NP-MRD: Showing NP-Card for (1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione (NP0320080)

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Record Information

Version

2.0

Created at

2022-09-11 21:29:24 UTC

Updated at

2022-09-11 21:29:24 UTC

NP-MRD ID

NP0320080

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione

Description

Dehydroxynoreupenifeldin belongs to the class of organic compounds known as tropolones. Tropolones are compounds containing tropone ring with a hydroxyl group at ring position 2. Based on a literature review very few articles have been published on Dehydroxynoreupenifeldin.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309112223292D          

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M  END

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M  END


  Mrv1652309112223292D          

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    6.4392   -4.3730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6825   -4.0443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0580   -4.5835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4677   -3.2478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6477   -3.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3166   -2.4011    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4967   -2.3101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0078   -2.9746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1879   -2.8836    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5190   -3.6392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6990   -3.5481    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  6  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  6  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 23 32  2  0  0  0  0
 32 33  1  0  0  0  0
 34 33  1  6  0  0  0
 20 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 12 37  1  0  0  0  0
 37 38  1  1  0  0  0
 37 39  1  0  0  0  0
  9 39  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0320080

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1=CC(=O)C(O)=CC2=C1C[C@@H]1CC[C@]3(C)OC4=C(C[C@@H]3CC(C)(C)\C=C\C[C@@]1(C)O2)C(C)=CC(=O)C(O)=C4

> <INCHI_IDENTIFIER>
InChI=1S/C33H40O6/c1-19-12-25(34)27(36)16-29-23(19)14-21-8-11-33(6)22(18-31(3,4)9-7-10-32(21,5)38-29)15-24-20(2)13-26(35)28(37)17-30(24)39-33/h7,9,12-13,16-17,21-22H,8,10-11,14-15,18H2,1-6H3,(H,34,36)(H,35,37)/b9-7+/t21-,22+,32+,33-/m0/s1

> <INCHI_KEY>
OZUFBPGYZATQSZ-KULONADFSA-N

> <FORMULA>
C33H40O6

> <MOLECULAR_WEIGHT>
532.677

> <EXACT_MASS>
532.282489008

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
79

> <JCHEM_AVERAGE_POLARIZABILITY>
59.58571484918233

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,4S,14S,17E,20R)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0^{4,14}.0^{6,12}.0^{22,28}]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione

> <JCHEM_LOGP>
5.429694021333335

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
10.449202535374349

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.819161560174166

> <JCHEM_PKA_STRONGEST_BASIC>
-3.2470922329785585

> <JCHEM_POLAR_SURFACE_AREA>
93.06000000000002

> <JCHEM_REFRACTIVITY>
159.63390000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(1S,4S,14S,17E,20R)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0^{4,14}.0^{6,12}.0^{22,28}]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 11-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   11-SEP-22         0                                  
HETATM    1  C   UNK     0      -0.754  -3.134   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.465  -4.647   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.703  -5.563   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.758  -7.102   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      -3.169  -7.720   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0      -0.589  -8.105   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      -0.985  -9.593   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       0.923  -7.816   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       1.641  -6.453   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.023  -5.043   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.935  -3.802   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.466  -3.972   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.405  -2.573   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       4.253  -1.040   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.744  -1.351   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       3.785   0.427   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.663  -0.422   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       6.687  -1.572   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.352  -1.831   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       8.970  -3.242   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       9.883  -2.001   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0      10.501  -3.412   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0      11.119  -4.822   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      12.658  -4.762   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      13.664  -5.928   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0      15.151  -5.527   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0      13.380  -7.441   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0      14.621  -8.354   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0      12.020  -8.163   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      10.607  -7.549   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       9.442  -8.556   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      10.206  -6.063   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       8.676  -5.893   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       8.058  -4.482   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       6.527  -4.312   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       5.615  -5.553   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0       4.084  -5.383   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0       4.702  -6.793   0.000  0.00  0.00           C+0
HETATM   39  O   UNK     0       3.172  -6.623   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   10                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10   39                                                  
CONECT   10    9    2   11                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13   37                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   16   17                                             
CONECT   15   14                                                            
CONECT   16   14                                                            
CONECT   17   14   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   22   34                                             
CONECT   21   20                                                            
CONECT   22   20   23                                                       
CONECT   23   22   24   32                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25   28   29                                                  
CONECT   28   27                                                            
CONECT   29   27   30                                                       
CONECT   30   29   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   23   33                                                  
CONECT   33   32   34                                                       
CONECT   34   33   20   35                                                  
CONECT   35   34   36                                                       
CONECT   36   35   37                                                       
CONECT   37   36   12   38   39                                             
CONECT   38   37                                                            
CONECT   39   37    9                                                       
MASTER        0    0    0    0    0    0    0    0   39    0   86    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₃H₄₀O₆

Average Mass

532.6770 Da

Monoisotopic Mass

532.28249 Da

IUPAC Name

(1S,4S,14S,17E,20R)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0^{4,14}.0^{6,12}.0^{22,28}]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione

Traditional Name

(1S,4S,14S,17E,20R)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0^{4,14}.0^{6,12}.0^{22,28}]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione

CAS Registry Number

Not Available

SMILES

CC1=CC(=O)C(O)=CC2=C1C[C@@H]1CC[C@]3(C)OC4=C(C[C@@H]3CC(C)(C)\C=C\C[C@@]1(C)O2)C(C)=CC(=O)C(O)=C4

InChI Identifier

InChI=1S/C33H40O6/c1-19-12-25(34)27(36)16-29-23(19)14-21-8-11-33(6)22(18-31(3,4)9-7-10-32(21,5)38-29)15-24-20(2)13-26(35)28(37)17-30(24)39-33/h7,9,12-13,16-17,21-22H,8,10-11,14-15,18H2,1-6H3,(H,34,36)(H,35,37)/b9-7+/t21-,22+,32+,33-/m0/s1

InChI Key

OZUFBPGYZATQSZ-KULONADFSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tropolones. Tropolones are compounds containing tropone ring with a hydroxyl group at ring position 2.

Kingdom

Organic compounds

Super Class

Hydrocarbon derivatives

Class

Tropones

Sub Class

Tropolones

Direct Parent

Tropolones

Alternative Parents

Substituents

Tropolone
Alkyl aryl ether
Vinylogous ester
Cyclic ketone
Oxacycle
Organoheterocyclic compound
Ether
Organic oxygen compound
Organic oxide
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.43	ChemAxon
pKa (Strongest Acidic)	9.82	ChemAxon
pKa (Strongest Basic)	-3.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	93.06 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	159.63 m³·mol⁻¹	ChemAxon
Polarizability	59.59 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

146683132

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione (NP0320080)

MOL for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)

3D MOL for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)

3D SDF for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)

3D-SDF for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)

PDB for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)

3D PDB for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)

SMILES for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)

INCHI for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)

Structure for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)

3D Structure for NP0320080 ((1s,4s,14s,17e,20r)-8,24-dihydroxy-4,11,16,16,20,27-hexamethyl-5,21-dioxapentacyclo[18.9.0.0⁴,¹⁴.0⁶,¹².0²²,²⁸]nonacosa-6(12),7,10,17,22(28),23,26-heptaene-9,25-dione)