NP-MRD: Showing NP-Card for {[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid (NP0314913)

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Record Information

Version

2.0

Created at

2022-09-11 13:16:49 UTC

Updated at

2022-09-11 13:16:49 UTC

NP-MRD ID

NP0314913

Secondary Accession Numbers

None

Natural Product Identification

Common Name

{[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid

Description

CHEMBL246363 belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides. Based on a literature review very few articles have been published on CHEMBL246363.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309112215162D          

 39 40  0  0  1  0            999 V2000
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M  END

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M  END


  Mrv1652309112215162D          

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    5.9060    3.5582    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.3737    4.2378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2606    2.8133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7929    2.1337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9705    2.1990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1475    1.3888    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.9699    1.3236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4377    2.0031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0830    2.7480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2601    1.9379    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 12 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  1  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  6  0  0  0
 26 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  1  0  0  0
 28 30  1  0  0  0  0
 30 31  1  1  0  0  0
 30 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
  3 35  1  0  0  0  0
 35 36  1  6  0  0  0
 36 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0314913

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CO[C@H]1C[C@H](C)CC2=C(O)C(=CC(O)=C2O)N=C(O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(O)=N)\C(C)=C\[C@H](C)[C@H]1O

> <INCHI_IDENTIFIER>
InChI=1S/C28H40N2O9/c1-14-10-18-24(33)19(13-20(31)25(18)34)30-27(35)15(2)8-7-9-21(37-5)26(39-28(29)36)17(4)12-16(3)23(32)22(11-14)38-6/h7-9,12-14,16,21-23,26,31-34H,10-11H2,1-6H3,(H2,29,36)(H,30,35)/b9-7-,15-8+,17-12+/t14-,16+,21+,22+,23-,26+/m1/s1

> <INCHI_KEY>
SSTZKOMSVQUZSD-LVBRMASUSA-N

> <FORMULA>
C28H40N2O9

> <MOLECULAR_WEIGHT>
548.633

> <EXACT_MASS>
548.273380876

> <JCHEM_ACCEPTOR_COUNT>
11

> <JCHEM_ATOM_COUNT>
79

> <JCHEM_AVERAGE_POLARIZABILITY>
56.15510320232575

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
7

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
{[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid

> <JCHEM_LOGP>
1.694711605477694

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
-0.3019172082597956

> <JCHEM_PKA_STRONGEST_ACIDIC>
-2.9808338070234344

> <JCHEM_PKA_STRONGEST_BASIC>
15.117214168153307

> <JCHEM_POLAR_SURFACE_AREA>
185.27999999999997

> <JCHEM_REFRACTIVITY>
161.37160000000006

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
{[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 11-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   11-SEP-22         0                                  
HETATM    1  C   UNK     0      12.799  -0.188   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0      12.137   1.202   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0      10.602   1.324   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      11.264  -0.066   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      10.391  -1.335   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.707  -1.275   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.485  -2.211   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.524  -3.751   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.216  -1.338   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       4.764  -1.851   0.000  0.00  0.00           O+0
HETATM   11  N   UNK     0       6.654   0.138   0.000  0.00  0.00           N+0
HETATM   12  C   UNK     0       5.997   1.690   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.462   1.811   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.800   3.202   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       2.264   3.324   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       4.673   4.470   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       4.011   5.861   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       6.208   4.349   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       6.870   2.958   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       8.405   2.836   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       7.081   5.617   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       6.419   7.008   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       4.884   7.129   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       7.292   8.276   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       8.827   8.154   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       9.700   9.423   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0       9.038  10.813   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       9.489   6.764   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       8.616   5.495   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0      11.024   6.642   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      11.898   7.910   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      11.686   5.252   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      10.813   3.983   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       9.278   4.105   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0      11.475   2.593   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0      13.011   2.471   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0      13.884   3.739   0.000  0.00  0.00           C+0
HETATM   38  N   UNK     0      13.222   5.130   0.000  0.00  0.00           N+0
HETATM   39  O   UNK     0      15.419   3.617   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   35                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12                                                       
CONECT   12   11   13   19                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19   21                                                  
CONECT   19   18   12   20                                                  
CONECT   20   19                                                            
CONECT   21   18   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25                                                       
CONECT   25   24   26   28                                                  
CONECT   26   25   27                                                       
CONECT   27   26                                                            
CONECT   28   25   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   33                                                       
CONECT   33   32   34   35                                                  
CONECT   34   33                                                            
CONECT   35   33    3   36                                                  
CONECT   36   35   37                                                       
CONECT   37   36   38   39                                                  
CONECT   38   37                                                            
CONECT   39   37                                                            
MASTER        0    0    0    0    0    0    0    0   39    0   80    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₄₀N₂O₉

Average Mass

548.6330 Da

Monoisotopic Mass

548.27338 Da

IUPAC Name

{[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid

Traditional Name

{[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid

CAS Registry Number

Not Available

SMILES

CO[C@H]1C[C@H](C)CC2=C(O)C(=CC(O)=C2O)N=C(O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(O)=N)\C(C)=C\[C@H](C)[C@H]1O

InChI Identifier

InChI=1S/C28H40N2O9/c1-14-10-18-24(33)19(13-20(31)25(18)34)30-27(35)15(2)8-7-9-21(37-5)26(39-28(29)36)17(4)12-16(3)23(32)22(11-14)38-6/h7-9,12-14,16,21-23,26,31-34H,10-11H2,1-6H3,(H2,29,36)(H,30,35)/b9-7-,15-8+,17-12+/t14-,16+,21+,22+,23-,26+/m1/s1

InChI Key

SSTZKOMSVQUZSD-LVBRMASUSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Macrolactams

Sub Class

Not Available

Direct Parent

Macrolactams

Alternative Parents

Substituents

Macrolactam
1-hydroxy-2-unsubstituted benzenoid
Phenol
Benzenoid
Carbamic acid ester
Carboxamide group
Lactam
Secondary alcohol
Secondary carboxylic acid amide
Carboxylic acid derivative
Dialkyl ether
Ether
Polyol
Azacycle
Organoheterocyclic compound
Organic oxide
Organic oxygen compound
Carbonyl group
Organonitrogen compound
Organooxygen compound
Hydrocarbon derivative
Organic nitrogen compound
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.69	ChemAxon
pKa (Strongest Acidic)	-3	ChemAxon
pKa (Strongest Basic)	15.12	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	185.28 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	161.37 m³·mol⁻¹	ChemAxon
Polarizability	56.16 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

23304430

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

44440189

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for {[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid (NP0314913)

MOL for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)

3D MOL for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)

3D SDF for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)

3D-SDF for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)

PDB for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)

3D PDB for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)

SMILES for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)

INCHI for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)

Structure for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)

3D Structure for NP0314913 ({[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-3,13,19,20,22-pentahydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),2,4,6,10,18(22),19-heptaen-9-yl]oxy}methanimidic acid)