NP-MRD: Showing NP-Card for 2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol (NP0316370)

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Record Information

Version

2.0

Created at

2022-09-11 15:31:25 UTC

Updated at

2022-09-11 15:31:25 UTC

NP-MRD ID

NP0316370

Secondary Accession Numbers

None

Natural Product Identification

Common Name

2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol

Description

2-({3-Ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]Hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond. 2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol is found in Pieris formosa. 2-({3-Ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]Hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004171513552D          

 36 40  0  0  0  0            999 V2000
    3.5559   -1.6285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.1169    0.0864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 36  1  0  0  0  0
M  END

     RDKit          3D

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M  END


  Mrv1533004171513552D          

 36 40  0  0  0  0            999 V2000
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    6.3025    2.6794    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3210    1.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1459    1.2612    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9177    0.5308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3394   -0.1783    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7398   -0.4452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5282   -0.2024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0568   -1.2069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0253   -0.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
  4 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 14 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 22 31  1  0  0  0  0
 31 32  1  0  0  0  0
  8 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 33 36  1  0  0  0  0
  6 36  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0316370

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCOC1CC23CC(CCC2C(=C)C2=C1C(C)(C)C(C2)OC1OC(CO)C(O)C(O)C1O)C(C)(O)C3

> <INCHI_IDENTIFIER>
InChI=1S/C28H44O8/c1-6-34-18-11-28-10-15(27(5,33)13-28)7-8-17(28)14(2)16-9-20(26(3,4)21(16)18)36-25-24(32)23(31)22(30)19(12-29)35-25/h15,17-20,22-25,29-33H,2,6-13H2,1,3-5H3

> <INCHI_KEY>
BIPGTJXUCHADMC-UHFFFAOYSA-N

> <FORMULA>
C28H44O8

> <MOLECULAR_WEIGHT>
508.652

> <EXACT_MASS>
508.303618377

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
80

> <JCHEM_AVERAGE_POLARIZABILITY>
56.84291726362164

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol

> <ALOGPS_LOGP>
1.45

> <JCHEM_LOGP>
0.6061422893333324

> <ALOGPS_LOGS>
-3.16

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.20007343548669

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.210518552171948

> <JCHEM_PKA_STRONGEST_BASIC>
-0.6500000123730668

> <JCHEM_POLAR_SURFACE_AREA>
128.84

> <JCHEM_REFRACTIVITY>
132.92950000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
3.53e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-APR-15         0                                  
HETATM    1  C   UNK     0       6.638  -3.040   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       5.531  -4.111   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       4.051  -3.689   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0       3.676  -2.195   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.160  -1.867   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.348  -0.520   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.218   0.161   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.058   0.737   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -0.409   2.201   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.177   2.354   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.075   0.976   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.615   1.302   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       3.962   2.803   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       4.834   0.347   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.854  -1.193   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       6.325  -1.650   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.717  -3.065   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       7.668  -2.403   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       7.214  -0.392   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       6.293   0.842   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       8.754  -0.372   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       9.507   0.971   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       8.719   2.295   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       9.472   3.638   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       8.685   4.962   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       9.438   6.305   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0      11.012   3.658   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0      11.765   5.002   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0      11.799   2.334   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0      13.339   2.354   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0      11.046   0.991   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0      11.834  -0.333   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0      -1.381  -0.831   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      -2.853  -0.378   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0      -1.973  -2.253   0.000  0.00  0.00           O+0
HETATM   36  C   UNK     0       0.047  -1.593   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5   15                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7   11   36                                             
CONECT    7    6    8                                                       
CONECT    8    7    9   33                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10    6   12                                                  
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15   20                                                  
CONECT   15   14    4   16                                                  
CONECT   16   15   17   18   19                                             
CONECT   17   16                                                            
CONECT   18   16                                                            
CONECT   19   16   20   21                                                  
CONECT   20   19   14                                                       
CONECT   21   19   22                                                       
CONECT   22   21   23   31                                                  
CONECT   23   22   24                                                       
CONECT   24   23   25   27                                                  
CONECT   25   24   26                                                       
CONECT   26   25                                                            
CONECT   27   24   28   29                                                  
CONECT   28   27                                                            
CONECT   29   27   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29   22   32                                                  
CONECT   32   31                                                            
CONECT   33    8   34   35   36                                             
CONECT   34   33                                                            
CONECT   35   33                                                            
CONECT   36   33    6                                                       
MASTER        0    0    0    0    0    0    0    0   36    0   80    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₄₄O₈

Average Mass

508.6520 Da

Monoisotopic Mass

508.30362 Da

IUPAC Name

2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol

Traditional Name

2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol

CAS Registry Number

Not Available

SMILES

CCOC1CC23CC(CCC2C(=C)C2=C1C(C)(C)C(C2)OC1OC(CO)C(O)C(O)C1O)C(C)(O)C3

InChI Identifier

InChI=1S/C28H44O8/c1-6-34-18-11-28-10-15(27(5,33)13-28)7-8-17(28)14(2)16-9-20(26(3,4)21(16)18)36-25-24(32)23(31)22(30)19(12-29)35-25/h15,17-20,22-25,29-33H,2,6-13H2,1,3-5H3

InChI Key

BIPGTJXUCHADMC-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Pieris formosa	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

O-glycosyl compounds

Alternative Parents

Substituents

Hexose monosaccharide
O-glycosyl compound
Monosaccharide
Oxane
Cyclic alcohol
Tertiary alcohol
Secondary alcohol
Acetal
Organoheterocyclic compound
Oxacycle
Ether
Dialkyl ether
Polyol
Primary alcohol
Hydrocarbon derivative
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.45	ALOGPS
logP	0.61	ChemAxon
logS	-3.2	ALOGPS
pKa (Strongest Acidic)	12.21	ChemAxon
pKa (Strongest Basic)	-0.65	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	128.84 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	132.93 m³·mol⁻¹	ChemAxon
Polarizability	56.84 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol (NP0316370)

MOL for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)

3D MOL for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)

3D SDF for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)

3D-SDF for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)

PDB for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)

3D PDB for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)

SMILES for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)

INCHI for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)

Structure for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)

3D Structure for NP0316370 (2-({3-ethoxy-14-hydroxy-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.0¹,¹⁰.0⁴,⁸]hexadec-4(8)-en-6-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol)