NP-MRD: Showing NP-Card for (4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate (NP0289715)

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Record Information

Version

2.0

Created at

2022-09-09 20:02:24 UTC

Updated at

2022-09-09 20:02:24 UTC

NP-MRD ID

NP0289715

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate

Description

NSC672990 belongs to the class of organic compounds known as eremophilane, 8,9-secoeremophilane and furoeremophilane sesquiterpenoids. These are sesquiterpenoids with a structure based either on the eremophilane skeleton, its 8,9-seco derivative, or the furoeremophilane skeleton. Eremophilanes have been shown to be derived from eudesmanes by migration of the methyl group at C-10 to C-5. (4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate is found in Petasites hybridus. Based on a literature review very few articles have been published on NSC672990.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309092222022D          

 24 26  0  0  1  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6119    0.6271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -1.4924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  6  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  6  0  0  0
 10 12  1  0  0  0  0
 12 13  1  6  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  6  0  0  0
 21 23  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  1  1  0  0  0
  8 24  1  0  0  0  0
M  END

     RDKit          3D

 50 52  0  0  0  0  0  0  0  0999 V2000
    8.2992    0.1510    0.6036 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4956    0.2459    0.6398 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.9050    1.2277   -0.7318 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6112    1.2667   -0.9530 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6965    0.5136   -0.0804 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1612   -0.1632    0.8727 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3365    0.5136   -0.2589 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4823   -0.2369    0.6183 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8362   -1.3024   -0.2598 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4793   -1.6696    0.3931 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.9378   -2.9831   -0.1802 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4499   -0.5462    0.1138 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.9908   -0.7751   -1.2981 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6009   -0.5629    1.1040 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5653    0.4608    0.6313 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9102    0.5401    0.3402 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8462   -0.6056    0.4666 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1899    1.8423   -0.0726 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0633    2.5049   -0.0284 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0738    1.7302    0.3820 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6201    1.9221    0.6208 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.2180    3.0893   -0.0551 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7670    0.7756    0.2021 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3946    0.6191    1.1893 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5832   -0.6884   -0.0393 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.7369    1.0826    0.1855 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.6575    0.0531    1.6541 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.5982    1.7871   -1.3783 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2465    1.8480   -1.7672 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0639   -0.7608    1.3852 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4950   -2.2017   -0.3259 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7135   -0.9435   -1.2981 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2979   -1.8176    1.4713 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9793   -3.2288    0.0986 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2587   -3.7689    0.2590 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7848   -3.0527   -1.2746 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1680   -0.6192   -2.0163 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7722   -0.0295   -1.5486 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3908   -1.7982   -1.3658 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0888   -1.5582    1.1520 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2256   -0.2680    2.0955 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2304   -0.5768    1.5246 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6835   -0.4696   -0.2507 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2875   -1.5473    0.2857 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1788    2.1625   -0.3584 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4967    2.1694    1.7113 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2461    2.9214   -1.0259 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.0089   -0.8029 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0050    0.1440    2.1047 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8314    1.5944    1.4537 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  1  6
 12 14  1  0
 14 15  1  0
 15 20  2  0
 20 19  1  0
 19 18  1  0
 18 16  2  0
 16 17  1  0
 20 21  1  0
 21 22  1  0
 21 23  1  0
 23 24  1  0
 24  8  1  0
 23 12  1  0
 16 15  1  0
  1 25  1  0
  1 26  1  0
  1 27  1  0
  3 28  1  0
  4 29  1  0
  8 30  1  1
  9 31  1  0
  9 32  1  0
 10 33  1  1
 11 34  1  0
 11 35  1  0
 11 36  1  0
 13 37  1  0
 13 38  1  0
 13 39  1  0
 14 40  1  0
 14 41  1  0
 18 45  1  0
 17 42  1  0
 17 43  1  0
 17 44  1  0
 21 46  1  1
 22 47  1  0
 23 48  1  6
 24 49  1  0
 24 50  1  0
M  END


  Mrv1652309092222022D          

 24 26  0  0  1  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6119    0.6271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -1.4924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  6  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  6  0  0  0
 10 12  1  0  0  0  0
 12 13  1  6  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  6  0  0  0
 21 23  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  1  1  0  0  0
  8 24  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0289715

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CS\C=C/C(=O)O[C@@H]1C[C@H](C)[C@@]2(C)CC3=C(OC=C3C)[C@H](O)[C@H]2C1

> <INCHI_IDENTIFIER>
InChI=1S/C19H26O4S/c1-11-10-22-18-14(11)9-19(3)12(2)7-13(8-15(19)17(18)21)23-16(20)5-6-24-4/h5-6,10,12-13,15,17,21H,7-9H2,1-4H3/b6-5-/t12-,13+,15+,17+,19+/m0/s1

> <INCHI_KEY>
PCGQGFYOHXONPG-LBOITUOKSA-N

> <FORMULA>
C19H26O4S

> <MOLECULAR_WEIGHT>
350.47

> <EXACT_MASS>
350.155180491

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
50

> <JCHEM_AVERAGE_POLARIZABILITY>
38.51576805956996

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(4aR,5S,7R,8aS,9R)-9-hydroxy-3,4a,5-trimethyl-4H,4aH,5H,6H,7H,8H,8aH,9H-naphtho[2,3-b]furan-7-yl (2Z)-3-(methylsulfanyl)prop-2-enoate

> <JCHEM_LOGP>
3.710265907333333

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.2177903960235

> <JCHEM_PKA_STRONGEST_BASIC>
-2.74810992532192

> <JCHEM_POLAR_SURFACE_AREA>
59.67

> <JCHEM_REFRACTIVITY>
96.24929999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(4aR,5S,7R,8aS,9R)-9-hydroxy-3,4a,5-trimethyl-4H,5H,6H,7H,8H,8aH,9H-naphtho[2,3-b]furan-7-yl (2Z)-3-(methylsulfanyl)prop-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 09-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   09-SEP-22         0                                  
HETATM    1  C   UNK     0      -4.001  -2.310   0.000  0.00  0.00           C+0
HETATM    2  S   UNK     0      -2.667  -3.080   0.000  0.00  0.00           S+0
HETATM    3  C   UNK     0      -2.667  -4.620   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.334  -5.390   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.000  -4.620   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       1.334  -5.390   0.000  0.00  0.00           O+0
HETATM    7  O   UNK     0       0.000  -3.080   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.001   0.770   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       8.133  -0.294   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       8.609   1.171   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       9.038  -1.540   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       8.133  -2.786   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       5.335  -4.620   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   24                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   14   23                                             
CONECT   13   12                                                            
CONECT   14   12   15                                                       
CONECT   15   14   16   20                                                  
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   15   21                                                  
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21   12   24                                                  
CONECT   24   23    8                                                       
MASTER        0    0    0    0    0    0    0    0   24    0   52    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₉H₂₆O₄S

Average Mass

350.4700 Da

Monoisotopic Mass

350.15518 Da

IUPAC Name

(4aR,5S,7R,8aS,9R)-9-hydroxy-3,4a,5-trimethyl-4H,4aH,5H,6H,7H,8H,8aH,9H-naphtho[2,3-b]furan-7-yl (2Z)-3-(methylsulfanyl)prop-2-enoate

Traditional Name

(4aR,5S,7R,8aS,9R)-9-hydroxy-3,4a,5-trimethyl-4H,5H,6H,7H,8H,8aH,9H-naphtho[2,3-b]furan-7-yl (2Z)-3-(methylsulfanyl)prop-2-enoate

CAS Registry Number

Not Available

SMILES

CS\C=C/C(=O)O[C@@H]1C[C@H](C)[C@@]2(C)CC3=C(OC=C3C)[C@H](O)[C@H]2C1

InChI Identifier

InChI=1S/C19H26O4S/c1-11-10-22-18-14(11)9-19(3)12(2)7-13(8-15(19)17(18)21)23-16(20)5-6-24-4/h5-6,10,12-13,15,17,21H,7-9H2,1-4H3/b6-5-/t12-,13+,15+,17+,19+/m0/s1

InChI Key

PCGQGFYOHXONPG-LBOITUOKSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Petasites hybridus	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as eremophilane, 8,9-secoeremophilane and furoeremophilane sesquiterpenoids. These are sesquiterpenoids with a structure based either on the eremophilane skeleton, its 8,9-seco derivative, or the furoeremophilane skeleton. Eremophilanes have been shown to be derived from eudesmanes by migration of the methyl group at C-10 to C-5.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Eremophilane, 8,9-secoeremophilane and furoeremophilane sesquiterpenoids

Alternative Parents

Substituents

Furoeremophilane sesquiterpenoid
Naphthofuran
Benzofuran
Vinylogous thioester
Furan
Acrylic acid or derivatives
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Heteroaromatic compound
Thioenolether
Secondary alcohol
Carboxylic acid ester
Sulfenyl compound
Monocarboxylic acid or derivatives
Organoheterocyclic compound
Oxacycle
Carboxylic acid derivative
Carbonyl group
Organic oxygen compound
Organosulfur compound
Organooxygen compound
Alcohol
Organic oxide
Hydrocarbon derivative
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.71	ChemAxon
pKa (Strongest Acidic)	13.22	ChemAxon
pKa (Strongest Basic)	-2.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	59.67 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	96.25 m³·mol⁻¹	ChemAxon
Polarizability	38.52 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

4579297

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5468625

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate (NP0289715)

MOL for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)

3D MOL for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)

3D SDF for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)

3D-SDF for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)

PDB for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)

3D PDB for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)

SMILES for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)

INCHI for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)

Structure for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)

3D Structure for NP0289715 ((4ar,5s,7r,8as,9r)-9-hydroxy-3,4a,5-trimethyl-4h,5h,6h,7h,8h,8ah,9h-naphtho[2,3-b]furan-7-yl (2z)-3-(methylsulfanyl)prop-2-enoate)