NP-MRD: Showing NP-Card for 12-demethylmulticaulin (NP0290392)

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Record Information

Version

2.0

Created at

2022-09-09 21:03:24 UTC

Updated at

2022-09-09 21:03:24 UTC

NP-MRD ID

NP0290392

Secondary Accession Numbers

None

Natural Product Identification

Common Name

12-demethylmulticaulin

Description

12-Demethylmulticaulin belongs to the class of organic compounds known as diterpenoids. These are terpene compounds formed by four isoprene units. 12-demethylmulticaulin is found in Salvia multicaulis. 12-demethylmulticaulin was first documented in 1997 (PMID: 9428161). 12-Demethylmulticaulin is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 40 42  0  0  0  0  0  0  0  0999 V2000
   -5.6262   -0.1238    0.7153 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1391   -0.0762    0.6383 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3670   -0.2605    1.7679 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9850   -0.2219    1.7278 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3450    0.0063    0.5314 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0787    0.1987   -0.6386 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4593    0.4278   -1.8446 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0923    0.4745   -1.9340 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6770    0.2893   -0.8001 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0546    0.3314   -0.8640 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7933    0.1432    0.2821 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2723    0.1809    0.2189 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7597    0.5584   -1.1678 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7975   -1.2124    0.4890 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1808   -0.0860    1.4899 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9367   -0.2751    2.6472 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7789   -0.1319    1.5712 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0528    0.0580    0.4174 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4699    0.1484   -0.5342 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2442    0.3537   -1.7850 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0711   -0.7033   -0.1089 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0673    0.8865    0.8367 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8868   -0.6815    1.6581 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9081   -0.4386    2.6962 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4766   -0.3754    2.6537 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0402    0.5729   -2.7346 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4379    0.6520   -2.8599 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5096    0.5130   -1.8243 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6835    0.8521    0.9735 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8583    0.6577   -1.1983 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4743   -0.2001   -1.9225 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2841    1.5145   -1.4674 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9669   -1.8818    0.8297 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6471   -1.2169    1.1936 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1734   -1.7032   -0.4477 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9407   -0.2348    2.5707 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3527   -0.3132    2.5333 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2945    0.5656   -1.5064 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9064    1.2813   -2.3341 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1745   -0.5294   -2.4697 H   0  0  0  0  0  0  0  0  0  0  0  0
 13 12  1  0
 12 14  1  0
 12 11  1  0
 11 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  2  0
 18  9  1  0
  9  8  1  0
  8  7  2  0
  7  6  1  0
  6 19  2  0
 19 20  1  0
 19  2  1  0
  2  1  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  9 10  2  0
 10 11  1  0
  5 18  1  0
  5  6  1  0
 13 30  1  0
 13 31  1  0
 13 32  1  0
 12 29  1  0
 14 33  1  0
 14 34  1  0
 14 35  1  0
 16 36  1  0
 17 37  1  0
  8 27  1  0
  7 26  1  0
 20 38  1  0
 20 39  1  0
 20 40  1  0
  1 21  1  0
  1 22  1  0
  1 23  1  0
  3 24  1  0
  4 25  1  0
 10 28  1  0
M  END


  Mrv1533004231520452D          

 20 22  0  0  0  0            999 V2000
    0.7954   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
  9 16  1  0  0  0  0
 16 17  1  0  0  0  0
  6 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
  4 19  2  0  0  0  0
 19 20  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0290392

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)C1=C(O)C=C2C(C=CC3=C(C)C(C)=CC=C23)=C1

> <INCHI_IDENTIFIER>
InChI=1S/C19H20O/c1-11(2)17-9-14-6-8-15-13(4)12(3)5-7-16(15)18(14)10-19(17)20/h5-11,20H,1-4H3

> <INCHI_KEY>
ZMSKUQUFEKLXGK-UHFFFAOYSA-N

> <FORMULA>
C19H20O

> <MOLECULAR_WEIGHT>
264.368

> <EXACT_MASS>
264.151415264

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
40

> <JCHEM_AVERAGE_POLARIZABILITY>
32.06227285647118

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
7,8-dimethyl-2-(propan-2-yl)phenanthren-3-ol

> <ALOGPS_LOGP>
5.85

> <JCHEM_LOGP>
5.9204859370000005

> <ALOGPS_LOGS>
-6.39

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.230506217051824

> <JCHEM_PKA_STRONGEST_BASIC>
-5.252759534426532

> <JCHEM_POLAR_SURFACE_AREA>
20.23

> <JCHEM_REFRACTIVITY>
85.21249999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.07e-04 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-isopropyl-7,8-dimethylphenanthren-3-ol

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 23-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-APR-15         0                                  
HETATM    1  C   UNK     0       1.485  -2.874   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.255  -1.540   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.485  -0.206   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.795  -1.540   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.565  -0.206   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.105  -0.206   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.875   1.127   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.415   1.127   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.185  -0.206   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      10.725  -0.206   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      11.495   1.127   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      11.495  -1.540   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      13.035  -1.540   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      10.725  -2.874   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       9.185  -2.874   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       8.415  -1.540   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       6.875  -1.540   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       6.105  -2.874   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       4.565  -2.874   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       3.795  -4.207   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5   19                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7   17                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   16                                                  
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15    9   17                                                  
CONECT   17   16    6   18                                                  
CONECT   18   17   19                                                       
CONECT   19   18    4   20                                                  
CONECT   20   19                                                            
MASTER        0    0    0    0    0    0    0    0   20    0   44    0
END

View in JSmol

Synonyms

Value	Source
12-Hydroxy-abieta-1,3,5(10),6,8,11,13-heptaene	ChEBI

Chemical Formula

C₁₉H₂₀O

Average Mass

264.3680 Da

Monoisotopic Mass

264.15142 Da

IUPAC Name

7,8-dimethyl-2-(propan-2-yl)phenanthren-3-ol

Traditional Name

2-isopropyl-7,8-dimethylphenanthren-3-ol

CAS Registry Number

Not Available

SMILES

CC(C)C1=C(O)C=C2C(C=CC3=C(C)C(C)=CC=C23)=C1

InChI Identifier

InChI=1S/C19H20O/c1-11(2)17-9-14-6-8-15-13(4)12(3)5-7-16(15)18(14)10-19(17)20/h5-11,20H,1-4H3

InChI Key

ZMSKUQUFEKLXGK-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Salvia multicaulis	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as diterpenoids. These are terpene compounds formed by four isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Diterpenoids

Alternative Parents

Substituents

Diterpenoid
Abietane diterpenoid
Phenanthrol
Phenanthrene
2-naphthol
Naphthalene
1-hydroxy-2-unsubstituted benzenoid
Benzenoid
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Aromatic homopolycyclic compound

Molecular Framework

Aromatic homopolycyclic compounds

External Descriptors

phenols (CHEBI:66408 )
diterpenoid (CHEBI:66408 )
phenanthrenes (CHEBI:66408 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.85	ALOGPS
logP	5.92	ChemAxon
logS	-6.4	ALOGPS
pKa (Strongest Acidic)	10.23	ChemAxon
pKa (Strongest Basic)	-5.3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	20.23 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	85.21 m³·mol⁻¹	ChemAxon
Polarizability	32.06 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

467783

PDB ID

Not Available

ChEBI ID

66408

Good Scents ID

Not Available

References

General References

Ulubelen A, Topcu G, Johansson CB: Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity. J Nat Prod. 1997 Dec;60(12):1275-80. doi: 10.1021/np9700681. [PubMed:9428161 ]
LOTUS database [Link]

Showing NP-Card for 12-demethylmulticaulin (NP0290392)

MOL for NP0290392 (12-demethylmulticaulin)

3D MOL for NP0290392 (12-demethylmulticaulin)

3D SDF for NP0290392 (12-demethylmulticaulin)

3D-SDF for NP0290392 (12-demethylmulticaulin)

PDB for NP0290392 (12-demethylmulticaulin)

3D PDB for NP0290392 (12-demethylmulticaulin)

SMILES for NP0290392 (12-demethylmulticaulin)

INCHI for NP0290392 (12-demethylmulticaulin)

Structure for NP0290392 (12-demethylmulticaulin)

3D Structure for NP0290392 (12-demethylmulticaulin)