NP-MRD: Showing NP-Card for (1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate (NP0321972)

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Record Information

Version

2.0

Created at

2022-09-12 00:28:07 UTC

Updated at

2022-09-12 00:28:07 UTC

NP-MRD ID

NP0321972

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate

Description

(1S,2R,4R,5R,6R,8R,9S,10S,11R,13R,14R,15S,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]Henicosan-15-yl 2-methylpropanoate belongs to the class of organic compounds known as limonoids. These are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17. (1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate is found in Melia azedarach. Based on a literature review very few articles have been published on (1S,2R,4R,5R,6R,8R,9S,10S,11R,13R,14R,15S,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]Henicosan-15-yl 2-methylpropanoate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309122202282D          

 43 49  0  0  1  0            999 V2000
    3.8166   -4.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1287   -3.6106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9462   -3.4991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6100   -2.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5191   -2.0344    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8268   -1.9063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7270   -0.8488    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0377   -0.5761    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8551   -0.1566    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.6329    0.1184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3774   -0.2371    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6524   -1.0149    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.5240   -1.0154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1164   -0.4184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8997    0.3777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9141   -0.6287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2969   -1.7593    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
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    2.0842    1.3553    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  5  4  1  6  0  0  0
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  9 41  1  0  0  0  0
 41 42  1  0  0  0  0
 23 42  1  0  0  0  0
 25 42  1  0  0  0  0
 42 43  1  6  0  0  0
M  END

     RDKit          3D

 85 91  0  0  0  0  0  0  0  0999 V2000
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 41 82  1  1
 43 83  1  0
 43 84  1  0
 43 85  1  0
M  END


  Mrv1652309122202282D          

 43 49  0  0  1  0            999 V2000
    3.8166   -4.3743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1287   -3.6106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9462   -3.4991    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6100   -2.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5191   -2.0344    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8268   -1.9063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7270   -0.8488    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0377   -0.5761    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8551   -0.1566    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.6329    0.1184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3774   -0.2371    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6524   -1.0149    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.5240   -1.0154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1164   -0.4184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8997    0.3777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9141   -0.6287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4952   -0.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1308   -1.4248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2969   -1.7593    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.8957   -2.3813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3756   -1.1382    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8037   -1.5846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9792   -1.5549    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7385   -1.6208    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7682   -0.7964    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.1945   -1.3892    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.1997   -2.1921    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5466   -1.0267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4309   -0.2099    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0238    0.3639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9081    1.1807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6492    1.5432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2229    0.9503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8364    0.2215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3817   -0.0675    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3021    0.7552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8196    0.6316    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.9487    1.5049    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6441    0.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0842    1.3553    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0306   -0.1269    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5927   -0.8261    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3590   -1.1194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  6  0  0  0
  7  9  1  0  0  0  0
  9 10  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 12 19  1  0  0  0  0
  5 19  1  0  0  0  0
 19 20  1  6  0  0  0
 19 21  1  0  0  0  0
  9 21  1  0  0  0  0
 21 22  1  6  0  0  0
 22 23  1  0  0  0  0
 23 24  1  1  0  0  0
 25 24  1  1  0  0  0
 25 26  1  0  0  0  0
 26 27  1  6  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  1  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  2  0  0  0  0
 29 35  1  0  0  0  0
 25 35  1  0  0  0  0
 35 36  1  1  0  0  0
 35 37  1  0  0  0  0
 37 38  1  1  0  0  0
 37 39  1  0  0  0  0
 39 40  2  0  0  0  0
 41 39  1  6  0  0  0
  9 41  1  0  0  0  0
 41 42  1  0  0  0  0
 23 42  1  0  0  0  0
 25 42  1  0  0  0  0
 42 43  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0321972

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)C(=O)O[C@@H]1OC[C@]23[C@@H](O)C[C@@H](OC(C)=O)[C@@]1(C)[C@@H]2C[C@H]1O[C@@]24[C@H](O)C[C@@H](C5=COC=C5)[C@]2(C)[C@@H](O)C(=O)[C@H]3[C@@]14C

> <INCHI_IDENTIFIER>
InChI=1S/C32H42O11/c1-14(2)26(38)42-27-28(4)18-10-22-30(6)24(31(18,13-40-27)19(34)11-21(28)41-15(3)33)23(36)25(37)29(5)17(16-7-8-39-12-16)9-20(35)32(29,30)43-22/h7-8,12,14,17-22,24-25,27,34-35,37H,9-11,13H2,1-6H3/t17-,18-,19-,20+,21+,22+,24-,25-,27-,28+,29+,30+,31+,32-/m0/s1

> <INCHI_KEY>
JICAVWDTFZENFS-QWPUBJKQSA-N

> <FORMULA>
C32H42O11

> <MOLECULAR_WEIGHT>
602.677

> <EXACT_MASS>
602.272712172

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
85

> <JCHEM_AVERAGE_POLARIZABILITY>
62.915082552442826

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,2R,4R,5R,6R,8R,9S,10S,11R,13R,14R,15S,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1^{9,11}.0^{1,13}.0^{2,10}.0^{5,9}]henicosan-15-yl 2-methylpropanoate

> <JCHEM_LOGP>
1.3109500633333333

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
7

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.378806688095143

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.353835935169199

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8438187543821476

> <JCHEM_POLAR_SURFACE_AREA>
161.96

> <JCHEM_REFRACTIVITY>
146.40949999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(1S,2R,4R,5R,6R,8R,9S,10S,11R,13R,14R,15S,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1^{9,11}.0^{1,13}.0^{2,10}.0^{5,9}]henicosan-15-yl 2-methylpropanoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 12-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   12-SEP-22         0                                  
HETATM    1  C   UNK     0       7.124  -8.165   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       7.707  -6.740   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       9.233  -6.532   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0       6.739  -5.490   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       6.569  -3.798   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.277  -3.558   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.090  -1.584   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       3.804  -1.075   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       5.329  -0.292   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       6.781   0.221   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       8.171  -0.443   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       8.684  -1.894   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0      10.312  -1.895   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0      11.417  -0.781   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0      11.013   0.705   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0      12.906  -1.174   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      13.991  -0.080   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      13.311  -2.660   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.021  -3.284   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       9.139  -4.445   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       6.301  -2.125   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       5.233  -2.958   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       3.694  -2.903   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       1.379  -3.026   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       1.434  -1.487   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       0.363  -2.593   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0      -0.373  -4.092   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0      -1.020  -1.917   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      -0.804  -0.392   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      -1.911   0.679   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      -1.695   2.204   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      -3.078   2.881   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0      -4.149   1.774   0.000  0.00  0.00           O+0
HETATM   34  C   UNK     0      -3.428   0.413   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       0.712  -0.126   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       0.564   1.410   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0       1.530   1.179   0.000  0.00  0.00           C+0
HETATM   38  O   UNK     0       1.771   2.809   0.000  0.00  0.00           O+0
HETATM   39  C   UNK     0       3.069   1.124   0.000  0.00  0.00           C+0
HETATM   40  O   UNK     0       3.891   2.530   0.000  0.00  0.00           O+0
HETATM   41  C   UNK     0       3.790  -0.237   0.000  0.00  0.00           C+0
HETATM   42  C   UNK     0       2.973  -1.542   0.000  0.00  0.00           C+0
HETATM   43  C   UNK     0       4.403  -2.090   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6   19                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10   21   41                                             
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13   19                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16                                                            
CONECT   19   12    5   20   21                                             
CONECT   20   19                                                            
CONECT   21   19    9   22                                                  
CONECT   22   21   23                                                       
CONECT   23   22   24   42                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26   35   42                                             
CONECT   26   25   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   29                                                       
CONECT   29   28   30   35                                                  
CONECT   30   29   31   34                                                  
CONECT   31   30   32                                                       
CONECT   32   31   33                                                       
CONECT   33   32   34                                                       
CONECT   34   33   30                                                       
CONECT   35   29   25   36   37                                             
CONECT   36   35                                                            
CONECT   37   35   38   39                                                  
CONECT   38   37                                                            
CONECT   39   37   40   41                                                  
CONECT   40   39                                                            
CONECT   41   39    9   42                                                  
CONECT   42   41   23   25   43                                             
CONECT   43   42                                                            
MASTER        0    0    0    0    0    0    0    0   43    0   98    0
END

View in JSmol

Synonyms

Value	Source
(1S,2R,4R,5R,6R,8R,9S,10S,11R,13R,14R,15S,18S,20R)-20-(Acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1,.0,.0,.0,]henicosan-15-yl 2-methylpropanoic acid	Generator

Chemical Formula

C₃₂H₄₂O₁₁

Average Mass

602.6770 Da

Monoisotopic Mass

602.27271 Da

IUPAC Name

Traditional Name

CAS Registry Number

Not Available

SMILES

CC(C)C(=O)O[C@@H]1OC[C@]23[C@@H](O)C[C@@H](OC(C)=O)[C@@]1(C)[C@@H]2C[C@H]1O[C@@]24[C@H](O)C[C@@H](C5=COC=C5)[C@]2(C)[C@@H](O)C(=O)[C@H]3[C@@]14C

InChI Identifier

InChI=1S/C32H42O11/c1-14(2)26(38)42-27-28(4)18-10-22-30(6)24(31(18,13-40-27)19(34)11-21(28)41-15(3)33)23(36)25(37)29(5)17(16-7-8-39-12-16)9-20(35)32(29,30)43-22/h7-8,12,14,17-22,24-25,27,34-35,37H,9-11,13H2,1-6H3/t17-,18-,19-,20+,21+,22+,24-,25-,27-,28+,29+,30+,31+,32-/m0/s1

InChI Key

JICAVWDTFZENFS-QWPUBJKQSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Melia azedarach	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as limonoids. These are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Triterpenoids

Direct Parent

Limonoids

Alternative Parents

Substituents

Limonoid skeleton
Steroid ester
Naphthopyran
Naphthalene
Dicarboxylic acid or derivatives
Pyran
Oxane
Heteroaromatic compound
Cyclic alcohol
Furan
Carboxylic acid ester
Secondary alcohol
Oxetane
Ketone
Carboxylic acid derivative
Oxacycle
Organoheterocyclic compound
Dialkyl ether
Ether
Polyol
Acetal
Carbonyl group
Organic oxide
Hydrocarbon derivative
Alcohol
Organooxygen compound
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.31	ChemAxon
pKa (Strongest Acidic)	11.35	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	161.96 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	146.41 m³·mol⁻¹	ChemAxon
Polarizability	62.92 Å³	ChemAxon
Number of Rings	7	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

162861715

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate (NP0321972)

MOL for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)

3D MOL for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)

3D SDF for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)

3D-SDF for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)

PDB for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)

3D PDB for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)

SMILES for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)

INCHI for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)

Structure for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)

3D Structure for NP0321972 ((1s,2r,4r,5r,6s,8r,9s,10s,11r,13r,14r,15s,18s,20r)-20-(acetyloxy)-6-(furan-3-yl)-4,8,18-trihydroxy-5,10,14-trimethyl-3-oxo-16,21-dioxahexacyclo[12.3.3.1⁹,¹¹.0¹,¹³.0²,¹⁰.0⁵,⁹]henicosan-15-yl 2-methylpropanoate)