NP-MRD: Showing NP-Card for (1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate (NP0327390)

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Record Information

Version

1.0

Created at

2022-09-12 09:55:49 UTC

Updated at

2022-09-12 09:55:50 UTC

NP-MRD ID

NP0327390

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate

Description

(3AS,4Z,7R,8R,8aR,9S,11S,12R,12aR)-7,8,9-Tris(acetyloxy)-11,12-epoxy-6,7,8,8a,9,10,11,12,12a,13-decahydro-1,5,8a,12-tetramethylbenzo[4,5]cyclodeca[1,2-b]furan-2(3aH)-one belongs to the class of organic compounds known as diterpene lactones. These are diterpenoids containing a lactone moiety. (1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate is found in Briareum excavatum. It was first documented in 2022 (PMID: 36130844). Based on a literature review a significant number of articles have been published on (3aS,4Z,7R,8R,8aR,9S,11S,12R,12aR)-7,8,9-Tris(acetyloxy)-11,12-epoxy-6,7,8,8a,9,10,11,12,12a,13-decahydro-1,5,8a,12-tetramethylbenzo[4,5]cyclodeca[1,2-b]furan-2(3aH)-one (PMID: 36130843) (PMID: 36130842) (PMID: 36130841) (PMID: 36130840).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309122211552D          

 35 38  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309122211552D          

 35 38  0  0  1  0            999 V2000
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 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 19 18  1  1  0  0  0
 13 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  1  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 24 29  1  0  0  0  0
 29 30  1  6  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
 29 34  1  0  0  0  0
  5 34  1  0  0  0  0
 11 34  1  0  0  0  0
 34 35  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0327390

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(=O)O[C@H]1C[C@@H]2O[C@]2(C)[C@@H]2CC3=C(C)C(=O)O[C@H]3\C=C(C)/C[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@]12C

> <INCHI_IDENTIFIER>
InChI=1S/C26H34O9/c1-12-8-18-17(13(2)24(30)34-18)10-20-25(6,21(32-15(4)28)11-22-26(20,7)35-22)23(33-16(5)29)19(9-12)31-14(3)27/h8,18-23H,9-11H2,1-7H3/b12-8-/t18-,19+,20+,21-,22-,23-,25+,26+/m0/s1

> <INCHI_KEY>
GBFXGXNAYJIMSC-JVRKQLTGSA-N

> <FORMULA>
C26H34O9

> <MOLECULAR_WEIGHT>
490.549

> <EXACT_MASS>
490.220282675

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
69

> <JCHEM_AVERAGE_POLARIZABILITY>
50.42052994766744

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1R,7S,8Z,11R,12R,13R,14S,16S,18R)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0^{3,7}.0^{16,18}]octadeca-3,8-dien-14-yl acetate

> <JCHEM_LOGP>
1.983254327333333

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.669608265343388

> <JCHEM_PKA_STRONGEST_BASIC>
-4.224275273107747

> <JCHEM_POLAR_SURFACE_AREA>
117.73000000000002

> <JCHEM_REFRACTIVITY>
122.13430000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1R,7S,8Z,11R,12R,13R,14S,16S,18R)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0^{3,7}.0^{16,18}]octadeca-3,8-dien-14-yl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 12-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   12-SEP-22         0                                  
HETATM    1  C   UNK     0       0.076  -3.322   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.373  -2.492   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       1.303  -0.953   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0       2.740  -3.200   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       4.038  -2.370   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       3.967  -0.832   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.265  -0.002   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       6.562   0.828   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       6.632  -0.710   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       8.170  -0.640   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.702  -2.248   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.069  -2.957   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       9.367  -2.127   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       9.618  -0.607   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       8.536   0.489   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      11.141  -0.377   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      11.849   0.991   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0      11.830  -1.754   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0      10.734  -2.835   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      10.804  -4.374   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       9.507  -5.204   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       9.577  -6.742   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       8.140  -4.495   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       6.843  -5.325   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       6.913  -6.864   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       8.280  -7.572   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       8.350  -9.110   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0       9.817  -7.663   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0       5.475  -4.617   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0       4.178  -5.447   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0       4.248  -6.985   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       2.951  -7.815   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       5.616  -7.694   0.000  0.00  0.00           O+0
HETATM   34  C   UNK     0       5.405  -3.078   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       4.108  -3.908   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6   34                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8    9                                                  
CONECT    8    7    9                                                       
CONECT    9    8    7   10   11                                             
CONECT   10    9                                                            
CONECT   11    9   12   34                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   19                                                  
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19                                                       
CONECT   19   18   13   20                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21   24                                                       
CONECT   24   23   25   29                                                  
CONECT   25   24   26                                                       
CONECT   26   25   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26                                                            
CONECT   29   24   30   34                                                  
CONECT   30   29   31                                                       
CONECT   31   30   32   33                                                  
CONECT   32   31                                                            
CONECT   33   31                                                            
CONECT   34   29    5   11   35                                             
CONECT   35   34                                                            
MASTER        0    0    0    0    0    0    0    0   35    0   76    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₆H₃₄O₉

Average Mass

490.5490 Da

Monoisotopic Mass

490.22028 Da

IUPAC Name

(1R,7S,8Z,11R,12R,13R,14S,16S,18R)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0^{3,7}.0^{16,18}]octadeca-3,8-dien-14-yl acetate

Traditional Name

(1R,7S,8Z,11R,12R,13R,14S,16S,18R)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0^{3,7}.0^{16,18}]octadeca-3,8-dien-14-yl acetate

CAS Registry Number

Not Available

SMILES

CC(=O)O[C@H]1C[C@@H]2O[C@]2(C)[C@@H]2CC3=C(C)C(=O)O[C@H]3\C=C(C)/C[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@]12C

InChI Identifier

InChI=1S/C26H34O9/c1-12-8-18-17(13(2)24(30)34-18)10-20-25(6,21(32-15(4)28)11-22-26(20,7)35-22)23(33-16(5)29)19(9-12)31-14(3)27/h8,18-23H,9-11H2,1-7H3/b12-8-/t18-,19+,20+,21-,22-,23-,25+,26+/m0/s1

InChI Key

GBFXGXNAYJIMSC-JVRKQLTGSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Briareum excavatum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as diterpene lactones. These are diterpenoids containing a lactone moiety.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Diterpene lactones

Alternative Parents

Substituents

Diterpene lactone
Diterpenoid
Briarane diterpenoid
Tetracarboxylic acid or derivatives
Oxepane
2-furanone
Dihydrofuran
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Carboxylic acid ester
Lactone
Ether
Oxirane
Oxacycle
Dialkyl ether
Carboxylic acid derivative
Organoheterocyclic compound
Organic oxygen compound
Hydrocarbon derivative
Organic oxide
Carbonyl group
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.98	ChemAxon
pKa (Strongest Acidic)	13.67	ChemAxon
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	117.73 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	122.13 m³·mol⁻¹	ChemAxon
Polarizability	50.42 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

10471767

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

14487899

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Cani I, Righini M, Cenni P, Foschi M: Teaching NeuroImage: Partially Reversible Widespread Leukoencephalopathy Associated With Atypical Hemolytic Uremic Syndrome. Neurology. 2022 Sep 21. pii: WNL.0000000000201378. doi: 10.1212/WNL.0000000000201378. [PubMed:36130844 ]
Sasaki R, Morimoto S, Ozawa F, Okano H, Yoshida M, Ishiura H, Tsuji S, Kuzuhara S, Kokubo Y: APOE Alleles With Tau and Abeta Pathology In Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula. Neurology. 2022 Sep 21. pii: WNL.0000000000201156. doi: 10.1212/WNL.0000000000201156. [PubMed:36130843 ]
Zhang Z, Wang M, Gill D, Liu X: Genetically Predicted Smoking and Alcohol Consumption and Functional Outcome After Ischemic Stroke. Neurology. 2022 Sep 21. pii: WNL.0000000000201291. doi: 10.1212/WNL.0000000000201291. [PubMed:36130842 ]
Khamis S, Mitakidou MR, Champion M, Goyal S, Jones RL, Siddiqui A, Sabanathan S, Hedderly T, Lin JP, Jungbluth H, Papandreou A: Clinical Reasoning: A Teenage Girl With Progressive Hyperkinetic Movements, Seizures, and Encephalopathy. Neurology. 2022 Sep 21. pii: WNL.0000000000201385. doi: 10.1212/WNL.0000000000201385. [PubMed:36130841 ]
Rosenberg A, Ohlund-Wistbacka U, Hall A, Bonnard A, Hagman G, Ryden M, Thunborg C, Wiggenraad F, Sandebring-Matton A, Solomon A, Kivipelto M: beta-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population. Neurology. 2022 Sep 21. pii: WNL.0000000000201043. doi: 10.1212/WNL.0000000000201043. [PubMed:36130840 ]
LOTUS database [Link]

Showing NP-Card for (1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate (NP0327390)

MOL for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)

3D MOL for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)

3D SDF for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)

3D-SDF for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)

PDB for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)

3D PDB for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)

SMILES for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)

INCHI for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)

Structure for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)

3D Structure for NP0327390 ((1r,7s,8z,11r,12r,13r,14s,16s,18r)-11,12-bis(acetyloxy)-4,9,13,18-tetramethyl-5-oxo-6,17-dioxatetracyclo[11.5.0.0³,⁷.0¹⁶,¹⁸]octadeca-3,8-dien-14-yl acetate)