NP-MRD: Showing NP-Card for 4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate (NP0328373)

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Record Information

Version

2.0

Created at

2022-09-12 11:47:24 UTC

Updated at

2022-09-12 11:47:24 UTC

NP-MRD ID

NP0328373

Secondary Accession Numbers

None

Natural Product Identification

Common Name

4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate

Description

4-[(3AS,4R,6aR,8S,9R,9aS,9bS)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-decahydro-2H-spiro[azuleno[4,5-b]furan-9,2'-oxirane]-4-yl]-2-methylidene-3-oxobutyl acetate belongs to the class of organic compounds known as guaianolides and derivatives. These are diterpene lactones with a structure characterized by the presence of a gamma-lactone fused to a guaiane, forming 3,6,9-trimethyl-azuleno[4,5-b]furan-2-one or a derivative. Based on a literature review very few articles have been published on 4-[(3aS,4R,6aR,8S,9R,9aS,9bS)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-decahydro-2H-spiro[azuleno[4,5-b]furan-9,2'-oxirane]-4-yl]-2-methylidene-3-oxobutyl acetate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309122213472D          

 32 35  0  0  1  0            999 V2000
   -0.8959    0.1422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8959   -0.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6103   -1.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3248   -0.6828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0393   -1.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7537   -0.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0393   -1.9203    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1814   -1.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1814   -1.9203    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5331   -0.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5331    0.1422    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2102    0.5002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3938    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1981    1.4881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1206    1.9495    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.1344    2.7341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5331    3.2191    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5331    4.0441    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2476    4.4566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9620    4.0441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2476    5.2816    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2005    2.7341    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7526    3.3472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0075    2.5626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9456    1.9495    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4600    1.3045    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2816    1.3785    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6059    0.6199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4102    0.4363    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9846    0.0771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0586   -0.7446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2764    0.5002    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  2  0  0  0  0
  2  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 24  1  1  0  0  0
 25 22  1  6  0  0  0
 15 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  1  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  2  0  0  0  0
 32 30  1  6  0  0  0
 26 32  1  0  0  0  0
 11 32  1  0  0  0  0
M  END

     RDKit          3D

 60 63  0  0  0  0  0  0  0  0999 V2000
    4.1756   -2.7148   -0.1403 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8978   -1.4452    0.0990 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9791   -0.4523    0.3347 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2682   -0.9369    0.2745 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9245   -1.4475   -0.8255 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3362   -1.9519   -0.7249 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3135   -1.4830   -1.9226 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4917   -1.0418    0.1251 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6046   -1.8818   -0.0741 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1585    0.3626    0.3891 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7077    0.7065    0.3663 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.0541    0.4111   -0.9556 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215   -0.4822   -0.8139 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1049   -1.4384   -1.7368 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2947   -0.5664    0.0722 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.5341   -0.5692   -0.8107 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3895    0.5932   -0.3662 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.1652    1.1471   -1.3736 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5388    1.2789   -1.2122 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4324    1.8548   -2.2307 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0301    0.8765   -0.1242 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2923    1.5521    0.1303 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.8524    2.6321   -0.5901 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6630    2.7783    0.6317 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5079    0.5881    0.9639 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.2939    1.1578    1.5970 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3821    1.4955    2.9414 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1295    1.1965    3.5262 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3743    1.8086    4.4913 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4296    0.0567    2.7849 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2476   -0.8347    3.2786 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1375    0.1652    1.4542 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.3594   -3.4212   -0.3118 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1745   -3.0733   -0.1546 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8153   -0.0752    1.3869 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7893    0.4357   -0.3062 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7405   -2.2228   -1.6990 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.3213   -2.8407   -0.0758 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.0103   -1.1786   -0.2925 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6141    0.7323    1.3520 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7206    0.9626   -0.3878 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7091    1.8610    0.3999 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8023   -0.0191   -1.6702 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3632    1.3543   -1.4313 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9019   -2.1604   -1.7516 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3377   -1.5557   -2.4923 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3368   -1.5661    0.6026 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2749   -0.3694   -1.8835 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0951   -1.5025   -0.7942 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9407    0.2801    0.5374 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9563    1.7591   -3.2261 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3392    1.1840   -2.2704 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7966    2.8584   -2.0004 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4000    3.0122   -1.4891 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8459    3.0778   -0.5191 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1950    0.2522    1.7956 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0409    2.1018    1.0563 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6678   -1.6768    2.7542 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5948   -0.7967    4.3317 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5884   -0.8289    1.2143 H   0  0  0  0  0  0  0  0  0  0  0  0
  6  5  1  0
  5  7  2  0
  5  4  1  0
  4  3  1  0
  3  2  1  0
  2  1  2  3
  2  8  1  0
  8  9  2  0
  8 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  2  3
 13 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  2  0
 17 22  1  0
 22 23  1  0
 23 24  1  0
 22 25  1  0
 25 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  2  0
 28 30  1  0
 30 31  2  3
 30 32  1  0
 32 11  1  0
 25 15  1  0
 32 26  1  0
 22 24  1  1
  6 37  1  0
  6 38  1  0
  6 39  1  0
  3 35  1  0
  3 36  1  0
  1 33  1  0
  1 34  1  0
 10 40  1  0
 10 41  1  0
 11 42  1  1
 12 43  1  0
 12 44  1  0
 14 45  1  0
 14 46  1  0
 15 47  1  1
 16 48  1  0
 16 49  1  0
 17 50  1  1
 20 51  1  0
 20 52  1  0
 20 53  1  0
 23 54  1  0
 23 55  1  0
 25 56  1  1
 26 57  1  6
 31 58  1  0
 31 59  1  0
 32 60  1  6
M  END


  Mrv1652309122213472D          

 32 35  0  0  1  0            999 V2000
   -0.8959    0.1422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8959   -0.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6103   -1.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3248   -0.6828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0393   -1.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7537   -0.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0393   -1.9203    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1814   -1.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1814   -1.9203    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5331   -0.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5331    0.1422    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2102    0.5002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3938    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1981    1.4881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1206    1.9495    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.1344    2.7341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5331    3.2191    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5331    4.0441    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2476    4.4566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9620    4.0441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2476    5.2816    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2005    2.7341    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7526    3.3472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0075    2.5626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9456    1.9495    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4600    1.3045    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2816    1.3785    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6059    0.6199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4102    0.4363    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9846    0.0771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0586   -0.7446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2764    0.5002    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  2  0  0  0  0
  2  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 24  1  1  0  0  0
 25 22  1  6  0  0  0
 15 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  1  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
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 32 30  1  6  0  0  0
 26 32  1  0  0  0  0
 11 32  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0328373

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(=O)OCC(=C)C(=O)C[C@H]1CC(=C)[C@@H]2C[C@H](OC(C)=O)[C@]3(CO3)[C@@H]2[C@H]2OC(=O)C(=C)[C@H]12

> <INCHI_IDENTIFIER>
InChI=1S/C24H28O8/c1-11-6-16(7-18(27)12(2)9-29-14(4)25)20-13(3)23(28)32-22(20)21-17(11)8-19(31-15(5)26)24(21)10-30-24/h16-17,19-22H,1-3,6-10H2,4-5H3/t16-,17+,19+,20-,21+,22+,24-/m1/s1

> <INCHI_KEY>
GTSOTOVVHXPNJT-NHRYLUQDSA-N

> <FORMULA>
C24H28O8

> <MOLECULAR_WEIGHT>
444.48

> <EXACT_MASS>
444.178417862

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
60

> <JCHEM_AVERAGE_POLARIZABILITY>
45.77172291144647

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
4-[(3aS,4R,6aR,8S,9R,9aS,9bS)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-decahydro-2H-spiro[azuleno[4,5-b]furan-9,2'-oxirane]-4-yl]-2-methylidene-3-oxobutyl acetate

> <JCHEM_LOGP>
1.605481478333332

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
19.88645020793066

> <JCHEM_PKA_STRONGEST_BASIC>
-4.214168207276861

> <JCHEM_POLAR_SURFACE_AREA>
108.50000000000003

> <JCHEM_REFRACTIVITY>
110.6979

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
4-[(3aS,4R,6aR,8S,9R,9aS,9bS)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxirane]-4-yl]-2-methylidene-3-oxobutyl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 12-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   12-SEP-22         0                                  
HETATM    1  C   UNK     0      -1.672   0.266   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.672  -1.274   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -3.006  -2.044   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      -4.340  -1.274   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0      -5.673  -2.044   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -7.007  -1.274   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      -5.673  -3.584   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      -0.339  -2.044   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0      -0.339  -3.584   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       0.995  -1.274   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.995   0.266   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -0.392   0.934   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -0.735   2.435   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -2.236   2.778   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       0.225   3.639   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -0.251   5.104   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       0.995   6.009   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       0.995   7.549   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       2.329   8.319   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       3.662   7.549   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       2.329   9.859   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       2.241   5.104   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       3.271   6.248   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       3.747   4.784   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       1.765   3.639   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       2.725   2.435   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       4.259   2.573   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       4.864   1.157   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       6.366   0.814   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       3.705   0.144   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       3.843  -1.390   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       2.383   0.934   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    8                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5                                                            
CONECT    8    2    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11                                                       
CONECT   11   10   12   32                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16   25                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18   22                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19                                                            
CONECT   22   17   23   24   25                                             
CONECT   23   22   24                                                       
CONECT   24   23   22                                                       
CONECT   25   22   15   26                                                  
CONECT   26   25   27   32                                                  
CONECT   27   26   28                                                       
CONECT   28   27   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   26   11                                                  
MASTER        0    0    0    0    0    0    0    0   32    0   70    0
END

View in JSmol

Synonyms

Value	Source
4-[(3AS,4R,6ar,8S,9R,9as,9BS)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-decahydro-2H-spiro[azuleno[4,5-b]furan-9,2'-oxirane]-4-yl]-2-methylidene-3-oxobutyl acetic acid	Generator

Chemical Formula

C₂₄H₂₈O₈

Average Mass

444.4800 Da

Monoisotopic Mass

444.17842 Da

IUPAC Name

4-[(3aS,4R,6aR,8S,9R,9aS,9bS)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-decahydro-2H-spiro[azuleno[4,5-b]furan-9,2'-oxirane]-4-yl]-2-methylidene-3-oxobutyl acetate

Traditional Name

4-[(3aS,4R,6aR,8S,9R,9aS,9bS)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxirane]-4-yl]-2-methylidene-3-oxobutyl acetate

CAS Registry Number

Not Available

SMILES

CC(=O)OCC(=C)C(=O)C[C@H]1CC(=C)[C@@H]2C[C@H](OC(C)=O)[C@]3(CO3)[C@@H]2[C@H]2OC(=O)C(=C)[C@H]12

InChI Identifier

InChI=1S/C24H28O8/c1-11-6-16(7-18(27)12(2)9-29-14(4)25)20-13(3)23(28)32-22(20)21-17(11)8-19(31-15(5)26)24(21)10-30-24/h16-17,19-22H,1-3,6-10H2,4-5H3/t16-,17+,19+,20-,21+,22+,24-/m1/s1

InChI Key

GTSOTOVVHXPNJT-NHRYLUQDSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as guaianolides and derivatives. These are diterpene lactones with a structure characterized by the presence of a gamma-lactone fused to a guaiane, forming 3,6,9-trimethyl-azuleno[4,5-b]furan-2-one or a derivative.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Guaianolides and derivatives

Alternative Parents

Substituents

Guaianolide-skeleton
Sesquiterpenoid
Guaiane sesquiterpenoid
Tricarboxylic acid or derivatives
Alpha-branched alpha,beta-unsaturated-ketone
Gamma butyrolactone
Alpha,beta-unsaturated ketone
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Tetrahydrofuran
Enone
Acryloyl-group
Lactone
Ketone
Carboxylic acid ester
Oxacycle
Organoheterocyclic compound
Ether
Oxirane
Dialkyl ether
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.61	ChemAxon
pKa (Strongest Acidic)	19.89	ChemAxon
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	108.5 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	110.7 m³·mol⁻¹	ChemAxon
Polarizability	45.77 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163058238

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate (NP0328373)

MOL for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)

3D MOL for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)

3D SDF for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)

3D-SDF for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)

PDB for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)

3D PDB for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)

SMILES for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)

INCHI for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)

Structure for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)

3D Structure for NP0328373 (4-[(3as,4r,6ar,8s,9r,9as,9bs)-8-(acetyloxy)-3,6-dimethylidene-2-oxo-octahydrospiro[azuleno[4,5-b]furan-9,2'-oxiran]-4-yl]-2-methylidene-3-oxobutyl acetate)