NP-MRD: Showing NP-Card for (1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate (NP0313028)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-11 10:17:56 UTC

Updated at

2022-09-11 10:17:56 UTC

NP-MRD ID

NP0313028

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate

Description

1-Homoacevaltrate belongs to the class of organic compounds known as tetracarboxylic acids and derivatives. These are carboxylic acids containing exactly four carboxyl groups. (1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate is found in Valeriana jatamansi. (1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate was first documented in 2002 (PMID: 12502349). Based on a literature review very few articles have been published on 1-Homoacevaltrate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309112212172D          

 35 37  0  0  1  0            999 V2000
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8999   -3.8520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5644   -4.6057    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.9769   -5.3202    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8019   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2144   -4.6057    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2144   -6.0346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0394   -6.0346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0394   -6.8596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0394   -5.2096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8644   -6.0346    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2769   -6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1019   -6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8644   -7.4636    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7439   -4.5195    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5724   -5.3264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9593   -4.7744    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  9  8  1  6  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 12 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
 20 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 34  1  1  0  0  0
 32 35  1  0  0  0  0
 35 18  1  1  0  0  0
  9 35  1  0  0  0  0
M  END

     RDKit          3D

 69 71  0  0  0  0  0  0  0  0999 V2000
    5.7819   -4.4129    1.3790 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1327   -3.0825    0.7971 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9530   -2.4260    0.0909 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.4217   -3.2388   -1.0394 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3976   -1.0437   -0.3423 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3364   -0.2966   -1.0455 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1298   -0.5004   -2.2371 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5847    0.6141   -0.3921 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5579    1.4037   -0.8773 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0143    2.7369   -0.8404 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2271    3.8553   -0.6705 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9329    3.7044   -0.6015 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0057    4.8724   -0.4167 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7383    6.0603   -0.3403 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0603    7.2565   -0.1683 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7735    8.5655   -0.0769 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1943    7.2329   -0.0870 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3591    2.3592   -0.7017 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8335    1.9777   -1.1251 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9592    0.5166   -1.0406 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.7557    0.1027    0.0554 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9104   -0.6260   -0.1216 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2242   -0.9079   -1.3190 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6970   -1.0276    1.0538 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9340   -1.8165    0.6079 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5240   -3.0471   -0.1436 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7545   -0.9294   -0.2901 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6490   -2.1535    1.7824 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8323   -2.8719    1.7817 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5454   -3.2003    3.0487 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2841   -3.2390    0.6568 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4538    0.0641   -0.8489 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.6962   -1.3151   -0.5516 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0575   -0.7750   -1.7671 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2110    1.2242   -0.2718 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.7505   -4.3297    2.5028 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4996   -5.1925    1.0599 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7564   -4.6939    1.0715 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9058   -3.2478   -0.0016 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.5252   -2.3590    1.5415 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1518   -2.2869    0.8415 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3671   -3.5107   -0.8691 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0129   -4.1968   -1.0606 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5895   -2.7811   -2.0476 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2423   -1.1582   -1.0631 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7186   -0.4392    0.5289 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4425    1.1526   -1.9749 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6377    4.8602   -0.5913 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5400    4.7285    0.5394 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7408    4.8989   -1.2599 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0386    8.6975    0.9854 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6869    8.4578   -0.7178 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0817    9.3283   -0.4722 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5997    2.6941   -1.4829 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3937    0.1731   -2.0084 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0439   -0.1694    1.6621 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0843   -1.7336    1.6644 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8363   -3.0073   -1.1985 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0151   -3.9446    0.3148 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4211   -3.2508   -0.0812 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5392   -1.2087   -1.3362 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4592    0.1439   -0.1192 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8545   -1.0620   -0.1372 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8885   -2.9356    3.9001 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4668   -2.5818    3.1470 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7429   -4.2727    3.0881 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1501   -2.0459   -0.6252 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4534   -1.6174    0.1834 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1992    1.2543    0.8409 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  5  6  1  0
  6  7  2  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 15 17  2  0
 12 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  2  0
 22 24  1  0
 24 25  1  0
 25 26  1  0
 25 27  1  0
 25 28  1  0
 28 29  1  0
 29 30  1  0
 29 31  2  0
 20 32  1  0
 32 33  1  0
 33 34  1  0
 32 35  1  0
 35  9  1  0
 35 18  1  0
 32 34  1  6
  1 36  1  0
  1 37  1  0
  1 38  1  0
  2 39  1  0
  2 40  1  0
  3 41  1  1
  4 42  1  0
  4 43  1  0
  4 44  1  0
  5 45  1  0
  5 46  1  0
  9 47  1  6
 11 48  1  0
 13 49  1  0
 13 50  1  0
 16 51  1  0
 16 52  1  0
 16 53  1  0
 19 54  1  0
 20 55  1  6
 24 56  1  0
 24 57  1  0
 26 58  1  0
 26 59  1  0
 26 60  1  0
 27 61  1  0
 27 62  1  0
 27 63  1  0
 30 64  1  0
 30 65  1  0
 30 66  1  0
 33 67  1  0
 33 68  1  0
 35 69  1  1
M  END


  Mrv1652309112212172D          

 35 37  0  0  1  0            999 V2000
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8999   -3.8520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5644   -4.6057    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.9769   -5.3202    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8019   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2144   -4.6057    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2144   -6.0346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0394   -6.0346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0394   -6.8596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0394   -5.2096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8644   -6.0346    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2769   -6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1019   -6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8644   -7.4636    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7439   -4.5195    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5724   -5.3264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9593   -4.7744    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  9  8  1  6  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 12 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
 20 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 34  1  1  0  0  0
 32 35  1  0  0  0  0
 35 18  1  1  0  0  0
  9 35  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0313028

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCC(C)CC(=O)O[C@@H]1OC=C(COC(C)=O)C2=C[C@H](OC(=O)CC(C)(C)OC(C)=O)[C@]3(CO3)[C@@H]12

> <INCHI_IDENTIFIER>
InChI=1S/C25H34O10/c1-7-14(2)8-20(28)34-23-22-18(17(12-31-23)11-30-15(3)26)9-19(25(22)13-32-25)33-21(29)10-24(5,6)35-16(4)27/h9,12,14,19,22-23H,7-8,10-11,13H2,1-6H3/t14?,19-,22+,23-,25+/m0/s1

> <INCHI_KEY>
QJEWSMDVLSEWAR-OPTATRBJSA-N

> <FORMULA>
C25H34O10

> <MOLECULAR_WEIGHT>
494.537

> <EXACT_MASS>
494.215197295

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
69

> <JCHEM_AVERAGE_POLARIZABILITY>
51.05602617563325

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,6S,7R,7aS)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1-yl 3-methylpentanoate

> <JCHEM_LOGP>
1.807010304666666

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
18.236658132411318

> <JCHEM_PKA_STRONGEST_BASIC>
-4.145194305540146

> <JCHEM_POLAR_SURFACE_AREA>
126.96000000000001

> <JCHEM_REFRACTIVITY>
120.68849999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
14

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1S,6S,7R,7aS)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1-yl 3-methylpentanoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 11-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   11-SEP-22         0                                  
HETATM    1  C   UNK     0      -2.667  -6.160   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.334  -6.930   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.000  -6.160   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.000  -4.620   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.334  -6.930   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.667  -6.160   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       2.667  -4.620   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0       4.001  -6.930   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       5.335  -6.160   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       5.335  -4.620   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       6.668  -3.850   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.002  -4.620   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       9.336  -3.850   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0      10.669  -4.620   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0      12.003  -3.850   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      12.003  -2.310   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      13.337  -4.620   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       8.002  -6.160   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       9.147  -7.190   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       8.520  -8.597   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       9.290  -9.931   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      10.830  -9.931   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      11.600  -8.597   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      11.600 -11.265   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      13.140 -11.265   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      13.140 -12.805   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      13.140  -9.725   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0      14.680 -11.265   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0      15.450 -12.598   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      16.990 -12.598   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      14.680 -13.932   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0       6.989  -8.436   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       6.668  -9.943   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0       5.524  -8.912   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0       6.668  -6.930   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10   35                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13   18                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15                                                            
CONECT   18   12   19   35                                                  
CONECT   19   18   20                                                       
CONECT   20   19   21   32                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25                                                       
CONECT   25   24   26   27   28                                             
CONECT   26   25                                                            
CONECT   27   25                                                            
CONECT   28   25   29                                                       
CONECT   29   28   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29                                                            
CONECT   32   20   33   34   35                                             
CONECT   33   32   34                                                       
CONECT   34   33   32                                                       
CONECT   35   32   18    9                                                  
MASTER        0    0    0    0    0    0    0    0   35    0   74    0
END

View in JSmol

Synonyms

Value	Source
1-Homoacevaltric acid	Generator

Chemical Formula

C₂₅H₃₄O₁₀

Average Mass

494.5370 Da

Monoisotopic Mass

494.21520 Da

IUPAC Name

(1S,6S,7R,7aS)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1-yl 3-methylpentanoate

Traditional Name

(1S,6S,7R,7aS)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1-yl 3-methylpentanoate

CAS Registry Number

Not Available

SMILES

CCC(C)CC(=O)O[C@@H]1OC=C(COC(C)=O)C2=C[C@H](OC(=O)CC(C)(C)OC(C)=O)[C@]3(CO3)[C@@H]12

InChI Identifier

InChI=1S/C25H34O10/c1-7-14(2)8-20(28)34-23-22-18(17(12-31-23)11-30-15(3)26)9-19(25(22)13-32-25)33-21(29)10-24(5,6)35-16(4)27/h9,12,14,19,22-23H,7-8,10-11,13H2,1-6H3/t14?,19-,22+,23-,25+/m0/s1

InChI Key

QJEWSMDVLSEWAR-OPTATRBJSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Valeriana jatamansi	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tetracarboxylic acids and derivatives. These are carboxylic acids containing exactly four carboxyl groups.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Tetracarboxylic acids and derivatives

Direct Parent

Tetracarboxylic acids and derivatives

Alternative Parents

Substituents

Tetracarboxylic acid or derivatives
Iridoid-skeleton
Bicyclic monoterpenoid
Monoterpenoid
Fatty acid ester
Fatty acyl
Carboxylic acid ester
Oxacycle
Ether
Oxirane
Dialkyl ether
Acetal
Organoheterocyclic compound
Organooxygen compound
Hydrocarbon derivative
Organic oxide
Carbonyl group
Organic oxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.81	ChemAxon
pKa (Strongest Acidic)	18.24	ChemAxon
pKa (Strongest Basic)	-4.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	126.96 Å²	ChemAxon
Rotatable Bond Count	14	ChemAxon
Refractivity	120.69 m³·mol⁻¹	ChemAxon
Polarizability	51.06 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00045526

Chemspider ID

9937440

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

11762744

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Tang Y, Liu X, Yu B: Iridoids from the rhizomes and roots of Valeriana jatamansi. J Nat Prod. 2002 Dec;65(12):1949-52. doi: 10.1021/np0203335. [PubMed:12502349 ]
LOTUS database [Link]

Showing NP-Card for (1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate (NP0313028)

MOL for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)

3D MOL for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)

3D SDF for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)

3D-SDF for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)

PDB for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)

3D PDB for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)

SMILES for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)

INCHI for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)

Structure for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)

3D Structure for NP0313028 ((1s,6s,7r,7as)-6-{[3-(acetyloxy)-3-methylbutanoyl]oxy}-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxiran]-1-yl 3-methylpentanoate)