H]2[C@@]1(C)C(\O)=C1\C(=O)[C@@H](CO)N(C)C1=O

> <INCHI_IDENTIFIER>
InChI=1S/C25H35NO4/c1-6-7-8-9-18-16(3)13-17-12-15(2)10-11-19(17)25(18,4)23(29)21-22(28)20(14-27)26(5)24(21)30/h6-9,13,15,17-20,27,29H,10-12,14H2,1-5H3/b7-6+,9-8+,23-21+/t15-,17+,18-,19-,20+,25-/m0/s1

> <INCHI_KEY>
GQYNYOOJEMDNNZ-KXBMYEHISA-N

> <FORMULA>
C25H35NO4

> <MOLECULAR_WEIGHT>
413.558

> <EXACT_MASS>
413.256608611

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
65

> <JCHEM_AVERAGE_POLARIZABILITY>
47.563010316389416

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3E,5R)-3-{[(1R,2S,4aR,6S,8aS)-1,3,6-trimethyl-2-[(1E,3E)-penta-1,3-dien-1-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione

> <JCHEM_LOGP>
3.440170563333332

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
10.075007157973278

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.714308771837005

> <JCHEM_PKA_STRONGEST_BASIC>
-0.7945102476342955

> <JCHEM_POLAR_SURFACE_AREA>
77.84

> <JCHEM_REFRACTIVITY>
122.83219999999994

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(3E,5R)-3-{[(1R,2S,4aR,6S,8aS)-1,3,6-trimethyl-2-[(1E,3E)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 12-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   12-SEP-22         0                                  
HETATM    1  C   UNK     0      -5.335  -3.080   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -4.001  -2.310   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -2.667  -3.080   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.000  -3.080   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.002  -0.000   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       3.390  -4.440   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       1.944  -4.440   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       0.405  -4.493   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       2.760  -5.746   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.184  -7.174   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       0.689  -7.546   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       3.363  -8.163   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       3.256  -9.700   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       1.872 -10.375   0.000  0.00  0.00           O+0
HETATM   27  N   UNK     0       4.669  -7.347   0.000  0.00  0.00           N+0
HETATM   28  C   UNK     0       6.097  -7.924   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       4.297  -5.853   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0       5.287  -4.673   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   17                                                  
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10                                                       
CONECT   10    9   11   16                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   10   17                                                  
CONECT   17   16    6   18   19                                             
CONECT   18   17                                                            
CONECT   19   17   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   22   29                                                  
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25   27                                                  
CONECT   25   24   26                                                       
CONECT   26   25                                                            
CONECT   27   24   28   29                                                  
CONECT   28   27                                                            
CONECT   29   27   21   30                                                  
CONECT   30   29                                                            
MASTER        0    0    0    0    0    0    0    0   30    0   64    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₅H₃₅NO₄

Average Mass

413.5580 Da

Monoisotopic Mass

413.25661 Da

IUPAC Name

(3E,5R)-3-{[(1R,2S,4aR,6S,8aS)-1,3,6-trimethyl-2-[(1E,3E)-penta-1,3-dien-1-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione

Traditional Name

(3E,5R)-3-{[(1R,2S,4aR,6S,8aS)-1,3,6-trimethyl-2-[(1E,3E)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione

CAS Registry Number

Not Available

SMILES

C\C=C\C=C\[C@H]1C(C)=C[C@H]2C[C@@H](C)CC[C@@H]2[C@@]1(C)C(\O)=C1\C(=O)[C@@H](CO)N(C)C1=O

InChI Identifier

InChI=1S/C25H35NO4/c1-6-7-8-9-18-16(3)13-17-12-15(2)10-11-19(17)25(18,4)23(29)21-22(28)20(14-27)26(5)24(21)30/h6-9,13,15,17-20,27,29H,10-12,14H2,1-5H3/b7-6+,9-8+,23-21+/t15-,17+,18-,19-,20+,25-/m0/s1

InChI Key

GQYNYOOJEMDNNZ-KXBMYEHISA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as n-alkylpyrrolidines. N-alkylpyrrolidines are compounds containing a pyrrolidine moiety that is substituted at the N1-position with an alkyl group. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyrrolidines

Sub Class

N-alkylpyrrolidines

Direct Parent

N-alkylpyrrolidines

Alternative Parents

Substituents

Pyrrolidone
2-pyrrolidone
3-pyrrolidone
N-alkylpyrrolidine
Tertiary carboxylic acid amide
Vinylogous acid
Carboxamide group
Ketone
Lactam
Cyclic ketone
Enol
Carboxylic acid derivative
Azacycle
Organic oxygen compound
Organic nitrogen compound
Primary alcohol
Organooxygen compound
Organonitrogen compound
Carbonyl group
Organic oxide
Hydrocarbon derivative
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.44	ChemAxon
pKa (Strongest Acidic)	4.71	ChemAxon
pKa (Strongest Basic)	-0.79	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	77.84 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	122.83 m³·mol⁻¹	ChemAxon
Polarizability	47.56 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00028830

Chemspider ID

78440076

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

54711946

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione (NP0330792)

MOL for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)

3D MOL for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)

3D SDF for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)

3D-SDF for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)

PDB for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)

3D PDB for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)

SMILES for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)

INCHI for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)

Structure for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)

3D Structure for NP0330792 ((3e,5r)-3-{[(1r,2s,4ar,6s,8as)-1,3,6-trimethyl-2-[(1e,3e)-penta-1,3-dien-1-yl]-4a,5,6,7,8,8a-hexahydro-2h-naphthalen-1-yl](hydroxy)methylidene}-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione)