NP-MRD: Showing NP-Card for 4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol (NP0313818)

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Record Information

Version

2.0

Created at

2022-09-11 11:35:42 UTC

Updated at

2022-09-11 11:35:43 UTC

NP-MRD ID

NP0313818

Secondary Accession Numbers

None

Natural Product Identification

Common Name

4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol

Description

3',7-Bis(hydroxymethyl)-3',4a,4b,7,10a-pentamethyl-4,4a,4b,5,6,6a,7,8,9,10,10a,10b-dodecahydro-3H-spiro[chrysene-2,1'-cyclopentane]-8,9-diol belongs to the class of organic compounds known as 12-hydroxysteroids. These are steroids carrying a hydroxyl group at the 12-position of the steroid backbone. 4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol is found in Phlomoides hamosa. 3',7-Bis(hydroxymethyl)-3',4a,4b,7,10a-pentamethyl-4,4a,4b,5,6,6a,7,8,9,10,10a,10b-dodecahydro-3H-spiro[chrysene-2,1'-cyclopentane]-8,9-diol is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004241510592D          

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M  END

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M  END


  Mrv1533004241510592D          

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  3  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
  7 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 24 28  1  0  0  0  0
 17 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 10 31  1  0  0  0  0
 16 31  1  0  0  0  0
 31 32  1  0  0  0  0
  7 33  1  0  0  0  0
  2 33  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0313818

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1(CO)CCC2(C1)CCC1(C)C(C=CC3C4(C)CC(O)C(O)C(C)(CO)C4CCC13C)=C2

> <INCHI_IDENTIFIER>
InChI=1S/C29H46O4/c1-24(17-30)10-12-29(16-24)13-11-27(4)19(14-29)6-7-22-25(2)15-20(32)23(33)26(3,18-31)21(25)8-9-28(22,27)5/h6-7,14,20-23,30-33H,8-13,15-18H2,1-5H3

> <INCHI_KEY>
WALCWEJDMSYABA-UHFFFAOYSA-N

> <FORMULA>
C29H46O4

> <MOLECULAR_WEIGHT>
458.683

> <EXACT_MASS>
458.339609961

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
79

> <JCHEM_AVERAGE_POLARIZABILITY>
54.53958278001893

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,4a,4b,5,6,6a,7,8,9,10,10a,10b-dodecahydro-3H-spiro[chrysene-2,1'-cyclopentane]-8,9-diol

> <ALOGPS_LOGP>
3.87

> <JCHEM_LOGP>
3.117754161

> <ALOGPS_LOGS>
-4.61

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.827165115022211

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.553641096938517

> <JCHEM_PKA_STRONGEST_BASIC>
-1.386884294640867

> <JCHEM_POLAR_SURFACE_AREA>
80.92

> <JCHEM_REFRACTIVITY>
133.38620000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.12e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3H-spiro[chrysene-2,1'-cyclopentane]-8,9-diol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-APR-15         0                                  
HETATM    1  C   UNK     0      12.879   2.839   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      12.358   1.390   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      13.854   1.023   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      14.919   2.135   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0      12.150  -0.136   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.635  -0.410   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       9.906   0.947   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       9.323   2.372   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.798   2.581   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       6.854   1.363   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.272   2.789   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.437  -0.062   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.963  -0.270   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.494  -1.280   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.968  -1.072   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       4.385   0.354   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       2.860   0.562   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       3.442  -0.864   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       1.916  -0.655   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       0.391  -0.447   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -0.553  -1.665   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -0.192   0.978   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      -1.718   1.186   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       0.751   2.195   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       1.221   3.662   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -0.612   2.913   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0      -0.672   4.452   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       2.277   1.987   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       3.220   3.205   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       4.746   2.997   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       5.329   1.571   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       5.376   3.111   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      10.971   2.059   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    5   33                                             
CONECT    3    2    4                                                       
CONECT    4    3                                                            
CONECT    5    2    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8   13   33                                             
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   12   31                                             
CONECT   11   10                                                            
CONECT   12   10   13   14                                                  
CONECT   13   12    7                                                       
CONECT   14   12   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17   31                                                  
CONECT   17   16   18   19   28                                             
CONECT   18   17                                                            
CONECT   19   17   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25   26   28                                             
CONECT   25   24                                                            
CONECT   26   24   27                                                       
CONECT   27   26                                                            
CONECT   28   24   17   29                                                  
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   10   16   32                                             
CONECT   32   31                                                            
CONECT   33    7    2                                                       
MASTER        0    0    0    0    0    0    0    0   33    0   74    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₉H₄₆O₄

Average Mass

458.6830 Da

Monoisotopic Mass

458.33961 Da

IUPAC Name

4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,4a,4b,5,6,6a,7,8,9,10,10a,10b-dodecahydro-3H-spiro[chrysene-2,1'-cyclopentane]-8,9-diol

Traditional Name

4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3H-spiro[chrysene-2,1'-cyclopentane]-8,9-diol

CAS Registry Number

Not Available

SMILES

CC1(CO)CCC2(C1)CCC1(C)C(C=CC3C4(C)CC(O)C(O)C(C)(CO)C4CCC13C)=C2

InChI Identifier

InChI=1S/C29H46O4/c1-24(17-30)10-12-29(16-24)13-11-27(4)19(14-29)6-7-22-25(2)15-20(32)23(33)26(3,18-31)21(25)8-9-28(22,27)5/h6-7,14,20-23,30-33H,8-13,15-18H2,1-5H3

InChI Key

WALCWEJDMSYABA-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Phlomoides hamosa	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 12-hydroxysteroids. These are steroids carrying a hydroxyl group at the 12-position of the steroid backbone.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Hydroxysteroids

Direct Parent

12-hydroxysteroids

Alternative Parents

Substituents

12-hydroxysteroid
Cyclic alcohol
Secondary alcohol
Organic oxygen compound
Hydrocarbon derivative
Primary alcohol
Organooxygen compound
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.87	ALOGPS
logP	3.12	ChemAxon
logS	-4.6	ALOGPS
pKa (Strongest Acidic)	13.55	ChemAxon
pKa (Strongest Basic)	-1.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	80.92 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	133.39 m³·mol⁻¹	ChemAxon
Polarizability	54.54 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol (NP0313818)

MOL for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)

3D MOL for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)

3D SDF for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)

3D-SDF for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)

PDB for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)

3D PDB for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)

SMILES for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)

INCHI for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)

Structure for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)

3D Structure for NP0313818 (4',7-bis(hydroxymethyl)-4',4a,4b,7,10a-pentamethyl-4,5,6,6a,8,9,10,10b-octahydro-3h-spiro[chrysene-2,1'-cyclopentane]-8,9-diol)