NP-MRD: Showing NP-Card for methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate (NP0309290)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-11 03:47:57 UTC

Updated at

2022-09-11 03:47:58 UTC

NP-MRD ID

NP0309290

Secondary Accession Numbers

None

Natural Product Identification

Common Name

methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate

Description

Methyl 6-hydroxy-7-{1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate belongs to the class of organic compounds known as iridoid o-glycosides. These are iridoid monoterpenes containing a glycosyl (usually a pyranosyl) moiety linked to the iridoid skeleton. methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate is found in Psychotria brachyceras. Methyl 6-hydroxy-7-{1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate is a very strong basic compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004251506542D          

 39 44  0  0  0  0            999 V2000
    4.4479   -4.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4479   -3.8867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1624   -3.4742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769   -3.8867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1624   -2.6492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769   -2.2367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769   -1.4117    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1624   -0.9992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1624   -0.1742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769    0.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769    1.0633    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5913    1.4758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5913    2.3008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3058    2.7133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3058    1.0633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0203    1.4758    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3058    0.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0203   -0.1742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5913   -0.1742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5913   -0.9992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4479   -1.4117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4479   -2.2367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -2.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1784   -1.8242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3534   -1.8242    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
  8 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 21 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 27 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  2  0  0  0  0
 37 38  1  0  0  0  0
 38 39  2  0  0  0  0
 31 39  1  0  0  0  0
 34 39  1  0  0  0  0
M  END

     RDKit          3D

 73 78  0  0  0  0  0  0  0  0999 V2000
   -1.3745    7.0357   -2.9433 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5036    5.9836   -2.0375 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9278    4.7329   -2.1742 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2329    4.5208   -3.1914 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1020    3.6854   -1.1964 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8387    3.8682   -0.0907 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0190    2.8750    0.8615 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3492    1.6062    0.7567 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1878    0.8214   -0.0462 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6209   -0.3269    0.6092 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.2137   -1.4109   -0.1680 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5753   -2.5755    0.4663 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.9373   -3.8011   -0.1493 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3249   -4.9616    0.5168 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0893   -2.7317    0.2726 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.3312   -2.5640   -1.1003 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7292   -1.6171    1.0645 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.6398   -1.9335    2.4132 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1312   -0.2644    0.7458 C   0  0  2  0  0  0  0  0  0  0  0  0
   -4.7358    0.1959   -0.4122 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0673    1.9057    0.0388 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4771    2.3662   -1.3690 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8462    2.3846   -2.0564 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6425    1.2450   -1.4055 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9503    0.2637   -2.3342 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7816    0.7351   -0.2694 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6064    0.2857    0.9236 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.5036    1.3200    1.4008 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9694    0.8628    2.7200 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9988   -0.2216    2.4699 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5434   -1.1461    1.3881 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4070   -0.9206    0.6419 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2884   -1.9232   -0.2261 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2995   -2.8040   -0.0861 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6097   -3.9811   -0.7415 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7423   -4.6496   -0.3396 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5634   -4.1957    0.6744 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2051   -3.0187    1.2908 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0907   -2.3186    0.9282 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7237    7.8131   -2.4614 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8870    6.7698   -3.8857 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3767    7.4476   -3.1979 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2987    4.8451    0.0329 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2274    1.1256    1.7296 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2082   -0.3685    1.6193 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3049   -2.4953    1.5283 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0959   -3.8343   -1.2309 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8233   -3.7206    0.0122 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1393   -5.3598    0.1120 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4590   -3.6835    0.6604 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0987   -1.9549   -1.2591 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8207   -1.5366    0.8216 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8402   -1.5719    2.8514 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3554    0.3815    1.6277 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0574    1.1292   -0.2210 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4988    2.6847    0.5483 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1787    1.6150   -1.7854 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3361    3.3531   -1.8301 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7677    2.1754   -3.1284 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5835    1.6613   -1.0153 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2035    0.7057   -3.1795 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2100   -0.1254   -0.6381 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8918    0.0711    1.7605 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3918    1.3218    0.8152 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4376    1.6961    3.2758 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0787    0.4905    3.2615 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1056   -0.8121    3.4041 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9623    0.2650    2.2301 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5390   -2.0689   -0.9440 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9928   -4.3733   -1.5428 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9847   -5.5836   -0.8627 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4411   -4.7394    0.9659 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8303   -2.6515    2.0796 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 12 15  1  0
 15 16  1  0
 15 17  1  0
 17 18  1  0
 17 19  1  0
 19 20  1  0
  8 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 24 26  1  0
 26 27  1  0
 27 28  1  0
 28 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  2  0
 32 33  1  0
 33 34  1  0
 34 35  2  0
 35 36  1  0
 36 37  2  0
 37 38  1  0
 38 39  2  0
 22  5  1  0
 32 27  1  0
 39 34  1  0
 19 10  1  0
 26 21  1  0
 39 31  1  0
  1 40  1  0
  1 41  1  0
  1 42  1  0
  6 43  1  0
  8 44  1  1
 10 45  1  1
 12 46  1  1
 13 47  1  0
 13 48  1  0
 14 49  1  0
 15 50  1  1
 16 51  1  0
 17 52  1  6
 18 53  1  0
 19 54  1  1
 20 55  1  0
 21 56  1  1
 22 57  1  6
 23 58  1  0
 23 59  1  0
 24 60  1  1
 25 61  1  0
 26 62  1  6
 27 63  1  1
 28 64  1  0
 29 65  1  0
 29 66  1  0
 30 67  1  0
 30 68  1  0
 33 69  1  0
 35 70  1  0
 36 71  1  0
 37 72  1  0
 38 73  1  0
M  END


  Mrv1533004251506542D          

 39 44  0  0  0  0            999 V2000
    4.4479   -4.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4479   -3.8867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1624   -3.4742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769   -3.8867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1624   -2.6492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769   -2.2367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769   -1.4117    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1624   -0.9992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1624   -0.1742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769    0.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769    1.0633    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5913    1.4758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5913    2.3008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3058    2.7133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3058    1.0633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0203    1.4758    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3058    0.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0203   -0.1742    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5913   -0.1742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5913   -0.9992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4479   -1.4117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4479   -2.2367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -2.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1784   -1.8242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3534   -1.8242    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
  8 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 21 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 27 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  2  0  0  0  0
 37 38  1  0  0  0  0
 38 39  2  0  0  0  0
 31 39  1  0  0  0  0
 34 39  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0309290

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C2C1CC(O)C2C1NCCC2=C1NC1=CC=CC=C21

> <INCHI_IDENTIFIER>
InChI=1S/C27H34N2O10/c1-36-25(35)14-10-37-26(39-27-24(34)23(33)22(32)17(9-30)38-27)18-13(14)8-16(31)19(18)21-20-12(6-7-28-21)11-4-2-3-5-15(11)29-20/h2-5,10,13,16-19,21-24,26-34H,6-9H2,1H3

> <INCHI_KEY>
OCAHJZIVWQCZJJ-UHFFFAOYSA-N

> <FORMULA>
C27H34N2O10

> <MOLECULAR_WEIGHT>
546.573

> <EXACT_MASS>
546.221345303

> <JCHEM_ACCEPTOR_COUNT>
10

> <JCHEM_ATOM_COUNT>
73

> <JCHEM_AVERAGE_POLARIZABILITY>
56.71070061925926

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
7

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
methyl 6-hydroxy-7-{1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate

> <ALOGPS_LOGP>
-0.15

> <JCHEM_LOGP>
-1.0636769466666662

> <ALOGPS_LOGS>
-2.28

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
13.189842615813944

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.206124384241598

> <JCHEM_PKA_STRONGEST_BASIC>
8.671703081990332

> <JCHEM_POLAR_SURFACE_AREA>
182.96

> <JCHEM_REFRACTIVITY>
134.2928

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.86e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methyl 6-hydroxy-7-{1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 25-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   25-APR-15         0                                  
HETATM    1  C   UNK     0       8.303  -8.795   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       8.303  -7.255   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       9.636  -6.485   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      10.970  -7.255   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       9.636  -4.945   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.970  -4.175   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      10.970  -2.635   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       9.636  -1.865   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0       9.636  -0.325   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0      10.970   0.445   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0      10.970   1.985   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0      12.304   2.755   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      12.304   4.295   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0      13.637   5.065   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0      13.637   1.985   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      14.971   2.755   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0      13.637   0.445   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0      14.971  -0.325   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0      12.304  -0.325   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      12.304  -1.865   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       8.303  -2.635   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       8.303  -4.175   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       6.838  -4.651   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       5.933  -3.405   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       4.393  -3.405   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       6.838  -2.159   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       6.362  -0.695   0.000  0.00  0.00           C+0
HETATM   28  N   UNK     0       7.393   0.450   0.000  0.00  0.00           N+0
HETATM   29  C   UNK     0       6.917   1.914   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       5.410   2.235   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       4.380   1.090   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       4.856  -0.374   0.000  0.00  0.00           C+0
HETATM   33  N   UNK     0       3.610  -1.280   0.000  0.00  0.00           N+0
HETATM   34  C   UNK     0       2.364  -0.374   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       0.858  -0.695   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      -0.173   0.450   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0       0.303   1.914   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0       1.810   2.235   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0       2.840   1.090   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6   22                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   21                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   19                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13   15                                                  
CONECT   13   12   14                                                       
CONECT   14   13                                                            
CONECT   15   12   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   10   20                                                  
CONECT   20   19                                                            
CONECT   21    8   22   26                                                  
CONECT   22   21    5   23                                                  
CONECT   23   22   24                                                       
CONECT   24   23   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   21   27                                                  
CONECT   27   26   28   32                                                  
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   32   39                                                  
CONECT   32   31   27   33                                                  
CONECT   33   32   34                                                       
CONECT   34   33   35   39                                                  
CONECT   35   34   36                                                       
CONECT   36   35   37                                                       
CONECT   37   36   38                                                       
CONECT   38   37   39                                                       
CONECT   39   38   31   34                                                  
MASTER        0    0    0    0    0    0    0    0   39    0   88    0
END

View in JSmol

Synonyms

Value	Source
Methyl 6-hydroxy-7-{1h,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4ah,5H,6H,7H,7ah-cyclopenta[c]pyran-4-carboxylic acid	Generator

Chemical Formula

C₂₇H₃₄N₂O₁₀

Average Mass

546.5730 Da

Monoisotopic Mass

546.22135 Da

IUPAC Name

methyl 6-hydroxy-7-{1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate

Traditional Name

methyl 6-hydroxy-7-{1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate

CAS Registry Number

Not Available

SMILES

COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C2C1CC(O)C2C1NCCC2=C1NC1=CC=CC=C21

InChI Identifier

InChI=1S/C27H34N2O10/c1-36-25(35)14-10-37-26(39-27-24(34)23(33)22(32)17(9-30)38-27)18-13(14)8-16(31)19(18)21-20-12(6-7-28-21)11-4-2-3-5-15(11)29-20/h2-5,10,13,16-19,21-24,26-34H,6-9H2,1H3

InChI Key

OCAHJZIVWQCZJJ-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Psychotria brachyceras	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as iridoid o-glycosides. These are iridoid monoterpenes containing a glycosyl (usually a pyranosyl) moiety linked to the iridoid skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene glycosides

Direct Parent

Iridoid O-glycosides

Alternative Parents

Substituents

Iridoid o-glycoside
Harman
Beta-carboline
Pyridoindole
Hexose monosaccharide
Glycosyl compound
Iridoid-skeleton
O-glycosyl compound
Aromatic monoterpenoid
Monoterpenoid
3-alkylindole
Indole
Indole or derivatives
Alkaloid or derivatives
Aralkylamine
Monosaccharide
Oxane
Benzenoid
Cyclic alcohol
Pyrrole
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Methyl ester
Heteroaromatic compound
Vinylogous ester
Secondary alcohol
Carboxylic acid ester
Amino acid or derivatives
Organoheterocyclic compound
Acetal
Monocarboxylic acid or derivatives
Azacycle
Oxacycle
Carboxylic acid derivative
Polyol
Secondary amine
Secondary aliphatic amine
Amine
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organonitrogen compound
Carbonyl group
Organic oxygen compound
Organic nitrogen compound
Organooxygen compound
Alcohol
Primary alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.15	ALOGPS
logP	-1.1	ChemAxon
logS	-2.3	ALOGPS
pKa (Strongest Acidic)	12.21	ChemAxon
pKa (Strongest Basic)	8.67	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	182.96 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	134.29 m³·mol⁻¹	ChemAxon
Polarizability	56.71 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

73809386

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate (NP0309290)

MOL for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)

3D MOL for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)

3D SDF for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)

3D-SDF for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)

PDB for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)

3D PDB for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)

SMILES for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)

INCHI for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)

Structure for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)

3D Structure for NP0309290 (methyl 6-hydroxy-7-{1h,2h,3h,4h,9h-pyrido[3,4-b]indol-1-yl}-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,6h,7h,7ah-cyclopenta[c]pyran-4-carboxylate)