NP-MRD: Showing NP-Card for (1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate (NP0308182)

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Record Information

Version

2.0

Created at

2022-09-11 01:48:15 UTC

Updated at

2022-09-11 01:48:15 UTC

NP-MRD ID

NP0308182

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate

Description

(1R,3aR,4S,6aS)-4-[(4,6-dimethoxy-2H-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-3a-yl acetate belongs to the class of organic compounds known as benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole. Dioxole is a five-membered unsaturated ring of two oxygen atoms and three carbon atoms. (1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate is found in Phryma leptostachya. Based on a literature review very few articles have been published on (1R,3aR,4S,6aS)-4-[(4,6-dimethoxy-2H-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-3a-yl acetate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309112203482D          

 37 42  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309112203482D          

 37 42  0  0  1  0            999 V2000
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 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 19 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 25 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 24 31  1  0  0  0  0
 17 32  1  0  0  0  0
 32 33  1  0  0  0  0
 34 33  1  6  0  0  0
  9 34  1  0  0  0  0
 12 34  1  0  0  0  0
  6 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
  5 37  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0308182

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC2=C(OCO2)C=C1[C@@H]1OC[C@@]2(OC(C)=O)[C@H](OC3=C(OC)C=C4OCOC4=C3OC)OC[C@@H]12

> <INCHI_IDENTIFIER>
InChI=1S/C25H26O12/c1-12(26)37-25-9-31-20(13-5-16-17(33-10-32-16)6-15(13)27-2)14(25)8-30-24(25)36-22-18(28-3)7-19-21(23(22)29-4)35-11-34-19/h5-7,14,20,24H,8-11H2,1-4H3/t14-,20-,24-,25-/m0/s1

> <INCHI_KEY>
NWADMKCKAVWMLW-DPVNQZASSA-N

> <FORMULA>
C25H26O12

> <MOLECULAR_WEIGHT>
518.471

> <EXACT_MASS>
518.142426277

> <JCHEM_ACCEPTOR_COUNT>
11

> <JCHEM_ATOM_COUNT>
63

> <JCHEM_AVERAGE_POLARIZABILITY>
50.272588099239115

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1R,3aR,4S,6aS)-4-[(4,6-dimethoxy-2H-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-3a-yl acetate

> <JCHEM_LOGP>
2.0504900696666666

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-3.7645056291561203

> <JCHEM_POLAR_SURFACE_AREA>
118.60000000000004

> <JCHEM_REFRACTIVITY>
120.17500000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(1R,3aR,4S,6aS)-4-[(4,6-dimethoxy-2H-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2H-1,3-benzodioxol-5-yl)-tetrahydro-1H-furo[3,4-c]furan-3a-yl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 11-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   11-SEP-22         0                                  
HETATM    1  C   UNK     0      -3.635  -5.387   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0      -4.111  -3.922   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0      -3.081  -2.778   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -3.557  -1.313   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.526  -0.169   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.020  -0.489   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -0.544  -1.953   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.574  -3.098   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -1.099  -4.562   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      -2.004  -5.808   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0      -1.099  -7.054   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.366  -6.578   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       0.366  -8.118   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0      -0.968  -8.888   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -2.301  -8.118   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      -0.968 -10.428   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       1.831  -7.054   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       2.307  -8.519   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       3.813  -8.839   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       4.843  -7.695   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       4.367  -6.230   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       5.398  -5.085   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       6.350  -8.015   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       6.826  -9.479   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       5.795 -10.624   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       4.289 -10.304   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       3.258 -11.448   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       1.752 -11.128   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       6.565 -11.957   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       8.071 -11.637   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       8.232 -10.106   0.000  0.00  0.00           O+0
HETATM   32  O   UNK     0       2.736  -5.808   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0       1.831  -4.562   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       0.366  -5.038   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0      -0.250   0.845   0.000  0.00  0.00           O+0
HETATM   36  C   UNK     0      -1.280   1.989   0.000  0.00  0.00           C+0
HETATM   37  O   UNK     0      -2.687   1.363   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    8                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6   37                                                  
CONECT    6    5    7   35                                                  
CONECT    7    6    8                                                       
CONECT    8    7    3    9                                                  
CONECT    9    8   10   34                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13   17   34                                             
CONECT   13   12   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14                                                            
CONECT   17   12   18   32                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20   26                                                  
CONECT   20   19   21   23                                                  
CONECT   21   20   22                                                       
CONECT   22   21                                                            
CONECT   23   20   24                                                       
CONECT   24   23   25   31                                                  
CONECT   25   24   26   29                                                  
CONECT   26   25   19   27                                                  
CONECT   27   26   28                                                       
CONECT   28   27                                                            
CONECT   29   25   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   24                                                       
CONECT   32   17   33                                                       
CONECT   33   32   34                                                       
CONECT   34   33    9   12                                                  
CONECT   35    6   36                                                       
CONECT   36   35   37                                                       
CONECT   37   36    5                                                       
MASTER        0    0    0    0    0    0    0    0   37    0   84    0
END

View in JSmol

Synonyms

Value	Source
(1R,3AR,4S,6as)-4-[(4,6-dimethoxy-2H-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-3a-yl acetic acid	Generator

Chemical Formula

C₂₅H₂₆O₁₂

Average Mass

518.4710 Da

Monoisotopic Mass

518.14243 Da

IUPAC Name

(1R,3aR,4S,6aS)-4-[(4,6-dimethoxy-2H-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-3a-yl acetate

Traditional Name

(1R,3aR,4S,6aS)-4-[(4,6-dimethoxy-2H-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2H-1,3-benzodioxol-5-yl)-tetrahydro-1H-furo[3,4-c]furan-3a-yl acetate

CAS Registry Number

Not Available

SMILES

COC1=CC2=C(OCO2)C=C1[C@@H]1OC[C@@]2(OC(C)=O)[C@H](OC3=C(OC)C=C4OCOC4=C3OC)OC[C@@H]12

InChI Identifier

InChI=1S/C25H26O12/c1-12(26)37-25-9-31-20(13-5-16-17(33-10-32-16)6-15(13)27-2)14(25)8-30-24(25)36-22-18(28-3)7-19-21(23(22)29-4)35-11-34-19/h5-7,14,20,24H,8-11H2,1-4H3/t14-,20-,24-,25-/m0/s1

InChI Key

NWADMKCKAVWMLW-DPVNQZASSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Phryma leptostachya	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole. Dioxole is a five-membered unsaturated ring of two oxygen atoms and three carbon atoms.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzodioxoles

Sub Class

Not Available

Direct Parent

Benzodioxoles

Alternative Parents

Substituents

Benzodioxole
Anisole
Furofuran
Alkyl aryl ether
Benzenoid
Tetrahydrofuran
Carboxylic acid ester
Monocarboxylic acid or derivatives
Oxacycle
Ether
Dialkyl ether
Carboxylic acid derivative
Acetal
Organooxygen compound
Carbonyl group
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.05	ChemAxon
pKa (Strongest Basic)	-3.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	118.6 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	120.18 m³·mol⁻¹	ChemAxon
Polarizability	50.27 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

162987075

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate (NP0308182)

MOL for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)

3D MOL for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)

3D SDF for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)

3D-SDF for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)

PDB for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)

3D PDB for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)

SMILES for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)

INCHI for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)

Structure for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)

3D Structure for NP0308182 ((1r,3ar,4s,6as)-4-[(4,6-dimethoxy-2h-1,3-benzodioxol-5-yl)oxy]-1-(6-methoxy-2h-1,3-benzodioxol-5-yl)-tetrahydro-1h-furo[3,4-c]furan-3a-yl acetate)