NP-MRD: Showing NP-Card for [3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid (NP0283874)

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Record Information

Version

2.0

Created at

2022-09-09 11:19:25 UTC

Updated at

2022-09-09 11:19:25 UTC

NP-MRD ID

NP0283874

Secondary Accession Numbers

None

Natural Product Identification

Common Name

[3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid

Description

AC1L7UWD belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom. [3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid is found in Penicillium italicum. AC1L7UWD is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 39 39  0  0  0  0  0  0  0  0999 V2000
   -4.0877    2.1725   -1.1645 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4722    0.7846   -1.5453 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0904   -0.2609   -0.5371 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6015   -0.3153   -0.2923 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3308   -1.3943    0.7322 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.0483   -1.0781    2.0172 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8809   -1.5007    1.0443 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0315   -0.7331    0.4994 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4219   -0.8972    0.8538 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7375   -1.8060    1.7088 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4823   -0.0727    0.2805 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7732   -0.1384    0.5327 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3443   -1.0420    1.4214 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4912    0.8692   -0.2548 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7895    1.0903   -0.2564 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3603    2.1197   -1.0854 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6235    2.8228   -1.8208 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7260    2.3479   -1.0831 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5472    1.5528   -1.0040 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3018    0.9902   -0.6912 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2558    1.4250   -1.2346 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9962    2.8076   -0.9478 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.7250   -2.0035 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4410    2.2636   -0.2932 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0624    0.5790   -2.5551 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5776    0.7464   -1.6521 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6575   -0.1057    0.3842 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4005   -1.2460   -0.9578 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0844   -0.6266   -1.2229 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2112    0.6624   -0.0019 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6636   -2.3579    0.3342 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3867   -1.2045    2.8982 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9661   -1.7207    2.1520 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4083   -0.0365    1.9956 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6080   -2.2665    1.7656 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2583    0.0132   -0.2072 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1086   -0.9239    2.4048 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4293    0.4798    0.3822 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.3820    1.7548   -0.5960 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  5  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 19  1  0
 19 20  1  0
 20 21  2  0
 14 15  2  0
 15 16  1  0
 16 18  1  0
 16 17  2  0
 20 11  1  0
  1 22  1  0
  1 23  1  0
  1 24  1  0
  2 25  1  0
  2 26  1  0
  3 27  1  0
  3 28  1  0
  4 29  1  0
  4 30  1  0
  5 31  1  6
  6 32  1  0
  6 33  1  0
  6 34  1  0
  7 35  1  0
  8 36  1  0
 13 37  1  0
 15 38  1  0
 18 39  1  0
M  END


  Mrv1533004251512542D          

 21 21  0  0  0  0            999 V2000
    2.5414   -3.1234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2559   -2.7109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9704   -3.1234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6848   -2.7109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3993   -3.1234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3993   -3.9484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1138   -2.7109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8282   -3.1234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5427   -2.7109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5427   -1.8859    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2572   -3.1234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0109   -2.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1824   -1.9809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.5629   -3.4009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3834   -3.3147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7189   -2.5610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2340   -1.8936    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.5394   -2.4748    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1504   -4.1154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3434   -3.9439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7303   -4.4959    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  7  5  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  4  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0283874

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCC(C)C=CC(=O)C1=C(O)C(OC1=O)=CC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C15H18O6/c1-3-4-5-9(2)6-7-10(16)13-14(19)11(8-12(17)18)21-15(13)20/h6-9,19H,3-5H2,1-2H3,(H,17,18)

> <INCHI_KEY>
DPHXIYPTUGEXJY-UHFFFAOYSA-N

> <FORMULA>
C15H18O6

> <MOLECULAR_WEIGHT>
294.303

> <EXACT_MASS>
294.1103383

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
39

> <JCHEM_AVERAGE_POLARIZABILITY>
30.172314107286383

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
2-[3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxo-2,5-dihydrofuran-2-ylidene]acetic acid

> <ALOGPS_LOGP>
2.49

> <JCHEM_LOGP>
2.637203256666666

> <ALOGPS_LOGS>
-4.13

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
3.0551518304430254

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.2552403914783063

> <JCHEM_PKA_STRONGEST_BASIC>
-7.359633254024184

> <JCHEM_POLAR_SURFACE_AREA>
100.9

> <JCHEM_REFRACTIVITY>
78.11719999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.17e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
[3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 25-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   25-APR-15         0                                  
HETATM    1  C   UNK     0       4.744  -5.830   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.078  -5.060   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       7.411  -5.830   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       8.745  -5.060   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      10.079  -5.830   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.079  -7.370   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      11.412  -5.060   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      12.746  -5.830   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      14.080  -5.060   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      14.080  -3.520   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0      15.413  -5.830   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      16.820  -5.204   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0      17.140  -3.698   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0      17.851  -6.348   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      19.382  -6.187   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      20.009  -4.781   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      19.103  -3.535   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0      21.540  -4.620   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0      17.081  -7.682   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0      15.574  -7.362   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      14.430  -8.392   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12   20                                                  
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15   19                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16                                                            
CONECT   19   14   20                                                       
CONECT   20   19   11   21                                                  
CONECT   21   20                                                            
MASTER        0    0    0    0    0    0    0    0   21    0   42    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₁₈O₆

Average Mass

294.3030 Da

Monoisotopic Mass

294.11034 Da

IUPAC Name

2-[3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxo-2,5-dihydrofuran-2-ylidene]acetic acid

Traditional Name

[3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid

CAS Registry Number

Not Available

SMILES

CCCCC(C)C=CC(=O)C1=C(O)C(OC1=O)=CC(O)=O

InChI Identifier

InChI=1S/C15H18O6/c1-3-4-5-9(2)6-7-10(16)13-14(19)11(8-12(17)18)21-15(13)20/h6-9,19H,3-5H2,1-2H3,(H,17,18)

InChI Key

DPHXIYPTUGEXJY-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Penicillium italicum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Dihydrofurans

Sub Class

Furanones

Direct Parent

Butenolides

Alternative Parents

Substituents

2-furanone
Dicarboxylic acid or derivatives
Acryloyl-group
Enol ester
Vinylogous acid
Alpha,beta-unsaturated ketone
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Enone
Carboxylic acid ester
Ketone
Lactone
Enol
Oxacycle
Carboxylic acid
Carboxylic acid derivative
Hydrocarbon derivative
Organic oxygen compound
Carbonyl group
Organooxygen compound
Organic oxide
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.49	ALOGPS
logP	2.64	ChemAxon
logS	-4.1	ALOGPS
pKa (Strongest Acidic)	1.26	ChemAxon
pKa (Strongest Basic)	-7.4	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	100.9 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	78.12 m³·mol⁻¹	ChemAxon
Polarizability	30.17 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

54687015

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for [3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid (NP0283874)

MOL for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)

3D MOL for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)

3D SDF for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)

3D-SDF for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)

PDB for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)

3D PDB for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)

SMILES for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)

INCHI for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)

Structure for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)

3D Structure for NP0283874 ([3-hydroxy-4-(4-methyloct-2-enoyl)-5-oxofuran-2-ylidene]acetic acid)