NP-MRD: Showing NP-Card for 13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one (NP0318128)

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Record Information

Version

2.0

Created at

2022-09-11 18:26:13 UTC

Updated at

2022-09-11 18:26:13 UTC

NP-MRD ID

NP0318128

Secondary Accession Numbers

None

Natural Product Identification

Common Name

13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one

Description

13-(2-Hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]Hexadecan-3-one belongs to the class of organic compounds known as sesterterpenoids. These are terpenes composed of five consecutive isoprene units. 13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one is found in Viburnum dilatatum. Based on a literature review very few articles have been published on 13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]Hexadecan-3-one.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309112220262D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309112220262D          

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    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4099    0.6131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
 25 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 14 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 18 34  1  0  0  0  0
 23 34  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0318128

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)=CC(=O)CC(C)(O)C1CCC2(C)C1CC1OC(=O)CC3(C)C(CCC2(C)C13)C(C)(C)O

> <INCHI_IDENTIFIER>
InChI=1S/C29H46O5/c1-17(2)13-18(30)15-29(8,33)19-9-11-27(6)20(19)14-21-24-26(5,16-23(31)34-21)22(25(3,4)32)10-12-28(24,27)7/h13,19-22,24,32-33H,9-12,14-16H2,1-8H3

> <INCHI_KEY>
AWMUQVARSMJTKO-UHFFFAOYSA-N

> <FORMULA>
C29H46O5

> <MOLECULAR_WEIGHT>
474.682

> <EXACT_MASS>
474.334524581

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
80

> <JCHEM_AVERAGE_POLARIZABILITY>
53.91919341617188

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0^{5,16}.0^{10,14}]hexadecan-3-one

> <JCHEM_LOGP>
4.213930940333332

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
18.74498257014167

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.580423767610476

> <JCHEM_PKA_STRONGEST_BASIC>
-0.6452094103302687

> <JCHEM_POLAR_SURFACE_AREA>
83.83

> <JCHEM_REFRACTIVITY>
133.4439

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0^{5,16}.0^{10,14}]hexadecan-3-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 11-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   11-SEP-22         0                                  
HETATM    1  C   UNK     0      10.512 -10.109   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      10.037  -8.644   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       8.530  -8.324   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      11.067  -7.500   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      10.591  -6.035   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0      11.622  -4.891   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       9.085  -5.715   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.609  -4.251   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      10.074  -3.775   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       7.144  -4.726   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       8.133  -2.786   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       9.038  -1.540   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.133  -0.294   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       6.829   0.762   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       2.667  -3.080   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       0.000  -3.080   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       1.334   0.770   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       0.000   3.080   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       2.104   3.644   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       0.564   0.976   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       4.001   2.310   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       6.365   1.144   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   10   11                                             
CONECT    9    8                                                            
CONECT   10    8                                                            
CONECT   11    8   12   16                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   16   32                                             
CONECT   15   14                                                            
CONECT   16   14   11   17                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19   34                                                  
CONECT   19   18   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23                                                       
CONECT   23   22   24   25   34                                             
CONECT   24   23                                                            
CONECT   25   23   26   30                                                  
CONECT   26   25   27   28   29                                             
CONECT   27   26                                                            
CONECT   28   26                                                            
CONECT   29   26                                                            
CONECT   30   25   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   14   33   34                                             
CONECT   33   32                                                            
CONECT   34   32   18   23                                                  
MASTER        0    0    0    0    0    0    0    0   34    0   74    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₉H₄₆O₅

Average Mass

474.6820 Da

Monoisotopic Mass

474.33452 Da

IUPAC Name

13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0^{5,16}.0^{10,14}]hexadecan-3-one

Traditional Name

13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0^{5,16}.0^{10,14}]hexadecan-3-one

CAS Registry Number

Not Available

SMILES

CC(C)=CC(=O)CC(C)(O)C1CCC2(C)C1CC1OC(=O)CC3(C)C(CCC2(C)C13)C(C)(C)O

InChI Identifier

InChI=1S/C29H46O5/c1-17(2)13-18(30)15-29(8,33)19-9-11-27(6)20(19)14-21-24-26(5,16-23(31)34-21)22(25(3,4)32)10-12-28(24,27)7/h13,19-22,24,32-33H,9-12,14-16H2,1-8H3

InChI Key

AWMUQVARSMJTKO-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Viburnum dilatatum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as sesterterpenoids. These are terpenes composed of five consecutive isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesterterpenoids

Direct Parent

Sesterterpenoids

Alternative Parents

Substituents

Sesterterpenoid
Delta valerolactone
Delta_valerolactone
B'-hydroxy-alpha,beta-unsaturated-ketone
Beta-hydroxy ketone
Oxane
Acryloyl-group
Enone
Alpha,beta-unsaturated ketone
Tertiary alcohol
Carboxylic acid ester
Ketone
Lactone
Organoheterocyclic compound
Oxacycle
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Alcohol
Hydrocarbon derivative
Organic oxygen compound
Carbonyl group
Organic oxide
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.21	ChemAxon
pKa (Strongest Acidic)	14.58	ChemAxon
pKa (Strongest Basic)	-0.65	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	83.83 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	133.44 m³·mol⁻¹	ChemAxon
Polarizability	53.92 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

162948354

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one (NP0318128)

MOL for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)

3D MOL for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)

3D SDF for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)

3D-SDF for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)

PDB for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)

3D PDB for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)

SMILES for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)

INCHI for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)

Structure for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)

3D Structure for NP0318128 (13-(2-hydroxy-6-methyl-4-oxohept-5-en-2-yl)-6-(2-hydroxypropan-2-yl)-5,9,10-trimethyl-2-oxatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadecan-3-one)