NP-MRD: Showing NP-Card for {[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid (NP0285247)

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Record Information

Version

2.0

Created at

2022-09-09 13:19:59 UTC

Updated at

2022-09-09 13:20:00 UTC

NP-MRD ID

NP0285247

Secondary Accession Numbers

None

Natural Product Identification

Common Name

{[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid

Description

{[13-Hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]Pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides. {[13-Hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]Pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004241513022D          

 44 46  0  0  0  0            999 V2000
    3.9597    3.4891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3015    2.9917    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4032    2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1393    2.5454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7210    1.9604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5362    2.0871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3443    1.2264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5374    0.3444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3336    0.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0268    0.5760    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    0.0549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3686   -0.7144    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5449   -0.6689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9598   -1.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1636   -1.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5785   -1.6164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7897   -2.4139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5860   -2.6297    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2047   -2.9956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1317   -2.2110    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
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 31 37  1  0  0  0  0
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 15 39  1  0  0  0  0
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 39 40  2  0  0  0  0
 13 41  1  0  0  0  0
 41 42  1  0  0  0  0
 41 43  1  0  0  0  0
 41 44  1  0  0  0  0
M  END

     RDKit          3D

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M  END


  Mrv1533004241513022D          

 44 46  0  0  0  0            999 V2000
    3.9597    3.4891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3015    2.9917    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1393    2.5454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7210    1.9604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5362    2.0871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3443    1.2264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5374    0.3444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3336    0.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0268    0.5760    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    0.0549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3686   -0.7144    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5449   -0.6689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9598   -1.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1636   -1.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5785   -1.6164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7897   -2.4139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5860   -2.6297    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2047   -2.9956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4084   -2.7798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1972   -1.9823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4009   -1.7665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1897   -0.9690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3934   -0.7531    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1916   -1.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7747   -0.3873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9785   -0.1715    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7672    0.6260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0290    0.8419    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3523    1.2077    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5635    0.4102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1486    0.9919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9373    1.7894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1411    2.0052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5224    2.3711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2939    3.1638    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0462    1.0529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4159   -3.7931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9523   -0.2372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1561   -0.0214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8383   -1.4399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0672   -1.7334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6094   -1.1465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1317   -2.2110    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  4  0  0  0
 21 22  2  0  0  0  0
 22 23  1  4  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 26 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  4  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
  3 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 37  1  0  0  0  0
 19 38  1  0  0  0  0
 15 39  1  0  0  0  0
  8 39  1  0  0  0  0
 39 40  2  0  0  0  0
 13 41  1  0  0  0  0
 41 42  1  0  0  0  0
 41 43  1  0  0  0  0
 41 44  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0285247

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1CC(C)CC2=C3OCOC3(C=C(NC(=O)C(C)=CC=CC(OC)C(OC(N)=O)C(C)=CC(C)C1O)C2=O)C(C)(C)O

> <INCHI_IDENTIFIER>
InChI=1S/C32H46N2O10/c1-17-12-21-26(36)22(15-32(31(5,6)39)28(21)42-16-43-32)34-29(37)18(2)10-9-11-23(40-7)27(44-30(33)38)20(4)14-19(3)25(35)24(13-17)41-8/h9-11,14-15,17,19,23-25,27,35,39H,12-13,16H2,1-8H3,(H2,33,38)(H,34,37)

> <INCHI_KEY>
YKDKEARSLSHDPX-UHFFFAOYSA-N

> <FORMULA>
C32H46N2O10

> <MOLECULAR_WEIGHT>
618.724

> <EXACT_MASS>
618.315245689

> <JCHEM_ACCEPTOR_COUNT>
9

> <JCHEM_ATOM_COUNT>
90

> <JCHEM_AVERAGE_POLARIZABILITY>
64.49154520187673

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl carbamate

> <ALOGPS_LOGP>
2.33

> <JCHEM_LOGP>
1.896350179999999

> <ALOGPS_LOGS>
-4.78

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.679440393589154

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.842506497717565

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9197218805722547

> <JCHEM_POLAR_SURFACE_AREA>
175.86999999999998

> <JCHEM_REFRACTIVITY>
166.20150000000007

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.02e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl carbamate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-APR-15         0                                  
HETATM    1  C   UNK     0       7.391   6.513   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       6.163   5.584   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       6.353   4.056   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       7.727   4.751   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       8.813   3.659   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.334   3.896   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       8.109   2.289   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.470   0.643   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.956   0.240   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      11.250   1.075   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0      12.444   0.103   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0      11.888  -1.334   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0      10.350  -1.249   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       9.258  -2.334   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       7.772  -1.932   0.000  0.00  0.00           C+0
HETATM   16  N   UNK     0       6.680  -3.017   0.000  0.00  0.00           N+0
HETATM   17  C   UNK     0       7.074  -4.506   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       8.561  -4.909   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       5.982  -5.592   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       4.496  -5.189   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       4.101  -3.700   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.615  -3.297   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.221  -1.809   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       0.734  -1.406   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0      -0.358  -2.492   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       3.313  -0.723   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       1.826  -0.320   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       1.432   1.169   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0      -0.054   1.571   0.000  0.00  0.00           O+0
HETATM   30  N   UNK     0       2.524   2.254   0.000  0.00  0.00           N+0
HETATM   31  C   UNK     0       2.919   0.766   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       4.011   1.852   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       3.616   3.340   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       2.130   3.743   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       4.708   4.426   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0       4.282   5.906   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0       1.953   1.965   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0       6.376  -7.080   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0       7.378  -0.443   0.000  0.00  0.00           C+0
HETATM   40  O   UNK     0       5.891  -0.040   0.000  0.00  0.00           O+0
HETATM   41  C   UNK     0      10.898  -2.688   0.000  0.00  0.00           C+0
HETATM   42  C   UNK     0       9.459  -3.236   0.000  0.00  0.00           C+0
HETATM   43  C   UNK     0      12.337  -2.140   0.000  0.00  0.00           C+0
HETATM   44  O   UNK     0      11.446  -4.127   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   35                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   39                                                  
CONECT    9    8   10   13                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12    9   14   41                                             
CONECT   14   13   15                                                       
CONECT   15   14   16   39                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   20   38                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   26                                                  
CONECT   24   23   25                                                       
CONECT   25   24                                                            
CONECT   26   23   27   31                                                  
CONECT   27   26   28                                                       
CONECT   28   27   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28                                                            
CONECT   31   26   32   37                                                  
CONECT   32   31   33                                                       
CONECT   33   32   34   35                                                  
CONECT   34   33                                                            
CONECT   35   33    3   36                                                  
CONECT   36   35                                                            
CONECT   37   31                                                            
CONECT   38   19                                                            
CONECT   39   15    8   40                                                  
CONECT   40   39                                                            
CONECT   41   13   42   43   44                                             
CONECT   42   41                                                            
CONECT   43   41                                                            
CONECT   44   41                                                            
MASTER        0    0    0    0    0    0    0    0   44    0   92    0
END

View in JSmol

Synonyms

Value	Source
{[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0,]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidate	Generator
{[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidate	Generator

Chemical Formula

C₃₂H₄₆N₂O₁₀

Average Mass

618.7240 Da

Monoisotopic Mass

618.31525 Da

IUPAC Name

13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl carbamate

Traditional Name

13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl carbamate

CAS Registry Number

Not Available

SMILES

COC1CC(C)CC2=C3OCOC3(C=C(NC(=O)C(C)=CC=CC(OC)C(OC(N)=O)C(C)=CC(C)C1O)C2=O)C(C)(C)O

InChI Identifier

InChI=1S/C32H46N2O10/c1-17-12-21-26(36)22(15-32(31(5,6)39)28(21)42-16-43-32)34-29(37)18(2)10-9-11-23(40-7)27(44-30(33)38)20(4)14-19(3)25(35)24(13-17)41-8/h9-11,14-15,17,19,23-25,27,35,39H,12-13,16H2,1-8H3,(H2,33,38)(H,34,37)

InChI Key

YKDKEARSLSHDPX-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Macrolactams

Sub Class

Not Available

Direct Parent

Macrolactams

Alternative Parents

Substituents

Macrolactam
Meta-dioxolane
Tertiary alcohol
Vinylogous ester
Carboxamide group
Ketone
Lactam
Secondary alcohol
Secondary carboxylic acid amide
Acetal
Carboximidic acid derivative
Carboxylic acid derivative
Dialkyl ether
Ether
Oxacycle
Azacycle
Organoheterocyclic compound
Imine
Carbonyl group
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organonitrogen compound
Organooxygen compound
Organic nitrogen compound
Organic oxygen compound
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.33	ALOGPS
logP	1.9	ChemAxon
logS	-4.8	ALOGPS
pKa (Strongest Acidic)	12.84	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	9	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	175.87 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	166.2 m³·mol⁻¹	ChemAxon
Polarizability	64.49 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

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METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for {[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid (NP0285247)

MOL for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)

3D MOL for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)

3D SDF for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)

3D-SDF for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)

PDB for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)

3D PDB for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)

SMILES for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)

INCHI for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)

Structure for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)

3D Structure for NP0285247 ({[13-hydroxy-23-(2-hydroxypropan-2-yl)-8,14-dimethoxy-4,10,12,16-tetramethyl-3,25-dioxo-20,22-dioxa-2-azatricyclo[16.6.1.0¹⁹,²³]pentacosa-1(24),4,6,10,18-pentaen-9-yl]oxy}methanimidic acid)