NP-MRD: Showing NP-Card for (2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol (NP0295627)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-10 04:42:51 UTC

Updated at

2022-09-10 04:42:51 UTC

NP-MRD ID

NP0295627

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol

Description

ZINC13378135 belongs to the class of organic compounds known as benzyl alcohols. These are organic compounds containing the phenylmethanol substructure. (2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol is found in Alternaria cichorii. Based on a literature review very few articles have been published on ZINC13378135.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 45 45  0  0  0  0  0  0  0  0999 V2000
   -3.9600    2.2344    1.6440 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3172    2.2515    0.3831 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5114    1.1475    0.0959 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1791    1.1405    0.3874 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5726    2.3323    1.0353 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3635    0.0469    0.0925 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9707    0.1296    0.4404 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8631   -0.9074    0.1333 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2616   -0.6212    0.7239 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0454   -0.0705    1.9311 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1785   -0.0250   -0.2783 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5074   -1.0887   -1.3286 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5146    0.2202    0.4775 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7408    1.1590   -0.8226 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0109   -1.0094   -0.4980 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3636   -1.0873   -0.8181 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8893   -2.2498   -1.4795 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8077   -3.0234   -0.7411 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1207    0.0429   -0.5106 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5348    0.1464   -0.8300 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0917   -0.9034   -1.4615 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9966    1.1946    2.0682 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9863    2.6395    1.4969 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4541    2.8452    2.3733 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2051    2.0220    1.7494 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3599    2.8714    1.5665 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2159    2.9586    0.2095 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1230   -0.8085   -1.0180 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4878   -1.8816    0.2477 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5960   -1.6979    0.9108 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2534    0.9548    1.9540 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6637   -1.8034   -1.4697 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3961   -1.6746   -0.9692 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7645   -0.5834   -2.2910 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4682   -0.1517    1.4934 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3362   -0.3824   -0.0131 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8098    1.3130    0.3658 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4731    1.7804   -0.1126 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3505   -1.8863   -0.7192 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0694   -2.2552   -2.5289 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9573   -3.0649   -1.3411 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7352   -2.7825    0.1807 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1675    0.3546    0.1670 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7019    1.1036   -1.4290 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9418   -0.9304   -2.4520 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 11 13  1  0
 11 14  1  0
  6 15  2  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 16 19  2  0
 19 20  1  0
 20 21  1  0
 19  3  1  0
  1 22  1  0
  1 23  1  0
  1 24  1  0
  5 25  1  0
  5 26  1  0
  5 27  1  0
  8 28  1  0
  8 29  1  0
  9 30  1  1
 10 31  1  0
 12 32  1  0
 12 33  1  0
 12 34  1  0
 13 35  1  0
 13 36  1  0
 13 37  1  0
 14 38  1  0
 15 39  1  0
 17 40  1  0
 17 41  1  0
 18 42  1  0
 20 43  1  0
 20 44  1  0
 21 45  1  0
M  END


  Mrv1652309102206422D          

 21 21  0  0  1  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  6  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  6 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  2  0  0  0  0
  3 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0295627

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=C(C)C(OC[C@H](O)C(C)(C)O)=CC(CO)=C1CO

> <INCHI_IDENTIFIER>
InChI=1S/C15H24O6/c1-9-12(21-8-13(18)15(2,3)19)5-10(6-16)11(7-17)14(9)20-4/h5,13,16-19H,6-8H2,1-4H3/t13-/m0/s1

> <INCHI_KEY>
MAQMWSUGBCIGLJ-ZDUSSCGKSA-N

> <FORMULA>
C15H24O6

> <MOLECULAR_WEIGHT>
300.351

> <EXACT_MASS>
300.157288493

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
45

> <JCHEM_AVERAGE_POLARIZABILITY>
32.178193993129256

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2S)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol

> <JCHEM_LOGP>
0.013339878333333416

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.376866928334685

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.17237007142693

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8756459515156383

> <JCHEM_POLAR_SURFACE_AREA>
99.38000000000001

> <JCHEM_REFRACTIVITY>
78.96919999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(2S)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 10-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   10-SEP-22         0                                  
HETATM    1  C   UNK     0       0.000   4.620   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       1.334   3.850   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.001   2.310   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.667  -0.000   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       4.001  -0.770   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       6.668  -2.310   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       5.335  -4.620   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.335  -6.160   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.875  -4.620   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       3.795  -4.620   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0      -2.667   0.000   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      -1.334   2.310   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -2.667   1.540   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   19                                                  
CONECT    4    3    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7   15                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12   13   14                                             
CONECT   12   11                                                            
CONECT   13   11                                                            
CONECT   14   11                                                            
CONECT   15    6   16                                                       
CONECT   16   15   17   19                                                  
CONECT   17   16   18                                                       
CONECT   18   17                                                            
CONECT   19   16    3   20                                                  
CONECT   20   19   21                                                       
CONECT   21   20                                                            
MASTER        0    0    0    0    0    0    0    0   21    0   42    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₂₄O₆

Average Mass

300.3510 Da

Monoisotopic Mass

300.15729 Da

IUPAC Name

(2S)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol

Traditional Name

(2S)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol

CAS Registry Number

Not Available

SMILES

COC1=C(C)C(OC[C@H](O)C(C)(C)O)=CC(CO)=C1CO

InChI Identifier

InChI=1S/C15H24O6/c1-9-12(21-8-13(18)15(2,3)19)5-10(6-16)11(7-17)14(9)20-4/h5,13,16-19H,6-8H2,1-4H3/t13-/m0/s1

InChI Key

MAQMWSUGBCIGLJ-ZDUSSCGKSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Alternaria cichorii	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as benzyl alcohols. These are organic compounds containing the phenylmethanol substructure.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Benzyl alcohols

Direct Parent

Benzyl alcohols

Alternative Parents

Substituents

Phenoxy compound
Methoxybenzene
Anisole
Benzyl alcohol
Phenol ether
Alkyl aryl ether
Toluene
Tertiary alcohol
1,2-diol
Secondary alcohol
Ether
Organic oxygen compound
Organooxygen compound
Primary alcohol
Aromatic alcohol
Hydrocarbon derivative
Alcohol
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.013	ChemAxon
pKa (Strongest Acidic)	13.17	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	99.38 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	78.97 m³·mol⁻¹	ChemAxon
Polarizability	32.18 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

25763833

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol (NP0295627)

MOL for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)

3D MOL for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)

3D SDF for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)

3D-SDF for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)

PDB for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)

3D PDB for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)

SMILES for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)

INCHI for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)

Structure for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)

3D Structure for NP0295627 ((2s)-1-[4,5-bis(hydroxymethyl)-3-methoxy-2-methylphenoxy]-3-methylbutane-2,3-diol)