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Record Information
Version2.0
Created at2022-09-09 23:35:45 UTC
Updated at2022-09-09 23:35:46 UTC
NP-MRD IDNP0292181
Secondary Accession NumbersNone
Natural Product Identification
Common Name2-[(1s,2s,4ar,8r,8as)-8-{[(3as,5ar,9s,9as,9bs)-5a,9-dimethyl-3-methylidene-2-oxo-octahydronaphtho[1,2-b]furan-9-yl]oxy}-1-hydroxy-4a,8-dimethyl-octahydronaphthalen-2-yl]prop-2-enal
Description(1S,8abeta)-alpha-Methylene-1beta-hydroxy-4aalpha,8-dimethyl-8beta-[[(5aR,3abeta,9abeta,9balpha)-2-oxo-3-methylene-5aalpha,9-dimethyldodecahydronaphtho[1,2-b]furan]-9alpha-yloxy]decahydronaphthalene-2alpha-acetaldehyde belongs to the class of organic compounds known as eudesmanolides, secoeudesmanolides, and derivatives. These are terpenoids with a structure based on the eudesmanolide (a 3,5a,9-trimethyl-naphtho[1,2-b]furan-2-one derivative) or secoeudesmanolide (a 3,6-dimethyl-5-(pentan-2-yl)-1-benzofuran-2-one derivative) skeleton. 2-[(1s,2s,4ar,8r,8as)-8-{[(3as,5ar,9s,9as,9bs)-5a,9-dimethyl-3-methylidene-2-oxo-octahydronaphtho[1,2-b]furan-9-yl]oxy}-1-hydroxy-4a,8-dimethyl-octahydronaphthalen-2-yl]prop-2-enal is found in Frullania tamarisci. Based on a literature review very few articles have been published on (1S,8abeta)-alpha-Methylene-1beta-hydroxy-4aalpha,8-dimethyl-8beta-[[(5aR,3abeta,9abeta,9balpha)-2-oxo-3-methylene-5aalpha,9-dimethyldodecahydronaphtho[1,2-b]furan]-9alpha-yloxy]decahydronaphthalene-2alpha-acetaldehyde.
Structure
Thumb
Synonyms
ValueSource
(1S,8Abeta)-a-methylene-1b-hydroxy-4aalpha,8-dimethyl-8b-[[(5ar,3abeta,9abeta,9balpha)-2-oxo-3-methylene-5aalpha,9-dimethyldodecahydronaphtho[1,2-b]furan]-9a-yloxy]decahydronaphthalene-2a-acetaldehydeGenerator
(1S,8Abeta)-α-methylene-1β-hydroxy-4aalpha,8-dimethyl-8β-[[(5ar,3abeta,9abeta,9balpha)-2-oxo-3-methylene-5aalpha,9-dimethyldodecahydronaphtho[1,2-b]furan]-9α-yloxy]decahydronaphthalene-2α-acetaldehydeGenerator
Chemical FormulaC30H44O5
Average Mass484.6770 Da
Monoisotopic Mass484.31887 Da
IUPAC Name2-[(1S,2S,4aR,8R,8aS)-8-{[(3aS,5aR,9S,9aS,9bS)-5a,9-dimethyl-3-methylidene-2-oxo-dodecahydronaphtho[1,2-b]furan-9-yl]oxy}-1-hydroxy-4a,8-dimethyl-decahydronaphthalen-2-yl]prop-2-enal
Traditional Name2-[(1S,2S,4aR,8R,8aS)-8-{[(3aS,5aR,9S,9aS,9bS)-5a,9-dimethyl-3-methylidene-2-oxo-octahydronaphtho[1,2-b]furan-9-yl]oxy}-1-hydroxy-4a,8-dimethyl-octahydronaphthalen-2-yl]prop-2-enal
CAS Registry NumberNot Available
SMILES
C[C@]12CCC[C@](C)(O[C@]3(C)CCC[C@]4(C)CC[C@H]([C@H](O)[C@@H]34)C(=C)C=O)[C@@H]1[C@H]1OC(=O)C(=C)[C@@H]1CC2
InChI Identifier
InChI=1S/C30H44O5/c1-18(17-31)20-9-15-27(3)11-7-13-29(5,24(27)22(20)32)35-30(6)14-8-12-28(4)16-10-21-19(2)26(33)34-23(21)25(28)30/h17,20-25,32H,1-2,7-16H2,3-6H3/t20-,21-,22-,23-,24+,25+,27+,28+,29+,30-/m0/s1
InChI KeyBVVIZGNQTGSFKF-DLLVIXNMSA-N
Experimental Spectra
Not Available
Predicted Spectra
Spectrum TypeDescriptionDepositor IDDepositor OrganizationDepositorDeposition DateView
1D NMR13C NMR Spectrum (1D, 25 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 100 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 252 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 1000 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 50 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 200 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 75 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 300 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 101 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 400 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 126 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 151 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 176 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 700 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 201 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 800 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR13C NMR Spectrum (1D, 226 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
1D NMR1H NMR Spectrum (1D, 900 MHz, H2O, predicted)Wishart LabWishart LabDavid Wishart2021-06-20View Spectrum
Chemical Shift Submissions
Not Available
Species
Species of Origin
Species NameSourceReference
Frullania tamarisciLOTUS Database
Chemical Taxonomy
Description Belongs to the class of organic compounds known as eudesmanolides, secoeudesmanolides, and derivatives. These are terpenoids with a structure based on the eudesmanolide (a 3,5a,9-trimethyl-naphtho[1,2-b]furan-2-one derivative) or secoeudesmanolide (a 3,6-dimethyl-5-(pentan-2-yl)-1-benzofuran-2-one derivative) skeleton.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassPrenol lipids
Sub ClassTerpene lactones
Direct ParentEudesmanolides, secoeudesmanolides, and derivatives
Alternative Parents
Substituents
  • Eudesmanolide
  • Eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoid
  • Sesquiterpenoid
  • Naphthofuran
  • Gamma butyrolactone
  • Alpha,beta-unsaturated aldehyde
  • Cyclic alcohol
  • Enal
  • Tetrahydrofuran
  • Enoate ester
  • Alpha,beta-unsaturated carboxylic ester
  • Secondary alcohol
  • Carboxylic acid ester
  • Lactone
  • Carboxylic acid derivative
  • Organoheterocyclic compound
  • Oxacycle
  • Monocarboxylic acid or derivatives
  • Dialkyl ether
  • Ether
  • Aldehyde
  • Carbonyl group
  • Alcohol
  • Organooxygen compound
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External DescriptorsNot Available
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP4.97ChemAxon
pKa (Strongest Acidic)14.51ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity135.06 m³·mol⁻¹ChemAxon
Polarizability54.53 ųChemAxon
Number of Rings5ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
HMDB IDNot Available
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID8895014
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound10719675
PDB IDNot Available
ChEBI IDNot Available
Good Scents IDNot Available
References
General References
  1. LOTUS database [Link]