NP-MRD: Showing NP-Card for (1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid (NP0314998)

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Record Information

Version

2.0

Created at

2022-09-11 13:24:38 UTC

Updated at

2022-09-11 13:24:39 UTC

NP-MRD ID

NP0314998

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid

Description

(1S,3S,4S,7R,8E,11R)-12-[(2S,3S,4R,5E)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]Tetradeca-8,12-diene-8-carboxylic acid belongs to the class of organic compounds known as ophiobolane sesterterpenoids. These are sesterterpnoids with a structure based on the ophiobolane backbone. Ophiobolane is a tricyclic compound consisting of two cyclopentane rings joined by a cyclooctane ring, and carries a methyl group at the 1-, 4-, and 8-position, as well as a 6-methylheptane group at the 12-position. (1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid is found in Halorosellinia oceanica. Based on a literature review very few articles have been published on (1S,3S,4S,7R,8E,11R)-12-[(2S,3S,4R,5E)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]Tetradeca-8,12-diene-8-carboxylic acid.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309112215242D          

 31 33  0  0  1  0            999 V2000
   -1.3277   -4.9718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5165   -5.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0193   -4.4948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2561   -3.7171    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0673   -3.5668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2797   -3.0898    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.0909   -3.2401    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0043   -2.3121    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.8069   -2.1618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5401   -1.6848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3475   -0.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0509   -0.4515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6783   -0.9873    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
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    2.4405   -0.6716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5829   -2.8815    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3625   -1.7495    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.2411   -5.8998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5701   -6.0502    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7769   -6.5271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2 29  1  0  0  0  0
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M  END

     RDKit          3D

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M  END


  Mrv1652309112215242D          

 31 33  0  0  1  0            999 V2000
   -1.3277   -4.9718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5165   -5.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2561   -3.7171    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.0673   -3.5668    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 29 31  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0314998

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]([C@H](O)[C@H](O)\C=C(/C)C(O)=O)C1=CC[C@]2(C)C[C@H]3[C@@H](C)CC[C@H]3\C(=C/C[C@@H]12)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C25H36O6/c1-13-5-6-17-18(24(30)31)7-8-20-16(9-10-25(20,4)12-19(13)17)15(3)22(27)21(26)11-14(2)23(28)29/h7,9,11,13,15,17,19-22,26-27H,5-6,8,10,12H2,1-4H3,(H,28,29)(H,30,31)/b14-11+,18-7+/t13-,15-,17-,19-,20-,21+,22-,25+/m0/s1

> <INCHI_KEY>
XHFDLHDZJBWKEA-XRPWXECCSA-N

> <FORMULA>
C25H36O6

> <MOLECULAR_WEIGHT>
432.557

> <EXACT_MASS>
432.251188879

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
67

> <JCHEM_AVERAGE_POLARIZABILITY>
47.71214118784804

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S,3S,4S,7R,8E,11R)-12-[(2S,3S,4R,5E)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0^{3,7}]tetradeca-8,12-diene-8-carboxylic acid

> <JCHEM_LOGP>
3.5631829666666666

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
4.906705235294547

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.263948557666538

> <JCHEM_PKA_STRONGEST_BASIC>
-3.3048637021286806

> <JCHEM_POLAR_SURFACE_AREA>
115.06000000000002

> <JCHEM_REFRACTIVITY>
119.60749999999994

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1S,3S,4S,7R,8E,11R)-12-[(2S,3S,4R,5E)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0^{3,7}]tetradeca-8,12-diene-8-carboxylic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 11-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   11-SEP-22         0                                  
HETATM    1  C   UNK     0      -2.478  -9.281   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.964  -9.561   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.036  -8.390   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -0.478  -6.939   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      -1.992  -6.658   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       0.522  -5.768   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       2.036  -6.048   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       0.008  -4.316   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -1.506  -4.035   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.008  -3.145   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       0.649  -1.647   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.962  -0.843   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       3.133  -1.843   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.374  -0.322   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.556  -1.254   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.978  -1.843   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       7.149  -0.843   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       7.028   0.692   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.462  -1.647   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       8.103  -3.145   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       6.568  -3.266   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       5.978  -4.688   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       7.067  -5.777   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       6.669  -7.265   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0       8.555  -5.379   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       4.556  -5.278   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       3.133  -4.688   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       2.543  -3.266   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      -0.450 -11.013   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0       1.064 -11.294   0.000  0.00  0.00           O+0
HETATM   31  O   UNK     0      -1.450 -12.184   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   29                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11   28                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   15   28                                             
CONECT   14   13                                                            
CONECT   15   13   16                                                       
CONECT   16   15   17   21                                                  
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   16   22                                                  
CONECT   22   21   23   26                                                  
CONECT   23   22   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23                                                            
CONECT   26   22   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   10   13                                                  
CONECT   29    2   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29                                                            
MASTER        0    0    0    0    0    0    0    0   31    0   66    0
END

View in JSmol

Synonyms

Value	Source
(1S,3S,4S,7R,8E,11R)-12-[(2S,3S,4R,5E)-6-Carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0,]tetradeca-8,12-diene-8-carboxylate	Generator

Chemical Formula

C₂₅H₃₆O₆

Average Mass

432.5570 Da

Monoisotopic Mass

432.25119 Da

IUPAC Name

(1S,3S,4S,7R,8E,11R)-12-[(2S,3S,4R,5E)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0^{3,7}]tetradeca-8,12-diene-8-carboxylic acid

Traditional Name

(1S,3S,4S,7R,8E,11R)-12-[(2S,3S,4R,5E)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0^{3,7}]tetradeca-8,12-diene-8-carboxylic acid

CAS Registry Number

Not Available

SMILES

C[C@H]([C@H](O)[C@H](O)\C=C(/C)C(O)=O)C1=CC[C@]2(C)C[C@H]3[C@@H](C)CC[C@H]3\C(=C/C[C@@H]12)C(O)=O

InChI Identifier

InChI=1S/C25H36O6/c1-13-5-6-17-18(24(30)31)7-8-20-16(9-10-25(20,4)12-19(13)17)15(3)22(27)21(26)11-14(2)23(28)29/h7,9,11,13,15,17,19-22,26-27H,5-6,8,10,12H2,1-4H3,(H,28,29)(H,30,31)/b14-11+,18-7+/t13-,15-,17-,19-,20-,21+,22-,25+/m0/s1

InChI Key

XHFDLHDZJBWKEA-XRPWXECCSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Halorosellinia oceanica	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as ophiobolane sesterterpenoids. These are sesterterpnoids with a structure based on the ophiobolane backbone. Ophiobolane is a tricyclic compound consisting of two cyclopentane rings joined by a cyclooctane ring, and carries a methyl group at the 1-, 4-, and 8-position, as well as a 6-methylheptane group at the 12-position.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesterterpenoids

Direct Parent

Ophiobolane sesterterpenoids

Alternative Parents

Substituents

Ophiobolane sesterterpenoid
Medium-chain hydroxy acid
Medium-chain fatty acid
Branched fatty acid
Hydroxy fatty acid
Methyl-branched fatty acid
Unsaturated fatty acid
Dicarboxylic acid or derivatives
Fatty acid
Fatty acyl
Secondary alcohol
1,2-diol
Carboxylic acid
Carboxylic acid derivative
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Organic oxygen compound
Alcohol
Carbonyl group
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.56	ChemAxon
pKa (Strongest Acidic)	4.26	ChemAxon
pKa (Strongest Basic)	-3.3	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	115.06 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	119.61 m³·mol⁻¹	ChemAxon
Polarizability	47.71 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

162922504

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid (NP0314998)

MOL for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)

3D MOL for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)

3D SDF for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)

3D-SDF for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)

PDB for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)

3D PDB for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)

SMILES for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)

INCHI for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)

Structure for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)

3D Structure for NP0314998 ((1s,3s,4s,7r,8e,11r)-12-[(2s,3s,4r,5e)-6-carboxy-3,4-dihydroxy-6-methylhex-5-en-2-yl]-1,4-dimethyltricyclo[9.3.0.0³,⁷]tetradeca-8,12-diene-8-carboxylic acid)