NP-MRD: Showing NP-Card for {[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid (NP0325692)

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Record Information

Version

2.0

Created at

2022-09-12 06:39:03 UTC

Updated at

2022-09-12 06:39:03 UTC

NP-MRD ID

NP0325692

Secondary Accession Numbers

None

Natural Product Identification

Common Name

{[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid

Description

Geldanamycin belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides. {[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid is found in Streptomyces griseus, Streptomyces hygroscopicus and Streptomyces melanosporofaciens. {[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid was first documented in 2022 (PMID: 35884999). Based on a literature review a small amount of articles have been published on geldanamycin (PMID: 36106341) (PMID: 36100007) (PMID: 36045611).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309122208392D          

 40 41  0  0  1  0            999 V2000
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    3.1304   -0.0220    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
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 35 39  1  0  0  0  0
  4 39  1  0  0  0  0
 39 40  2  0  0  0  0
M  END

     RDKit          3D

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M  END


  Mrv1652309122208392D          

 40 41  0  0  1  0            999 V2000
    0.0569   -1.4216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4053   -2.5241    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4942   -1.7039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2417   -0.9185    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2489   -1.3708    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3165   -3.3444    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.0712   -3.0112    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7371   -3.4982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2276   -4.1646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4729   -4.4977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8070   -4.0107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0523   -4.3438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9634   -5.1640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3864   -3.8568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6316   -4.1899    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4752   -3.0366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8093   -2.5495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0546   -2.8827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3887   -2.3957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6339   -2.7288    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8982   -1.7293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6529   -1.3962    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  6  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  1  0  0  0
 10 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  6  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 19 24  1  0  0  0  0
 24 25  1  6  0  0  0
 25 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
 34 35  1  4  0  0  0
 35 36  2  0  0  0  0
 36 37  1  0  0  0  0
  3 37  1  0  0  0  0
 37 38  2  0  0  0  0
 35 39  1  0  0  0  0
  4 39  1  0  0  0  0
 39 40  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0325692

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CO[C@@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(N=C(O)\C(C)=C\C=C/[C@@H](OC)[C@H](OC(O)=N)\C(C)=C\[C@@H](C)[C@@H]1O)C2=O

> <INCHI_IDENTIFIER>
InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17-,22-,23-,24+,26-/m1/s1

> <INCHI_KEY>
QTQAWLPCGQOSGP-VKNBREQOSA-N

> <FORMULA>
C29H40N2O9

> <MOLECULAR_WEIGHT>
560.644

> <EXACT_MASS>
560.273380876

> <JCHEM_ACCEPTOR_COUNT>
10

> <JCHEM_ATOM_COUNT>
80

> <JCHEM_AVERAGE_POLARIZABILITY>
57.23863339434417

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
{[(4E,6Z,8R,9R,10E,12R,13S,14R,16R)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid

> <JCHEM_LOGP>
1.1050911109468071

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
5.743700371548116

> <JCHEM_PKA_STRONGEST_ACIDIC>
-4.205786967813441

> <JCHEM_PKA_STRONGEST_BASIC>
10.797251582435184

> <JCHEM_POLAR_SURFACE_AREA>
167.96

> <JCHEM_REFRACTIVITY>
164.40650000000005

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
{[(4E,6Z,8R,9R,10E,12R,13S,14R,16R)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 12-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   12-SEP-22         0                                  
HETATM    1  C   UNK     0       0.106  -2.654   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       1.515  -2.032   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       2.758  -2.941   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.167  -2.319   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.333  -0.788   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.843  -0.041   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.952  -1.110   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.474   1.364   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.005   1.198   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       9.039   2.339   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       8.568   3.805   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.321  -0.309   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       7.322  -1.482   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       9.636  -1.362   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      11.058  -0.771   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       9.471  -2.893   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      10.714  -3.803   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      11.488  -2.471   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      10.548  -5.334   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      11.957  -4.712   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0      12.122  -3.181   0.000  0.00  0.00           C+0
HETATM   22  N   UNK     0      11.651  -1.715   0.000  0.00  0.00           N+0
HETATM   23  O   UNK     0      13.531  -2.559   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      11.791  -6.243   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      13.200  -5.621   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0      14.443  -6.530   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      11.625  -7.774   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      10.216  -8.396   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       8.973  -7.487   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       7.564  -8.108   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       7.398  -9.640   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       6.321  -7.199   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       4.912  -7.821   0.000  0.00  0.00           O+0
HETATM   34  N   UNK     0       6.487  -5.668   0.000  0.00  0.00           N+0
HETATM   35  C   UNK     0       5.244  -4.759   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       3.835  -5.381   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0       2.592  -4.472   0.000  0.00  0.00           C+0
HETATM   38  O   UNK     0       1.183  -5.094   0.000  0.00  0.00           O+0
HETATM   39  C   UNK     0       5.410  -3.228   0.000  0.00  0.00           C+0
HETATM   40  O   UNK     0       6.819  -2.606   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   37                                                  
CONECT    4    3    5   39                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10   12                                                  
CONECT   10    9   11                                                       
CONECT   11   10                                                            
CONECT   12    9   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17                                                       
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   20   24                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21                                                            
CONECT   24   19   25   27                                                  
CONECT   25   24   26                                                       
CONECT   26   25                                                            
CONECT   27   24   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   33   34                                                  
CONECT   33   32                                                            
CONECT   34   32   35                                                       
CONECT   35   34   36   39                                                  
CONECT   36   35   37                                                       
CONECT   37   36    3   38                                                  
CONECT   38   37                                                            
CONECT   39   35    4   40                                                  
CONECT   40   39                                                            
MASTER        0    0    0    0    0    0    0    0   40    0   82    0
END

View in JSmol

Synonyms

Value	Source
Geldanomycin	MeSH

Chemical Formula

C₂₉H₄₀N₂O₉

Average Mass

560.6440 Da

Monoisotopic Mass

560.27338 Da

IUPAC Name

{[(4E,6Z,8R,9R,10E,12R,13S,14R,16R)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid

Traditional Name

{[(4E,6Z,8R,9R,10E,12R,13S,14R,16R)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid

CAS Registry Number

Not Available

SMILES

CO[C@@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(N=C(O)\C(C)=C\C=C/[C@@H](OC)[C@H](OC(O)=N)\C(C)=C\[C@@H](C)[C@@H]1O)C2=O

InChI Identifier

InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17-,22-,23-,24+,26-/m1/s1

InChI Key

QTQAWLPCGQOSGP-VKNBREQOSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Streptomyces griseus	LOTUS Database	35616633
Streptomyces hygroscopicus	LOTUS Database	35616633
Streptomyces melanosporofaciens	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Macrolactams

Sub Class

Not Available

Direct Parent

Macrolactams

Alternative Parents

Substituents

Macrolactam
Vinylogous ester
Vinylogous amide
Carbamic acid ester
Carboxamide group
Ketone
Lactam
Secondary alcohol
Secondary carboxylic acid amide
Cyclic ketone
Carboxylic acid derivative
Dialkyl ether
Ether
Azacycle
Organoheterocyclic compound
Organic oxide
Organic oxygen compound
Carbonyl group
Hydrocarbon derivative
Organonitrogen compound
Organooxygen compound
Organic nitrogen compound
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.11	ChemAxon
pKa (Strongest Acidic)	-4.2	ChemAxon
pKa (Strongest Basic)	10.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	167.96 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	164.41 m³·mol⁻¹	ChemAxon
Polarizability	57.24 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00018795

Chemspider ID

21249187

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Geldanamycin

METLIN ID

Not Available

PubChem Compound

5281885

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Shahini E, Pasculli G, Mastropietro A, Stolfi P, Tieri P, Vergni D, Cozzolongo R, Pesce F, Giannelli G: Network Proximity-Based Drug Repurposing Strategy for Early and Late Stages of Primary Biliary Cholangitis. Biomedicines. 2022 Jul 13;10(7):1694. doi: 10.3390/biomedicines10071694. [PubMed:35884999 ]
Souza ED, Silva E Souza JFD, Oliveira Netto PM, Carvalheira LR, Batista RITP, Quintao CCR, Louro ID, Camargo LSA: Inhibition of Hsp90 during in vitro maturation under thermoneutral or heat shock conditions compromises the developmental competence of bovine oocytes. Zygote. 2022 Dec;30(6):854-862. doi: 10.1017/S0967199422000387. Epub 2022 Sep 15. [PubMed:36106341 ]
Thompson BH, Sharp CP, Dry IR, Dalziel RG, Gaunt ER: 1 Cellular protein TTC4 and its cofactor HSP90 are pro-viral for bovine herpesvirus 1. Virus Res. 2022 Nov;321:198927. doi: 10.1016/j.virusres.2022.198927. Epub 2022 Sep 11. [PubMed:36100007 ]
Wang G, Qu F, Zhou J, Zhu B, Gao Y: Elevated THBS3 predicts poor overall survival for clear cell renal cell carcinoma and identifies LncRNA/RBP/THBS3 mRNA networks. Cell Cycle. 2023 Feb;22(3):316-330. doi: 10.1080/15384101.2022.2117910. Epub 2022 Aug 31. [PubMed:36045611 ]
LOTUS database [Link]

Showing NP-Card for {[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid (NP0325692)

MOL for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)

3D MOL for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)

3D SDF for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)

3D-SDF for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)

PDB for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)

3D PDB for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)

SMILES for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)

INCHI for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)

Structure for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)

3D Structure for NP0325692 ({[(4e,6z,8r,9r,10e,12r,13s,14r,16r)-3,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-20,22-dioxo-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18-hexaen-9-yl]oxy}methanimidic acid)