NP-MRD: Showing NP-Card for (1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate (NP0325005)

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Record Information

Version

2.0

Created at

2022-09-12 05:25:58 UTC

Updated at

2022-09-12 05:25:58 UTC

NP-MRD ID

NP0325005

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate

Description

CHEMBL3814910 belongs to the class of organic compounds known as tigliane and ingenane diterpenoids. These are diterpenoids containing the tigliane or ingenane carbon skeleton. The tigliane skeleton is a tetracyclic ring that consists of the 4/7/6/3 ring junction. It is derived from casbane by 6,10- and 5,14-cyclizations and is a framework of phorbol. The ingenane skeleton is derived by rearrangement of tigliane. (1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate is found in Euphorbia kansui. It was first documented in 2022 (PMID: 36130844). Based on a literature review a significant number of articles have been published on CHEMBL3814910 (PMID: 36130843) (PMID: 36130842) (PMID: 36130841) (PMID: 36130840) (PMID: 36130836) (PMID: 36130839).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309122207252D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309122207252D          

 39 42  0  0  1  0            999 V2000
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    4.4290    2.2974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8184    1.8139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1698    1.0288    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5466    0.5440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0477   -0.1113    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9381    0.0867    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3929   -0.5789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -0.3590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9458   -0.8713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5618    0.4656    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8829    0.9343    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3427    0.7288    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6733    1.2110    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4102   -0.6723    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9191   -1.3352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2351   -0.8924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8834   -0.3571    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.8349    0.4664    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.5724    0.0966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2192    0.6087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2748   -0.3361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 13 12  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 14 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  1  0  0  0
 22 23  2  0  0  0  0
 24 22  1  1  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  6  0  0  0
 28 30  1  0  0  0  0
 13 30  1  0  0  0  0
 24 30  1  0  0  0  0
 30 31  1  6  0  0  0
 24 32  1  0  0  0  0
 32 33  1  1  0  0  0
 32 34  1  0  0  0  0
 35 34  1  6  0  0  0
 36 35  1  6  0  0  0
 21 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0325005

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCC\C=C/C=C/C(=O)O[C@@H]1C(COC(C)=O)=C[C@H]2[C@H]3[C@@H](C[C@@H](C)[C@@]4(C=C(C)[C@H](O)[C@@]14O)C2=O)C3(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C32H44O7/c1-7-8-9-10-11-12-13-14-25(34)39-29-22(18-38-21(4)33)16-23-26-24(30(26,5)6)15-20(3)31(28(23)36)17-19(2)27(35)32(29,31)37/h11-14,16-17,20,23-24,26-27,29,35,37H,7-10,15,18H2,1-6H3/b12-11-,14-13+/t20-,23+,24-,26+,27+,29-,31+,32-/m1/s1

> <INCHI_KEY>
JKTMSYUQFQWQFC-HQDWXLFTSA-N

> <FORMULA>
C32H44O7

> <MOLECULAR_WEIGHT>
540.697

> <EXACT_MASS>
540.308703757

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
83

> <JCHEM_AVERAGE_POLARIZABILITY>
60.03713491203141

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,4S,5R,6R,9S,10R,12R,14R)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0^{1,5}.0^{10,12}]pentadeca-2,7-dien-6-yl (2E,4Z)-deca-2,4-dienoate

> <JCHEM_LOGP>
4.856670515333333

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.926021895178408

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.132923360155148

> <JCHEM_PKA_STRONGEST_BASIC>
-3.534042010279469

> <JCHEM_POLAR_SURFACE_AREA>
110.13000000000001

> <JCHEM_REFRACTIVITY>
151.3737

> <JCHEM_ROTATABLE_BOND_COUNT>
11

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(1S,4S,5R,6R,9S,10R,12R,14R)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0^{1,5}.0^{10,12}]pentadeca-2,7-dien-6-yl (2E,4Z)-deca-2,4-dienoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 12-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   12-SEP-22         0                                  
HETATM    1  C   UNK     0       3.742  15.250   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.450  14.413   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.529  12.875   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.237  12.037   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.317  10.499   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.024   9.661   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.104   8.123   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.475   7.423   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       1.555   5.885   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.927   5.185   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       4.219   6.023   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0       3.006   3.647   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       4.378   2.947   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.634   3.862   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       5.388   5.383   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       6.582   6.356   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       8.021   5.809   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       9.215   6.782   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       8.267   4.288   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       7.128   3.386   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       7.784   1.920   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       6.620   1.016   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       7.556  -0.208   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       5.485   0.162   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       4.467  -1.081   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       2.973  -0.670   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       1.765  -1.626   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       2.915   0.869   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       1.648   1.744   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       4.373   1.360   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       3.124   2.261   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0       6.366  -1.255   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       5.449  -2.492   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       7.906  -1.666   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       9.116  -0.667   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       9.025   0.871   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0      10.402   0.180   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0      11.609   1.136   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0      11.713  -0.627   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13                                                       
CONECT   13   12   14   30                                                  
CONECT   14   13   15   20                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17                                                            
CONECT   20   14   21                                                       
CONECT   21   20   22   36                                                  
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25   30   32                                             
CONECT   25   24   26                                                       
CONECT   26   25   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   13   24   31                                             
CONECT   31   30                                                            
CONECT   32   24   33   34                                                  
CONECT   33   32                                                            
CONECT   34   32   35                                                       
CONECT   35   34   36   37                                                  
CONECT   36   35   21   37                                                  
CONECT   37   36   35   38   39                                             
CONECT   38   37                                                            
CONECT   39   37                                                            
MASTER        0    0    0    0    0    0    0    0   39    0   84    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₂H₄₄O₇

Average Mass

540.6970 Da

Monoisotopic Mass

540.30870 Da

IUPAC Name

(1S,4S,5R,6R,9S,10R,12R,14R)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0^{1,5}.0^{10,12}]pentadeca-2,7-dien-6-yl (2E,4Z)-deca-2,4-dienoate

Traditional Name

(1S,4S,5R,6R,9S,10R,12R,14R)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0^{1,5}.0^{10,12}]pentadeca-2,7-dien-6-yl (2E,4Z)-deca-2,4-dienoate

CAS Registry Number

Not Available

SMILES

CCCCC\C=C/C=C/C(=O)O[C@@H]1C(COC(C)=O)=C[C@H]2[C@H]3[C@@H](C[C@@H](C)[C@@]4(C=C(C)[C@H](O)[C@@]14O)C2=O)C3(C)C

InChI Identifier

InChI=1S/C32H44O7/c1-7-8-9-10-11-12-13-14-25(34)39-29-22(18-38-21(4)33)16-23-26-24(30(26,5)6)15-20(3)31(28(23)36)17-19(2)27(35)32(29,31)37/h11-14,16-17,20,23-24,26-27,29,35,37H,7-10,15,18H2,1-6H3/b12-11-,14-13+/t20-,23+,24-,26+,27+,29-,31+,32-/m1/s1

InChI Key

JKTMSYUQFQWQFC-HQDWXLFTSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Euphorbia kansui	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tigliane and ingenane diterpenoids. These are diterpenoids containing the tigliane or ingenane carbon skeleton. The tigliane skeleton is a tetracyclic ring that consists of the 4/7/6/3 ring junction. It is derived from casbane by 6,10- and 5,14-cyclizations and is a framework of phorbol. The ingenane skeleton is derived by rearrangement of tigliane.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Tigliane and ingenane diterpenoids

Alternative Parents

Substituents

Ingenane diterpenoid
Fatty acid ester
Dicarboxylic acid or derivatives
Fatty acyl
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Tertiary alcohol
1,2-diol
Carboxylic acid ester
Secondary alcohol
Ketone
Carboxylic acid derivative
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Carbonyl group
Alcohol
Organooxygen compound
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.86	ChemAxon
pKa (Strongest Acidic)	12.13	ChemAxon
pKa (Strongest Basic)	-3.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	110.13 Å²	ChemAxon
Rotatable Bond Count	11	ChemAxon
Refractivity	151.37 m³·mol⁻¹	ChemAxon
Polarizability	60.04 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

58925530

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

127051148

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Cani I, Righini M, Cenni P, Foschi M: Teaching NeuroImage: Partially Reversible Widespread Leukoencephalopathy Associated With Atypical Hemolytic Uremic Syndrome. Neurology. 2022 Sep 21. pii: WNL.0000000000201378. doi: 10.1212/WNL.0000000000201378. [PubMed:36130844 ]
Sasaki R, Morimoto S, Ozawa F, Okano H, Yoshida M, Ishiura H, Tsuji S, Kuzuhara S, Kokubo Y: APOE Alleles With Tau and Abeta Pathology In Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula. Neurology. 2022 Sep 21. pii: WNL.0000000000201156. doi: 10.1212/WNL.0000000000201156. [PubMed:36130843 ]
Zhang Z, Wang M, Gill D, Liu X: Genetically Predicted Smoking and Alcohol Consumption and Functional Outcome After Ischemic Stroke. Neurology. 2022 Sep 21. pii: WNL.0000000000201291. doi: 10.1212/WNL.0000000000201291. [PubMed:36130842 ]
Khamis S, Mitakidou MR, Champion M, Goyal S, Jones RL, Siddiqui A, Sabanathan S, Hedderly T, Lin JP, Jungbluth H, Papandreou A: Clinical Reasoning: A Teenage Girl With Progressive Hyperkinetic Movements, Seizures, and Encephalopathy. Neurology. 2022 Sep 21. pii: WNL.0000000000201385. doi: 10.1212/WNL.0000000000201385. [PubMed:36130841 ]
Rosenberg A, Ohlund-Wistbacka U, Hall A, Bonnard A, Hagman G, Ryden M, Thunborg C, Wiggenraad F, Sandebring-Matton A, Solomon A, Kivipelto M: beta-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population. Neurology. 2022 Sep 21. pii: WNL.0000000000201043. doi: 10.1212/WNL.0000000000201043. [PubMed:36130840 ]
Yu H, Cai G, Wu J, Li Q: Clinical Phenotypic Variability and Significance of Pneumolabyrinth After Tympanum-Penetrating Injury. Ear Nose Throat J. 2022 Sep 21:1455613221128132. doi: 10.1177/01455613221128132. [PubMed:36130836 ]
Silverman A, Beres S: Child Neurology: Horner Syndrome in an Otherwise Well-Appearing Infant. Neurology. 2022 Sep 21. pii: WNL.0000000000201377. doi: 10.1212/WNL.0000000000201377. [PubMed:36130839 ]
Harada Y, Wang SH, Juel VC: Clinical Reasoning: A 36-Year-Old Man With Asymmetric Muscle Weakness. Neurology. 2022 Sep 21. pii: WNL.0000000000201379. doi: 10.1212/WNL.0000000000201379. [PubMed:36130838 ]
Guest O, Memon AA, Chukweubuka A, Zaheer M, Siddiqi N: Robotic low anterior resection for locally advanced rectal cancer - A video vignette. Colorectal Dis. 2022 Sep 21. doi: 10.1111/codi.16345. [PubMed:36130837 ]
Pellicori P, Kalra PR, Clark AL, Friday JM, Cleland JGF: Chronic kidney disease (CKD) and CKD-ism in heart failure - what a mess! Eur J Heart Fail. 2022 Sep 21. doi: 10.1002/ejhf.2696. [PubMed:36130835 ]
LOTUS database [Link]

Showing NP-Card for (1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate (NP0325005)

MOL for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)

3D MOL for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)

3D SDF for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)

3D-SDF for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)

PDB for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)

3D PDB for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)

SMILES for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)

INCHI for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)

Structure for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)

3D Structure for NP0325005 ((1s,4s,5r,6r,9s,10r,12r,14r)-7-[(acetyloxy)methyl]-4,5-dihydroxy-3,11,11,14-tetramethyl-15-oxotetracyclo[7.5.1.0¹,⁵.0¹⁰,¹²]pentadeca-2,7-dien-6-yl (2e,4z)-deca-2,4-dienoate)