NP-MRD: Showing NP-Card for 4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one (NP0307239)

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Record Information

Version

2.0

Created at

2022-09-11 00:14:00 UTC

Updated at

2022-09-11 00:14:00 UTC

NP-MRD ID

NP0307239

Secondary Accession Numbers

None

Natural Product Identification

Common Name

4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one

Description

4-{5-[2-(1,2,4A-trimethyl-5-methylidene-decahydronaphthalen-1-yl)ethyl]-3,6-dihydro-2H-pyran-2-yl}-5-hydroxy-2,5-dihydrofuran-2-one belongs to the class of organic compounds known as diterpene lactones. These are diterpenoids containing a lactone moiety. 4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one is found in Fasciospongia cavernosa. 4-{5-[2-(1,2,4A-trimethyl-5-methylidene-decahydronaphthalen-1-yl)ethyl]-3,6-dihydro-2H-pyran-2-yl}-5-hydroxy-2,5-dihydrofuran-2-one is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL SDF PDB SMILES InChI


  Mrv1533004161507572D          

 29 32  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3873    0.7284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3873    0.7284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2118    0.7572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5991    1.4857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4236    1.5144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8109    2.2429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3738    2.9425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5493    2.9137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1619    2.1853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7611    3.6710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5780    3.7858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7213    4.5982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4628    4.9599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9929    4.9855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3994    4.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5869    4.5557    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  2  0  0  0  0
  7 13  1  0  0  0  0
  2 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END


  Mrv1533004161507572D          

 29 32  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3873    0.7284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3873    0.7284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2118    0.7572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5991    1.4857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4236    1.5144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8109    2.2429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3738    2.9425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5493    2.9137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1619    2.1853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7611    3.6710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5780    3.7858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7213    4.5982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4628    4.9599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9929    4.9855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3994    4.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5869    4.5557    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  2  0  0  0  0
  7 13  1  0  0  0  0
  2 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0307239

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1CCC2(C)C(CCCC2=C)C1(C)CCC1=CCC(OC1)C1=CC(=O)OC1O

> <INCHI_IDENTIFIER>
InChI=1S/C25H36O4/c1-16-6-5-7-21-24(16,3)12-10-17(2)25(21,4)13-11-18-8-9-20(28-15-18)19-14-22(26)29-23(19)27/h8,14,17,20-21,23,27H,1,5-7,9-13,15H2,2-4H3

> <INCHI_KEY>
CVAZWHZRZNYCOV-UHFFFAOYSA-N

> <FORMULA>
C25H36O4

> <MOLECULAR_WEIGHT>
400.559

> <EXACT_MASS>
400.261359639

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
65

> <JCHEM_AVERAGE_POLARIZABILITY>
46.52551414455812

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
4-{5-[2-(1,2,4a-trimethyl-5-methylidene-decahydronaphthalen-1-yl)ethyl]-3,6-dihydro-2H-pyran-2-yl}-5-hydroxy-2,5-dihydrofuran-2-one

> <ALOGPS_LOGP>
4.22

> <JCHEM_LOGP>
5.0422299676666675

> <ALOGPS_LOGS>
-5.07

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
11.731975996757972

> <JCHEM_PKA_STRONGEST_ACIDIC>
5.488879736325379

> <JCHEM_PKA_STRONGEST_BASIC>
-4.205785291637656

> <JCHEM_POLAR_SURFACE_AREA>
55.760000000000005

> <JCHEM_REFRACTIVITY>
114.81629999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
3.39e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2H-naphthalen-1-yl)ethyl]-3,6-dihydro-2H-pyran-2-yl}-5-hydroxy-5H-furan-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 16-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   16-APR-15         0                                  
HETATM    1  C   UNK     0      -2.667   0.000   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.000  -3.080   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.334  -3.850   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       2.667  -0.000   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.667  -4.620   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       0.000  -0.000   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       0.723   1.360   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -0.723   1.360   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -2.262   1.413   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -2.985   2.773   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -4.524   2.827   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -5.247   4.187   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      -4.431   5.493   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -2.892   5.439   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -2.169   4.079   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -5.154   6.852   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      -6.679   7.067   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      -6.946   8.583   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0      -8.331   9.258   0.000  0.00  0.00           O+0
HETATM   27  O   UNK     0      -5.587   9.306   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0      -4.479   8.237   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0      -2.962   8.504   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   13                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    7   11                                             
CONECT    6    5                                                            
CONECT    7    5    8   13                                                  
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10    5   12                                                  
CONECT   12   11                                                            
CONECT   13    7    2   14   15                                             
CONECT   14   13                                                            
CONECT   15   13   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   22                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   23                                                  
CONECT   21   20   22                                                       
CONECT   22   21   17                                                       
CONECT   23   20   24   28                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25   28                                                       
CONECT   28   27   23   29                                                  
CONECT   29   28                                                            
MASTER        0    0    0    0    0    0    0    0   29    0   64    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₅H₃₆O₄

Average Mass

400.5590 Da

Monoisotopic Mass

400.26136 Da

IUPAC Name

4-{5-[2-(1,2,4a-trimethyl-5-methylidene-decahydronaphthalen-1-yl)ethyl]-3,6-dihydro-2H-pyran-2-yl}-5-hydroxy-2,5-dihydrofuran-2-one

Traditional Name

4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2H-naphthalen-1-yl)ethyl]-3,6-dihydro-2H-pyran-2-yl}-5-hydroxy-5H-furan-2-one

CAS Registry Number

Not Available

SMILES

CC1CCC2(C)C(CCCC2=C)C1(C)CCC1=CCC(OC1)C1=CC(=O)OC1O

InChI Identifier

InChI=1S/C25H36O4/c1-16-6-5-7-21-24(16,3)12-10-17(2)25(21,4)13-11-18-8-9-20(28-15-18)19-14-22(26)29-23(19)27/h8,14,17,20-21,23,27H,1,5-7,9-13,15H2,2-4H3

InChI Key

CVAZWHZRZNYCOV-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Fasciospongia cavernosa	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as diterpene lactones. These are diterpenoids containing a lactone moiety.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Diterpene lactones

Alternative Parents

Substituents

Diterpene lactone
Diterpenoid
Clerodane diterpenoid
2-furanone
Pyran
Dihydrofuran
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Carboxylic acid ester
Hemiacetal
Lactone
Ether
Oxacycle
Dialkyl ether
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Organoheterocyclic compound
Carbonyl group
Organic oxygen compound
Hydrocarbon derivative
Organic oxide
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.22	ALOGPS
logP	5.04	ChemAxon
logS	-5.1	ALOGPS
pKa (Strongest Acidic)	5.49	ChemAxon
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	55.76 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	114.82 m³·mol⁻¹	ChemAxon
Polarizability	46.53 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

72752738

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one (NP0307239)

MOL for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)

3D MOL for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)

3D SDF for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)

3D-SDF for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)

PDB for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)

3D PDB for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)

SMILES for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)

INCHI for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)

Structure for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)

3D Structure for NP0307239 (4-{5-[2-(1,2,4a-trimethyl-5-methylidene-hexahydro-2h-naphthalen-1-yl)ethyl]-3,6-dihydro-2h-pyran-2-yl}-5-hydroxy-5h-furan-2-one)