NP-MRD: Showing NP-Card for 8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol (NP0325873)

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Record Information

Version

2.0

Created at

2022-09-12 06:57:54 UTC

Updated at

2022-09-12 06:57:54 UTC

NP-MRD ID

NP0325873

Secondary Accession Numbers

None

Natural Product Identification

Common Name

8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol

Description

5,11,18-Trimethyl-8,21-bis(propan-2-yl)-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]Docosa-3(12),4,6,8,10,15(20),16,18-octaene-1,14,16-triol belongs to the class of organic compounds known as isoflavans. These are polycyclic compounds with a structure based on the 3-phenyl-3,4-dihydro-2H-1-benzopyran skeleton. 8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol is found in Curcuma parviflora. 5,11,18-Trimethyl-8,21-bis(propan-2-yl)-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]Docosa-3(12),4,6,8,10,15(20),16,18-octaene-1,14,16-triol is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004171519552D          

 34 38  0  0  0  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1533004171519552D          

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 10 22  2  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
  9 31  2  0  0  0  0
 25 31  1  0  0  0  0
 26 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0325873

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)C1CC2(O)OC3=C4C(C)=CC=C(C(C)C)C4=CC(C)=C3CC2(O)C2=C(O)C=C(C)C=C12

> <INCHI_IDENTIFIER>
InChI=1S/C30H36O4/c1-15(2)20-9-8-18(6)26-21(20)12-19(7)24-13-29(32)27-22(10-17(5)11-25(27)31)23(16(3)4)14-30(29,33)34-28(24)26/h8-12,15-16,23,31-33H,13-14H2,1-7H3

> <INCHI_KEY>
LMJGACDAZUETDD-UHFFFAOYSA-N

> <FORMULA>
C30H36O4

> <MOLECULAR_WEIGHT>
460.614

> <EXACT_MASS>
460.261359639

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
70

> <JCHEM_AVERAGE_POLARIZABILITY>
54.11816475782738

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
5,11,18-trimethyl-8,21-bis(propan-2-yl)-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3,5,7,9,11,15,17,19-octaene-1,14,16-triol

> <ALOGPS_LOGP>
5.06

> <JCHEM_LOGP>
7.489000290666668

> <ALOGPS_LOGS>
-6.11

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
10.798331802765835

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.900906383837642

> <JCHEM_PKA_STRONGEST_BASIC>
-4.126869956889148

> <JCHEM_POLAR_SURFACE_AREA>
69.92

> <JCHEM_REFRACTIVITY>
136.8977

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
3.54e-04 g/l

> <JCHEM_TRADITIONAL_IUPAC>
8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3,5,7,9,11,15,17,19-octaene-1,14,16-triol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-APR-15         0                                  
HETATM    1  C   UNK     0      11.344   4.771   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       9.804   4.771   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       9.034   6.105   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       9.034   3.437   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.494   3.437   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.724   2.104   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       5.954   3.437   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0       5.184   2.104   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       4.414   0.770   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.184  -0.564   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.724  -0.564   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.494   0.770   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       8.264  -0.564   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       9.034   0.770   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       9.804  -0.564   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       9.034  -1.897   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0      11.344  -0.564   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      12.114   0.770   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      13.654   0.770   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      11.344   2.104   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       9.804   2.104   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       4.414  -1.897   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       5.184  -3.231   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       2.874  -1.897   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       2.104  -0.564   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       0.564  -0.564   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -0.206   0.770   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       0.564   2.104   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       2.104   2.104   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       2.874   3.437   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       2.874   0.770   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      -0.206  -1.897   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       0.564  -3.231   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      -1.746  -1.897   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5   21                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7    8   12                                             
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10   31                                                  
CONECT   10    9   11   22                                                  
CONECT   11   10   12                                                       
CONECT   12   11    6   13   14                                             
CONECT   13   12                                                            
CONECT   14   12   15   21                                                  
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21                                                       
CONECT   21   20    4   14                                                  
CONECT   22   10   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25                                                       
CONECT   25   24   26   31                                                  
CONECT   26   25   27   32                                                  
CONECT   27   26   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29    9   25                                                  
CONECT   32   26   33   34                                                  
CONECT   33   32                                                            
CONECT   34   32                                                            
MASTER        0    0    0    0    0    0    0    0   34    0   76    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₀H₃₆O₄

Average Mass

460.6140 Da

Monoisotopic Mass

460.26136 Da

IUPAC Name

5,11,18-trimethyl-8,21-bis(propan-2-yl)-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3,5,7,9,11,15,17,19-octaene-1,14,16-triol

Traditional Name

8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3,5,7,9,11,15,17,19-octaene-1,14,16-triol

CAS Registry Number

Not Available

SMILES

CC(C)C1CC2(O)OC3=C4C(C)=CC=C(C(C)C)C4=CC(C)=C3CC2(O)C2=C(O)C=C(C)C=C12

InChI Identifier

InChI=1S/C30H36O4/c1-15(2)20-9-8-18(6)26-21(20)12-19(7)24-13-29(32)27-22(10-17(5)11-25(27)31)23(16(3)4)14-30(29,33)34-28(24)26/h8-12,15-16,23,31-33H,13-14H2,1-7H3

InChI Key

LMJGACDAZUETDD-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Curcuma parviflora	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as isoflavans. These are polycyclic compounds with a structure based on the 3-phenyl-3,4-dihydro-2H-1-benzopyran skeleton.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Isoflavonoids

Sub Class

Isoflavans

Direct Parent

Isoflavans

Alternative Parents

Substituents

Isoflavan
Dibenzopyran
Xanthene
Naphthopyran
Chromane
Benzopyran
Naphthalene
1-benzopyran
Tetralin
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Benzenoid
Pyran
Tertiary alcohol
Hemiacetal
Organoheterocyclic compound
Oxacycle
Polyol
Organooxygen compound
Alcohol
Hydrocarbon derivative
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.06	ALOGPS
logP	7.49	ChemAxon
logS	-6.1	ALOGPS
pKa (Strongest Acidic)	9.9	ChemAxon
pKa (Strongest Basic)	-4.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	69.92 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	136.9 m³·mol⁻¹	ChemAxon
Polarizability	54.12 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

85122910

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol (NP0325873)

MOL for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)

3D MOL for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)

3D SDF for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)

3D-SDF for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)

PDB for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)

3D PDB for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)

SMILES for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)

INCHI for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)

Structure for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)

3D Structure for NP0325873 (8,21-diisopropyl-5,11,18-trimethyl-2-oxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4,6,8,10,15,17,19-octaene-1,14,16-triol)