NP-MRD: Showing NP-Card for (4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one (NP0286001)

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Record Information

Version

2.0

Created at

2022-09-09 14:24:05 UTC

Updated at

2022-09-09 14:24:06 UTC

NP-MRD ID

NP0286001

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one

Description

Daphnicyclidin G belongs to the class of organic compounds known as azulenes. These are polycyclic aromatic compounds containing the azulene skeleton, which consists of the cyclopentadiene ring fused to a cycloheptadiene ring. (4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one is found in Daphniphyllum macropodum. Based on a literature review very few articles have been published on Daphnicyclidin G.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309092216242D          

 25 30  0  0  1  0            999 V2000
    0.0865    2.8733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6739    2.2939    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5504    1.4782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2881    1.1087    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0260    0.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7009    0.7115    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.3608    0.2163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1593    0.4234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4953    1.1769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1157    1.9093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5633    2.5188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0590    3.1717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2822    2.8939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3064    2.0693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6767    1.5362    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4697    2.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8674    1.6961    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4878    2.4286    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8238    3.1821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2907    3.8117    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6224    3.3892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7823    4.1985    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3860    2.4567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7435    1.7132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2783    1.0318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  6  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
  6 15  1  0  0  0  0
 15 16  1  1  0  0  0
 15 17  1  0  0  0  0
 17  4  1  6  0  0  0
 18 17  1  6  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 13 21  1  0  0  0  0
 21 22  2  0  0  0  0
 11 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 25  1  0  0  0  0
M  END

     RDKit          3D

 50 55  0  0  0  0  0  0  0  0999 V2000
   -4.4518    0.5514   -0.5000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5755    0.0114    0.5628 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.1872   -1.3982    0.1838 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7701   -1.2941   -0.1008 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0449   -2.4596    0.3647 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3258   -1.8426    0.7019 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2247   -2.2533   -0.3978 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6760   -2.1019    0.0966 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0580   -0.6681   -0.2212 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2184    0.3420   -0.3762 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6373    1.5032   -1.1450 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6246    2.3047   -1.1592 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5000    1.7192   -0.4095 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8464    0.5198    0.0802 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0797   -0.3765    0.9034 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5265   -0.0913    2.3701 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3651   -0.3346    0.9168 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.2495    0.7662    0.7583 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1250    1.7943   -0.2609 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.4439    1.4121   -1.5622 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7573    2.4102   -0.2943 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6738    3.6773   -0.2145 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0303    1.5024   -1.6898 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9201    0.7937   -0.6608 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4219   -0.4835   -0.3452 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5258    1.6456   -0.5669 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5094    0.2358   -0.2316 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3224    0.0529   -1.5063 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1357   -0.0508    1.5199 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3166   -2.0826    1.0524 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7592   -1.7615   -0.6960 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5185   -2.8283    1.3221 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9742   -3.2470   -0.3848 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7012   -2.3360    1.6408 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1446   -1.6417   -1.3147 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0869   -3.3107   -0.6789 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6602   -2.2339    1.1932 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3458   -2.8135   -0.3835 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6349    3.2654   -1.6596 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2999    0.9909    2.5183 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6294   -0.2013    2.3768 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0032   -0.7550    3.0575 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6930   -0.8739    1.8739 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3689    1.2942    1.7557 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8131    2.6504    0.0173 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3841    2.2574   -2.1070 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3913    2.5449   -1.7761 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1052    1.0304   -2.6703 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9595    1.4687    0.2224 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9134    0.6952   -1.1482 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 23  1  0
 23 24  1  0
 24 25  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  1
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 18  2  1  0
 17  4  1  0
 15  6  1  0
 25  9  1  0
 21 13  1  0
 14 10  1  0
  1 26  1  0
  1 27  1  0
  1 28  1  0
  2 29  1  1
  3 30  1  0
  3 31  1  0
  5 32  1  0
  5 33  1  0
  6 34  1  1
  7 35  1  0
  7 36  1  0
  8 37  1  0
  8 38  1  0
 23 47  1  0
 23 48  1  0
 24 49  1  0
 24 50  1  0
 12 39  1  0
 16 40  1  0
 16 41  1  0
 16 42  1  0
 17 43  1  1
 18 44  1  1
 19 45  1  1
 20 46  1  0
M  END


  Mrv1652309092216242D          

 25 30  0  0  1  0            999 V2000
    0.0865    2.8733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6739    2.2939    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5504    1.4782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2881    1.1087    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0260    0.3707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7009    0.7115    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.3608    0.2163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1593    0.4234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4953    1.1769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1157    1.9093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5633    2.5188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0590    3.1717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2822    2.8939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3064    2.0693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6767    1.5362    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4697    2.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8674    1.6961    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4878    2.4286    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8238    3.1821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2907    3.8117    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6224    3.3892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7823    4.1985    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3860    2.4567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7435    1.7132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2783    1.0318    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  6  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
  6 15  1  0  0  0  0
 15 16  1  1  0  0  0
 15 17  1  0  0  0  0
 17  4  1  6  0  0  0
 18 17  1  6  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 13 21  1  0  0  0  0
 21 22  2  0  0  0  0
 11 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 25  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0286001

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]1CN2C[C@H]3CCC4=C5C(CCO4)=CC4=C5[C@@]3(C)[C@H]2[C@H]1C(O)C4=O

> <INCHI_IDENTIFIER>
InChI=1S/C21H25NO3/c1-10-8-22-9-12-3-4-14-16-11(5-6-25-14)7-13-17(16)21(12,2)20(22)15(10)19(24)18(13)23/h7,10,12,15,19-20,24H,3-6,8-9H2,1-2H3/t10-,12+,15+,19?,20+,21-/m0/s1

> <INCHI_KEY>
PYXQAQFMQJTSTQ-PQLWOAINSA-N

> <FORMULA>
C21H25NO3

> <MOLECULAR_WEIGHT>
339.435

> <EXACT_MASS>
339.183443669

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
50

> <JCHEM_AVERAGE_POLARIZABILITY>
36.93876517235748

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(4S,5R,8R,9S,10S)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1^{7,10}.0^{4,8}.0^{9,19}.0^{13,18}]henicosa-1(19),13(18),17(20)-trien-2-one

> <JCHEM_LOGP>
0.4899482853333328

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.081520128318193

> <JCHEM_PKA_STRONGEST_BASIC>
10.253189237209249

> <JCHEM_POLAR_SURFACE_AREA>
49.769999999999996

> <JCHEM_REFRACTIVITY>
97.65249999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(4S,5R,8R,9S,10S)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1^{7,10}.0^{4,8}.0^{9,19}.0^{13,18}]henicosa-1(19),13(18),17(20)-trien-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 09-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   09-SEP-22         0                                  
HETATM    1  C   UNK     0       0.161   5.363   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.258   4.282   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.027   2.759   0.000  0.00  0.00           C+0
HETATM    4  N   UNK     0       2.404   2.070   0.000  0.00  0.00           N+0
HETATM    5  C   UNK     0       3.782   0.692   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.042   1.328   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.273   0.404   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.764   0.790   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.391   2.197   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       7.683   3.564   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       8.518   4.702   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.577   5.921   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.127   5.402   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.172   3.863   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.997   2.868   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       4.610   4.358   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       3.486   3.166   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       2.777   4.533   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       3.404   5.940   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       2.409   7.115   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       4.895   6.326   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       5.194   7.837   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0      10.054   4.586   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      10.721   3.198   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       9.853   1.926   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   18                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5   17                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7   15                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   25                                                  
CONECT   10    9   11   14                                                  
CONECT   11   10   12   23                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   21                                                  
CONECT   14   13   10   15                                                  
CONECT   15   14    6   16   17                                             
CONECT   16   15                                                            
CONECT   17   15    4   18                                                  
CONECT   18   17    2   19                                                  
CONECT   19   18   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   13   22                                                  
CONECT   22   21                                                            
CONECT   23   11   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24    9                                                       
MASTER        0    0    0    0    0    0    0    0   25    0   60    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₁H₂₅NO₃

Average Mass

339.4350 Da

Monoisotopic Mass

339.18344 Da

IUPAC Name

(4S,5R,8R,9S,10S)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1^{7,10}.0^{4,8}.0^{9,19}.0^{13,18}]henicosa-1(19),13(18),17(20)-trien-2-one

Traditional Name

(4S,5R,8R,9S,10S)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1^{7,10}.0^{4,8}.0^{9,19}.0^{13,18}]henicosa-1(19),13(18),17(20)-trien-2-one

CAS Registry Number

Not Available

SMILES

C[C@H]1CN2C[C@H]3CCC4=C5C(CCO4)=CC4=C5[C@@]3(C)[C@H]2[C@H]1C(O)C4=O

InChI Identifier

InChI=1S/C21H25NO3/c1-10-8-22-9-12-3-4-14-16-11(5-6-25-14)7-13-17(16)21(12,2)20(22)15(10)19(24)18(13)23/h7,10,12,15,19-20,24H,3-6,8-9H2,1-2H3/t10-,12+,15+,19?,20+,21-/m0/s1

InChI Key

PYXQAQFMQJTSTQ-PQLWOAINSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Daphniphyllum macropodum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as azulenes. These are polycyclic aromatic compounds containing the azulene skeleton, which consists of the cyclopentadiene ring fused to a cycloheptadiene ring.

Kingdom

Organic compounds

Super Class

Hydrocarbons

Class

Unsaturated hydrocarbons

Sub Class

Olefins

Direct Parent

Azulenes

Alternative Parents

Substituents

Azulene
Pyrrolizidine
N-alkylpyrrolidine
Pyrrolidine
Ketone
Secondary alcohol
Tertiary amine
Tertiary aliphatic amine
Organoheterocyclic compound
Azacycle
Oxacycle
Organic oxide
Organic nitrogen compound
Amine
Organopnictogen compound
Organic oxygen compound
Organooxygen compound
Organonitrogen compound
Alcohol
Carbonyl group
Hydrocarbon derivative
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.49	ChemAxon
pKa (Strongest Acidic)	13.08	ChemAxon
pKa (Strongest Basic)	10.25	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	49.77 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	97.65 m³·mol⁻¹	ChemAxon
Polarizability	36.94 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

102305516

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one (NP0286001)

MOL for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)

3D MOL for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)

3D SDF for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)

3D-SDF for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)

PDB for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)

3D PDB for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)

SMILES for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)

INCHI for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)

Structure for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)

3D Structure for NP0286001 ((4s,5r,8r,9s,10s)-3-hydroxy-5,9-dimethyl-14-oxa-7-azahexacyclo[15.2.1.1⁷,¹⁰.0⁴,⁸.0⁹,¹⁹.0¹³,¹⁸]henicosa-1(19),13(18),17(20)-trien-2-one)