NP-MRD: Showing NP-Card for fuscin (NP0306294)

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Record Information

Version

2.0

Created at

2022-09-10 22:40:46 UTC

Updated at

2022-09-10 22:40:46 UTC

NP-MRD ID

NP0306294

Secondary Accession Numbers

None

Natural Product Identification

Common Name

fuscin

Description

Fuscin belongs to the class of organic compounds known as dihydropyranones. Dihydropyranones are compounds containing a hydrogenated pyran ring which bears a ketone, and contains one double bond. Fuscin is an extremely weak basic (essentially neutral) compound (based on its pKa). Lipofuscin accumulation is a major risk factor implicated in macular degeneration, a degenerative disease of the eye, as well as Stargardt disease, an inherited juvenile form of macular degeneration. Other possible treatments:CentrophenoxineAcetyl-L-carnitineGinkgo bilobaDimethylethanolamineWet macular degeneration can be treated using selective photothermolysis where a pulsed unfocused laser predominantly heats and kills lipofuscin-rich cells, leaving untouched healthy cells to multiply and fill in the gaps. Abnormal accumulation of lipofuscin known as lipofuscinosis is associated with a family of neurodegenerative disorders – neuronal ceroid lipofuscinoses, the most common of these is Batten disease. The accumulation of lipofuscin-like material may be the result of an imbalance between formation and disposal mechanisms: Such accumulation can be induced in rats by administering a protease inhibitor (leupeptin); after a period of three months, the levels of the lipofuscin-like material return to normal, indicating the action of a significant disposal mechanism. fuscin is found in Oidiodendron fuscum, Oidiodendron griseum and Oidiodendron rhodogenum. A tetrahydropyridoether can remove lipofuscin from retinal pigment epithelial cells.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 36 38  0  0  0  0  0  0  0  0999 V2000
    4.2743   -0.0268    0.9945 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6268    0.2464   -0.3692 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7641    1.5976   -0.6439 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7292    2.4518   -0.8591 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9617    3.6852   -1.0876 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3579    2.0043   -0.8374 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1129    0.7157   -0.5985 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2969    0.2825   -0.5827 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5694   -0.9827   -0.3318 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8891   -1.4728   -0.2957 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9414   -0.5118   -0.1780 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2089   -1.2093   -0.6354 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0839    0.0000    1.2240 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6329    0.5859   -1.1702 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3531    1.3024   -0.8615 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5412   -1.9222   -0.0782 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2454   -3.1266    0.1576 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9185   -1.4843   -0.0979 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9835   -2.3685    0.1412 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2079   -0.2098   -0.3481 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6049   -0.6546    1.6009 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2917   -0.4470    0.8640 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4260    0.9455    1.5396 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2236   -0.3373   -1.1102 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5225    2.6885   -1.0044 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2250   -2.2837   -0.3203 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1062   -0.7146   -0.1981 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2626   -1.2011   -1.7346 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0284    1.1019    1.3036 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1026   -0.2771    1.6187 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3154   -0.4333    1.8995 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4708    0.0618   -2.1576 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4928    1.2719   -1.2949 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4570    2.0245   -0.0260 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0972    1.8796   -1.7909 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7413   -3.1819    0.7083 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 11 13  1  0
 11 14  1  0
 14 15  1  0
  9 16  1  0
 16 17  2  0
 16 18  1  0
 18 19  1  0
 18 20  2  0
 20  2  1  0
 20  7  1  0
 15  8  1  0
  1 21  1  0
  1 22  1  0
  1 23  1  0
  2 24  1  6
  6 25  1  0
 12 26  1  0
 12 27  1  0
 12 28  1  0
 13 29  1  0
 13 30  1  0
 13 31  1  0
 14 32  1  0
 14 33  1  0
 15 34  1  0
 15 35  1  0
 19 36  1  0
M  END


  Mrv1533004171519002D          

 20 22  0  0  0  0            999 V2000
   -0.1105   -0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -3.4914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.3480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6465   -1.5322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6465   -2.5928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    0.0809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    0.0809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
  8 15  1  0  0  0  0
  9 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
  2 19  1  0  0  0  0
  7 19  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0306294

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1OC(=O)C=C2C3=C(OC(C)(C)CC3)C(=O)C(O)=C12

> <INCHI_IDENTIFIER>
InChI=1S/C15H16O5/c1-7-11-9(6-10(16)19-7)8-4-5-15(2,3)20-14(8)13(18)12(11)17/h6-7,17H,4-5H2,1-3H3

> <INCHI_KEY>
OSJKAGRXDVEZQO-UHFFFAOYSA-N

> <FORMULA>
C15H16O5

> <MOLECULAR_WEIGHT>
276.288

> <EXACT_MASS>
276.099773615

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
36

> <JCHEM_AVERAGE_POLARIZABILITY>
28.093103798316683

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
5-hydroxy-4,8,8-trimethyl-2H,4H,6H,8H,9H,10H-pyrano[3,2-f]isochromene-2,6-dione

> <ALOGPS_LOGP>
1.26

> <JCHEM_LOGP>
1.1133832763333338

> <ALOGPS_LOGS>
-2.67

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.245556601345651

> <JCHEM_PKA_STRONGEST_BASIC>
-4.121653542606386

> <JCHEM_POLAR_SURFACE_AREA>
72.83

> <JCHEM_REFRACTIVITY>
73.9534

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.85e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
fuscin

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 17-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   17-APR-15         0                                  
HETATM    1  C   UNK     0      -0.206  -1.183   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.564  -2.516   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0      -0.206  -3.850   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0       0.564  -5.184   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      -0.206  -6.517   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       2.104  -5.184   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.874  -3.850   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.414  -3.850   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.184  -2.516   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       6.724  -2.516   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       7.494  -3.850   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.673  -2.860   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.673  -4.840   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.724  -5.184   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       5.184  -5.184   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       4.414  -1.183   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       5.184   0.151   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       2.874  -1.183   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.104  -2.516   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       2.104   0.151   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   19                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7                                                       
CONECT    7    6    8   19                                                  
CONECT    8    7    9   15                                                  
CONECT    9    8   10   16                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12   13   14                                             
CONECT   12   11                                                            
CONECT   13   11                                                            
CONECT   14   11   15                                                       
CONECT   15   14    8                                                       
CONECT   16    9   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19   20                                                  
CONECT   19   18    2    7                                                  
CONECT   20   18                                                            
MASTER        0    0    0    0    0    0    0    0   20    0   44    0
END

View in JSmol

Synonyms

Value	Source
9,10-Dihydro-5-hydroxy-4,8,8-trimethyl-2-H,4-H-benzo(1,2-b-4,3-c)-dipyran-2,6(8H)-dione	MeSH

Chemical Formula

C₁₅H₁₆O₅

Average Mass

276.2880 Da

Monoisotopic Mass

276.09977 Da

IUPAC Name

5-hydroxy-4,8,8-trimethyl-2H,4H,6H,8H,9H,10H-pyrano[3,2-f]isochromene-2,6-dione

Traditional Name

fuscin

CAS Registry Number

Not Available

SMILES

CC1OC(=O)C=C2C3=C(OC(C)(C)CC3)C(=O)C(O)=C12

InChI Identifier

InChI=1S/C15H16O5/c1-7-11-9(6-10(16)19-7)8-4-5-15(2,3)20-14(8)13(18)12(11)17/h6-7,17H,4-5H2,1-3H3

InChI Key

OSJKAGRXDVEZQO-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Oidiodendron fuscum	LOTUS Database	35616633
Oidiodendron griseum	LOTUS Database	35616633
Oidiodendron rhodogenum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as dihydropyranones. Dihydropyranones are compounds containing a hydrogenated pyran ring which bears a ketone, and contains one double bond.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyrans

Sub Class

Pyranones and derivatives

Direct Parent

Dihydropyranones

Alternative Parents

Substituents

Dihydropyranone
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Carboxylic acid ester
Ketone
Lactone
Carboxylic acid derivative
Enol
Oxacycle
Monocarboxylic acid or derivatives
Carbonyl group
Organic oxide
Hydrocarbon derivative
Organic oxygen compound
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.26	ALOGPS
logP	1.11	ChemAxon
logS	-2.7	ALOGPS
pKa (Strongest Acidic)	8.25	ChemAxon
pKa (Strongest Basic)	-4.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	72.83 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	73.95 m³·mol⁻¹	ChemAxon
Polarizability	28.09 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Lipofuscin

METLIN ID

Not Available

PubChem Compound

54682467

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for fuscin (NP0306294)

MOL for NP0306294 (fuscin)

3D MOL for NP0306294 (fuscin)

3D SDF for NP0306294 (fuscin)

3D-SDF for NP0306294 (fuscin)

PDB for NP0306294 (fuscin)

3D PDB for NP0306294 (fuscin)

SMILES for NP0306294 (fuscin)

INCHI for NP0306294 (fuscin)

Structure for NP0306294 (fuscin)

3D Structure for NP0306294 (fuscin)