NP-MRD: Showing NP-Card for 5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol (NP0320874)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-11 22:46:14 UTC

Updated at

2022-09-11 22:46:14 UTC

NP-MRD ID

NP0320874

Secondary Accession Numbers

None

Natural Product Identification

Common Name

5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol

Description

ES-242-6 belongs to the class of organic compounds known as arylnaphthalene lignans. These are lignans containing the arylnaphthalene skeleton, especially 9-(2H-1,3-benzodioxol-5-yl)-1H,3H-naphtho[2,3-c]furan-1-one or a derivative thereof. Arylnaphthalene lignans occur in nature and exhibit diverse biological activities. 5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol is found in Blackwellomyces pseudomilitaris. Based on a literature review very few articles have been published on ES-242-6.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309122200462D          

 40 45  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  2  0  0  0  0
 27 28  1  0  0  0  0
 14 28  2  0  0  0  0
 19 28  1  0  0  0  0
 16 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 15 33  1  0  0  0  0
 13 34  1  0  0  0  0
  8 34  1  0  0  0  0
 34 35  2  0  0  0  0
  3 35  1  0  0  0  0
 12 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 39 40  1  0  0  0  0
 11 40  1  0  0  0  0
M  END

     RDKit          3D

 74 79  0  0  0  0  0  0  0  0999 V2000
    2.6796   -4.8110    1.9338 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6655   -3.8993    1.5390 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0953   -2.6919    0.9630 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4246   -2.3876    0.7817 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8588   -1.2069    0.2182 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2104   -0.9360    0.0508 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2146   -1.8272    0.4385 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9430   -0.2751   -0.1888 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3158    0.9328   -0.7644 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6000    1.2795   -0.9644 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    1.7994   -1.1375 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9592    1.5117   -0.9642 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6023    0.3129   -0.3942 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7964    0.0301   -0.2295 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5276   -0.5982   -1.1999 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8970   -0.8734   -1.0418 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4827   -0.4909    0.1229 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8099   -0.7301    0.3337 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7667    0.1448    1.1196 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3823    0.5122    2.2894 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7285    0.2374    2.4285 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4823    0.5595    3.5805 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6316    1.1342    3.2593 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2924    1.4024    3.1048 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5282    2.0289    4.0798 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1344    2.4169    5.2941 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6818    1.0309    1.9263 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4186    0.4123    0.9558 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5675   -1.5726   -2.1710 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7547   -2.6598   -2.4824 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5257   -2.3231   -2.9778 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.5715   -2.3887   -4.4951 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9380   -1.0355   -2.4717 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5937   -0.5638   -0.0145 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1661   -1.7650    0.5586 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0806    2.4983   -1.4001 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4635    3.8523   -1.6593 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.4720    4.2034   -3.1426 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7653    4.0378   -1.2086 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6375    3.0980   -1.7564 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2616   -5.8001    2.2012 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2719   -4.4110    2.7508 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3975   -4.9987    1.0826 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1639   -3.1072    1.0940 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9739   -2.2531    1.4250 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3099   -2.5925   -0.3630 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1724   -1.2392    0.5257 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4906    0.9950   -0.8602 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4412   -1.1772   -0.2994 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6053    1.6672    3.5731 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4680    0.0693    3.5078 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9779    0.2398    4.5020 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1431    1.4069    4.1606 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7021    3.3496    5.1076 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3854    2.5941    6.0934 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8137    1.6108    5.6816 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3589    1.2223    1.7691 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5790   -1.9126   -1.9664 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5996   -0.8454   -3.0177 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8269   -3.1607   -2.6749 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5685   -2.0420   -4.8601 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8029   -1.7562   -4.9749 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4718   -3.4607   -4.8044 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1722   -1.1008   -2.3992 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1195   -0.2240   -3.2370 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -1.9373    0.6681 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8886    2.5505   -0.6126 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6180    2.0755   -2.2972 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1657    4.6218   -1.1645 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6347    3.2666   -3.7181 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2780    4.9096   -3.3439 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4928    4.6503   -3.4636 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4734    2.9775   -2.8638 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6747    3.4118   -1.5357 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3 35  2  0
 35 34  1  0
 34 13  2  0
 13 12  1  0
 12 11  2  0
 11 40  1  0
 40 39  1  0
 39 37  1  0
 37 38  1  0
 37 36  1  0
 11  9  1  0
  9 10  1  0
  9  8  2  0
  8  5  1  0
  5  6  1  0
  6  7  1  0
  5  4  2  0
 13 14  1  0
 14 15  2  0
 15 33  1  0
 33 31  1  0
 31 32  1  0
 31 30  1  0
 30 29  1  0
 29 16  1  0
 16 17  2  0
 17 18  1  0
 17 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  1  0
 20 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 24 27  1  0
 27 28  2  0
  4  3  1  0
 28 14  1  0
  8 34  1  0
 16 15  1  0
 28 19  1  0
 36 12  1  0
  1 41  1  0
  1 42  1  0
  1 43  1  0
 35 66  1  0
 40 73  1  0
 40 74  1  0
 37 69  1  1
 38 70  1  0
 38 71  1  0
 38 72  1  0
 36 67  1  0
 36 68  1  0
 10 48  1  0
  7 45  1  0
  7 46  1  0
  7 47  1  0
  4 44  1  0
 33 64  1  0
 33 65  1  0
 31 60  1  1
 32 61  1  0
 32 62  1  0
 32 63  1  0
 29 58  1  0
 29 59  1  0
 18 49  1  0
 22 50  1  0
 22 51  1  0
 22 52  1  0
 23 53  1  0
 26 54  1  0
 26 55  1  0
 26 56  1  0
 27 57  1  0
M  END


  Mrv1652309122200462D          

 40 45  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  2  0  0  0  0
 27 28  1  0  0  0  0
 14 28  2  0  0  0  0
 19 28  1  0  0  0  0
 16 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 15 33  1  0  0  0  0
 13 34  1  0  0  0  0
  8 34  1  0  0  0  0
 34 35  2  0  0  0  0
  3 35  1  0  0  0  0
 12 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 39 40  1  0  0  0  0
 11 40  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0320874

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC2=C(C3=C(COC(C)C3)C(O)=C2C(OC)=C1)C1=C2CC(C)OCC2=C(O)C2=C(OC)C=C(OC)C=C12

> <INCHI_IDENTIFIER>
InChI=1S/C32H34O8/c1-15-7-19-23(13-39-15)31(33)29-21(9-17(35-3)11-25(29)37-5)27(19)28-20-8-16(2)40-14-24(20)32(34)30-22(28)10-18(36-4)12-26(30)38-6/h9-12,15-16,33-34H,7-8,13-14H2,1-6H3

> <INCHI_KEY>
LIELYYSFQZFDLQ-UHFFFAOYSA-N

> <FORMULA>
C32H34O8

> <MOLECULAR_WEIGHT>
546.616

> <EXACT_MASS>
546.225368055

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
74

> <JCHEM_AVERAGE_POLARIZABILITY>
59.13335821202878

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
5-{10-hydroxy-7,9-dimethoxy-3-methyl-1H,3H,4H-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1H,3H,4H-naphtho[2,3-c]pyran-10-ol

> <JCHEM_LOGP>
5.026089519999998

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
8.80802753821818

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.126485887681156

> <JCHEM_PKA_STRONGEST_BASIC>
-3.7241405797974196

> <JCHEM_POLAR_SURFACE_AREA>
95.84000000000002

> <JCHEM_REFRACTIVITY>
152.5002

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
5-{10-hydroxy-7,9-dimethoxy-3-methyl-1H,3H,4H-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1H,3H,4H-naphtho[2,3-c]pyran-10-ol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 12-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   12-SEP-22         0                                  
HETATM    1  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       5.335   0.000   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       8.002  -3.080   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       8.002  -4.620   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       9.336  -5.390   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       9.336  -2.310   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      10.669  -3.080   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      10.669  -4.620   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0      12.003  -2.310   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      12.003  -0.770   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      10.669   0.000   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      10.669   1.540   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       9.336   2.310   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       9.336   3.850   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      10.669   4.620   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0      10.669   6.160   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0      12.003   3.850   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      13.337   4.620   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      13.337   6.160   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      14.670   6.930   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      14.670   3.850   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      14.670   2.310   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      16.004   1.540   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0      17.338   2.310   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      13.337   1.540   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      12.003   2.310   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       8.002   4.620   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0       6.668   3.850   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0       6.668   2.310   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       8.002   1.540   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       9.336  -0.770   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       8.002   0.000   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      13.337   0.000   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0      14.670  -0.770   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0      16.004   0.000   0.000  0.00  0.00           C+0
HETATM   39  O   UNK     0      14.670  -2.310   0.000  0.00  0.00           O+0
HETATM   40  C   UNK     0      13.337  -3.080   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   35                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6    8                                                  
CONECT    6    5    7                                                       
CONECT    7    6                                                            
CONECT    8    5    9   34                                                  
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12   40                                                  
CONECT   12   11   13   36                                                  
CONECT   13   12   14   34                                                  
CONECT   14   13   15   28                                                  
CONECT   15   14   16   33                                                  
CONECT   16   15   17   29                                                  
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   20   28                                                  
CONECT   20   19   21   23                                                  
CONECT   21   20   22                                                       
CONECT   22   21                                                            
CONECT   23   20   24                                                       
CONECT   24   23   25   27                                                  
CONECT   25   24   26                                                       
CONECT   26   25                                                            
CONECT   27   24   28                                                       
CONECT   28   27   14   19                                                  
CONECT   29   16   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   32   33                                                  
CONECT   32   31                                                            
CONECT   33   31   15                                                       
CONECT   34   13    8   35                                                  
CONECT   35   34    3                                                       
CONECT   36   12   37                                                       
CONECT   37   36   38   39                                                  
CONECT   38   37                                                            
CONECT   39   37   40                                                       
CONECT   40   39   11                                                       
MASTER        0    0    0    0    0    0    0    0   40    0   90    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₂H₃₄O₈

Average Mass

546.6160 Da

Monoisotopic Mass

546.22537 Da

IUPAC Name

5-{10-hydroxy-7,9-dimethoxy-3-methyl-1H,3H,4H-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1H,3H,4H-naphtho[2,3-c]pyran-10-ol

Traditional Name

5-{10-hydroxy-7,9-dimethoxy-3-methyl-1H,3H,4H-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1H,3H,4H-naphtho[2,3-c]pyran-10-ol

CAS Registry Number

Not Available

SMILES

COC1=CC2=C(C3=C(COC(C)C3)C(O)=C2C(OC)=C1)C1=C2CC(C)OCC2=C(O)C2=C(OC)C=C(OC)C=C12

InChI Identifier

InChI=1S/C32H34O8/c1-15-7-19-23(13-39-15)31(33)29-21(9-17(35-3)11-25(29)37-5)27(19)28-20-8-16(2)40-14-24(20)32(34)30-22(28)10-18(36-4)12-26(30)38-6/h9-12,15-16,33-34H,7-8,13-14H2,1-6H3

InChI Key

LIELYYSFQZFDLQ-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Blackwellomyces pseudomilitaris	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as arylnaphthalene lignans. These are lignans containing the arylnaphthalene skeleton, especially 9-(2H-1,3-benzodioxol-5-yl)-1H,3H-naphtho[2,3-c]furan-1-one or a derivative thereof. Arylnaphthalene lignans occur in nature and exhibit diverse biological activities.

Kingdom

Organic compounds

Super Class

Lignans, neolignans and related compounds

Class

Arylnaphthalene lignans

Sub Class

Not Available

Direct Parent

Arylnaphthalene lignans

Alternative Parents

Substituents

Arylnaphthalene lignan skeleton
Biphenol
Naphthopyran
1-naphthol
Benzopyran
Isochromane
Naphthalene
2-benzopyran
Phenol ether
Anisole
Alkyl aryl ether
Phenol
Pyran
Benzenoid
Organoheterocyclic compound
Oxacycle
Ether
Dialkyl ether
Organooxygen compound
Hydrocarbon derivative
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.03	ChemAxon
pKa (Strongest Acidic)	8.13	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	95.84 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	152.5 m³·mol⁻¹	ChemAxon
Polarizability	59.13 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00016710

Chemspider ID

8432375

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10256892

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol (NP0320874)

MOL for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)

3D MOL for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)

3D SDF for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)

3D-SDF for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)

PDB for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)

3D PDB for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)

SMILES for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)

INCHI for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)

Structure for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)

3D Structure for NP0320874 (5-{10-hydroxy-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-5-yl}-7,9-dimethoxy-3-methyl-1h,3h,4h-naphtho[2,3-c]pyran-10-ol)