NP-MRD: Showing NP-Card for 2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid (NP0301646)

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Record Information

Version

2.0

Created at

2022-09-10 14:44:43 UTC

Updated at

2022-09-10 14:44:43 UTC

NP-MRD ID

NP0301646

Secondary Accession Numbers

None

Natural Product Identification

Common Name

2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid

Description

2-{4A-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-decahydronaphthalen-2-yl}prop-2-enoic acid belongs to the class of organic compounds known as eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoids. These are sesquiterpenoids with a structure based on the eudesmane skeleton. 2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid is found in Cratystylis conocephala. Based on a literature review very few articles have been published on 2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-decahydronaphthalen-2-yl}prop-2-enoic acid.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652309102216442D          

 24 25  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
  9 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6 24  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0301646

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)=CC(=O)OC1CC(=C)C2CC(CCC2(C)C1)C(=C)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C20H28O4/c1-12(2)8-18(21)24-16-9-13(3)17-10-15(14(4)19(22)23)6-7-20(17,5)11-16/h8,15-17H,3-4,6-7,9-11H2,1-2,5H3,(H,22,23)

> <INCHI_KEY>
OBNRKFRUUOSIDI-UHFFFAOYSA-N

> <FORMULA>
C20H28O4

> <MOLECULAR_WEIGHT>
332.44

> <EXACT_MASS>
332.198759382

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
52

> <JCHEM_AVERAGE_POLARIZABILITY>
37.39445915556926

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-decahydronaphthalen-2-yl}prop-2-enoic acid

> <JCHEM_LOGP>
4.442965151000001

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.770107687946129

> <JCHEM_PKA_STRONGEST_BASIC>
-6.808679425709113

> <JCHEM_POLAR_SURFACE_AREA>
63.6

> <JCHEM_REFRACTIVITY>
93.52129999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 10-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   10-SEP-22         0                                  
HETATM    1  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.000  -3.080   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.000  -4.620   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      -1.334  -5.390   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0       1.334  -5.390   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.001   0.770   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       8.002  -0.000   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       9.336  -0.770   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       9.336  -2.310   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0      10.669  -0.000   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      12.003  -0.770   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      13.337  -0.000   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      12.003  -2.310   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       5.335  -4.620   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    6                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3                                                            
CONECT    6    2    7   24                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   11   23                                             
CONECT   10    9                                                            
CONECT   11    9   12                                                       
CONECT   12   11   13   20                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17                                                       
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17                                                            
CONECT   20   12   21                                                       
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21    9   24                                                  
CONECT   24   23    6                                                       
MASTER        0    0    0    0    0    0    0    0   24    0   50    0
END

View in JSmol

Synonyms

Value	Source
2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-decahydronaphthalen-2-yl}prop-2-enoate	Generator

Chemical Formula

C₂₀H₂₈O₄

Average Mass

332.4400 Da

Monoisotopic Mass

332.19876 Da

IUPAC Name

2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-decahydronaphthalen-2-yl}prop-2-enoic acid

Traditional Name

2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid

CAS Registry Number

Not Available

SMILES

CC(C)=CC(=O)OC1CC(=C)C2CC(CCC2(C)C1)C(=C)C(O)=O

InChI Identifier

InChI=1S/C20H28O4/c1-12(2)8-18(21)24-16-9-13(3)17-10-15(14(4)19(22)23)6-7-20(17,5)11-16/h8,15-17H,3-4,6-7,9-11H2,1-2,5H3,(H,22,23)

InChI Key

OBNRKFRUUOSIDI-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Cratystylis conocephala	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoids. These are sesquiterpenoids with a structure based on the eudesmane skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoids

Alternative Parents

Substituents

Eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoid
Fatty acid ester
Fatty acyl
Dicarboxylic acid or derivatives
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Carboxylic acid ester
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.44	ChemAxon
pKa (Strongest Acidic)	4.77	ChemAxon
pKa (Strongest Basic)	-6.8	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	63.6 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	93.52 m³·mol⁻¹	ChemAxon
Polarizability	37.39 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163011357

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid (NP0301646)

MOL for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)

3D MOL for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)

3D SDF for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)

3D-SDF for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)

PDB for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)

3D PDB for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)

SMILES for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)

INCHI for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)

Structure for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)

3D Structure for NP0301646 (2-{4a-methyl-6-[(3-methylbut-2-enoyl)oxy]-8-methylidene-octahydronaphthalen-2-yl}prop-2-enoic acid)