NP-MRD: Showing NP-Card for (2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine (NP0300093)

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Record Information

Version

2.0

Created at

2022-09-10 12:18:06 UTC

Updated at

2022-09-10 12:18:06 UTC

NP-MRD ID

NP0300093

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine

Description

(2-{3-[(1R,5S,6S)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine belongs to the class of organic compounds known as aromatic monoterpenoids. These are monoterpenoids containing at least one aromatic ring. (2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine is found in Zanthoxylum avicennae. Based on a literature review very few articles have been published on (2-{3-[(1R,5S,6S)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309102214182D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309102214182D          

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    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  4  5  1  0  0  0  0
  5  6  1  1  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
  8 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
  6 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
  5 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4 23  1  0  0  0  0
 23 24  1  1  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 26 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  2  0  0  0  0
 24 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0300093

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC=C(CCN(C)C)C=C1[C@H]1CC(C)=C[C@H]([C@H]1C(C)=C)C1=CC(CCN(C)C)=CC=C1OC

> <INCHI_IDENTIFIER>
InChI=1S/C32H46N2O2/c1-22(2)32-28(26-20-24(14-16-33(4)5)10-12-30(26)35-8)18-23(3)19-29(32)27-21-25(15-17-34(6)7)11-13-31(27)36-9/h10-13,18,20-21,28-29,32H,1,14-17,19H2,2-9H3/t28-,29+,32+/m0/s1

> <INCHI_KEY>
ZULSSCAFEXMMQF-NPLMNSEMSA-N

> <FORMULA>
C32H46N2O2

> <MOLECULAR_WEIGHT>
490.732

> <EXACT_MASS>
490.355928729

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
82

> <JCHEM_AVERAGE_POLARIZABILITY>
58.34634263772058

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2-{3-[(1R,5S,6S)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine

> <JCHEM_LOGP>
6.206232202333332

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
2

> <JCHEM_PKA_STRONGEST_BASIC>
9.541363243849382

> <JCHEM_POLAR_SURFACE_AREA>
24.94

> <JCHEM_REFRACTIVITY>
155.28929999999994

> <JCHEM_ROTATABLE_BOND_COUNT>
11

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(2-{3-[(1R,5S,6S)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 10-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   10-SEP-22         0                                  
HETATM    1  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.000  -0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.000  -3.080   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -2.667  -0.000   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -2.667   1.540   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -4.001   2.310   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0      -4.001   3.850   0.000  0.00  0.00           N+0
HETATM   12  C   UNK     0      -5.335   4.620   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -2.667   4.620   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      -2.667  -4.620   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0      -1.334  -5.390   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       0.000  -4.620   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       1.334  -5.390   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.334  -6.930   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.667  -4.620   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       4.001   2.310   0.000  0.00  0.00           C+0
HETATM   29  N   UNK     0       4.001   3.850   0.000  0.00  0.00           N+0
HETATM   30  C   UNK     0       2.667   4.620   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       5.335   4.620   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0       5.335  -4.620   0.000  0.00  0.00           O+0
HETATM   36  C   UNK     0       4.001  -5.390   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5   23                                                  
CONECT    5    4    6   19                                                  
CONECT    6    5    7   16                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   14                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11                                                            
CONECT   14    8   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15    6   17                                                  
CONECT   17   16   18                                                       
CONECT   18   17                                                            
CONECT   19    5   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23                                                       
CONECT   23   22    4   24                                                  
CONECT   24   23   25   34                                                  
CONECT   25   24   26                                                       
CONECT   26   25   27   32                                                  
CONECT   27   26   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29                                                            
CONECT   32   26   33                                                       
CONECT   33   32   34                                                       
CONECT   34   33   24   35                                                  
CONECT   35   34   36                                                       
CONECT   36   35                                                            
MASTER        0    0    0    0    0    0    0    0   36    0   76    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₂H₄₆N₂O₂

Average Mass

490.7320 Da

Monoisotopic Mass

490.35593 Da

IUPAC Name

(2-{3-[(1R,5S,6S)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine

Traditional Name

(2-{3-[(1R,5S,6S)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine

CAS Registry Number

Not Available

SMILES

COC1=CC=C(CCN(C)C)C=C1[C@H]1CC(C)=C[C@H]([C@H]1C(C)=C)C1=CC(CCN(C)C)=CC=C1OC

InChI Identifier

InChI=1S/C32H46N2O2/c1-22(2)32-28(26-20-24(14-16-33(4)5)10-12-30(26)35-8)18-23(3)19-29(32)27-21-25(15-17-34(6)7)11-13-31(27)36-9/h10-13,18,20-21,28-29,32H,1,14-17,19H2,2-9H3/t28-,29+,32+/m0/s1

InChI Key

ZULSSCAFEXMMQF-NPLMNSEMSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Zanthoxylum avicennae	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aromatic monoterpenoids. These are monoterpenoids containing at least one aromatic ring.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Monoterpenoids

Direct Parent

Aromatic monoterpenoids

Alternative Parents

Substituents

Aromatic monoterpenoid
Monocyclic monoterpenoid
P-menthane monoterpenoid
Phenethylamine
Anisole
Phenoxy compound
Methoxybenzene
Phenol ether
Alkyl aryl ether
Aralkylamine
Monocyclic benzene moiety
Benzenoid
Tertiary amine
Tertiary aliphatic amine
Ether
Amine
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	6.21	ChemAxon
pKa (Strongest Basic)	9.54	ChemAxon
Physiological Charge	2	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	24.94 Å²	ChemAxon
Rotatable Bond Count	11	ChemAxon
Refractivity	155.29 m³·mol⁻¹	ChemAxon
Polarizability	58.35 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

162964897

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine (NP0300093)

MOL for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)

3D MOL for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)

3D SDF for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)

3D-SDF for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)

PDB for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)

3D PDB for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)

SMILES for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)

INCHI for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)

Structure for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)

3D Structure for NP0300093 ((2-{3-[(1r,5s,6s)-5-{5-[2-(dimethylamino)ethyl]-2-methoxyphenyl}-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-4-methoxyphenyl}ethyl)dimethylamine)