NP-MRD: Showing NP-Card for [16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol (NP0302904)

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Record Information

Version

2.0

Created at

2022-09-10 16:46:37 UTC

Updated at

2022-09-10 16:46:37 UTC

NP-MRD ID

NP0302904

Secondary Accession Numbers

None

Natural Product Identification

Common Name

[16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol

Description

[16-(Hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]Henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton. [16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol is found in Papaver nudicaule. Based on a literature review very few articles have been published on [16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]Henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309102218462D          

 31 35  0  0  0  0            999 V2000
    2.6153   -2.2287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4402   -2.2412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8635   -1.5331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6884   -1.5457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0900   -2.2663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9149   -2.2789    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1117   -0.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7101   -0.1169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8852   -0.1043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4837    0.6163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6587    0.6289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4619   -0.8125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6370   -0.7999    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2137   -1.5080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1335    0.5912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9584    0.5787    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3817    1.2868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2066    1.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6082    0.5536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4331    0.5410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8347   -0.1796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4113   -0.8877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5864   -0.8752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1631   -1.5833    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3382   -1.5708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1849   -0.1545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3600   -0.1420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9366   -0.8501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9540   -1.5092    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7127   -1.1851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6389   -0.3634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  2  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  2  0  0  0  0
 19 26  1  0  0  0  0
 26 27  1  0  0  0  0
 16 27  1  0  0  0  0
 27 28  1  0  0  0  0
  7 28  1  0  0  0  0
 22 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 21 31  1  0  0  0  0
M  END

     RDKit          3D

 58 62  0  0  0  0  0  0  0  0999 V2000
   -5.2635   -1.2856    2.1554 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2519   -0.5299    1.7645 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2724   -0.2831    0.8889 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9908   -0.7040    0.9781 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5549   -1.6033    2.0713 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5548   -2.6715    2.0081 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9862   -0.4164    0.0718 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3972    0.3611   -1.0235 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6699    0.8052   -1.1498 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9873    1.6526   -2.3411 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0167    0.7898   -3.4740 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6376    0.5124   -0.2192 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9441    1.0304   -0.4124 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9677    2.4081    0.1976 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4407    0.5712   -2.2011 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8206    0.0700   -1.8626 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7542   -0.2211   -2.8529 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9152   -1.0975   -2.4953 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3593   -0.9387   -1.0619 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5759   -1.4718   -0.6947 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0449   -1.0831    0.6074 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3384   -0.2586    1.4303 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1431    0.2045    0.9819 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3458    1.0408    1.8109 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7108    2.4407    1.6461 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5964   -0.1226   -0.2956 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2434    0.2723   -0.5355 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.4077   -0.8257    0.2368 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0021   -0.1064    2.5990 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0982   -1.0116    2.6140 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1946   -1.4503    1.2616 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9433   -2.0517    2.9254 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0195   -0.6756    2.7698 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8784   -1.7402    1.3327 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8083   -1.1998    3.1132 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5925   -2.0479    1.9817 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2951   -3.1342    1.0888 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1952    1.8045   -2.2959 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5971    2.5805   -2.5158 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5030    1.1188   -4.1944 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9370    2.3276    1.2826 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6078    3.0975   -0.2960 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9006    2.7761   -0.0658 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5339    1.5823   -2.5794 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8723   -0.1710   -2.9766 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1307    0.7398   -3.3723 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2588   -0.7437   -3.7237 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7891   -0.6519   -3.1035 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8478   -2.1439   -2.8066 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1587   -2.1431   -1.2857 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6673    2.6747    0.5825 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1164    3.0442    2.3231 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7928    2.5426    1.9257 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9474    1.2135   -0.0660 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6405   -1.8053   -0.2391 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8265   -0.7641    1.2387 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.0094   -0.4353    2.9435 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8835   -1.8724    3.3093 H   0  0  0  0  0  0  0  0  0  0  0  0
 25 24  1  0
 24 23  1  0
 23 26  2  0
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 28  7  1  0
  7  8  2  0
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 15 16  1  0
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 19 20  2  0
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 29 30  1  0
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  8  9  1  0
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 13 14  1  0
 12  3  1  0
  3  2  1  0
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  3  4  2  0
  4  5  1  0
  5  6  1  0
 22 23  1  0
 19 26  1  0
 31 21  1  0
 16 27  1  0
  4  7  1  0
 25 51  1  0
 25 52  1  0
 25 53  1  0
 27 54  1  1
 28 55  1  0
 28 56  1  0
 15 44  1  0
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 17 46  1  0
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 18 48  1  0
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 20 50  1  0
 30 57  1  0
 30 58  1  0
 10 38  1  0
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 11 40  1  0
 14 41  1  0
 14 42  1  0
 14 43  1  0
  1 32  1  0
  1 33  1  0
  1 34  1  0
  5 35  1  0
  5 36  1  0
  6 37  1  0
M  END


  Mrv1652309102218462D          

 31 35  0  0  0  0            999 V2000
    2.6153   -2.2287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4402   -2.2412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8635   -1.5331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6884   -1.5457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0900   -2.2663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9149   -2.2789    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1117   -0.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7101   -0.1169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8852   -0.1043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4837    0.6163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6587    0.6289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4619   -0.8125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6370   -0.7999    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2137   -1.5080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1335    0.5912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9584    0.5787    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3817    1.2868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2066    1.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6082    0.5536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4331    0.5410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8347   -0.1796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4113   -0.8877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5864   -0.8752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1631   -1.5833    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1849   -0.1545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3600   -0.1420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9366   -0.8501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9540   -1.5092    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7127   -1.1851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6389   -0.3634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  2  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 21 22  2  0  0  0  0
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 23 24  1  0  0  0  0
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 23 26  2  0  0  0  0
 19 26  1  0  0  0  0
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 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
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M  END
> <DATABASE_ID>
NP0302904

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=C2C3CC4=C(CN3CCC2=CC2=C1OCO2)C(CO)=C(OC)C(OC)=C4CO

> <INCHI_IDENTIFIER>
InChI=1S/C23H27NO7/c1-27-20-15(9-25)13-7-17-19-12(6-18-22(23(19)29-3)31-11-30-18)4-5-24(17)8-14(13)16(10-26)21(20)28-2/h6,17,25-26H,4-5,7-11H2,1-3H3

> <INCHI_KEY>
LEBRYAVYMBTAIK-UHFFFAOYSA-N

> <FORMULA>
C23H27NO7

> <MOLECULAR_WEIGHT>
429.469

> <EXACT_MASS>
429.178752213

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
58

> <JCHEM_AVERAGE_POLARIZABILITY>
46.19032969960569

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
[16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol

> <JCHEM_LOGP>
1.394179919

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.89084244691205

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.275824648712447

> <JCHEM_PKA_STRONGEST_BASIC>
4.786098301702771

> <JCHEM_POLAR_SURFACE_AREA>
89.85000000000001

> <JCHEM_REFRACTIVITY>
114.291

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
[16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 10-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   10-SEP-22         0                                  
HETATM    1  C   UNK     0       4.882  -4.160   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       6.422  -4.184   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       7.212  -2.862   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       8.752  -2.885   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       9.501  -4.230   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0      11.041  -4.254   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0       9.542  -1.563   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.792  -0.218   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.252  -0.195   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       6.503   1.150   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       4.963   1.174   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       6.462  -1.517   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       4.922  -1.493   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       4.132  -2.815   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       9.582   1.104   0.000  0.00  0.00           C+0
HETATM   16  N   UNK     0      11.122   1.080   0.000  0.00  0.00           N+0
HETATM   17  C   UNK     0      11.912   2.402   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      13.452   2.379   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      14.202   1.033   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      15.742   1.010   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      16.491  -0.335   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      15.701  -1.657   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      14.161  -1.634   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      13.371  -2.955   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0      11.831  -2.932   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      13.412  -0.288   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      11.872  -0.265   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      11.082  -1.587   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0      16.714  -2.817   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0      18.130  -2.212   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      17.993  -0.678   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   12                                                  
CONECT    4    3    5    7                                                  
CONECT    5    4    6                                                       
CONECT    6    5                                                            
CONECT    7    4    8   28                                                  
CONECT    8    7    9   15                                                  
CONECT    9    8   10   12                                                  
CONECT   10    9   11                                                       
CONECT   11   10                                                            
CONECT   12    9    3   13                                                  
CONECT   13   12   14                                                       
CONECT   14   13                                                            
CONECT   15    8   16                                                       
CONECT   16   15   17   27                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20   26                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22   31                                                  
CONECT   22   21   23   29                                                  
CONECT   23   22   24   26                                                  
CONECT   24   23   25                                                       
CONECT   25   24                                                            
CONECT   26   23   19   27                                                  
CONECT   27   26   16   28                                                  
CONECT   28   27    7                                                       
CONECT   29   22   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   21                                                       
MASTER        0    0    0    0    0    0    0    0   31    0   70    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₃H₂₇NO₇

Average Mass

429.4690 Da

Monoisotopic Mass

429.17875 Da

IUPAC Name

[16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol

Traditional Name

[16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol

CAS Registry Number

Not Available

SMILES

COC1=C2C3CC4=C(CN3CCC2=CC2=C1OCO2)C(CO)=C(OC)C(OC)=C4CO

InChI Identifier

InChI=1S/C23H27NO7/c1-27-20-15(9-25)13-7-17-19-12(6-18-22(23(19)29-3)31-11-30-18)4-5-24(17)8-14(13)16(10-26)21(20)28-2/h6,17,25-26H,4-5,7-11H2,1-3H3

InChI Key

LEBRYAVYMBTAIK-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Papaver nudicaule	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Protoberberine alkaloids and derivatives

Sub Class

Not Available

Direct Parent

Protoberberine alkaloids and derivatives

Alternative Parents

Substituents

Protoberberine skeleton
Tetrahydroprotoberberine skeleton
Tetrahydroisoquinoline
Benzodioxole
Anisole
Alkyl aryl ether
Aralkylamine
Benzenoid
Tertiary aliphatic amine
Tertiary amine
Organoheterocyclic compound
Azacycle
Oxacycle
Acetal
Ether
Aromatic alcohol
Primary alcohol
Organooxygen compound
Organonitrogen compound
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Amine
Hydrocarbon derivative
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.39	ChemAxon
pKa (Strongest Acidic)	14.28	ChemAxon
pKa (Strongest Basic)	4.79	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	89.85 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	114.29 m³·mol⁻¹	ChemAxon
Polarizability	46.19 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163050599

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for [16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol (NP0302904)

MOL for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)

3D MOL for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)

3D SDF for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)

3D-SDF for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)

PDB for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)

3D PDB for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)

SMILES for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)

INCHI for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)

Structure for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)

3D Structure for NP0302904 ([16-(hydroxymethyl)-3,17,18-trimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-2,4(8),9,15(20),16,18-hexaen-19-yl]methanol)