NP-MRD: Showing NP-Card for (3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one (NP0290433)

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Record Information

Version

2.0

Created at

2022-09-09 21:06:52 UTC

Updated at

2022-09-09 21:06:53 UTC

NP-MRD ID

NP0290433

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one

Description

6-Hydroxyramulosin belongs to the class of organic compounds known as benzopyrans. These are organic compounds containing a benzene ring fused to a pyran ring. Pyran a six-membered heterocyclic, non-aromatic ring, made up of five carbon atoms and one oxygen atom and containing two double bonds. (3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one is found in Truncatella laurocerasi. (3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one was first documented in 2008 (PMID: 19035568). Based on a literature review a small amount of articles have been published on 6-Hydroxyramulosin (PMID: 34668831) (PMID: 25920279).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 28 29  0  0  0  0  0  0  0  0999 V2000
    2.6726   -0.9322   -0.6639 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4918    0.4355   -0.0432 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5632    0.3537    1.1293 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1238    0.2832    0.8344 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4173   -1.1216    0.7094 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8469   -1.1780    0.2880 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.6164   -2.0184    1.0934 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5041    0.1811    0.1262 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5541    0.9512   -0.7287 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9319    1.6264   -1.8756 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2779    1.0057   -0.3924 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7571    1.7112   -1.1238 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3637    2.6264   -1.9130 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1153    1.4171   -0.9839 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7181   -0.9827   -1.0887 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0079   -1.1042   -1.5311 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6179   -1.7090    0.1106 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4879    0.7419    0.3442 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8435   -0.5575    1.7264 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7577    1.2088    1.8175 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4394    0.7818    1.6777 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2777   -1.6869    1.6738 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2234   -1.6466   -0.0223 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9071   -1.6436   -0.7419 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5456   -1.9902    0.7315 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4698    0.0232   -0.3715 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6279    0.6610    1.1273 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3279    2.5627   -1.7387 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  1  0
  9 10  1  0
  9 11  2  0
 11 12  1  0
 12 13  2  0
 12 14  1  0
 14  2  1  0
 11  4  1  0
  1 15  1  0
  1 16  1  0
  1 17  1  0
  2 18  1  1
  3 19  1  0
  3 20  1  0
  4 21  1  1
  5 22  1  0
  5 23  1  0
  6 24  1  6
  7 25  1  0
  8 26  1  0
  8 27  1  0
 10 28  1  0
M  END


  Mrv1652309092223062D          

 14 15  0  0  1  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.2868   -0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  4  3  1  6  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  1  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  4 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
  2 14  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0290433

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@@H]1C[C@@H]2C[C@@H](O)CC(O)=C2C(=O)O1

> <INCHI_IDENTIFIER>
InChI=1S/C10H14O4/c1-5-2-6-3-7(11)4-8(12)9(6)10(13)14-5/h5-7,11-12H,2-4H2,1H3/t5-,6-,7-/m1/s1

> <INCHI_KEY>
VXOJVQJURAQQOK-FSDSQADBSA-N

> <FORMULA>
C10H14O4

> <MOLECULAR_WEIGHT>
198.218

> <EXACT_MASS>
198.089208931

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
28

> <JCHEM_AVERAGE_POLARIZABILITY>
20.07743874099335

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3R,4aS,6R)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-1H-2-benzopyran-1-one

> <JCHEM_LOGP>
0.06356593933333357

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.217670512920371

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.483893045607063

> <JCHEM_PKA_STRONGEST_BASIC>
-2.756263212191776

> <JCHEM_POLAR_SURFACE_AREA>
66.76

> <JCHEM_REFRACTIVITY>
50.398900000000005

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(3R,4aS,6R)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 09-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   09-SEP-22         0                                  
HETATM    1  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       8.002  -0.000   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       5.335  -4.620   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       2.667  -4.620   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0       1.334  -2.310   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   14                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5   11                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9    4   12                                                  
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12    2                                                       
MASTER        0    0    0    0    0    0    0    0   14    0   30    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₀H₁₄O₄

Average Mass

198.2180 Da

Monoisotopic Mass

198.08921 Da

IUPAC Name

(3R,4aS,6R)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-1H-2-benzopyran-1-one

Traditional Name

(3R,4aS,6R)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one

CAS Registry Number

Not Available

SMILES

C[C@@H]1C[C@@H]2C[C@@H](O)CC(O)=C2C(=O)O1

InChI Identifier

InChI=1S/C10H14O4/c1-5-2-6-3-7(11)4-8(12)9(6)10(13)14-5/h5-7,11-12H,2-4H2,1H3/t5-,6-,7-/m1/s1

InChI Key

VXOJVQJURAQQOK-FSDSQADBSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Truncatella laurocerasi	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as benzopyrans. These are organic compounds containing a benzene ring fused to a pyran ring. Pyran a six-membered heterocyclic, non-aromatic ring, made up of five carbon atoms and one oxygen atom and containing two double bonds.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzopyrans

Sub Class

Not Available

Direct Parent

Benzopyrans

Alternative Parents

Substituents

Benzopyran
Delta valerolactone
Delta_valerolactone
Oxane
Vinylogous acid
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Carboxylic acid ester
Lactone
Secondary alcohol
Monocarboxylic acid or derivatives
Enol
Carboxylic acid derivative
Oxacycle
Hydrocarbon derivative
Organic oxide
Alcohol
Carbonyl group
Organooxygen compound
Organic oxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.064	ChemAxon
pKa (Strongest Acidic)	9.48	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	66.76 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	50.4 m³·mol⁻¹	ChemAxon
Polarizability	20.08 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

34501411

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

54707040

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Zhang YL, Ge HM, Li F, Song YC, Tan RX: New phytotoxic metabolites from Pestalotiopsis sp. HC02, a Fungus Residing in Chondracris rosee gut. Chem Biodivers. 2008 Nov;5(11):2402-7. doi: 10.1002/cbdv.200890204. [PubMed:19035568 ]
Cimmino A, Bahmani Z, Masi M, Abdollahzadeh J, Amini J, Tuzi A, Evidente A: Phytotoxins produced by Didymella glomerata and Truncatella angustata, associated with grapevine trunk diseases (GTDs) in Iran. Nat Prod Res. 2022 Sep;36(17):4322-4329. doi: 10.1080/14786419.2021.1979544. Epub 2021 Oct 20. [PubMed:34668831 ]
Chen S, Zhang Z, Li L, Liu X, Ren F: Two new ramulosin derivatives from the entomogenous fungus Truncatella angustata. Nat Prod Commun. 2015 Feb;10(2):341-4. [PubMed:25920279 ]
LOTUS database [Link]

Showing NP-Card for (3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one (NP0290433)

MOL for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)

3D MOL for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)

3D SDF for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)

3D-SDF for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)

PDB for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)

3D PDB for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)

SMILES for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)

INCHI for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)

Structure for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)

3D Structure for NP0290433 ((3r,4as,6r)-6,8-dihydroxy-3-methyl-3,4,4a,5,6,7-hexahydro-2-benzopyran-1-one)