NP-MRD: Showing NP-Card for 16,27-dimethyl 14,25-diethyl-24,32-dihydroxy-31-methoxy-33-oxo-12,22-dioxa-1,9,18,29-tetraazadodecacyclo[23.13.1.1⁶,⁹.0²,²³.0³,²¹.0⁵,¹⁹.0⁶,¹⁷.0¹¹,¹³.0²⁸,³⁶.0³⁰,³⁵.0³⁶,³⁹.0¹⁴,⁴⁰]tetraconta-3,5(19),16,20,27,29,31,34-octaene-16,27-dicarboxylate (NP0287385)

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Record Information

Version

2.0

Created at

2022-09-09 16:26:14 UTC

Updated at

2022-09-09 16:26:14 UTC

NP-MRD ID

NP0287385

Secondary Accession Numbers

None

Natural Product Identification

Common Name

16,27-dimethyl 14,25-diethyl-24,32-dihydroxy-31-methoxy-33-oxo-12,22-dioxa-1,9,18,29-tetraazadodecacyclo[23.13.1.1⁶,⁹.0²,²³.0³,²¹.0⁵,¹⁹.0⁶,¹⁷.0¹¹,¹³.0²⁸,³⁶.0³⁰,³⁵.0³⁶,³⁹.0¹⁴,⁴⁰]tetraconta-3,5(19),16,20,27,29,31,34-octaene-16,27-dicarboxylate

Description

16,27-Dimethyl 14,25-diethyl-24,32-dihydroxy-31-methoxy-33-oxo-12,22-dioxa-1,9,18,29-tetraazadodecacyclo[23.13.1.1⁶,⁹.0²,²³.0³,²¹.0⁵,¹⁹.0⁶,¹⁷.0¹¹,¹³.0²⁸,³⁶.0³⁰,³⁵.0³⁶,³⁹.0¹⁴,⁴⁰]Tetraconta-3(21),4,16,19,27,29,31,34-octaene-16,27-dicarboxylate belongs to the class of organic compounds known as aspidospermatan-type alkaloids. These are tryptophan-derived alkaloids that are derived from the fusion of tryptamine and a terpene unit (generally either 9 or 10 carbons). Aspidospermine and aspidospermidine (along with tabersonine) are the archetypical members of the Aspidosperma alkaloids. 16,27-Dimethyl 14,25-diethyl-24,32-dihydroxy-31-methoxy-33-oxo-12,22-dioxa-1,9,18,29-tetraazadodecacyclo[23.13.1.1⁶,⁹.0²,²³.0³,²¹.0⁵,¹⁹.0⁶,¹⁷.0¹¹,¹³.0²⁸,³⁶.0³⁰,³⁵.0³⁶,³⁹.0¹⁴,⁴⁰]Tetraconta-3(21),4,16,19,27,29,31,34-octaene-16,27-dicarboxylate is a very strong basic compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004251509212D          

 57 68  0  0  0  0            999 V2000
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M  END

     RDKit          3D

103114  0  0  0  0  0  0  0  0999 V2000
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 56102  1  6
M  END


  Mrv1533004251509212D          

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 33 35  1  0  0  0  0
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 25 42  2  0  0  0  0
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 43 44  2  0  0  0  0
 20 44  1  0  0  0  0
 23 44  1  0  0  0  0
 28 45  1  0  0  0  0
 45 46  2  0  0  0  0
 45 47  1  0  0  0  0
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 21 49  1  0  0  0  0
  3 49  1  0  0  0  0
 49 50  1  0  0  0  0
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  3 51  1  0  0  0  0
 16 51  1  0  0  0  0
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  5 54  1  0  0  0  0
 54 55  2  0  0  0  0
 54 56  1  0  0  0  0
 56 57  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0287385

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCC12CC(C(=O)OC)=C3NC4=C(C=C5C6C(OC5=C4)C(O)C4(CC)CC(C(=O)OC)=C5N=C7C(=CC(=O)C(O)=C7OC)C55CCN6C45)C33CCN(CC4OC14)C23

> <INCHI_IDENTIFIER>
InChI=1S/C43H46N4O10/c1-6-40-15-19(36(51)54-4)33-43(22-13-24(48)29(49)30(53-3)27(22)45-33)9-11-47(39(40)43)28-18-12-21-23(14-25(18)56-31(28)34(40)50)44-32-20(37(52)55-5)16-41(7-2)35-26(57-35)17-46-10-8-42(21,32)38(41)46/h12-14,26,28,31,34-35,38-39,44,49-50H,6-11,15-17H2,1-5H3

> <INCHI_KEY>
OOLHCCPNGZDTFV-UHFFFAOYSA-N

> <FORMULA>
C43H46N4O10

> <MOLECULAR_WEIGHT>
778.859

> <EXACT_MASS>
778.321393697

> <JCHEM_ACCEPTOR_COUNT>
12

> <JCHEM_ATOM_COUNT>
103

> <JCHEM_AVERAGE_POLARIZABILITY>
82.02467059851308

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
16,27-dimethyl 14,25-diethyl-24,32-dihydroxy-31-methoxy-33-oxo-12,22-dioxa-1,9,18,29-tetraazadodecacyclo[23.13.1.1⁶,⁹.0²,²³.0³,²¹.0⁵,¹⁹.0⁶,¹⁷.0¹¹,¹³.0²⁸,³⁶.0³⁰,³⁵.0³⁶,³⁹.0¹⁴,⁴⁰]tetraconta-3,5(19),16,20,27,29,31,34-octaene-16,27-dicarboxylate

> <ALOGPS_LOGP>
3.02

> <JCHEM_LOGP>
1.3316605938588684

> <ALOGPS_LOGS>
-3.49

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
12

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
13.268863838178842

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.206683667776183

> <JCHEM_PKA_STRONGEST_BASIC>
7.418410973901492

> <JCHEM_POLAR_SURFACE_AREA>
171.98999999999998

> <JCHEM_REFRACTIVITY>
208.35769999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.50e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
16,27-dimethyl 14,25-diethyl-24,32-dihydroxy-31-methoxy-33-oxo-12,22-dioxa-1,9,18,29-tetraazadodecacyclo[23.13.1.1⁶,⁹.0²,²³.0³,²¹.0⁵,¹⁹.0⁶,¹⁷.0¹¹,¹³.0²⁸,³⁶.0³⁰,³⁵.0³⁶,³⁹.0¹⁴,⁴⁰]tetraconta-3,5(19),16,20,27,29,31,34-octaene-16,27-dicarboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 25-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   25-APR-15         0                                  
HETATM    1  C   UNK     0      -0.885  -1.366   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.595  -1.793   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.704  -0.725   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.224  -0.298   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -0.146   1.197   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.963   2.265   0.000  0.00  0.00           C+0
HETATM    7  N   UNK     0       1.285   3.579   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0       2.360   4.329   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.834   4.116   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       0.255   2.689   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0      -1.270   2.477   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       1.202   1.474   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       0.623   0.047   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       2.914   1.574   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.306   3.114   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.443   1.838   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       3.750   2.652   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.928   1.661   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0       4.293  -0.083   0.000  0.00  0.00           N+0
HETATM   20  C   UNK     0       4.663  -1.578   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       3.554  -2.646   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       4.227  -4.031   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       5.752  -3.819   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       6.931  -4.811   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       8.379  -4.286   0.000  0.00  0.00           C+0
HETATM   26  N   UNK     0       9.737  -5.011   0.000  0.00  0.00           N+0
HETATM   27  C   UNK     0      10.847  -3.943   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      12.383  -4.053   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      13.246  -2.777   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      12.573  -1.392   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      14.109  -1.502   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      14.782  -2.887   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      13.436  -0.117   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0      14.299   1.159   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0      12.763   1.268   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      11.227   1.378   0.000  0.00  0.00           C+0
HETATM   37  N   UNK     0      10.364   0.103   0.000  0.00  0.00           N+0
HETATM   38  C   UNK     0       8.642  -0.592   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0       8.694  -2.131   0.000  0.00  0.00           C+0
HETATM   40  C   UNK     0      10.174  -2.558   0.000  0.00  0.00           C+0
HETATM   41  C   UNK     0      11.037  -1.283   0.000  0.00  0.00           C+0
HETATM   42  C   UNK     0       8.648  -2.770   0.000  0.00  0.00           C+0
HETATM   43  C   UNK     0       7.470  -1.779   0.000  0.00  0.00           C+0
HETATM   44  C   UNK     0       6.022  -2.303   0.000  0.00  0.00           C+0
HETATM   45  C   UNK     0      13.056  -5.438   0.000  0.00  0.00           C+0
HETATM   46  O   UNK     0      12.193  -6.713   0.000  0.00  0.00           O+0
HETATM   47  O   UNK     0      14.592  -5.548   0.000  0.00  0.00           O+0
HETATM   48  C   UNK     0      15.455  -4.272   0.000  0.00  0.00           C+0
HETATM   49  C   UNK     0       2.074  -2.220   0.000  0.00  0.00           C+0
HETATM   50  O   UNK     0       0.965  -3.288   0.000  0.00  0.00           O+0
HETATM   51  C   UNK     0       2.813   0.343   0.000  0.00  0.00           C+0
HETATM   52  O   UNK     0      -0.112   5.331   0.000  0.00  0.00           O+0
HETATM   53  C   UNK     0       0.467   6.758   0.000  0.00  0.00           C+0
HETATM   54  C   UNK     0      -1.626   1.623   0.000  0.00  0.00           C+0
HETATM   55  O   UNK     0      -1.996   3.118   0.000  0.00  0.00           O+0
HETATM   56  O   UNK     0      -2.735   0.555   0.000  0.00  0.00           O+0
HETATM   57  C   UNK     0      -4.215   0.982   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   49   51                                             
CONECT    4    3    5                                                       
CONECT    5    4    6   54                                                  
CONECT    6    5    7   16                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   15                                                  
CONECT    9    8   10   52                                                  
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15                                                       
CONECT   15   14    8   16                                                  
CONECT   16   15    6   17   51                                             
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20   51                                                  
CONECT   20   19   21   44                                                  
CONECT   21   20   22   49                                                  
CONECT   22   21   23                                                       
CONECT   23   22   24   44                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26   42                                                  
CONECT   26   25   27                                                       
CONECT   27   26   28   40                                                  
CONECT   28   27   29   45                                                  
CONECT   29   28   30                                                       
CONECT   30   29   31   33   41                                             
CONECT   31   30   32                                                       
CONECT   32   31                                                            
CONECT   33   30   34   35                                                  
CONECT   34   33   35                                                       
CONECT   35   34   33   36                                                  
CONECT   36   35   37                                                       
CONECT   37   36   38   41                                                  
CONECT   38   37   39                                                       
CONECT   39   38   40                                                       
CONECT   40   39   27   41   42                                             
CONECT   41   40   30   37                                                  
CONECT   42   40   25   43                                                  
CONECT   43   42   44                                                       
CONECT   44   43   20   23                                                  
CONECT   45   28   46   47                                                  
CONECT   46   45                                                            
CONECT   47   45   48                                                       
CONECT   48   47                                                            
CONECT   49   21    3   50                                                  
CONECT   50   49                                                            
CONECT   51   19    3   16                                                  
CONECT   52    9   53                                                       
CONECT   53   52                                                            
CONECT   54    5   55   56                                                  
CONECT   55   54                                                            
CONECT   56   54   57                                                       
CONECT   57   56                                                            
MASTER        0    0    0    0    0    0    0    0   57    0  136    0
END

View in JSmol

Synonyms

Value	Source
16,27-Dimethyl 14,25-diethyl-24,32-dihydroxy-31-methoxy-33-oxo-12,22-dioxa-1,9,18,29-tetraazadodecacyclo[23.13.1.1,.0,.0,.0,.0,.0,.0,.0,.0,.0,]tetraconta-3(21),4,16,19,27,29,31,34-octaene-16,27-dicarboxylic acid	Generator
16,27-Dimethyl 14,25-diethyl-24,32-dihydroxy-31-methoxy-33-oxo-12,22-dioxa-1,9,18,29-tetraazadodecacyclo[23.13.1.1⁶,⁹.0²,²³.0³,²¹.0⁵,¹⁹.0⁶,¹⁷.0¹¹,¹³.0²⁸,³⁶.0³⁰,³⁵.0³⁶,³⁹.0¹⁴,⁴⁰]tetraconta-3(21),4,16,19,27,29,31,34-octaene-16,27-dicarboxylic acid	Generator

Chemical Formula

C₄₃H₄₆N₄O₁₀

Average Mass

778.8590 Da

Monoisotopic Mass

778.32139 Da

IUPAC Name

Traditional Name

CAS Registry Number

Not Available

SMILES

CCC12CC(C(=O)OC)=C3NC4=C(C=C5C6C(OC5=C4)C(O)C4(CC)CC(C(=O)OC)=C5N=C7C(=CC(=O)C(O)=C7OC)C55CCN6C45)C33CCN(CC4OC14)C23

InChI Identifier

InChI=1S/C43H46N4O10/c1-6-40-15-19(36(51)54-4)33-43(22-13-24(48)29(49)30(53-3)27(22)45-33)9-11-47(39(40)43)28-18-12-21-23(14-25(18)56-31(28)34(40)50)44-32-20(37(52)55-5)16-41(7-2)35-26(57-35)17-46-10-8-42(21,32)38(41)46/h12-14,26,28,31,34-35,38-39,44,49-50H,6-11,15-17H2,1-5H3

InChI Key

OOLHCCPNGZDTFV-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aspidospermatan-type alkaloids. These are tryptophan-derived alkaloids that are derived from the fusion of tryptamine and a terpene unit (generally either 9 or 10 carbons). Aspidospermine and aspidospermidine (along with tabersonine) are the archetypical members of the Aspidosperma alkaloids.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Aspidospermatan-type alkaloids

Sub Class

Not Available

Direct Parent

Aspidospermatan-type alkaloids

Alternative Parents

Substituents

Aspidosperma alkaloid
Carbazole
Coumaran
Indolizidine
Dihydroindole
Indole or derivatives
Para-oxazepine
Alkyl aryl ether
Secondary aliphatic/aromatic amine
Aralkylamine
Epoxypiperidine
Piperidine
N-alkylpyrrolidine
Benzenoid
Dicarboxylic acid or derivatives
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Methyl ester
Pyrroline
Pyrrolidine
Vinylogous ester
Vinylogous amide
Cyclic ketone
Ketimine
Tertiary aliphatic amine
Tertiary amine
Carboxylic acid ester
Amino acid or derivatives
Secondary alcohol
Ketone
Carboxylic acid derivative
Oxacycle
Dialkyl ether
Azacycle
Enamine
Oxirane
Organoheterocyclic compound
Ether
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Secondary amine
Organic oxygen compound
Amine
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Imine
Carbonyl group
Organic nitrogen compound
Alcohol
Organooxygen compound
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.02	ALOGPS
logP	1.33	ChemAxon
logS	-3.5	ALOGPS
pKa (Strongest Acidic)	8.21	ChemAxon
pKa (Strongest Basic)	7.42	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	12	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	171.99 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	208.36 m³·mol⁻¹	ChemAxon
Polarizability	82.02 Å³	ChemAxon
Number of Rings	12	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]