NP-MRD: Showing NP-Card for (3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate (NP0291764)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-09 22:58:34 UTC

Updated at

2022-09-09 22:58:35 UTC

NP-MRD ID

NP0291764

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate

Description

(3S,6S)-2,6-dihydroxy-2-methyl-6-[(1R,2R,4S,5R,7R,11S,14S,15R)-4,5,11-trihydroxy-2,15-dimethyl-8-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]Heptadec-9-en-14-yl]heptan-3-yl 1H-pyrrole-2-carboxylate belongs to the class of organic compounds known as pentahydroxy bile acids, alcohols and derivatives. These are bile acids, alcohols or derivatives bearing five hydroxyl groups. (3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate is found in Vitex canescens. Based on a literature review very few articles have been published on (3S,6S)-2,6-dihydroxy-2-methyl-6-[(1R,2R,4S,5R,7R,11S,14S,15R)-4,5,11-trihydroxy-2,15-dimethyl-8-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]Heptadec-9-en-14-yl]heptan-3-yl 1H-pyrrole-2-carboxylate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309102200582D          

 41 45  0  0  1  0            999 V2000
    0.0276   -3.4005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0853   -4.2178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1981   -5.0350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9025   -4.1049    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7320   -4.3306    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2383   -3.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0556   -3.7922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5619   -3.1408    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9106   -2.6345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2132   -3.6472    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0683   -2.4895    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8390   -1.6970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5218   -1.2340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1731   -1.7404    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3708   -0.9394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9853   -1.5952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2655   -0.8192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0777   -0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3580    0.1019    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6095   -1.3047    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.4216   -1.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9534   -1.7902    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.7655   -1.6450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6731   -2.5662    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.2049   -3.1969    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8610   -2.7114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3292   -2.0807    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.0489   -2.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5171   -2.2259    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.2368   -3.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4247   -3.1470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8928   -2.5163    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5330   -3.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0429   -5.0948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8601   -5.2077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3665   -4.5563    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1710   -5.9718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9720   -6.1695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0315   -6.9924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2673   -7.3032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7355   -6.6725    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  6  0  0  0
  8 10  1  6  0  0  0
 11  8  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  6  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 20 18  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  1  0  0  0
 22 24  1  0  0  0  0
 24 25  1  1  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 20 27  1  0  0  0  0
 27 28  1  1  0  0  0
 27 29  1  0  0  0  0
 29 16  1  1  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 11 32  1  0  0  0  0
 14 32  1  0  0  0  0
 32 33  1  1  0  0  0
  5 34  1  6  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 37 38  2  0  0  0  0
 38 39  1  0  0  0  0
 39 40  2  0  0  0  0
 40 41  1  0  0  0  0
 37 41  1  0  0  0  0
M  END

     RDKit          3D

 88 92  0  0  0  0  0  0  0  0999 V2000
    5.3313   -1.7410    2.6632 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3336   -0.6405    1.6544 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9591   -1.0329    0.3413 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1826    0.3860    2.1675 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9759    0.0274    1.4841 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8250   -0.9096    1.3197 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8659   -1.8213    0.1792 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7848   -2.8113   -0.0673 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6279   -3.7607    1.1022 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3760   -3.6874   -1.0532 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5583   -2.3971   -0.7476 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.3222   -3.6385   -0.9454 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6763   -3.2144   -0.4418 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6551   -1.8042   -0.9190 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.5647   -1.7881   -2.3033 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7308   -0.9484   -0.4737 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7666   -1.3468    0.2495 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8002   -0.4049    0.6511 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9578   -0.7517    0.9658 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4462    1.0340    0.6844 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.6539    1.8712    0.8658 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6304    1.6261   -0.2239 C   0  0  1  0  0  0  0  0  0  0  0  0
   -7.3848    2.8019   -0.4248 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0431    1.1320   -1.5175 C   0  0  1  0  0  0  0  0  0  0  0  0
   -6.8393    1.6974   -2.5451 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6484    1.5852   -1.7606 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7143    1.3650   -0.5869 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.1009    2.7585   -0.3320 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5852    0.4627   -0.9245 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.2117    1.0000   -0.5975 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1259    0.0073   -0.9018 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3351   -1.3335   -0.2604 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.5968   -1.1924    1.1788 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1184    1.0353    0.5425 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0842    2.3638    0.8739 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9100    2.6310    2.1030 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2334    3.4501   -0.0802 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4349    3.4014   -1.4515 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5234    4.6775   -1.9412 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3739    5.5025   -0.8561 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2027    4.7511    0.2382 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3349   -1.7534    3.1585 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2236   -2.7384    2.1938 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5868   -1.5422    3.4554 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2228   -2.1030    0.2809 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9241   -0.4568    0.2295 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3259   -0.6553   -0.4745 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4650    0.1932    3.0839 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8324    0.5351    2.5067 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9307   -0.2184    1.2057 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6494   -1.3825    2.3082 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8801   -2.3499    0.2513 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9906   -1.2694   -0.8042 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2847   -4.6294    0.9453 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6204   -4.1102    1.2355 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9439   -3.3108    2.0641 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8226   -3.0937   -1.7137 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8459   -2.0903   -1.8023 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0813   -4.5565   -0.5652 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4922   -3.8020   -2.0680 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4941   -3.8203   -0.9064 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7887   -3.2504    0.6353 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4739   -1.5776   -2.6448 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8168   -2.3845    0.5254 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7030    1.2354    1.5090 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4452    2.9449    1.0520 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1242    1.5304    1.8455 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3690    0.8701    0.1079 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3580    2.6496   -0.3399 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1573    0.0354   -1.6506 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9895    2.6609   -2.3893 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6666    2.6263   -2.1312 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2380    0.9735   -2.6070 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5708    3.1315   -1.2204 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5736    2.8179    0.6148 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9871    3.4550   -0.2308 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6005    0.3721   -2.0612 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1334    1.4025    0.4300 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0290    1.8539   -1.2790 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8334    0.4790   -0.7572 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2015   -0.1857   -2.0147 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6588   -1.3846    1.4030 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4443   -0.1507    1.5693 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0412   -1.9252    1.8377 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5104    2.4901   -2.0394 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6763    4.9490   -2.9582 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3954    6.5774   -0.9087 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0645    5.1649    1.2086 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  2  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  8 10  1  6
  8 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  6
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 22 24  1  0
 24 25  1  0
 24 26  1  0
 26 27  1  0
 27 28  1  1
 27 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 32 33  1  1
  5 34  1  0
 34 35  1  0
 35 36  2  0
 35 37  1  0
 37 38  2  0
 38 39  1  0
 39 40  2  0
 40 41  1  0
 32 11  1  0
 41 37  1  0
 32 14  1  0
 29 16  1  0
 27 20  1  0
  1 42  1  0
  1 43  1  0
  1 44  1  0
  3 45  1  0
  3 46  1  0
  3 47  1  0
  4 48  1  0
  5 49  1  1
  6 50  1  0
  6 51  1  0
  7 52  1  0
  7 53  1  0
  9 54  1  0
  9 55  1  0
  9 56  1  0
 10 57  1  0
 11 58  1  6
 12 59  1  0
 12 60  1  0
 13 61  1  0
 13 62  1  0
 15 63  1  0
 17 64  1  0
 20 65  1  1
 21 66  1  0
 21 67  1  0
 22 68  1  1
 23 69  1  0
 24 70  1  1
 25 71  1  0
 26 72  1  0
 26 73  1  0
 28 74  1  0
 28 75  1  0
 28 76  1  0
 29 77  1  6
 30 78  1  0
 30 79  1  0
 31 80  1  0
 31 81  1  0
 33 82  1  0
 33 83  1  0
 33 84  1  0
 38 85  1  0
 39 86  1  0
 40 87  1  0
 41 88  1  0
M  END


  Mrv1652309102200582D          

 41 45  0  0  1  0            999 V2000
    0.0276   -3.4005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0853   -4.2178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1981   -5.0350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9025   -4.1049    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7320   -4.3306    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2383   -3.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0556   -3.7922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5619   -3.1408    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9106   -2.6345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2132   -3.6472    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0683   -2.4895    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8390   -1.6970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5218   -1.2340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1731   -1.7404    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3708   -0.9394    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9853   -1.5952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2655   -0.8192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0777   -0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3580    0.1019    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6095   -1.3047    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.4216   -1.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9534   -1.7902    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.7655   -1.6450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6731   -2.5662    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.2049   -3.1969    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8610   -2.7114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3292   -2.0807    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.0489   -2.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5171   -2.2259    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.2368   -3.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4247   -3.1470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8928   -2.5163    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5330   -3.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0429   -5.0948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8601   -5.2077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3665   -4.5563    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1710   -5.9718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9720   -6.1695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0315   -6.9924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2673   -7.3032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7355   -6.6725    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  6  0  0  0
  8 10  1  6  0  0  0
 11  8  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  6  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 20 18  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  1  0  0  0
 22 24  1  0  0  0  0
 24 25  1  1  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 20 27  1  0  0  0  0
 27 28  1  1  0  0  0
 27 29  1  0  0  0  0
 29 16  1  1  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 11 32  1  0  0  0  0
 14 32  1  0  0  0  0
 32 33  1  1  0  0  0
  5 34  1  6  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 37 38  2  0  0  0  0
 38 39  1  0  0  0  0
 39 40  2  0  0  0  0
 40 41  1  0  0  0  0
 37 41  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0291764

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)(O)[C@H](CC[C@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C)OC(=O)C1=CC=CN1

> <INCHI_IDENTIFIER>
InChI=1S/C32H47NO8/c1-28(2,38)26(41-27(37)21-7-6-14-33-21)10-12-31(5,39)25-9-13-32(40)19-15-22(34)20-16-23(35)24(36)17-29(20,3)18(19)8-11-30(25,32)4/h6-7,14-15,18,20,23-26,33,35-36,38-40H,8-13,16-17H2,1-5H3/t18-,20-,23+,24-,25-,26-,29+,30+,31-,32+/m0/s1

> <INCHI_KEY>
AVXVGYYNQOOFRN-DHSBGKAXSA-N

> <FORMULA>
C32H47NO8

> <MOLECULAR_WEIGHT>
573.727

> <EXACT_MASS>
573.330167477

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
88

> <JCHEM_AVERAGE_POLARIZABILITY>
63.67628345879669

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
6

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(3S,6S)-2,6-dihydroxy-2-methyl-6-[(1R,2R,4S,5R,7R,11S,14S,15R)-4,5,11-trihydroxy-2,15-dimethyl-8-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-9-en-14-yl]heptan-3-yl 1H-pyrrole-2-carboxylate

> <JCHEM_LOGP>
2.1050472896666665

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.480110530165852

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.572544670167495

> <JCHEM_PKA_STRONGEST_BASIC>
-2.902402962609858

> <JCHEM_POLAR_SURFACE_AREA>
160.31

> <JCHEM_REFRACTIVITY>
153.33409999999995

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(3S,6S)-2,6-dihydroxy-2-methyl-6-[(1R,2R,4S,5R,7R,11S,14S,15R)-4,5,11-trihydroxy-2,15-dimethyl-8-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-9-en-14-yl]heptan-3-yl 1H-pyrrole-2-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 10-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   10-SEP-22         0                                  
HETATM    1  C   UNK     0       0.051  -6.348   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.159  -7.873   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.370  -9.399   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      -1.685  -7.663   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0       1.366  -8.084   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.312  -6.868   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.837  -7.079   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.782  -5.863   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.566  -4.918   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       5.998  -6.808   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       5.727  -4.647   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.299  -3.168   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.574  -2.304   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.790  -3.249   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       8.159  -1.754   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       9.306  -2.978   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       9.829  -1.529   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      11.345  -1.258   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      11.868   0.190   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0      12.338  -2.436   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      13.854  -2.164   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      14.846  -3.342   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      16.362  -3.071   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      14.323  -4.790   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      15.316  -5.967   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0      12.807  -5.061   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      11.814  -3.884   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      11.291  -5.332   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      10.299  -4.155   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       9.775  -5.603   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       8.259  -5.874   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       7.267  -4.697   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       6.595  -6.083   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0       1.947  -9.510   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0       3.472  -9.721   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0       4.417  -8.505   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0       4.053 -11.147   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0       5.548 -11.516   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0       5.659 -13.052   0.000  0.00  0.00           C+0
HETATM   40  C   UNK     0       4.232 -13.633   0.000  0.00  0.00           C+0
HETATM   41  N   UNK     0       3.240 -12.455   0.000  0.00  0.00           N+0
CONECT    1    2                                                            
CONECT    2    1    3    4    5                                             
CONECT    3    2                                                            
CONECT    4    2                                                            
CONECT    5    2    6   34                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   10   11                                             
CONECT    9    8                                                            
CONECT   10    8                                                            
CONECT   11    8   12   32                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   16   32                                             
CONECT   15   14                                                            
CONECT   16   14   17   29                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21   27                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27                                                       
CONECT   27   26   20   28   29                                             
CONECT   28   27                                                            
CONECT   29   27   16   30                                                  
CONECT   30   29   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   11   14   33                                             
CONECT   33   32                                                            
CONECT   34    5   35                                                       
CONECT   35   34   36   37                                                  
CONECT   36   35                                                            
CONECT   37   35   38   41                                                  
CONECT   38   37   39                                                       
CONECT   39   38   40                                                       
CONECT   40   39   41                                                       
CONECT   41   40   37                                                       
MASTER        0    0    0    0    0    0    0    0   41    0   90    0
END

View in JSmol

Synonyms

Value	Source
(3S,6S)-2,6-Dihydroxy-2-methyl-6-[(1R,2R,4S,5R,7R,11S,14S,15R)-4,5,11-trihydroxy-2,15-dimethyl-8-oxotetracyclo[8.7.0.0,.0,]heptadec-9-en-14-yl]heptan-3-yl 1H-pyrrole-2-carboxylic acid	Generator

Chemical Formula

C₃₂H₄₇NO₈

Average Mass

573.7270 Da

Monoisotopic Mass

573.33017 Da

IUPAC Name

(3S,6S)-2,6-dihydroxy-2-methyl-6-[(1R,2R,4S,5R,7R,11S,14S,15R)-4,5,11-trihydroxy-2,15-dimethyl-8-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-9-en-14-yl]heptan-3-yl 1H-pyrrole-2-carboxylate

Traditional Name

(3S,6S)-2,6-dihydroxy-2-methyl-6-[(1R,2R,4S,5R,7R,11S,14S,15R)-4,5,11-trihydroxy-2,15-dimethyl-8-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-9-en-14-yl]heptan-3-yl 1H-pyrrole-2-carboxylate

CAS Registry Number

Not Available

SMILES

CC(C)(O)[C@H](CC[C@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C)OC(=O)C1=CC=CN1

InChI Identifier

InChI=1S/C32H47NO8/c1-28(2,38)26(41-27(37)21-7-6-14-33-21)10-12-31(5,39)25-9-13-32(40)19-15-22(34)20-16-23(35)24(36)17-29(20,3)18(19)8-11-30(25,32)4/h6-7,14-15,18,20,23-26,33,35-36,38-40H,8-13,16-17H2,1-5H3/t18-,20-,23+,24-,25-,26-,29+,30+,31-,32+/m0/s1

InChI Key

AVXVGYYNQOOFRN-DHSBGKAXSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Vitex canescens	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pentahydroxy bile acids, alcohols and derivatives. These are bile acids, alcohols or derivatives bearing five hydroxyl groups.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Bile acids, alcohols and derivatives

Direct Parent

Pentahydroxy bile acids, alcohols and derivatives

Alternative Parents

Substituents

Pentahydroxy bile acid, alcohol, or derivatives
Ecdysteroid
25-hydroxysteroid
20-hydroxysteroid
3-hydroxysteroid
3-hydroxy-delta-7-steroid
2-hydroxysteroid
14-hydroxysteroid
6-oxosteroid
3-beta-hydroxysteroid
Hydroxysteroid
Oxosteroid
Delta-7-steroid
Pyrrole-2-carboxylic acid or derivatives
Cyclohexenone
Substituted pyrrole
Cyclic alcohol
Heteroaromatic compound
Tertiary alcohol
Pyrrole
Secondary alcohol
Ketone
Carboxylic acid ester
Polyol
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organoheterocyclic compound
Azacycle
Organooxygen compound
Organic oxide
Hydrocarbon derivative
Organopnictogen compound
Organic nitrogen compound
Alcohol
Carbonyl group
Organonitrogen compound
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.11	ChemAxon
pKa (Strongest Acidic)	12.57	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	160.31 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	153.33 m³·mol⁻¹	ChemAxon
Polarizability	63.68 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163186441

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate (NP0291764)

MOL for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)

3D MOL for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)

3D SDF for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)

3D-SDF for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)

PDB for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)

3D PDB for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)

SMILES for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)

INCHI for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)

Structure for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)

3D Structure for NP0291764 ((3s,6s)-6-[(1s,3as,5ar,7r,8s,9ar,9br,11ar)-3a,7,8-trihydroxy-9a,11a-dimethyl-5-oxo-1h,2h,3h,5ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-1-yl]-2,6-dihydroxy-2-methylheptan-3-yl 1h-pyrrole-2-carboxylate)